Ali Alirezaie Alavijeh; Masoomeh Dadpey; Farid Barati; Mohammad Barati
Abstract
Objective(s): In the developed countries, one of the leading causes of death is cancer. Cancer cells with their unique and destructive characteristics impose high costs on communities.
Methods: In this study, we will review the latest cancer researches and diagnostic tools.
Results: Existing ...
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Objective(s): In the developed countries, one of the leading causes of death is cancer. Cancer cells with their unique and destructive characteristics impose high costs on communities.
Methods: In this study, we will review the latest cancer researches and diagnostic tools.
Results: Existing technologies, using clinical markers and studying the polymeric screeners of cancer cells, have created kits that make cancer diagnosis at early stages. The study of the survival mechanism in malaria and honey bee and the development of bacterial engineering has created new approaches to create powerful tools for cancer detection and control.
Conclusions: The completion of these processes will create the potential for cancer eradication. Study of the survival mechanisms in nature and purposive modeling of it will lead to provide many solutions to solve the problems. These studies can lead to develop accurate diagnostic and therapeutic tools.
Elham Zendedel; Fatemeh Gheybi; Jamshidkhan Chamani; Mahmoud Reza Jaafari
Abstract
Abstract Curcumin, which is derived from the turmeric rhizomes (curcuma longa) as a natural polyphenol, is a substantially lipophilic molecule. This commonly used substance is employed as a spice and coloring agent in food and contains potent antioxidant, as well as anti-inflammatory, and anti-proliferative ...
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Abstract Curcumin, which is derived from the turmeric rhizomes (curcuma longa) as a natural polyphenol, is a substantially lipophilic molecule. This commonly used substance is employed as a spice and coloring agent in food and contains potent antioxidant, as well as anti-inflammatory, and anti-proliferative tumor activities. The developed nanomicelle formulations of curcumin are used to promote the bio-availability and solubility of the above-mentioned lipophilic molecule. The present investigation aimed to examine the anti-proliferative activity of nanomicelle and free curcuminoids by using different cancer and normal cells using a tetrazolium dye-based assay. To this end, various cell lines were treated with nanomicelle or free curcuminoids at different concentration of 5, 10, 20, 30, and 40 µM for 48 h at 37 ºC. Our results demonstrated that the half maximal inhibitory concentrations of the micellar form of curcuminoids for different cancer cell lines were as high as its levels measured for its free form but in normal cells, the toxicity of nanomicelles is lower than free form of curcuminoids.
