@article { author = {Fávaro, Wagner and Villela, Renata and Ceragioli, Helder and Duran, Nelson}, title = {Fourier Transform Infrared Spectroscopy as diagnostic tools for bladder cancer treatment: Doxorubicin and Cisplatin and Reduced Graphene Oxide as nanocarrier}, journal = {Nanomedicine Research Journal}, volume = {6}, number = {3}, pages = {228-236}, year = {2021}, publisher = {Tehran University of Medical Sciences}, issn = {2476-3489}, eissn = {2476-7123}, doi = {10.22034/nmrj.2021.03.003}, abstract = {Aim: The use of Fourier Transform Infrared Spectroscopy (FTIR) as diagnostic tools for bladder cancer associate to histopathology analysis.Material and Methods: FTIR imagens of normal and bladder cancer tissues in rats o Brucker model V 70 spectrophotometer equipped with the MCT detector (Mercury Cadmium Telluride), under attenuated total reflectance (ATR). Histopathology analysis of rat tissues and comparison of diagnostics in both methods.Results: All the spectroscopic parameters analyzed showing that the progress of cancer treatment were consistent with the histopathological analyses. The ratio of FTIR bands intensity of protein/lipid (I1633/I1743) was highly increased (ratio of 3.33) in the cancer tissues compared with normal one (ratio of 1.22). After treatment with DOX-CIS-rGO nanocarrier a value of protein/lipid ratio was 1.38.Conclusion: All data of the ATR-FTIR imagens will be important tools for the most complex and expensive histopathological analysis. The ATR-FTIR diagnosis will be an important data in the final decision related to progress in the chemotherapeutic treatment. Of course, the fast analysis by ATR-FTIR methodology compared to histopathology could be an important support for monitoring all these studies.}, keywords = {FTIR spectroscopy,Bladder cancer,Doxirubicin,Cisplatin. Reduced Graphene oxide}, url = {https://www.nanomedicine-rj.com/article_247463.html}, eprint = {https://www.nanomedicine-rj.com/article_247463_ba7f58f3748c56bafd5a1270e68d1154.pdf} }