%0 Journal Article %T In-vitro Antioxidant and Cytotoxicity (sk-mel-3 cell) Activity of Green Synthesised Copper Nanoparticle using P. pellucida Plant Aqueous Extract %J Nanomedicine Research Journal %I Tehran University of Medical Sciences %Z 2476-3489 %A V P, Shilapa %A Vilgeena, Wilson %A S, Bhagyasree %A Alby Babu, E %A Nidhina, Davis %A Meena, Kurup %A K, Muddukrishnaiah %D 2021 %\ 09/01/2021 %V 6 %N 3 %P 279-286 %! In-vitro Antioxidant and Cytotoxicity (sk-mel-3 cell) Activity of Green Synthesised Copper Nanoparticle using P. pellucida Plant Aqueous Extract %K P. Pellucida %K CuNPs %K Antioxidant %K Cytotoxicity %K FE-SEM %K EDAX %R 10.22034/nmrj.2021.03.008 %X Green synthesis of metallic nanoparticles using medicinal plant extract treated to environmentally friendly, stable, cost-effective. Present work to study In-vitro antioxidant and cytotoxicity of green synthesised CuNPs using P. Pellucida plant extract. Copper nanoparticles were synthesised biogenically using P. Pellucida plant aqueous extract. CuNPs Characterised by using FE-SEM, U.V., FT-IR, EDAX. Biogenically synthesised copper nanoparticles conducted in-vitro Antioxidant (DPPH) and cytotoxicity (SK-MEL-3 cell). The results CuNPs were characterised by using U.V. spectroscopy absorbance 575 nm. Scanning electronic microscope showing the distribution and shape (5-20 nm) of the nanoparticles. X-ray spectrum showed different peaks for CuNPs detected at 2θ values 35.45°, 44.32°, and 65.25°. EDAX elemental spectroscopy conformed to the copper metal inside the nanoparticle (69.7%). The synthesised CuNPs showed good free radical scavenger activity than the ascorbic acid, and it also showed significant cytotoxicity (16μg/mL) against human skin cell lines (SK-MEL-3 cell). The current study conclusion recommended that green synthesised (P. Pellucida) CuNPs be used for therapeutic application. %U https://www.nanomedicine-rj.com/article_247469_412e7e3126a5524f4a5aa0372586f8f1.pdf