ORIGINAL_ARTICLE
Virology, Epidemiology and Control of SARS-CoV-2: A Perspective
SARS-CoV-2 is a new human-infecting coronavirus, which is the causative agent of COVID-19 disease. The World Health Organization announced this disease as a pandemic on 11 March 2020. The genome of SARS-CoV-2 is ~30kb in length which encodes sixteen nonstructural and four main structural proteins. The structural spike protein enables SARS-CoV-2 to bind to host cell receptor angiotensin-converting enzyme 2 (ACE2), which leads to viral infection. COVID-19 is considered as a respiratory disease that affects just the lungs in most cases. There are no specific therapeutics or effective vaccines available to control COVID-19, which makes it a continuing threat to global public health. Consequently, the principal approach to prevent this disease is supportive care. Due to their potential to increase drug bioavailability, a number of approaches in pharmaceutical nanotechnology are currently being tested against SARS-CoV-2. This includes nano-based products designed for detection, prevention and treatment of COVID-19. Such approaches may help to control this current pandemic and pave the way for prevention and treatment of future coronavirus outbreaks.
https://www.nanomedicine-rj.com/article_244768_9f44c0fb0a814cc7c4a507a43343b172.pdf
2021-04-01
96
104
10.22034/nmrj.2021.02.001
SARS-CoV-2
Pandemic
viral infection
Respiratory disease
Control
Elnaz
Saeidi
elinaz.saeidi@yahoo.com
1
Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
AUTHOR
Reza
Ranjbar
ranjbarre@gmail.com
2
Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
AUTHOR
Soheil
Zangoei-Fard
soheilzangooiefard@yahoo.com
3
Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
AUTHOR
Paul
Guest
paulcguest@yahoo.com
4
Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
AUTHOR
Amirhossein
Sahebkar
amir_saheb2000@yahoo.com
5
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
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70
ORIGINAL_ARTICLE
An overview of antimicrobial efficacy of curcumin-silver nanoparticles
With emerging drug resistance microorganism, the search for a new biocidal agent has begun. The silver nanoparticle is a synthetic material with potent antimicrobial activity that applies to a diverse library of microorganisms. But toxicity and safety concerns of chemically prepared silver nanoparticles toward human and environment limited the extensive industrial biomedical application of silver nanoparticles. On the other hand, curcumin is a natural phenolic compound of the Indian spice turmeric that contains mild antimicrobial activity against various microorganisms. However, instability, poor absorption and low solubility of curcumin prevent its wide application in biomedical researches. Simultaneous application of these two materials is the subject of the provided manuscript. Curcumin formulation and silver nanoparticles can be applied separately or together, but the state of the art is applying curcumin for the synthesis of silver nanoparticles that represent a better biocidal activity and lower cytotoxicity in comparison to chemically synthesized silver nanoparticles.
https://www.nanomedicine-rj.com/article_244769_d38d5bc8d7803418c1bf4ac5ed167c53.pdf
2021-04-01
105
111
10.22034/nmrj.2021.02.002
Antimicrobial Properties
curcumin
Silver nanoparticles
Green synthesis
Toxicity
Elham
Mohammadi
elham.mt.2017@gmail.com
1
Radiation Biology Research Center, Iran University of Medical Sciences (IUMS).
AUTHOR
Seyed Meysam
Amini
sm.amini1987@gmail.com
2
Medical Nanotechnology Department, School of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS).
AUTHOR
Seyed Hossein
Mostafavi
viahossein@yahoo.com
3
Department of Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Seyed Mohammad
Amini
mohammadamini86@gmail.com
4
Department of Bioengineering, University of California, Riverside, Riverside, CA 92521
LEAD_AUTHOR
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48. Abdellah AM, Sliem MA, Bakr M, Amin RM. Green synthesis and biological activity of silver–curcumin nanoconjugates. Future Medicinal Chemistry. 2018;10(22):2577-88.
50
ORIGINAL_ARTICLE
Preparation of O/W nanoemulsion containing saffron aqueous solution and sesame oil and evaluation of its properties
Objective(s): The oil-in-water (O/W) nanoemulsion is employed in a diverse range of biomedical applications due to the unique properties. Saffron is the valuable medicinal food product with many health benefits. Sesame oil is an edible vegetable oil with medicinal properties and potential applications. The aim of this study was to prepare and evaluate O/W nanoemulsion containing aqueous solution of saffron as hydrophilic medium and sesame oil as lipophilic medium. Methods: In the presence study, the O/W nanoemulsion was prepared by sesame oil in the presence of saffron aqueous solution and poly ethylene glycol (PEG) using span 80 surfactants and homogenizer at room temperature. The sample size was characterized by dynamic light scattering (DLS) and atomic force microscopy (AFM). The rheological properties of nanoemulsion were determined by measurement of viscosity at room temperature. The antibacterial activity of samples was measured against an important pathogen bacterium, Escherichia coli (E. coli) using inhibition zone diameter. The cytotoxicity of samples was investigated by MTT assay for HEK239 human cell line at three different concentrations for 1 and 5 days of time.Results: Based on the results, the nanoemulsions showed the antibacterial activity with low toxicity. The presence of saffron and PEG increased the size, viscosity and antibacterial activity.Conclusions: The study showed that nanoemulsions based on aqueous solution of saffron and sesame oil can be a good candidate for medicinal applications.
https://www.nanomedicine-rj.com/article_244770_c9670610b18632e221ed037724b63187.pdf
2021-04-01
112
116
10.22034/nmrj.2021.02.003
O/W nanoemulsion
Saffron
Sesame oil
PEG
Elham
Karimi
karimi96.elham@gmail.com
1
Department of Food Sciences and Technology, Faculty of pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
AUTHOR
Negar
Motakef-Kazemi
negar.motakef@gmail.com
2
Department of Medical Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
LEAD_AUTHOR
1. Ataei F, Dorranian D, Motakef-Kazemi N. Bismuth-based metal–organic framework prepared by pulsed laser ablation method in liquid. Journal of Theoretical and Applied Physics. 2020;14(S1):1-8.
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2. Motakef Kazemi N, Sandalnia M. In Situ Production and Deposition of Bismuth Oxide Nanoparticles on Cotton Fabric. Iranian Journal of Science and Technology, Transactions A: Science. 2020;44(4):1217-23.
2
3. Motakef Kazemi N, Salimi AA. Chitosan Nanoparticle for Loading and Release of Nitrogen, Potassium, and Phosphorus Nutrients. Iranian Journal of Science and Technology, Transactions A: Science. 2019;43(6):2781-6.
3
4. Ataei F, Dorranian D, Motakef-Kazemi N. Synthesis of MOF-5 nanostructures by laser ablation method in liquid and evaluation of its properties. Journal of Materials Science: Materials in Electronics. 2021;32(3):3819-33.
4
5. Hajiashrafi S, Motakef Kazemi N. Green synthesis of zinc oxide nanoparticles using parsley extract. Nanomedicine Research Journal. 2018;3(1):44–50.
5
6. Motakef Kazemi N, Yaqoubi M. Green synthesis and characterization of bismuth oxide nanoparticle using mentha pulegium extract. Iranian Journal of Pharmaceutical Research. 2020;19(2):70–79.
6
7. Feizi Langaroudi N, Motakef Kazemi N. Preparation and characterization of O/W nanoemulsion with Mint essential oil and Parsley aqueous extract and the presence effect of chitosan. Nanomedicine Research Journal. 2019;4(1):48-55.
7
8. Tadros T, Izquierdo P, Esquena J, Solans C. Formation and stability of nano-emulsions. Advances in Colloid and Interface Science. 2004;108-109:303-18.
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9. Ee SL, Duan X, Liew J, Nguyen QD. Droplet size and stability of nano-emulsions produced by the temperature phase inversion method. Chemical Engineering Journal. 2008;140(1-3):626-31.
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10. Lin C-C, Lin H-Y, Chen H-C, Yu M-W, Lee M-H. Stability and characterisation of phospholipid-based curcumin-encapsulated microemulsions. Food Chemistry. 2009;116(4):923-8.
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11. Solans C, Izquierdo P, Nolla J, Azemar N, Garciacelma M. Nano-emulsions. Current Opinion in Colloid & Interface Science. 2005;10(3-4):102-10.
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12. McClements DJ, Rao J. Food-Grade Nanoemulsions: Formulation, Fabrication, Properties, Performance, Biological Fate, and Potential Toxicity. Critical Reviews in Food Science and Nutrition. 2011;51(4):285-330.
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13. Izquierdo P, Feng J, Esquena J, Tadros TF, Dederen JC, Garcia MJ, et al. The influence of surfactant mixing ratio on nano-emulsion formation by the pit method. Journal of Colloid and Interface Science. 2005;285(1):388-94.
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14. Ahmed K, Li Y, McClements DJ, Xiao H. Nanoemulsion- and emulsion-based delivery systems for curcumin: Encapsulation and release properties. Food Chemistry. 2012;132(2):799-807.
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18. Sankaran Nair S, Prabhakaran Nair K, Rajendrakumar PK. Micro and nanoparticles blended sesame oil bio‐lubricant: study of its tribological and rheological properties. Micro & Nano Letters. 2018;13(12):1743-6.
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21. Motakef Kazemi N, Rashidian M, Taghizadeh Dabbagh S, Yaqoubi M. Synthesis and characterization of bismuth oxide nanoparticles by thermal decomposition of bismuth-based MOF and evaluation of its nanocomposite. Iranian Journal of Chemistry and Chemical Engineering. 2020 Doi: 10.30492/ijcce.2019.37263.
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22. Adibzadeh P, Motakef Kazemi N. Preparation and characterization of curcumin-silver nanoparticle and evaluation of the effect of poly ethylene glycol and temperature. Journal of Nanoanalysis. 2018;5(3):156-162.
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23. Cowan MM. Plant Products as Antimicrobial Agents. Clinical Microbiology Reviews. 1999;12(4):564-82.
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25. Seow YX, Yeo CR, Chung HL, Yuk H-G. Plant Essential Oils as Active Antimicrobial Agents. Critical Reviews in Food Science and Nutrition. 2013;54(5):625-44.
25
26. Moghimi R, Ghaderi L, Rafati H, Aliahmadi A, McClements DJ. Superior antibacterial activity of nanoemulsion of Thymus daenensis essential oil against E. coli. Food Chemistry. 2016;194:410-5.
26
27. Donsì F, Ferrari G. Essential oil nanoemulsions as antimicrobial agents in food. Journal of Biotechnology. 2016;233:106-20.
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28. Semeniuc CA, Pop CR, Rotar AM. Antibacterial activity and interactions of plant essential oil combinations against Gram-positive and Gram-negative bacteria. Journal of Food and Drug Analysis. 2017;25(2):403-8.
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34
ORIGINAL_ARTICLE
Antibacterial Properties of Silver Nanoparticle (AgNPs) on Stainless Steel 316L
Objective(s) : The probability of contracting an infection when implanting an Stainless Steel 316L (SS316L) implant has been increasing. Infection due to implant placement is called osteomyelitis which is bone inflammation caused by biofilms formed by pyogenic bacteria. Biofilms can be prevented by giving antibacterial agents. This study aims to examine the potential of silver nanoparticles (AgNPs) as an antibacterial agent in SS316L implants. Methods : AgNPs are made through a chemical synthesis process using the Gallic acid reduction method. AgNPs solution with 5 variations of precursor concentration, namely 0.1 mM, 1 mM, 10 mM, 100 mM each added with gelatin was sprayed on SS316L by the airbrush spray coating method with a distance between nozzle and substrate of 20 cm at a pressure of 40 psi. Result : AgNPs solutions produced from various concentrations of AgNO3 precursors have a range of λmax = 401.5 nm- 424.5 nm and a particle size distribution of 0.97 - 4.88 nm. The AgNPs layer on SS316L was characterized by its crystalline phase, crystal size, and anti-bacterial activity. It has a cubic structure with a phase fraction of 6.5-19%. Based on the antibacterial activity test, all AgNPs layer samples had inhibitory zone diameters in the range of 12-16 mm. AgNPs (10mM) + Gelatin layer showed the best antibacterial ability with an inhibitory zone diameter of 16.63 mm.Conclusion : The variation in the concentration of the 10 mM AgNPs precursor-Gelatin can be developed into a coating on the surface of the SS316L implant material.
https://www.nanomedicine-rj.com/article_244771_467e4445d01bc1324b126fe0a4561da0.pdf
2021-04-01
117
127
10.22034/nmrj.2021.02.004
Osteomyelitis
AgNPs
SS316L
Airbrush spray Coating
Antibacteria
Aminatun
-
aminatun@fst.unair.ac.id
1
Department of Physics, Faculty of Science and Technology, Universitas Airlangga- Mulyorejo Kampus C, Surabaya 60115 Indonesia
LEAD_AUTHOR
Ilham
Furqon
ilham.alif.furqon.2015@fst.unair.ac.id
2
Department of Physics, Faculty of Science and Technology, Universitas Airlangga- Mulyorejo Kampus C, Surabaya 60115 Indonesia
AUTHOR
Dyah
Hikmawati
dyah.hikmawati@fst.unair.ac.id
3
Department of Physics, Faculty of Science and Technology, Universitas Airlangga- Mulyorejo Kampus C, Surabaya 60115 Indonesia
AUTHOR
Che Azurahanim
Che Abdullah
4
Department of Physics, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Malaysia
AUTHOR
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26
ORIGINAL_ARTICLE
Green synthesis and characterization of zinc oxide nanoparticles using Berberis tinctoria Lesch. leaves and fruits extract of multi-biological applications.
Abstract: The green synthesis of B. tinctoria zinc oxide nanoparticles (ZnO NPs) was rendered by using leaves and fruits extract. These extracts acted as a capping and reducing agent in stabilizing the formation of ZnO NPs. The obtained NPs were characterized by using absorption spectroscopy analysis (UV-vis) and Fourier-transform infrared spectroscopy (FT-IR) which showed a distinct peak at 274 nm, 467cm-1 and 456 cm-1. Further, the formation has been confirmed by powder X-ray diffraction (XRD) and the obtained XRD pattern fitted well with the JCPDS card, showing the pure crystalline nature of synthesized NPs Patten. The Scanning Electron Microscopy (SEM) analysis revealed hexagonal particle shape and Energy Dispersive X-ray (EDX) by confirming the strong signals of Zinc and oxygen. The results of Dynamic Light Scattering (DLS) showed that NPs obtained from both NPs of 244nm and 256nm size with the surface zeta potentials of -15.0mV and -18.9mV. Antibacterial and anti-biofilm efficacy of synthesized nanoparticles were evaluated against six human pathogenic bacteria, resulted that antibacterial/ anti-biofilm activity was increased upon increasing the concentration dose range. The obtained NPs exhibited significant antioxidants potential, which was made to study the anticancer activity against Raw 264.7 and Caco-2 cancer cell lines, which showed absolvable activity.
https://www.nanomedicine-rj.com/article_244772_44a012cc8c6c6bd0c95fec70b250ebb7.pdf
2021-04-01
128
147
10.22034/nmrj.2021.02.005
Berberis tinctoria
ZnO NPs
Antibacterial
Anti-biofilm
antioxidants
anti-cancer
Vignesh
Arumugam
arumugamvignesh90@gmail.com
1
Department of Botany, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.
AUTHOR
Selvakumar
Subramaniam
selvs20@yahoo.com
2
Department of Biochemistry, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India
AUTHOR
Vasanth
Krishnan
vasanthlabbu@gmail.com
3
Department of Botany, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.
LEAD_AUTHOR
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55
ORIGINAL_ARTICLE
In vitro release kinetics study of Diallyl Disulphide entrapped into mesoporous silica matrix & evaluation of its antimicrobial activity
Diallyl disulphide (DADS) is one of the major constituents of garlic which has antimicrobial activity as well as many other advantages for human health. Sulphur present in DADS is main the reactive one to deal with the microbes. Mesoporous silica nanomaterial (MSNs) is evaluated as a potential drug carrier for any organic drug molecule to keep it intact for in vitro sustained release. Comparing two different body fluids, the dissolution rate of DADS is more in SBF than SGF because of its acidic nature. In two mediums the release mechanism is super case II transport as in both cases the ‘n’ value of Koresmeyer Peppas model is greater than 0.89. MIC value of DADS against Salmonella typhi is 0.941 mg/ml. Besides this microscopic analysis confirm the deformation of microbial cells. This means MSN's entrapped with DADS and subsequently released in pH 7.4 is much more concerned with the high amount of drug availability in body fluids.
https://www.nanomedicine-rj.com/article_244773_9f6ec1a2523767e23fec74fdcb1d0794.pdf
2021-04-01
148
157
10.22034/nmrj.2021.02.006
Diallyl Disulphide
Mesoporous silica nanoparticles
Sustained-release
kinetic modeling
MIC
Pritha
Pal
prithapal.rs@jadavpuruniversity.in
1
School of Materials Science & Nanotechnology, Jadavpur University, Kolkata-32, India.
AUTHOR
Rajib
Dey
rdey@metal.jdvu.ac.in
2
Metallurgical & Material Engg. Dept. Jadavpur University, Kolkata-32, India
AUTHOR
Satadal
Das
drsatdas@hotmail.com
3
Senior Consultant Microbiologist, Peerless Hospital & B. K. Roy Research Centre, Kolkata, India.
AUTHOR
Mahua
Chaudhuri
mgcju.nano@gmail.com
4
School of Materials Science & Nanotechnology, Jadavpur University, Kolkata-32, India.
LEAD_AUTHOR
1. Pal, P., Dey, R., Das, S., & Chaudhuri, M. G., 2018. Nanomaterials in Relation To Their Drug Delivery and Release Mechanisms: a Review Exemplified With Some Herbal Drugs, World Journal of Pharmaceutical Research, 7(9), pp. 1782–1804.
1
2. Tao Z. Mesoporous silica-based nanodevices for biological applications. RSC Advances. 2014;4(36):18961.
2
3. Somade OT, Ugbaja RN, Alli AA, Odubote OT, Yusuf TS, Busari BT. Diallyl disulfide, an organo-sulfur compound in garlic and onion attenuates trichloromethane-induced hepatic oxidative stress, activation of NFkB and apoptosis in rats. Journal of Nutrition & Intermediary Metabolism. 2018;13:10-9.
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4. Tepe B, Sokmen M, Akpulat H, Sokmen A. In vitro antioxidant activities of the methanol extracts of five species from Turkey. Food Chemistry. 2005;92(1):89-92.
4
5. Lanzotti V. The analysis of onion and garlic. Journal of Chromatography A. 2006;1112(1-2):3-22.
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6. Corzomartinez M, Corzo N, Villamiel M. Biological properties of onions and garlic. Trends in Food Science & Technology. 2007;18(12):609-25.
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7. Leuschner RGK, Ielsch V. Antimicrobial effects of garlic, clove and red hot chilli onListeria monocytogenesin broth model systems and soft cheese. International Journal of Food Sciences and Nutrition. 2003;54(2):127-33.
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8. Mostafa MG, Mima T, Ohnishi ST, Mori K. S-Allylcysteine Ameliorates Doxorubicin Toxicity in the Heart and Liver in Mice. Planta Medica. 2000;66(2):148-51.
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9. Yin M-c, Cheng W-s. Antioxidant and antimicrobial effects of four garlic-derived organosulfur compounds in ground beef. Meat Science. 2003;63(1):23-8.
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13
14. O’Gara EA, Hill DJ, Maslin DJ. Activities of Garlic Oil, Garlic Powder, and Their Diallyl Constituents against Helicobacter pylori. Applied and Environmental Microbiology. 2000;66(5):2269-73.
14
15. Lampe JW. Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies. The American Journal of Clinical Nutrition. 1999;70(3):475s-90s.
15
16. Fukushima, S., Takada, N., Wanibuchi, H., Hori, T., Min, W., & Ogawa, M., 2001. Recent Advances on the Nutritional Effects Associated with the Use of Garlic as a Supplement Suppression of Chemical Carcinogenesis by Water-Soluble Organosulfur, (1988), pp. 1049–1053.
16
17. Kaushik, M. L., & Jalalpure, S. S., 2011. Asian Journal of Pharmaceutical and Clinical Research. Asian Journal of Pharmaceutical and Clinical Research, 4(3), pp. 9–11.
17
18. Pukkela P, Borra S. Machine Learning Based Plant Leaf Disease Detection and Severity Assessment Techniques: State-of-the-Art. Lecture Notes in Computational Vision and Biomechanics: Springer International Publishing; 2017. p. 199-226.
18
19. Tasci B, Kutuk H, Koca I. Determination of alliin and allicin in the plant of Allium scorodoprasum L. subsp. rotundum by using the infrared spectroscopy technique. Acta Horticulturae. 2016(1143):133-8.
19
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21. Nariyal, R. K., Kothari, P., & Bisht, B., 2014. FTIR Measurements of SiO2 Glass Prepared by Sol-Gel Technique. Chemical Science Transactions, 3(3), pp. 1064–1066.
21
22. Zhou C, Hu X, Chao C, Li H, Zhang S, Yan X, et al. Quantitation of Allicin in Garlic-based Products: Comparisons among Spectrophotometry, GC and HPLC. Advance Journal of Food Science and Technology. 2015;9(4):269-77.
22
23. Dash, S., Murthy, P. N., Nath, L., & Chowdhury, P., 2010. Kinetic modeling on drug release from controlled drug delivery systems. Acta Poloniae Pharmaceutica - Drug Research, 67(3), pp. 217–223.
23
ORIGINAL_ARTICLE
A new ethosomal nanoparticle for controlled release of black cumin compounds against cancer cells
Black cumin contains biologically active compounds such as Thymoquinone, which have strong anti-cancer properties. However, most of these agents have poor stability and solubility that limits its use as drugs. In this work, an anti-cancer ethosomal nanostructure containing black cumin extract (BCE) was prepared to release as transdermal-controlled. After synthesis and evaluation the vesicles for size and charge, as well as determining the ratio of in vitro and ex vivo permeability, experiments to assay their cell toxicity and apoptosis were also investigated. It was confirmed the stable shape (containing 5% soy lecithin, 45% ethanol, and 1.5% cholesterol with a zeta potential of -61±2 and polydispersity index of 0.14± 0.012.), spherical morphology (20nm) and the effective release rate (40% after 24h in ex vivo permeability test) of these loaded ethosomal nanocarriers using the HPLC, DLS, FTIR, TGA methods and the in vitro and ex vivo release tests,. MTT bioassay with BCE (96µg/ml compared to 200 µg/ml) and DOX separately and their ethosomal forms showed the higher cellular toxicity of ethosomic forms on MCF-7. Flow cytometry also proved strong apoptosis in the MCF-7 cells treated with ethosomal compared to non-ethosomal forms (~64.7% for BCE (5.90% in late apoptotic stage), and ~21.6% of BCE-Eth (~71.8% in late apoptosis stage). In conclusion, our findings show that this new nanoparticle not only improves the enclosure of plant metabolites and chemotherapeutic agents but also increases the effectiveness of metabolites by increasing their controlled release and so on reduces the side effects of chemotherapy drugs.
https://www.nanomedicine-rj.com/article_244774_daed47357693ea0f8c24024ecb41b3c2.pdf
2021-04-01
158
169
10.22034/nmrj.2021.02.007
Ethosome
Black Cumin
Nanocarrier
Breast cancer
Cytotoxicity
Shilan
Nasri
shilannasri@yahoo.com
1
Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
AUTHOR
Mahdi
Rahaie
mrahaie@ut.ac.ir
2
Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
LEAD_AUTHOR
Bahman
Ebrahimi-Hoseinzadeh
bahman.ebrahimi@ut.ac.ir
3
Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
AUTHOR
Ashrafalsadat
Hatamian-Zarmi
hatamian_a@ut.ac.ir
4
Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
AUTHOR
Razi
Sahraeian
s.razi@ippi.ac.ir
5
Iran Polymer and Petrochemical Institute, Tehran, Iran
AUTHOR
1. Wang Y, Zhao R, Wang S, Liu Z, Tang R. In vivo dual-targeted chemotherapy of drug resistant cancer by rationally designed nanocarrier. Biomaterials. 2016;75:71-81.
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3. Ambrož M, Boušová I, Skarka A, Hanušová V, Králová V, Matoušková P, et al. The Influence of Sesquiterpenes from Myrica rubra on the Antiproliferative and Pro-Oxidative Effects of Doxorubicin and Its Accumulation in Cancer Cells. Molecules. 2015;20(8):15343-58.
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18. Bhattacharya S, Ahir M, Patra P, Mukherjee S, Ghosh S, Mazumdar M, et al. PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a. Biomaterials. 2015;51:91-107.
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20. Mura S, Pirot F, Manconi M, Falson F, Fadda AM. Liposomes and niosomes as potential carriers for dermal delivery of minoxidil. Journal of Drug Targeting. 2007;15(2):101-8.
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23. Xie J, Ji Y, Xue W, Ma D, Hu Y. Hyaluronic acid-containing ethosomes as a potential carrier for transdermal drug delivery. Colloids and Surfaces B: Biointerfaces. 2018;172:323-9.
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28. Abdel Messih HA, Ishak RAH, Geneidi AS, Mansour S. Nanoethosomes for transdermal delivery of tropisetron HCl: multi-factorial predictive modeling, characterization, and ex vivo skin permeation. Drug Development and Industrial Pharmacy. 2017;43(6):958-71.
28
29. Baharetha HM, Nassar ZD, Aisha AF, Ahamed MBK, Al-Suede FSR, Kadir MOA, et al. Proapoptotic and Antimetastatic Properties of Supercritical CO2 Extract of Nigella sativa Linn. Against Breast Cancer Cells. Journal of Medicinal Food. 2013;16(12):1121-30.
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38
39. Peram MR, Jalalpure S, Kumbar V, Patil S, Joshi S, Bhat K, et al. Factorial design based curcumin ethosomal nanocarriers for the skin cancer delivery: in vitro evaluation. Journal of Liposome Research. 2019;29(3):291-311.
39
40. Zhang Z, Chen Y, Xu H, Wo Y, Zhang Z, Liu Y, et al. 5-Aminolevulinic acid loaded ethosomal vesicles with high entrapment efficiency for in vitro topical transdermal delivery and photodynamic therapy of hypertrophic scars. Nanoscale. 2016;8(46):19270-9.
40
ORIGINAL_ARTICLE
Green Synthesis of Stable Silver Nanoparticles Using Teucrium polium Extract: In-vitro Anticancer Activity on NALM-6
Abstract: The therapeutic effect of silver nanoparticles on leukaemia cancerous cells has been demonstrated in several studies. However, most of these nanoparticles are toxic to normal cells as well as cancerous cells. In the present study, green chemistry has been applied for the synthesis of silver nanoparticles by Teucrium polium (T.P) extract. The synthesized nanoparticles were spherical with an average diameter of 14.3 ± 9.7 nm and a surface charge of -0.84 mV. Based on the FTIR results, the silver nanoparticles have been coated with T.P extract phytochemicals. The extract was not toxic toward cancerous cells. However, the T.P extract coated silver nanoparticles (T.P@AgNPs) with concentrations ≥ 50 µg/mL could eradicate the NALM-6 cancerous cells in a significant amount. Based on the flow cytometry analysis, the predominant mechanism of cancerous cell death is the apoptosis in NALM-6 cancerous cells; and the T.P@AgNPs had no toxic effect on normal PBMC cells.
https://www.nanomedicine-rj.com/article_244775_0deadaf6478db2d1a0bee0f0fe176181.pdf
2021-04-01
170
178
10.22034/nmrj.2021.02.008
Silver nanoparticles
Green synthesis
Acute lymphoblastic leukaemia
Seyed Mohammad
Amini
sma88nano@gmail.com
1
Radiation Biology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.
AUTHOR
Maryam
Samareh Salavati Pour
m.samareh72@gmail.com
2
Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Reza
Vahidi
reza.vahidi2009@gmail.com
3
Research Center for Hydatid Disease in Iran, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Seyedeh Mehrnaz
Kouhbananinejad
m.kouhbanani@gmail.com
4
Department of Hematology and Laboratory Sciences, Faculty of Allied Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Mahla
Sattarzadeh Bardsiri
sabasatarzadeh3261@gmail.com
5
Department of Hematology and Laboratory Sciences, Faculty of Allied Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Alireza
Farsinejad
farsinezhad239@yahoo.com
6
Department of Hematology and Laboratory Sciences, Faculty of Allied Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Mohamad
Mirzaei-Parsa
mj.mirzaei@kmu.ac.ir
7
Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran
LEAD_AUTHOR
1. Richard-Carpentier G, Kantarjian H, Jabbour E. Recent Advances in Adult Acute Lymphoblastic Leukemia. Current Hematologic Malignancy Reports. 2019.
1
2. Ghasemimehr N, Farsinejad A, Mirzaee Khalilabadi R, Yazdani Z, Fatemi A. The telomerase inhibitor MST-312 synergistically enhances the apoptotic effect of doxorubicin in pre-B acute lymphoblastic leukemia cells. Biomedicine & Pharmacotherapy. 2018;106:1742-50.
2
3. Neshastehriz A, Amini SM, Mohammadi A, Mahdavi SR, Mahabadi VP, Akbari A. In-vitro investigation of green synthesized gold nanoparticle’s role in combined photodynamic and radiation therapy of cancerous cells. Advances in Natural Sciences: Nanoscience and Nanotechnology. 2020;11(4):045006.
3
4. Amini SM, Mohammadi E, Askarian‐Amiri S, Azizi Y, Shakeri‐Zadeh A, Neshastehriz A. Investigating the in vitro photothermal effect of green synthesized apigenin‐coated gold nanoparticle on colorectal carcinoma. IET Nanobiotechnology. 2021;15(3):329-37.
4
5. Chugh H, Sood D, Chandra I, Tomar V, Dhawan G, Chandra R. Role of gold and silver nanoparticles in cancer nano-medicine. Artificial Cells, Nanomedicine, and Biotechnology. 2018;46(sup1):1210-20.
5
6. Castiglioni S, Caspani C, Cazzaniga A, Maier JA. Short-and long-term effects of silver nanoparticles on human microvascular endothelial cells. World journal of biological chemistry, 2014;5 (4):457.
6
7. He Y, Li X, Zheng Y, Wang Z, Ma Z, Yang Q, et al. A green approach for synthesizing silver nanoparticles, and their antibacterial and cytotoxic activities. New Journal of Chemistry. 2018;42(4):2882-8.
7
8. Hashemi SF, Tasharrofi N, Saber MM. Green synthesis of silver nanoparticles using Teucrium polium leaf extract and assessment of their antitumor effects against MNK45 human gastric cancer cell line. Journal of Molecular Structure. 2020;1208:127889.
8
9. Al-Sheddi ES, Farshori NN, Al-Oqail MM, Al-Massarani SM, Saquib Q, Wahab R, et al. Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA). Bioinorganic Chemistry and Applications. 2018;2018:1-12.
9
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The Anti-Mycobacterial Activity Of Ag, ZnO, And Ag- ZnO Nanoparticles Against MDR- And XDR-Mycobacterium tuberculosis
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40
ORIGINAL_ARTICLE
Overcoming the antibiotic resistance of Acinetobacter baumannii by using nanofluid containing functionalized carbon nanotubes
Objective: Acinetobacter baumannii is critical for healthcare-associated infections with significant regional differences in the resistance rate, but its risk factors and infection trends have not been well studied. Carbon nanotubes are substantially cylindrical molecules made entirely of carbon atoms and can use as nanocarriers. Multi-wall carbon nanotubes, through their unique properties, hold great promise in the fight against multidrug-resistant bacterial infections. In this research, antimicrobial effects study and the ability to overcome antibiotic resistance evaluation of nanofluid containing functionalized carbon nanotubes on A. baumannii were done. Methods: Multi-wall carbon nanotubes provided from the United States Research and the nanofluid prepared after carbon nanotube functionalization. Microplate, Alamar Blue Cell viability assay, carried out after incubation of A. baumannii affected with the nanofluid (100µg/ml) for 24h. Results: Antimicrobial effect of functionalized carbon nanotubes nanofluid was found on the A. baumannii in a dose-specific concentration manner. Conclusion: This study showed that functionalized carbon nanotubes nanofluid could have antimicrobial effects on A. baumannii by overcoming bacterial antibiotic resistance. Although to get more accurate results, to prevent nosocomial infections, more specific cellular and molecular studies are necessary.
https://www.nanomedicine-rj.com/article_244776_4040623741daa9632aa7cac62cfcadf4.pdf
2021-04-01
179
187
10.22034/nmrj.2021.02.009
Antimicrobial effect
Acinetobacter baumannii
Carbon nanotubes
nanofluid
Antibiotic resistance
Mohammad Reza
Yazdani
mh.yazdani69@yahoo.com
1
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
AUTHOR
Mojgan
Sheikhpour
m_sheikhpour@pasteur.ac.ir
2
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.
LEAD_AUTHOR
Seyed Davar
Siadat
d.siadat@gmail.com
3
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.
AUTHOR
Parvaneh
Safarian
parvaneh.saffarian@srbiau.ac.ir
4
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
AUTHOR
1. Jung J, Park W. Acinetobacter species as model microorganisms in environmental microbiology: current state and perspectives. Applied Microbiology and Biotechnology. 2015;99(6):2533-48.
1
2. Venditti C, Vulcano A, D’Arezzo S, Gruber CEM, Selleri M, Antonini M, et al. Epidemiological investigation of an Acinetobacter baumannii outbreak using core genome multilocus sequence typing. Journal of Global Antimicrobial Resistance. 2019;17:245-9.
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3. Gordon NC, Wareham DW. Multidrug-resistant Acinetobacter baumannii: mechanisms of virulence and resistance. International Journal of Antimicrobial Agents. 2010;35(3):219-26.
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4. Hui, J., et al., Drug-resistant gene based genotyping forAcinetobacter baumanniiin tracing epidemiological events and for clinical treatment within nosocomial settings. Chinese medical journal, 2009. 122(3): p. 301-306.
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5. Peleg AY, Seifert H, Paterson DL. Acinetobacter baumannii : Emergence of a Successful Pathogen. Clinical Microbiology Reviews. 2008;21(3):538-82.
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29. Banihashemi K, Amirmozafari N, Mehregan I, Bakhtiari R, Sobouti B. Antibacterial effect of carbon nanotube containing chemical compounds on drug-resistant isolates of Acinetobacter baumannii. Iranian Journal of Microbiology. 2021.
29
ORIGINAL_ARTICLE
Loading Efficiency of Doxorubicin-Loaded Beta-1,3- Glucan Nanoparticles: An Artificial Neural Networks Study
Purpose: Artificial neural networks (ANNs) were used to optimize a formulation of β-1,3-glucan nanoparticles containing doxorubicin (Dox) through a study of the critical parameters affecting the drug's loading efficiency. Methods: Using an ANNs model, we evaluated the effect of four input variables, involved in preparation of the carrier system, including concentrations of succinic anhydride (Sa), NaOH and polyethyleneimine (PEI) as well as ratio of Dox/Carrier, on loading efficiency of Dox as output parameter, when Dox was conjugated to the carrier (Con-Dox-Glu) or in unconjugated form (Un-Dox-Glu).Results: The model demonstrated that increasing Sa and PEI leads to reduced loading efficiency, while the effect of NaOH on loading efficiency does not appear to be important in both Con-Dox-Glu and Un-Dox-Glu delivery system. Ratio of Dox/Carrier showed complex effects on loading efficiency: while a certain value was required to provide maximum loading efficiency in Con-Dox-Glu, a different critical value was associated with obtaining minimum loading efficiency in Un-Dox-Glu.Conclusion: By defining the effects of each parameter on the loading efficiency of Glu-Dox nanoparticles, this study demonstrated the feasibility of using an ANN model to optimize the conditions for achieving maximum loading efficiency in both conjugated and non-conjugated drug delivery system.
https://www.nanomedicine-rj.com/article_244777_b88106a8e2fba25311d2a313043f0f4e.pdf
2021-04-01
188
194
10.22034/nmrj.2021.02.010
Artificial neural networks. Glu-Dox nanoparticle
loading efficiency
conjugated Dox
unconjugated Dox
Zahra
Nasrollahi
znasrollahi2@gmail.com
1
Medical Faculty, Qom University of Medical Sciences, Qom, Iran
AUTHOR
SamiraSamira
Khani
samira.khani1@gmail.com
2
Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran.
AUTHOR
Esmaeil
Mollarazi
emollarazi@yahoo.com
3
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, Ministry of Health and Medical Education (MOHME), Tehran, Iran.
AUTHOR
Fatemeh
Atyabi
atyabifa@tums.ac.ir
4
Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Amir
Amani
aamani@tums.ac.ir
5
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
LEAD_AUTHOR
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