Fateme Ghourchian; Leila Torkian; Negar Motakef Kazemi
Abstract
Objective(s): Hydroxyapatite (HAP) is a natural calcium apatite mineral. Hydroxyapatite has many applications in the field of biomedicine and drug delivery systems. Titanium dioxide (TiO2) is becoming increasingly important because of its potential use in new medical treatments. In this study, titania-hydroxyapatite ...
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Objective(s): Hydroxyapatite (HAP) is a natural calcium apatite mineral. Hydroxyapatite has many applications in the field of biomedicine and drug delivery systems. Titanium dioxide (TiO2) is becoming increasingly important because of its potential use in new medical treatments. In this study, titania-hydroxyapatite composite nanoparticles were evaluated as a potential drug carrier for ibuprofen.Methods: Titania-hydroxyapatite composite nanoparticles (titania-HAP) with two different titania weight ratios (30 and 70 wt%) were prepared and loaded with ibuprofen (IBU) as a pain reliever drug. The composites were studied as potential carriers of ibuprofen by X-ray diffraction (XRD) patterns, field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) analyzes, energy dispersive X-ray spectrum (EDX), Fourier transform infrared spectroscopy (FTIR), and thermal gravimetric analysis (TGA). Cytotoxicity of nanocomposites was investigated in vitro on osteosarcoma cell line by MTT assay. Results: The functional groups were investigated by FTIR. Size and morphology of samples were evaluated by FESEM and TEM. Chemical composition and phase formation were confirmed by EDX and XRD patterns. Based on the results of MTT assay, no significant effect was observed on MG-63 cell lines. TGA was used to determine the amount of ibuprofen loaded on the composites.Conclusions: Ibuprofen release was studied in neutral and acidic simulated media by ultraviolet–visible (UV-visible) spectroscopy and the results showed better sustained release of the drug in acidic medium. Titania-hydroxyapatite composite nanoparticle can have a good potential for medicinal applications.
nanomedicine
Yasaman Rahvar; Negar Motakef-Kazemi; Reza Hosseini Doust
Abstract
Objective(s): In recent years, nanomaterials with anti-bacterial activity have acted as antibiotics, and a new method of nanotechnology treatment is available. Nanoparticles (NPs) are effective against drug-resistant strains. Metal-organic frameworks (MOFs) are highly porous composite materials with ...
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Objective(s): In recent years, nanomaterials with anti-bacterial activity have acted as antibiotics, and a new method of nanotechnology treatment is available. Nanoparticles (NPs) are effective against drug-resistant strains. Metal-organic frameworks (MOFs) are highly porous composite materials with attractive applications. This material has attracted a lot of attention due to its unique properties such as anti-bacterial application. Zn2(BDC)2(DABCO) MOF is a Zn-MOF based organic framework (Zn-MOF) with various applications.Methods: In the present study, this Zn-MOF was synthesized by solution at room temperature and solvothermal at 90 ºC methods. The samples were characterized by Fourier transform infrared (FTIR), X-ray diffraction (XRD), dynamic light scattering (DLS), zeta potential, field emission scanning electron microscopy (FESEM), and diffuse reflection spectroscopy (DRS). Finally, the anti-bacterial activities of samples were investigated against Escherichia coli (E. coli) as gram-negative bacteria and Staphylococcus aureus (S. aureus) as gram-positive bacteria.Results: FTIR and XRD results were evaluated functional groups and crystal structure respectively. DLS and zeta potential results were studied size and distribution diagram, and surface charge respectively. The morphology and size were observed by SEM images in the nanometer scale. The Ultraviolet (UV) protective property and band gap energy were investigated by DRS absorption. The antibacterial activity was confirmed against E. coli were and S. aureus. Conclusions: This work showed that Zn2(BDC)2(DABCO) MOF can be a good candidate for medicinal applications.
Fereshte Haftan; Negar Motakef-Kazemi
Abstract
Objective(s): Copper (Cu) is a very strong poison metal in the environment. Therefore, copper sorbent can be of great help to the medical field. Metal organic framework (MOF) has attracted considerable attention as sorbent because of high porosity and surface area. In this work, MOF-5 is one of zinc-based ...
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Objective(s): Copper (Cu) is a very strong poison metal in the environment. Therefore, copper sorbent can be of great help to the medical field. Metal organic framework (MOF) has attracted considerable attention as sorbent because of high porosity and surface area. In this work, MOF-5 is one of zinc-based metal–organic framework was used for copper absorption from aqueous solution. Then, polyurethane (PU) nanocomposite was modified with MOF-5 by press method as copper sorbent.Methods: The samples were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) analysis, field emission scanning electron microscope (FESEM), BET surface area, and Ultraviolet–visible (UV–Vis) spectroscopy. The effect of amount and concentration were investigated on adsorption of copper in water solution. Based on the results, MOF-5 and its polyurethane nanocomposite were demonstrated the potential utility for copper removal from water solution.Results: FESEM results confirmed that the samples are in nano scale. The copper absorption was approved by UV–Vis spectroscopy and BET surface area. The absorption value was increased by increase of amount and concentration.Conclusions: This work focuses on preparing an efficient copper sorbent based on MOF-5 and its PU nanocomposite. MOF-5 is composed of zinc metal and benzene 1,4-dicarboxylic acid with the formula Zn4O(BDC)3 as good candidate for adsorption of copper from aqueous solution. The results indicate that this nanocomposite can have a good potential to develop environmental applications.
nanomedicine
Elham Karimi; Negar Motakef-Kazemi
Abstract
Objective(s): The oil-in-water (O/W) nanoemulsion is employed in a diverse range of biomedical applications due to the unique properties. Saffron is the valuable medicinal food product with many health benefits. Sesame oil is an edible vegetable oil with medicinal properties and potential applications. ...
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Objective(s): The oil-in-water (O/W) nanoemulsion is employed in a diverse range of biomedical applications due to the unique properties. Saffron is the valuable medicinal food product with many health benefits. Sesame oil is an edible vegetable oil with medicinal properties and potential applications. The aim of this study was to prepare and evaluate O/W nanoemulsion containing aqueous solution of saffron as hydrophilic medium and sesame oil as lipophilic medium. Methods: In the presence study, the O/W nanoemulsion was prepared by sesame oil in the presence of saffron aqueous solution and poly ethylene glycol (PEG) using span 80 surfactants and homogenizer at room temperature. The sample size was characterized by dynamic light scattering (DLS) and atomic force microscopy (AFM). The rheological properties of nanoemulsion were determined by measurement of viscosity at room temperature. The antibacterial activity of samples was measured against an important pathogen bacterium, Escherichia coli (E. coli) using inhibition zone diameter. The cytotoxicity of samples was investigated by MTT assay for HEK239 human cell line at three different concentrations for 1 and 5 days of time.Results: Based on the results, the nanoemulsions showed the antibacterial activity with low toxicity. The presence of saffron and PEG increased the size, viscosity and antibacterial activity.Conclusions: The study showed that nanoemulsions based on aqueous solution of saffron and sesame oil can be a good candidate for medicinal applications.
Masomeh Odar; CNegar Motakef-Kazemi
Abstract
Objective(s): Lead is a very strong poison in the environment. Lead toxicity can be affected on the human body and caused disease. Therefore, the design of lead sorbent can be had the great help to the medical field. In this work, the nanohydroxyapatite (n-HA) was used for removal of lead from aqueous ...
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Objective(s): Lead is a very strong poison in the environment. Lead toxicity can be affected on the human body and caused disease. Therefore, the design of lead sorbent can be had the great help to the medical field. In this work, the nanohydroxyapatite (n-HA) was used for removal of lead from aqueous solution. Then, polycaprolactone (PCL) nanocomposite was modified with n-HA by simple preparation method as lead sorbent. Methods: The samples were characterized by X-ray diffraction (XRD) analysis, field emission scanning electron microscope (FE-SEM), BET surface area, and Ultraviolet–visible (UV–Vis) spectroscopy. The effect of parameters including pH and temperature of solution, amount and concentration of sorbent was investigated on lead absorption. Results: FE-SEM results confirmed that the samples are in nano scale. The lead absorption was approved by UV–Vis spectroscopy and BET surface area. The absorption value was increased by increase of concentration, pH, and temperature. Conclusions: This work focuses on preparing an efficient lead sorbent system based on nanohydroxyapatite and its polycaprolactone nanocomposite. The results indicate that this nanocomposite can have a good potential to develop different adsorbents.
Najmeh Najmeh Feizi Langaroudi; Negar Motakef Kazemi
Abstract
ABSTRACT Objective(s): The oil-in-water (O/W) nanoemulsion is expanded in biomedical application due to their special properties. Mint and Parsley are known herbs with many health benefits. Chitosan (Ch) is a low toxic, biodegradable, biocompatible and safe polymer with the antibacterial activity which ...
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ABSTRACT Objective(s): The oil-in-water (O/W) nanoemulsion is expanded in biomedical application due to their special properties. Mint and Parsley are known herbs with many health benefits. Chitosan (Ch) is a low toxic, biodegradable, biocompatible and safe polymer with the antibacterial activity which is used in production of nanomaterial. The aim of this study was to evaluate the nanoemulsion to achieve good antibacterial activity and suitable stability with low cytotoxicity. Methods: In the presence study, the O/W nanoemulsion was prepared by Mint essential oil in the presence of Parsley aqueous extract and chitosan aqueous solution using Span 80 and Tween 80 surfactants and high-intensity homogenizer at room temperature for 30 min. The result samples were characterized by scanning electron microscopy (SEM) and dynamic light scattering (DLS). The stability of nanoemulsion was evaluated for 50 days at different temperatures for optimized samples. The antibacterial activity of samples was measured against an important pathogen bacterium, Escherichia coli (E. coli) using inhibition zone diameter. The rheological properties of nanoemulsion were determined by presentation of viscosity at room temperature. The cytotoxicity of samples was investigated by MTT assay for HEK239 human cell line at three different concentrations for three periods of time. Results: Our results showed the nanoemulsion with nanometer size. The presence of chitosan was caused more particles with the smaller size. The low temperature was needed to protection of nanoemulsion stability and prevention of particle growth. Conclusions: Our study indicated that the nanoemulsion improved its antibacterial activity with low cytotoxicity and suitable stability.
Shirin Hajiashrafi; Negar Motakef-Kazemi
Abstract
Objective(s): In recent years, green synthesis of nanoparticles is under exploration due to wide medicine and biological applications and research interest in nanotechnology. Green synthesis of zinc oxide nanoparticles (ZnO NPs) is becoming increasingly importance as eco-friendly. The objectives ...
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Objective(s): In recent years, green synthesis of nanoparticles is under exploration due to wide medicine and biological applications and research interest in nanotechnology. Green synthesis of zinc oxide nanoparticles (ZnO NPs) is becoming increasingly importance as eco-friendly. The objectives of this study were the production of zinc oxide nanoparticles using parsley extract.
Methods: In the present study, ZnO NPs were synthesized from an extract of parsley at different temperatures (at room temperature and 90°C) and obtained the optimum time for preparation of ZnO NPs. The samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Dynamic light scattering (DLS), and Diffuse Reflection Spectroscopy (DRS). The antibacterial activities of the samples were determined against Escherichia coli (E. coli).
Results: XRD results of ZnO NPs were correctly synthesized and crystalline structure was similar to the previously reported pattern. The nanoparticle morphology was observed for ZnO nanostructured based on the SEM images. DLS analysis showed samples in the nanometer scale. The DRS absorption spectra of nanoparticles showed the Ultraviolet (UV) protective properties. The antibacterial activities against E.coli were observed because of the presence of ZnO NPs.
Conclusions: This result showed that the parsley extract is good candidate for the synthesis of ZnO nanoparticles with antibacterial activities against Escherichia coli. The result indicated that ZnO NPs can have a good potential for different applications.
