%0 Journal Article %T Synthesis and Biochemical effects of magnetite nanoparticle by surfactant-free electrochemical method in an aqueous system:the current density effect %J Nanomedicine Research Journal %I Tehran University of Medical Sciences %Z 2476-3489 %A Aliahmad, Mousa %A Rahdar, Abbas %A Sadeghfar, Fardin %A Bagheri, Samira %A Hajinezhad, Mohammad Reza %D 2016 %\ 07/01/2016 %V 1 %N 1 %P 39-46 %! Synthesis and Biochemical effects of magnetite nanoparticle by surfactant-free electrochemical method in an aqueous system:the current density effect %K VSM %K FESEM %K Magnetite nanoparticles %K The current density %R 10.7508/nmrj.2016.01.006 %X Obejective(s): In this research, magnetite nanoparticles with an average size of 23-36 nm were successfully synthesized via surfactant-free electrochemical method using iron as the anode and water as the electrolyte in a closed aqueous system in the presence of NaOH at room temperature. Methods: The effect of the current density on product formation and particle size was investigated. Particle size was controlled by adjusting the current density. It was found that particle size decreases by decreasing the current density. In addition, the effect of current density  on the structural and optical properties of nanostructures were studied by X-ray diffraction, Field emission scanning electron microscopy, Fourier transformed infrared, and vibrating sample magnetometer techniques.  Results: The results obtained from the magnetization property study of samples at room temperature showed coactivity and saturation manetization of 0-100 Oe and 27.2- 40.5 emu. g-1, respectively. Finally, the results of biological activity study of nanoparticles on liver and kidney function in male wistar rats demonstrated that oral administration of NPs caused significant alterations to the levels of aspartate transaminase, alanine transaminase, and alkaline phosphatase in serum. Conclusions: No significant changes were detected in the groups treated with 10 and 100 ppm/ day nanostructure (P>0.05). There was a significant increase in the serum level of creatinine and blood urea nitrogen level (p<0.05) in rats treated with high oral doses of the nanostructure. %U https://www.nanomedicine-rj.com/article_20582_7aa9f1dae4b44bad32fb35e360f3577c.pdf