Preparation, statistical optimization and in vitro characterization of solid lipid nanoparticles as a potential vehicle for transdermal delivery of tramadol hydrochloride as a hydrophilic Compound

Mina Abbasnia; Ali Reza Vatanara; Reza Mahjub

Volume 5, Issue 2 , April 2020, , Pages 120-131

http://dx.doi.org/10.22034/nmrj.2020.02.003

Abstract
  As encapsulation of hydrophilic drugs in the solid lipid nanoparticles (SLNs) is still a challenging issue, the aim of this study was to prepare SLNs containing tramadol hydrochloride as a hydrophilic compound.The SLNs were prepared using glycerol monostearate (GMS), soy lecithin and tween 80 by double ...  Read More