Farnaz Fattahi; Akbar Khoddami; Ozan Avinc
Abstract
Numerous Scientists have discovered the procedure of nanotechnology, explicitlynanofibers, asdrug delivery systems for transdermal uses. Nanofibers canbe used to deliver drugs and are capable of controlled release for a continued periodof time. Poly (Lactic Acid) (PLA) is the lastly interesting employed ...
Read More
Numerous Scientists have discovered the procedure of nanotechnology, explicitlynanofibers, asdrug delivery systems for transdermal uses. Nanofibers canbe used to deliver drugs and are capable of controlled release for a continued periodof time. Poly (Lactic Acid) (PLA) is the lastly interesting employed synthetic polymer in biomedical application owing to its well categorized biodegradable properties. PLA(−[CH(CH3)COO]n–)is linear biodegradable aliphatic polyester which can be derived from 100% renewable bioresources like rice and wheatthrough fermentation and polymerization. PLA has been accepted by FDA to be applied in biomaterials, such as sutures, bone plates, abdominal mesh, and drug delivery systems. PLA holds stereoisomers,for instancePoly(L-Lactide)(PLLA), Poly(D-Lactide) (PDLA), and Poly(DL-Lactide) (PDLLA). PLGA is a copolymer of PLA and Poly(Glycolic Acid) (PGA) that are most usually used biodegradable synthetic polymers for biomedical applications such as scaffolds and drug delivery systems The objective of this review paper is to highpoint the possibility of PLA nanofibres as drug deliverysubstances and to give full information about the newprogresses about the PLA , PLLA and PLGA nanofibers fabrication as noveldrug delivery systems.
Fatemeh Mehrabi; Tayebeh Shamspur; Ali Mostafavi; Asma Saljooqi; Fariba Fathirad
Abstract
Objective(s): The purpose of this study was to compare novel sandwich-structured nanofibrous membranes, and coaxial and usual methods, to provide sustained-release delivery of morphine for drug delivery. In this work, synthesis ofnanofibrous cellulose acetate (NFC) was carried out by electrospinning. ...
Read More
Objective(s): The purpose of this study was to compare novel sandwich-structured nanofibrous membranes, and coaxial and usual methods, to provide sustained-release delivery of morphine for drug delivery. In this work, synthesis ofnanofibrous cellulose acetate (NFC) was carried out by electrospinning. Methods: A weighed amount of cellulose acetate (CA) powder was dissolved in 3:1 v/v acetone/dimethylformamide (DMF) to obtain a CA solution at a concentration of 8 to16% w/v. Acetaminophen or morphine-loaded CA solutions were prepared by dissolving CA powder and Acetaminophen (A) or morphine in the weight ratio of 5:1, in an acetone/DMF mixture. Under optimum condition, they were electrospun into sandwich structured membranes with the coaxial method and cellulose acetate as the surface layer and cellulose acetate/drugs as the core. Results: Characterization of the radius of fiber is shown as 52.9 ± 0.1nm with scanning electron microscopy (SEM). The full range drug release profiles of nanofibers are shown as 80.7% of the contained drug in 8h. The drug release from nanofiber was controlled through a typical Fickian diffusion mechanism from the cellulose acetate matrix by a release exponent value of 0.24 for conventional nanofiber, 0.35 for coaxial nanofiber and 0.40 (less than 0.45) for sandwich nanofibers. Conclusions: All the cellulose acetate nanofibers showed that they could release large amounts of drugs in vitro for more than one day. However, among these three methods, the best one is a sandwich method because its release is slower than that of the other methods.
Aliakbar Tarlani; Mohsen Isari; Avideh Khazraei; Mahboubeh Eslami Moghadam
Abstract
Objective(s): In a new approach, following the development in metal oxide chemistry, the ibuprofen as low water soluble nonsteroidal anti-inflammatory drug diffused into synthetic sol-gel derived nano porous g-alumina by an impregnation method in order to increase the solubility and control the drug ...
Read More
Objective(s): In a new approach, following the development in metal oxide chemistry, the ibuprofen as low water soluble nonsteroidal anti-inflammatory drug diffused into synthetic sol-gel derived nano porous g-alumina by an impregnation method in order to increase the solubility and control the drug release in physiological environment. Methods: Sol-gel method was utilized for the fabrication of alumina by controlled hydrolysis of an aluminum alkoxide source. This vehicle favors high surface area, pore diameter and pore volume as well as hydroxyl rich surface which is needed for the drug formulation. Two different percent of the medication were loaded on the synthetic g-alumina. The samples were characterized by X-ray diffraction (XRD),BET (Brunauer, Emmett and Teller), FT-IR and thermogravimetric analysis (TGA). Results: The results showed that the drug molecules were well-distributed into the pores. 25 and 50% w/w of ibuprofen were prepared for drug release test which was studied by UV-Vis techniques. The release kinetic was obtained in simulated body fluid (SBF), simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). The solubility of the drug reached to 90 and 84% for 25% (γ-Al-IBU25) and 50% (γ-Al-IBU50) drug loaded samples after 4 h of loading time, respectively. These results are comparable to reported commercial alumina with low amount of 25% release. The percent of the drug release is as follow for three environments: SBF > SIF > SGF. Conclusions: It could be concluded that the new formulation led to enhancement solubility and controlled release of ibuprofen in the mentioned media.
)
)