nanomedicine
Majid Reza Akbarizadeh; Mahin Naderifar; Farideh Mousazadeh; Niloofar Zafarnia; Mina Sarani
Abstract
Iron oxide nanoparticles are one of the most applied metal nanoparticles with advantageous properties in biomedicine that can be cost-effectively and rapidly produced through green synthesizing methods. The purpose of this study was to study the toxicity of iron oxide nanoparticles (Fe2O3 NPs), which ...
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Iron oxide nanoparticles are one of the most applied metal nanoparticles with advantageous properties in biomedicine that can be cost-effectively and rapidly produced through green synthesizing methods. The purpose of this study was to study the toxicity of iron oxide nanoparticles (Fe2O3 NPs), which were green synthesized by Prosopis farcta extract, on brain glioblastoma cells (U87). Powder X-ray Diffraction (PXRD), Vibrating-Sample Magnetometer (VSM), Field Energy Scanning Electron Microscopy (FESEM), Energy-Dispersive Spectroscopy (EDX), and Raman technics were performed to evaluate the physicochemical properties of this product. According to results, the green synthesized Fe2O3 nanoparticles contained a spherical morphology in the size range of 20-45 nm with superparamagnetic features. Additionally, their cytotoxic activity was surveyed against U87 cells by MTT assay, and the outcomes indicated the lack of any cytotoxic activity until reaching the concentration of 500 μg/mL. Therefore, our synthesized Fe2O3 NPs can be proposed as a proper candidate for being applied in the drug delivery of cancer treatments.
Saba Talesh; Mohammad Koohi; Ehsan Zayerzadeh; Jalal Hasan; Meisam Shabanian
Abstract
Iron oxide nanoparticles (IONPS) have potential different applications in nanomedicine. These new applications of IONPS have raised exposure risk of this nanomaterials to humans. Up to now, all aspects of IONPS toxicity are not fully clear following animal’s exposure with these novel compounds. ...
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Iron oxide nanoparticles (IONPS) have potential different applications in nanomedicine. These new applications of IONPS have raised exposure risk of this nanomaterials to humans. Up to now, all aspects of IONPS toxicity are not fully clear following animal’s exposure with these novel compounds. This study aimed to investigate the acute toxicity effects of IONPS in laboratory animals regarding pathotoxicological analysis and clinical aspects. Twenty four male Wistar rats were randomly chosen, and divided into four groups of six rats each. The first, second, and the third groups received 50, 500, and 5000 mg/kg of IONPS solution orally for five days through gavage, respectively. Animal mortality, clinical sings and body weight were evaluated during the study. Fourteen days after the last administration, rats were euthanized for further investigation for histopathological evaluation. There were no death observed in all groups. High and middle dose of the IONPS caused symptoms like lethargy, ataxia, anorexia, isolation, and respiratory arrhythmia over the period of the study. The subjects of the low dose group showed no signs of toxicity. Specific histopathological complications, like hyaline cast in the kidneys, hyperemia and interstitial thickening in the lungs, hemorrhage in the heart and hepatic degeneration in the liver were observed in high dose group. Thus, it can be concluded that, toxicity of IONPS in rats is dose-dependent. This particular size of IONPS can induce serious pathological abnormalities and clinical symptoms in high dose.
