Curcumin-loaded albumin nanoparticles synthesis, characterization and in-vitro evaluation of cytotoxic effects against U-87 MG cells

Masoumeh Keshavarz; Navid Ahmadi Nasab; Maryam Saeidifar; Sara Nikoofal; Omid Safa

Volume 7, Issue 3 , July 2022, , Pages 245-253

  Objective(s): Curcumin (Cur) as a natural bioactive compound has shown potential capability to fight a variety of malignancies. In this study, bovine serum albumin nanoparticles (BSA NPs) were applied to improve bioavailability and increase the effectiveness of the hydrophobic curcumin against human ...  Read More

Mesenchymal stem/stromal (MSCs)-derived exosome inhibits retinoblastoma Y-79 cell line proliferation and induces their apoptosis

Hadis Kheradjoo; Alireza Nouralishahi; Mohamad Saeid Hoseinzade Firozabdi; Saman Mohammadzadehsaliani

Volume 7, Issue 3 , July 2022, , Pages 264-269

  Aims: Based on the literature, mesenchymal stem/stromal cell derived exosome has dual role in tumor therapy or progress. We evaluated the possible anti-tumor effect of the MSCs-exosome on retinoblastoma Y-79 cell cells in vitro.Methods: To verify the efficient isolation of exosome, the MSCs-exosome structure ...  Read More

Preparation and characterization of bovine serum albumin nanocarrier conjugated to exosome to sustained release of 5-flurouracil: Release and antitumoral evaluation

Ghazaleh Rahimi; Maryam Saeidifar; Monireh Ganjali; Esmaeil Salahi

Volume 7, Issue 1 , January 2022, , Pages 73-82

  One of the new strategies for improving of chemotherapy in cancer treatment is the use of nanocarriers for sustained release of anticancer drugs. The present study aims to investigate the bovine serum albumin nanoparticles (BSANP) with exosomes (Exo) for prolonged release of 5-Flurouracil (5FU) as an ...  Read More

Chemotherapeutic activity of Silymarin combined with doxorubicin liposomes in 4T1 breast cancer cells

Fatemeh Gheybi; Seyedeh Hoda Alavizadeh; Seyed Mahdi Rezayat; Elham Zendedel; Mahmoud Jaafari

Volume 4, Issue 1 , February 2019, , Pages 29-34

  Cancer is the second leading cause of death worldwide. Despite great efforts over many years, today cancer treatment is not very effective. The main reasons for cancer chemotherapy failure are high cytotoxicity, low response rates in solid tumors, and development of resistance. Different experimental ...  Read More

Pluronic based nano-delivery systems; Prospective warrior in war against cancer

Pouya Dehghankelishadi; Farid Dorkoosh

Volume 1, Issue 1 , July 2016, , Pages 1-7

  Pluronic based nano-particulate systems are innovative platforms for delivery of anti-cancer agents. These systems due to their pharmacological properties and suitable physicochemical characteristics are great opportunity for development cancer therapeutics. This mini-review tries to provide a more detailed ...  Read More

Preparation and Evaluation anticancer activity of D-glucosamine Nanoparticles on Metastatic cancer Model in vivo

Neda Soleimani; Masoumeh Tavakoli-Yaraki; Baharak Farhangi

Volume 1, Issue 1 , July 2016, , Pages 53-58

  Objective(s): Breast cancer imposes a highest rate of malignancy among the women all around the world. Chitin and its derivatives such as D-glucosamine-carboxymethyl chitin and Di-hydroxy propyl chitin have immune-modulating effects and influence on innate and acquisitive immunity which lead to cell ...  Read More