ORIGINAL_ARTICLE
Dermal toxicity of Colloidal Nanosilver in Albino Rabbit: A New Approach to Physicochemical Properties
Objective(s): Silver nanoparticles have been widely used as new potent antimicrobial agents in cosmetic and hygienic products, as well as in new medical devices. Serious concerns have been expressed on the potential health risks of dermal applications of nanosilver containing consumer products (AgNPs), therefore regulatory health risk assessment has become necessary for the safe usage of AgNPs in biomedical products with special emphasis to their dermal toxicity potentials. We aimed in the present study to compare the dermal toxicity of three different AgNP containing disinfectantsin an albino rabbit model and tried to determine the role of size and other physicochemical properties on their possible dermal toxicity. Methods: After the characterization of all three samples by transmission electron microscopy (TEM), X-Ray Diffraction (XRD) and Dynamic Light Scattering (DLS) , corrosive and irritant potentials of AgNPs in three different sizes of three colloidal AgNPs were scored by the OECD 404 guideline with necessary modifications and were applied under the specified concentrations via nanosilver skin patches on the shaved skin of young female albino rabbits. All skin reactions were recorded in 3 min as well as in 1, 4, 24, 48 and 72 hours from the application and compared with the control group and followed up for 14 days. Results: Although short-term observations didn’t show any significant changes in the weight of animals and macroscopic variables, long-term histopathological abnormalities were seen in the skin of all test groups, which was not associated with the size and other physicochemical properties of AgNP samples. The toxicity manifestations were dry skin, scaling in doses lower than 100 ppm and erythema in higher doses up to 4000 ppm which was reversed. Conclusions: This finding creates a new issue in the possible dermal effects of all colloidal AgNPs, containing nano health products, which should be considered in future studies by focusing on other physicochemical properties of AgNPs and possible underlying mechanisms of toxicity by conducting cellular models.
https://www.nanomedicine-rj.com/article_26346_f0c3dcc0ba6c303b46970068b70fd50a.pdf
2017-09-01
142
149
10.22034/nmrj.2017.03.001
Dermal toxicity
Irritation
Corrosion
Nanosilver
AgNPs
Commercial products
Albino rabbit
Anoushe
Raesian
anousheraesian@yahoo.com
1
Pharmaceutical Sciences Research Center, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Sepideh
Arbabi Bidgoli
arbabi@iaups.ac.ir
2
Department of Toxicology and Pharmacology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
LEAD_AUTHOR
Seyed Mahdi
Rezayat Sorkhabadi
rezayat@tums.ac.ir
3
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
1.Munger MA, Radwanski P, Hadlock GC, Stoddard G, Shaaban A, Falconer J, Grainger DW, Deering-Rice CE. In vivo human time-exposure study of orally dosed commercial silver nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine, 2014;10 (1):1-9.
1
2.Dekkers S, Oomen AG, Bleeker EA, Vandebriel RJ, Micheletti C, Cabellos J, Janer G, Fuentes N, Vázquez-Campos S, Borges T. Towards a nanospecific approach for risk assessment. Regulatory Toxicology and Pharmacology, 2016;80:46-59.
2
3.Huk A, Izak-Nau E, Reidy B, Boyles M, Duschl A, Lynch I, Dušinska M. Is the toxic potential of nanosilver dependent on its size? Particle and fibre toxicology, 2014;11 (1):65
3
4.El-Badawy A Feldhake D, Venkatapathy R State of the Science Literature Review: Everything Nanosilver and More [Report] / U.S. Environmental Protection Agency,Office of Research and Development,Washington, DC 20460. , 2010.
4
5.Dastjerdi R, Montazer M. A review on the application of inorganic nano-structured materials in the modification of textiles: focus on anti-microbial properties. Colloids and Surfaces B: Biointerfaces, 2010;79 (1):5-18
5
6.Ge L, Li Q, Wang M, Ouyang J, Li X, Xing MM. Nanosilver particles in medical applications: synthesis, performance, and toxicity. International journal of nanomedicine, 2014;9:2399.
6
7.Arora S, Jain J, Rajwade J, Paknikar K. Interactions of silver nanoparticles with primary mouse fibroblasts and liver cells. Toxicology and applied pharmacology, 2009;236 (3):310-318
7
8.Bidgoli SA, Mahdavi M, Rezayat SM, Korani M, Amani A, Ziarati P. Toxicity assessment of nanosilver wound dressing in Wistar rat. Acta Medica Iranica, 2013;51 (4):203
8
9.Massarsky A, Trudeau VL, Moon TW. Predicting the environmental impact of nanosilver. Environmental toxicology and pharmacology, 2014;38 (3):861-873.
9
10.Kim HR, Park YJ, Da Young Shin SMO, Chung KH. Appropriate in vitro methods for genotoxicity testing of silver nanoparticles. Environmental health and toxicology, 2013;28.
10
11.Sadeghi B, Garmaroudi FS, Hashemi M, Nezhad H, Nasrollahi A, Ardalan S, Ardalan S. Comparison of the anti-bacterial activity on the nanosilver shapes: nanoparticles, nanorods and nanoplates. Advanced Powder Technology, 2012;23 (1):22-26.
11
12.Korani M, Rezayat S, Gilani K, Bidgoli SA, Adeli S. Acute and subchronic dermal toxicity of nanosilver in guinea pig. International journal of nanomedicine, 2011;6:855.
12
13.Korani M, Rezayat SM, Bidgoli SA. Sub-chronic dermal toxicity of silver nanoparticles in guinea pig: special emphasis to heart, bone and kidney toxicities. Iranian journal of pharmaceutical research: IJPR, 2013;12 (3):511.
13
14.GUIDELINE DUT. OECD Guidelines for the Testing of Chemicals: OECD, OECD Publishing, Paris, France; 2001.
14
15.Chaloupka K, Malam Y, Seifalian AM. Nanosilver as a new generation of nanoproduct in biomedical applications. Trends in biotechnology, 2010;28 (11):580-588.
15
16.Bidgoli SA, Mahdavi M, Rezayat SM, Korani M, Amani A, Ziarati P. Toxicity assessment of nanosilver wound dressing in Wistar rat. Acta Medica Iranica, 2013;51 (4):203.
16
17.Stebounova LV, Adamcakova-Dodd A, Kim JS, Park H, T O'Shaughnessy P, Grassian VH, Thorne PS. Nanosilver induces minimal lung toxicity or inflammation in a subacute murine inhalation model. Particle and fibre toxicology, 2011;8 (1):5.
17
18.Kim YS, Song MY, Park JD, Song KS, Ryu HR, Chung YH, Chang HK, Lee JH, Oh KH, Kelman BJ. Subchronic oral toxicity of silver nanoparticles. Particle and fibre toxicology, 2010;7 (1):20.
18
19.Heshmati M, ArbabiBidgoli S, Khoei S, Rezayat SM, Parivar K. Mutagenic effects of nanosilver consumer products: a new approach to physicochemical properties. Iranian journal of pharmaceutical research: IJPR, 2015;14 (4):1171
19
20.Guo X, Li Y, Yan J, Ingle T, Jones MY, Mei N, Boudreau MD, Cunningham CK, Abbas M, Paredes AM. Size-and coating-dependent cytotoxicity and genotoxicity of silver nanoparticles evaluated using in vitro standard assays. Nanotoxicology, 2016;10 (9):1373-1384.
20
ORIGINAL_ARTICLE
Preparation and characterization of a carbon-based magnetic nanostructure via co-precipitation method: Peroxidase-like activity assay with 3,3ʹ,5,5ʹ-tetramethylbenzidine
Objective(S): Natural and artificial enzymes have shown important roles in biotechnological processes. Recently, design and synthesis of artificial enzymes especially peroxidase mimics has been interested by many researchers. Due to disadvantages of natural peroxidases, there is a desirable reason of current research interest in artificial peroxidase mimics. Methods: In this study, magnetic multiwall carbon nanotubes with a structure of Fe3O4/MWCNTs as enzyme mimetic were fabricated using in situ co-precipitation method. The structure, composition, and morphology of Fe3O4/MWCNTs nanocomposite were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). The magnetic properties were investigated by the vibrating sample magnetometer (VSM). Peroxidase-like catalytic activity of nanocomposite was investigated using colorimetric and electrochemical tests with 3,3ʹ,5,5ʹ-tetramethylbenzidine (TMB) substrate. Results: The obtained data proved the synthesis of Fe3O4/MWCNTs nanocomposite. The average crystallite size of nanostructures was estimated about 12 nm by Debye–Scherer equation. It was found that Fe3O4/MWCNTs nanocomposite exhibit peroxidase-like activity. Colorimetric and electrochemical data demonstrated that prepared nanocomplex has higher catalytic activity toward H2O2 than pure MWCNT nanocatalyst. From electrochemical tests concluded that the Fe3O4/MWCNTs electrode exhibited the better redox response to H2O2, which is ~ 2 times larger than that of the MWCNTs. Conclusions: The synthesis of Fe3O4nanoparticles on MWCNTs was successfully performed by in situ co-precipitation process. Fe3O4/MWCNTs nanocatalyst exhibited a good peroxidase-like activity. These biomimetic catalysts have some advantages such as simplicity, stability and cost effectiveness that can be used in the design of enzyme-based devices for various applied fields.
https://www.nanomedicine-rj.com/article_26815_ee372984465f3ef95a17551e3439bba8.pdf
2017-09-01
150
157
10.22034/nmrj.2017.03.002
Magnetic carbon nanotubes
Nanozyme
Peroxidase-like activity
Characterization
Navvabeh
Salarizadeh
salarinavabeh@yahoo.com
1
Department of Biochemistry and Biophysics, Education and Research Center of Science and Biotechnology, Malek Ashtar University of Technology, Tehran, Iran
AUTHOR
Minoo
Sadri
mnsadri@yahoo.com
2
Department of Biochemistry and Biophysics, Education and Research Center of Science and Biotechnology, Malek Ashtar University of Technology, Tehran, Iran
LEAD_AUTHOR
1. Zhao K, GW, Zheng S, Zhang C, Xian Y. SDS–MoS2 nanoparticles as highly-efficient peroxidase mimetics for colorimetric detection of H2O2 and glucose. Talanta, 2015;141:47-52.
1
2. Wang H, Li S, Si Y, Sun Z, Li S, Lin Y. Recyclable enzyme mimic of cubic Fe3O4 nanoparticles loaded on graphene oxide-dispersed carbon nanotubes with enhanced peroxidase-like catalysis and electrocatalysis. Journal of Materials Chemistry B, 2014;2 (28):4442-4448.
2
3. Wei J, Chen X, Shi S, Mo S, Zheng N. An investigation of the mimetic enzyme activity of two-dimensional Pd-based nanostructures. Nanoscale, 2015;7(45):19018-26.
3
4. Zhu S, Zhao XE, You J, Xu G, Wang H. Carboxylic-group-functionalized single-walled carbon nanohorns as peroxidase mimetics and their application to glucose detection. Analyst, 2015;140(18):6398-6403.
4
5. Song L, Huang C, Zhang W, Ma M, Chen Z, Gu N, Zhang Y. Graphene oxide-based Fe2O3 hybrid enzyme mimetic with enhanced peroxidase and catalase-like activities. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2016;506:747-755.
5
6. Deng J, Wen X, Li J. Fabrication highly dispersed Fe3O4 nanoparticles on carbon nanotubes and its application as a mimetic enzyme to degrade Orange II. Environmental technology, 2016;37 (17):2214-2221.
6
7. Shu J, Qiu Z, Wei Q, Zhuang J, Tang D. Cobalt-porphyrin-platinum-functionalized reduced graphene oxide hybrid nanostructures: A novel peroxidase mimetic system for improved electrochemical immunoassay. Scientific reports, 2015;5:15113.
7
8. Li B, Chen D, Wang J, Yan Z, Jiang L, Duan D, He J, Luo Z, Zhang J, Yuan F. MOFzyme: Intrinsic protease-like activity of Cu-MOF. Scientific reports, 2014;4.
8
9. Wang G-L, Jin L-Y, Dong Y-M, Wu X-M, Li Z-J. Intrinsic enzyme mimicking activity of gold nanoclusters upon visible light triggering and its application for colorimetric trypsin detection. Biosensors and Bioelectronics, 2015;64:523-529.
9
10. Köhler V, Turner NJ. Artificial concurrent catalytic processes involving enzymes. Chemical Communications, 2015;51 (3):450-464.
10
11. Lin Y, Li Z, Chen Z, Ren J, Qu X. Mesoporous silica-encapsulated gold nanoparticles as artificial enzymes for self-activated cascade catalysis. Biomaterials, 2013;34(11):2600-10.
11
12. Wei H, Wang E. Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes. Chemical Society Reviews, 2013;42 (14):6060-6093.
12
13. Torres E, Ayala M. Biocatalysis based on heme peroxidases: peroxidases as potential industrial biocatalysts: Springer Science & Business Media; 2010.
13
14. Yang Z, Cao Y, Li J, Lu M, Jiang Z, Hu X. Smart CuS nanoparticles as peroxidase mimetics for the design of novel label-free chemiluminescent immunoassay. ACS applied materials & interfaces, 2016;8(19):12031-8.
14
15. Yang Z, Cao Y, Li J, Lu M, Jiang Z, Hu X. Smart CuS nanoparticles as peroxidase mimetics for the design of novel label-free chemiluminescent immunoassay. ACS applied materials & interfaces, 2016;8 (19):12031-12038.
15
16. Zhao K, Gu W, Zheng S, Zhang C, Xian Y. SDS–MoS2 nanoparticles as highly-efficient peroxidase mimetics for colorimetric detection of H2O2 and glucose. Talanta, 2015;141: 47-52.
16
17. Kermani HA, Shockravi A, Moosavi-Movahedi Z, Khalafi-Nezhad A, Behrouz S, Tsai F-Y, Hakimelahi G, Seyedarabi A, Moosavi-Movahedi A. A surfactant–heme–sulfonyl imidazole system as a nano-artificial enzyme. Journal of the Iranian Chemical Society, 2013;10 (5):961-968.
17
18. Moosavi-Movahedi Z, Gharibi H, Hadi-Alijanvand H, Akbarzadeh M, Esmaili M, Atri MS, Sefidbakht Y, Bohlooli M, Nazari K, Javadian S. Caseoperoxidase, mixed β-casein–SDS–hemin–imidazole complex: a nano artificial enzyme. Journal of Biomolecular Structure and Dynamics, 2015;33 (12):2619-2632.
18
19. Kosman J, Juskowiak B. Peroxidase-mimicking DNAzymes for biosensing applications: a review. Analytica chimica acta, 2011;707 (1):7-17.
19
20. Zhang Y, Xu C, Li B. Self-assembly of hemin on carbon nanotube as highly active peroxidase mimetic and its application for biosensing. RSC Advances, 2013;3 (17):6044-6050.
20
21. Luo L, Zhang Y, Li F, Si X, Ding Y, Deng D, Wang T. Enzyme mimics of spinel-type Cox Ni 1− x Fe2O4 magnetic nanomaterial for eletroctrocatalytic oxidation of hydrogen peroxide. Analytica chimica acta, 2013;788:46-51.
21
22. Gao L, Zhuang J, Nie L, Zhang J, Zhang Y, Gu N, Wang T, Feng J, Yang D, Perrett S. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nature nanotechnology, 2007;2 (9):577-583.
22
23. Liu T, Zhao K, Jin L, Zhu J, Dong Y, Yan Y, Wang P, He D. Peroxidase-Like Properties of Multiple Nano-Metallic Oxides under Various Conditions. General Chemistry, 2016;2 (1).
23
24. Shi Y, Huang J, Wang J, Su P, Yang Y. A magnetic nanoscale Fe3O4/P β-CD composite as an efficient peroxidase mimetic for glucose detection. Talanta, 2015;143:457-463.
24
25. Zubir NA, Yacou C, Motuzas J, Zhang X, Da Costa JCD. Structural and functional investigation of graphene oxide–Fe3O4 nanocomposites for the heterogeneous Fenton-like reaction. Scientific reports, 2014;4.
25
26. Zhu M, Diao G. Review on the progress in synthesis and application of magnetic carbon nanocomposites. Nanoscale, 2011;3 (7):2748-2767.
26
27. Lin L, Song X, Chen Y, Rong M, Zhao T, Wang Y, Jiang Y, Chen X. Intrinsic peroxidase-like catalytic activity of nitrogen-doped graphene quantum dots and their application in the colorimetric detection of H2O2 and glucose. Analytica chimica acta, 2015;869:89-95.
27
28. Chen J, Ge J, Zhang L, Li Z, Qu L. Poly (styrene sulfonate) and Pt bifunctionalized graphene nanosheets as an artificial enzyme to construct a colorimetric chemosensor for highly sensitive glucose detection. Sensors and Actuators B: Chemical, 2016;233:438-444.
28
29. Li L, Zeng C, Ai L, Jiang J. Synthesis of reduced graphene oxide-iron nanoparticles with superior enzyme-mimetic activity for biosensing application. Journal of Alloys and Compounds, 2015;639:470-477.
29
30. Zuo X, Peng C, Huang Q, Song S, Wang L, Li D, Fan C. Design of a carbon nanotube/magnetic nanoparticle-based peroxidase-like nanocomplex and its application for highly efficient catalytic oxidation of phenols. Nano Research, 2009;2 (8):617-623.
30
31. Cui R, Han Z, Zhu JJ. Helical carbon nanotubes: intrinsic peroxidase catalytic activity and its application for biocatalysis and biosensing. Chemistry-A European Journal, 2011;17 (34):9377-9384.
31
32. Turdean GL, Popescu IC, Curulli A, Palleschi G. Iron (III) protoporphyrin IX—single-wall carbon nanotubes modified electrodes for hydrogen peroxide and nitrite detection. Electrochimica Acta, 2006;51 (28):6435-6441.
32
33. Liang M, Fan K, Pan Y, Jiang H, Wang F, Yang D, Lu D, Feng J, Zhao J, Yang L. Fe3O4 magnetic nanoparticle peroxidase mimetic-based colorimetric assay for the rapid detection of organophosphorus pesticide and nerve agent. Analytical chemistry, 2012;85 (1):308-312.
33
34. Lee JW, Jeon HJ, Shin H-J, Kang JK. Superparamagnetic Fe3O4 nanoparticles–carbon nitride nanotube hybrids for highly efficient peroxidase mimetic catalysts. Chemical Communications, 2012;48 (3):422-424.
34
35. Song Y, Wang X, Zhao C, Qu K, Ren J, Qu X. Label‐free colorimetric detection of single nucleotide polymorphism by using single‐walled carbon nanotube intrinsic peroxidase‐like activity. Chemistry-A European Journal, 2010;16 (12):3617-3621.
35
36. Singh C, Bansal S, Kumar V, Singhal S. Beading of cobalt substituted nickel ferrite nanoparticles on the surface of carbon nanotubes: a study of their synthesis mechanism, structure, magnetic, optical and their application as photocatalyst. Ceramics International, 2015;41 (3):3595-3604.
36
37. Gong J-L, Wang B, Zeng G-M, Yang C-P, Niu C-G, Niu Q-Y, Zhou W-J, Liang Y. Removal of cationic dyes from aqueous solution using magnetic multi-wall carbon nanotube nanocomposite as adsorbent. Journal of hazardous materials, 2009;164 (2):1517-1522.
37
38. Safari J, Gandomi-Ravandi S. Fe3O4–CNTs nanocomposites: a novel and excellent catalyst in the synthesis of diarylpyrimidinones using grindstone chemistry. RSC Advances, 2014;4 (22):11486-11492.
38
39. Xu Z, Ding L, Long Y, Xu L, Wang L, Xu C. Preparation and evaluation of superparamagnetic surface molecularly imprinted polymer nanoparticles for selective extraction of bisphenol A in packed food. Analytical methods, 2011;3 (8):1737-1744.
39
40. Zhang P, Mo Z, Wang Y, Han L, Zhang C, Zhao G, Li Z. One-step hydrothermal synthesis of magnetic responsive TiO2 nanotubes/Fe3O4/graphene composites with desirable photocatalytic properties and reusability. RSC Advances, 2016;6 (45):39348-39355.
40
41. Lu K, Jiang R, Gao X, Ma H. Fe3O4/carbon nanotubes/polyaniline ternary composites with synergistic effects for high performance supercapacitors. RSC Advances, 2014;4 (94):52393-52401.
41
ORIGINAL_ARTICLE
Fabrication and Characterization of Nanocapsules of PLGA Containing BSA Using Electrospray Technique
Objective(s): Encapsulated pharmaceuticals are presently the object of comprehensive investigations in many research centers due to their increased therapeutic efficiency, bioavailability, and high dissolution rate. There are different procedures for encapsulation and choice of procedure influences the size of particles for intended applications. Methods: In this study, Nanocapsules of Poly-Lactic-co-Glycolic Acid (PLGA) containing Bovine Serum Albumin (BSA) at ratios of 0.25/0.25, 0.4/0.1 and 0.45/0.05 were fabricated by electrospraying method. Also, the effect of some parameters in electrospraying was evaluated, including PLGA concentration, voltage and flow rate on the morphology and size of particles. Results: BSA loaded PLGA Nanocapsules were successfully prepared by using electrospraying technique. The formation of capsules was confirmed by TEM. SEM results of the samples showed that decreasing the flow rate and increasing voltage decreased the average size of nanocapsules and led to producing the capsules with a size in the range of 85-260 nm. The presence of the drug in nanocapsules was confirmed by DSC results. Drug release test showed that about 90% of BSA had been released during 24 h. Conclusions: PLGA nanocapsules containing therapeutic proteins were produced by the electrospraying technique under different operation parameters and physical properties.
https://www.nanomedicine-rj.com/article_26906_de8577c23c40f689bd663064ea2dc31f.pdf
2017-09-01
158
164
10.22034/nmrj.2017.03.003
Nanocapsule
Electrospraying
Drug release
PLGA
BSA
Mahsa
Musaei
mahsa_musaie@yahoo.com
1
Department of Textile Engineering, Faculty of Engineering, University of Guilan, Rasht, Iran
AUTHOR
Javad
Mokhtari
j.mokhtari@guilan.ac.ir
2
Department of Textile Engineering, Faculty of Engineering, University of Guilan, Rasht, Iran
LEAD_AUTHOR
Mahdi
Nouri
mnouri69@guilan.ac.ir
3
Department of Textile Engineering, Faculty of Engineering, University of Guilan, Rasht, Iran
AUTHOR
Zahra
Pedram Rad
z.pedramrad2tex@yahoo.com
4
Department of Textile Engineering, Faculty of Engineering, University of Guilan, Rasht, Iran
AUTHOR
1.Billon A, Bataille B, Cassanas G, Jacob M. Development of spray-dried acetaminophen microparticles using experimental designs. International journal of pharmaceutics, 2000;203 (1):159-168.
1
2.Horn D, Rieger J. Organic nanoparticles in the aqueous phase—theory, experiment, and use. Angewandte Chemie International Edition, 2001;40 (23):4330-4361.
2
3.Kesisoglou F, Panmai S, Wu Y. Nanosizing—oral formulation development and biopharmaceutical evaluation. Advanced drug delivery reviews, 2007;59 (7):631-644.
3
4.Nornoo AO, Zheng H, Lopes LB, Johnson-Restrepo B, Kannan K, Reed R. Oral microemulsions of paclitaxel: In situ and pharmacokinetic studies. European Journal of Pharmaceutics and Biopharmaceutics, 2009;71 (2):310-317.
4
5.Rabinow BE. Nanosuspensions in drug delivery. Nature reviews Drug discovery, 2004;3 (9):785.
5
6.Zgoulli S, Grek V, Barre G, Goffinet G, Thonart P, Zinner S. Microencapsulation of erythromycin and clarithromycin using a spray-drying technique. Journal of microencapsulation, 1999;16 (5):565-571.
6
7.Xie J, Marijnissen JC, Wang C-H. Microparticles developed by electrohydrodynamic atomization for the local delivery of anticancer drug to treat C6 glioma in vitro. Biomaterials, 2006;27 (17):3321-3332.
7
8.Chow AH, Tong HH, Chattopadhyay P, Shekunov BY. Particle engineering for pulmonary drug delivery. Pharmaceutical research, 2007;24 (3):411-437.
8
9.Hildebrand GE, Tack JW. Microencapsulation of peptides and proteins. International journal of pharmaceutics, 2000;196 (2):173-176.
9
10.Mok H, Park TG. Water-free microencapsulation of proteins within PLGA microparticles by spray drying using PEG-assisted protein solubilization technique in organic solvent. European Journal of Pharmaceutics and Biopharmaceutics, 2008;70 (1):137-144.
10
11.Cardoso MT, Talebi M, Soares P, Yurteri C, Van Ommen J. Functionalization of lactose as a biological carrier for bovine serum albumin by electrospraying. International journal of pharmaceutics, 2011;414 (1):1-5.
11
12.Johansen P, Merkle HP, Gander B. Technological considerations related to the up-scaling of protein microencapsulation by spray-drying. European Journal of Pharmaceutics and Biopharmaceutics, 2000;50 (3):413-417.
12
13.Bohr A, Kristensen J, Stride E, Dyas M, Edirisinghe M. Preparation of microspheres containing low solubility drug compound by electrohydrodynamic spraying. International journal of pharmaceutics, 2011;412 (1):59-67.
13
14.Zhu L, Li M, Liu X, Jin Y. Drug-Loaded PLGA Electrospraying Porous Microspheres for the Local Therapy of Primary Lung Cancer via Pulmonary Delivery. ACS Omega, 2017;2 (5):2273-2279.
14
15.Xu Y, Hanna MA. Electrospray encapsulation of water-soluble protein with polylactide: Effects of formulations on morphology, encapsulation efficiency and release profile of particles. International journal of pharmaceutics, 2006;320 (1):30-36.
15
16.Pareta R, Brindley A, Edirisinghe M, Jayasinghe S, Luklinska Z. Electrohydrodynamic atomization of protein (bovine serum albumin). Journal of Materials Science: Materials in Medicine, 2005;16 (10):919-925.
16
17.Rad ZP, Tavanai H, Moradi A. Production of feather keratin nanopowder through electrospraying. Journal of Aerosol Science, 2012;51:49-56.
17
18.Jayasinghe S, Edirisinghe M. Effect of viscosity on the size of relics produced by electrostatic atomization. Journal of Aerosol Science, 2002;33 (10):1379-1388.
18
19.Yaghoobi N, Majidi RF, ali Faramarzi M, Baharifar H, Amani A. Preparation, Optimization and Activity Evaluation of PLGA/Streptokinase Nanoparticles Using Electrospray. Advanced pharmaceutical bulletin, 2017;7 (1):131.
19
20.Nguyen DN, Clasen C, Van den Mooter G. Pharmaceutical applications of electrospraying. Journal of pharmaceutical sciences, 2016;105 (9):2601-2620.
20
21.Voruganti S, Padman JSC. FORMULATION AND EVALUATION OF BSA LOADED PLGA MICROPARTICLES. International Journal of Pharmaceutical Sciences and Research, 2013;4 (3):1013.
21
22.Pinon-Segundo E, Ganem-Quintanar A, Alonso-Pérez V, Quintanar-Guerrero D. Preparation and characterization of triclosan nanoparticles for periodontal treatment. International journal of pharmaceutics, 2005;294 (1):217-232.
22
ORIGINAL_ARTICLE
Magnetic ZnFe2O4@polyhydroxybenzoic acid nanostructure for efficient B.subtilis capturing
Objective(s): This work focuses on preparing an efficient bacterial capture system based on the magnetic polyphenolic nanostructure. For a reason, a one-step hydrothermally route was employed to prepare ZnFe2O4@hydroxybenzoic acid - resorcinol nanohybrid. Methods: The nanostructure was characterized by X–ray diffraction (XRD), field emission scanning electron microscopy (FE–SEM), transmission electron microscopy (TEM) vibration sample magnetometry (VSM) and zeta potential measurement. Bacillus subtilis was employed as a sample pathogen to evaluate bacterial capture efficiency of the nanohybrid. Results: Characterization results confirmed that the hybrid material is in nano scale. Moreover, it has a magnetic saturation of 6.7 emu g-1 which is in right level to be employed for magnetic separation. Effect of relevant variables on capturing efficiency including pH, contact time and adsorbent dosage was investigated, and optimum levels were obtained. Conclusions: It found that the capturing efficiency is independent of solution pH. Moreover, capturing experiments showed fast equilibrium time of 20 min with the effectiveness more than 99%.
https://www.nanomedicine-rj.com/article_27276_967ee7c4fc870612be7960072093313a.pdf
2017-09-01
165
170
10.22034/nmrj.2017.03.004
Subtilis
Polymer
Magnetic nanohybrid
ZnFe2O4
Mostafa
Hossein Beyki
mhosseinbaki@yahoo.com
1
School of Chemistry, University College of Science, University of Tehran, Tehran, Iran
LEAD_AUTHOR
Farzaneh
Shemirani
shemiran@ut.ac.ir
2
School of Chemistry, University College of Science, University of Tehran, Tehran, Iran
AUTHOR
1. Muñoz-Bonilla A, Fernández-García M. Polymeric materials with antimicrobial activity. Progress in Polymer Science, 2012;37 (2):281-339.
1
2. Lee I, Roh J, Lee J, Song J, Jang J. Antibacterial performance of various amine functional polymers coated silica nanoparticles. Polymer, 2016;83:223-229.
2
3. El-Refaie Kenawy, S. D. Worley, Broughton aR. The chemistry and applications of antimicrobial polymers: A state-of-the-art review. Biomacromolecules, 2007;8 (5):1359 - 1384.
3
4. Izquierdo-Barba I, Sanchez-Salcedo S, Colilla M, Feito MJ, Ramirez-Santillan C, Portoles MT, Vallet-Regi M. Inhibition of bacterial adhesion on biocompatible zwitterionic SBA-15 mesoporous materials. Acta Biomaterialia, 2011;7 (7):2977-2985.
4
5. Karam L, Casetta M, Chihib NE, Bentiss F, Maschke U, Jama C. Optimization of cold nitrogen plasma surface modification process for setting up antimicrobial low density polyethylene films. Journal of the Taiwan Institute of Chemical Engineers, 2016;64:299-305.
5
6. Prabhu YT, Rao KV, Kumari BS, Kumar VSS, Pavani T. Synthesis of Fe3O4 nanoparticles and its antibacterial application. International Nano Letters, 2015;5 (2):85-92.
6
7. Koohi MK, Hejazy M, Najafi D, Sajadi SM. Investigation of hematotoxic effect of nano ZnO, nano Fe3O4 and nano SiO2 in vitro. Nanomedicine Research Journal, 2017;2 (2):93-99.
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8. Wei Z, Zhou Z, Yang M, Lin C, Zhao Z, Huang D, Chen Z, Gao J. Multifunctional Ag@Fe2O3 yolk–shell nanoparticles for simultaneous capture, kill, and removal of pathogen. Journal of Materials Chemistry, 2011;21 (41).
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9. Prorokova NP, Vavilova SY, Kuznetsov OY, Buznik VM. Antimicrobial properties of polypropylene yarn modified by metal nanoparticles stabilized by polyethylene. Nanotechnologies in Russia, 2015;10 (9-10):732-740.
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10.Orsuwan A, Shankar S, Wang L-F, Sothornvit R, Rhim J-W. Preparation of antimicrobial agar/banana powder blend films reinforced with silver nanoparticles. Food Hydrocolloids, 2016;60:476-485.
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11.Zhou C, Li Y-H, Jiang Z-H, Ahn K-D, Hu T-J, Wang Q-H, Wang C-H. Poly[(mercaptopropyl)methylsiloxane] (PMMS)-based antibacterial polymer coatings prepared by a two-step sequential thiol–ene click chemistry. Chinese Chemical Letters, 2016;27 (5):685-688.
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12.Huang KS, Yang CH, Huang SL, Chen CY, Lu YY, Lin YS. Recent Advances in Antimicrobial Polymers: A Mini-Review. International Journal of Molecular Sciences, 2016;17 (9).
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18.Pourjavadi A, Nazari M, Hosseini SH. Synthesis of magnetic graphene oxide-containing nanocomposite hydrogels for adsorption of crystal violet from aqueous solution. RSC Advances, 2015;5 (41):32263-32271.
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19.Chang L, Wang J, Tong C, Zhao L, Liu X. Comparison of antimicrobial activities of polyacrylonitrile fibers modified with quaternary phosphonium salts having different alkyl chain lengths. Journal of Applied Polymer Science, 2016;133 (29).
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21.Changwa Yao, Qiaoshi Zeng, G. F. Goya, T. Torres, Jinfang Liu, Haiping Wu, Mingyuan Ge, Yuewu Zeng, Youwen Wang, Jiang aJZ. ZnFe2O4Nanocrystals: Synthesis and Magnetic Properties. Journal of Physical Chemistry C, 2007;111:12274-12278.
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23.Drasler B, Drobne D, Novak S, Valant J, Boljte S, Otrin L, Rappolt M, Sartori B, Iglic A, Kralj-Iglic V, Sustar V, Makovec D, Gyergyek S, Hocevar M, Godec M, Zupanc J. Effects of magnetic cobalt ferrite nanoparticles on biological and artificial lipid membranes. International Journal of Nanomedicine, 2014;9:1559-1581.
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24.Zhang Y, Evans JRG. Alignment of layered double hydroxide platelets. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2012;408:71-78.
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30
ORIGINAL_ARTICLE
Biofabrication of manganese nanoparticle using aegle marmelos fruit extract and assessment of its biological activities
Objective(s): The present investigation dealt with the biological production of manganese nanoparticles using Aegle marmelos fruit and assessing the antioxidant and antibiofilm activities. Methods: The nanoparticles were produced using the fruit extract of Aegle marmelos as the reducing agent with potassium permanganate as the substrate. Manganese nanoparticles synthesized were characterized by UV-Vis spectroscopy, Scanning Electron Microscopy, FT-IR spectroscopy and X Ray Diffractometry. Antibiofilm and antioxidant activities of the nanoparticles were assessed by DPPH and crystal violet staining methods respectively and were statistically analysed using SPSS software. Results: The characterisation study reported that the average crystallite size of the formed nanoparticle was 23.7nm. The results indicated that biofilms of gram positive and gram negative bacteria were inhibited at 80 and 100 μg of nanoparticles/ml respectively showing more activity against gram positive bacterial biofilms. The highest activity was observed against E.coli as 1.217±0.43 at 80 μg/ml and B.subtilis as 1.705±0.37 at 100 μg/ml. Maximum activity of nanoparticle against reactive oxygen species was found to be at a concentration of 5mg/ml as 27.31±0.03%. Conclusions: This study demonstrated that the biologically synthesized manganese nanoparticles are environment-friendly with its potential applications against pathogens and could be implied for various other biological purposes.
https://www.nanomedicine-rj.com/article_27460_ee30e9f4a0f1378289ee9478b1596ec9.pdf
2017-09-01
171
178
10.22034/nmrj.2017.03.005
Aegle marmelos
Manganese nanoparticle
Characterization studies
Anti-biofilm
Antioxidant
Keerthana
Sivanesan
keerthana7793@gmail.com
1
Centre for Biotechnology, Anna University, Tamilnadu, India
AUTHOR
Priyanga
Jayakrishnan
priyanga.jeyakrishnan@gmail.com
2
Centre for Biotechnology, Anna University, Tamilnadu, India
AUTHOR
Sirajunnisa
Abdul Razack
siraj.razack@gmail.com
3
Centre for Biotechnology, Anna University, Tamilnadu, India
AUTHOR
Pavithra
Sellaperumal
pavithra.sellaperumal@gmail.com
4
Centre for Biotechnology, Anna University, Tamilnadu, India
AUTHOR
Geethalakshmi
Ramakrishnan
geetha7792@gmail.com
5
Centre for Biotechnology, Anna University, Tamilnadu, India
AUTHOR
Renganathan
Sahadevan
renganathansahadevan@rediffmail.com
6
Centre for Biotechnology, Anna University, Tamilnadu, India
LEAD_AUTHOR
1. Prabu HJ, Johnson I. Plant-mediated biosynthesis and characterization of silver nanoparticles by leaf extracts of Tragia involucrata, Cymbopogon citronella, Solanum verbascifolium and Tylophora ovata. Karbala International Journal of Modern Science, 2015;1 (4):237-246.
1
2. Seabra AB, Durán N. Nanotoxicology of metal oxide nanoparticles. Metals, 2015;5 (2):934-975.
2
3. Rana S, Kalaichelvan P. Antibacterial activities of metal nanoparticles. Antibacterial Activities of Metal Nanoparticles, 2011;11 (02):21-23.
3
4. Moon SA, Salunke BK, Alkotaini B, Sathiyamoorthi E, Kim BS. Biological synthesis of manganese dioxide nanoparticles by Kalopanax pictus plant extract. IET Nanobiotechnology, 2015;9 (4):220-225.
4
5. Kumar H, Manisha SP, Sangwan P. Synthesis and characterization of MnO2 nanoparticles using co-precipitation technique. International Journal of Chemistry and Chemical Engineering, 2013;3 (3):155-160.
5
6. Mittal AK, Chisti Y, Banerjee UC. Synthesis of metallic nanoparticles using plant extracts. Biotechnology advances, 2013;31 (2):346-356.
6
7. Salunke BK, Sawant SS, Lee S-I, Kim BS. Comparative study of MnO2 nanoparticle synthesis by marine bacterium Saccharophagus degradans and yeast Saccharomyces cerevisiae. Applied microbiology and biotechnology, 2015;99 (13):5419-5427.
7
8. Dahiya R, Tomar RS, Shrivastava V. Evaluation of Antimicrobial Potential of Aegle Marmelos Fruit Extract against Selected Microorganisms.
8
9. Kothari S, Mishra V, Bharat S, Tonpay SD. Antimicrobial activity and phytochemical screening of serial extracts from leaves of Aegle marmelos (Linn.). Acta Pol Pharm, 2011;68 (5):687-692.
9
10.Karumaran S, Nethaji S, Rajakumar R. Antimicrobial and antioxidant activity of leaf extracts of Aegle marmelos.
10
11.Jayandran M, Haneefa MM, Balasubramanian V. Green synthesis and characterization of Manganese nanoparticles using natural plant extracts and its evaluation of antimicrobial activity. 2015.
11
12.Murugan K, Krishnasamy S, Kalyanasundaram V, Al-Sohaibani S. Nanotechnological Approach For Exploring The Antibiofilm A Potential Of An Ethanomedicinal Herb Andrographis Paniculata For Controlling Lung Infection Causing Pseudomonas Aeruginosa. Digest Journal of Nanomaterials & Biostructures (DJNB), 2013;8 (1).
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13.Liu J, Luo J, Ye H, Sun Y, Lu Z, Zeng X. In vitro and in vivo antioxidant activity of exopolysaccharides from endophytic bacterium Paenibacillus polymyxa EJS-3. Carbohydrate Polymers, 2010;82 (4):1278-1283.
13
14.Nithya Deva Krupa A, Raghavan V. Biosynthesis of silver nanoparticles using Aegle marmelos (Bael) fruit extract and its application to prevent adhesion of bacteria: a strategy to control microfouling. Bioinorganic chemistry and applications, 2014;2014.
14
15.Dada A, Adekola F, Odebunmi E. Investigation of the synthesis and characterization of manganese nanoparticles and its ash rice husk supported nanocomposite. Book of Proceedings of 1 st African International Conference/Workshop on Applications of Nanotechnology to Energy, Health and Environment–March 23 rd–29 th; 2014.
15
16.Dallas P, Sharma VK, Zboril R. Silver polymeric nanocomposites as advanced antimicrobial agents: classification, synthetic paths, applications, and perspectives. Advances in colloid and interface science, 2011;166 (1):119-135.
16
17.Kanmani P, Yuvaraj N, Paari K, Pattukumar V, Arul V. Production and purification of a novel exopolysaccharide from lactic acid bacterium Streptococcus phocae PI80 and its functional characteristics activity in vitro. Bioresource Technology, 2011;102 (7):4827-4833.
17
18.Suriyavathana.M RK. Nanoparticles Synthesis and Antibacterial Study on Anisomeles Malabarica using Manganese Oxide (MnO). International Journal of ChemTech Research, 2015;8 (11):466-473.
18
19.Rajendran, P. Paramasivam and K.E. Geckeler. Synthesis and Fabrication of Nanomaterials. First Edition. BLOOMSBURY PUBLISHING INDIA PVT. LTD, New Delhi; 2015. 311-4.
19
20.Sinha A, Singh VN, Mehta BR, Khare SK. Synthesis and characterization of monodispersed orthorhombic manganese oxide nanoparticles produced by Bacillus sp. cells simultaneous to its bioremediation. Journal of hazardous materials, 2011;192 (2):620-627.
20
21.Shanmugasundaram T, Radhakrishnan M, Gopikrishnan V, Pazhanimurugan R, Balagurunathan R. A study of the bactericidal, anti-biofouling, cytotoxic and antioxidant properties of actinobacterially synthesised silver nanoparticles. Colloids and Surfaces B: Biointerfaces, 2013;111:680-687.
21
22.Ramamurthy C, Padma M, Mareeswaran R, Suyavaran A, Kumar MS, Premkumar K, Thirunavukkarasu C. The extra cellular synthesis of gold and silver nanoparticles and their free radical scavenging and antibacterial properties. Colloids and Surfaces B: Biointerfaces, 2013;102:808-815.
22
ORIGINAL_ARTICLE
Preparation of basil seed mucilage aerogels loaded with paclitaxel nanoparticles by the combination of phase inversion technique and gas antisolvent process
Objective(S): In this work, paclitaxel (PX), a promising anticancer drug, was loaded in the basil seed mucilage (BSM) aerogels by implementation of supercritical carbon dioxide (SC-CO2) technology. Then, the effects of operating conditions were studied on the PX mean particle size (MPS), particle size distribution (PSD) and drug loading efficiency (DLE). Methods: The employed SC-CO2 process in this research is the combination of phase inversion technique and gas antisolvent (GAS) process. The effect of DMSO/water ratio (4 and 6 (v/v)), pressure (10-20 MPa), CO2 addition rate (1–3 mL/min) and ethanol concentration (5-10%) were studied on MPS, PSD and DLE. Scanning electron microscopy (SEM) and Zetasizer were used for particle analysis. DLE was investigated by utilizing the high-performance liquid chromatography (HPLC). Results: Nanoparticles of paclitaxel (MPS of 82–131 nm depending on process variables) with narrow PSD were successfully loaded in BSM aerogel with DLE of 28–52%. Experimental results indicated that higher DMSO/water ratio, ethanol concentration, pressure and CO2 addition rate reduced MPS and DLE. Conclusions: A modified semi batch SC-CO2 process based on the combination of gas antisolvent process and phase inversion methods using DMSO as co-solvent and ethanol as a secondary solvent was developed for the loading of an anticancer drug, PX, in ocimum basilicum mucilage aerogel. The experimental results determined that the mean particle size, particle size distribution, and drug loading efficiency be controlled with operating conditions.
https://www.nanomedicine-rj.com/article_27555_f218ddc381f8cbd944147d1382deddfb.pdf
2017-09-01
179
188
10.22034/nmrj.2017.03.006
Aerogels
Basil seed mucilage (BSM)
Paclitaxel
Gas antisolvent process (GAS)
Supercritical drying
Seyyed
Ghoreishi
ghoreshi@cc.iut.ac.ir
1
Department of Chemical Engineering, Isfahan University of Technology, Isfahan, Iran
LEAD_AUTHOR
Iman
Akbari
i.akbari@ce.iut.ac.ir
2
Department of Chemical Engineering, Isfahan University of Technology, Isfahan, Iran
AUTHOR
Ali
Hedayati
hedayati@ce.iut.ac.ir
3
Department of Chemical Engineering, Isfahan University of Technology, Isfahan, Iran
AUTHOR
1. Ravar F, Saadat E, Gholami M, Dehghankelishadi P, Mahdavi M, Azami S, Dorkoosh FA. Hyaluronic acid-coated liposomes for targeted delivery of paclitaxel, in-vitro characterization and in-vivo evaluation. Journal of Controlled Release, 2016;229:10-22.
1
2. Li S, Wang X, Li W, Yuan G, Pan Y, Chen H. Preparation and characterization of a novel conformed bipolymer paclitaxel-nanoparticle using tea polysaccharides and zein, Carbohydrate polymers, 2016;146:52-7.
2
3. Nasiri J, Motamedi E, Naghavi MR. Comparative study of adsorptive role of carbonaceous materials in removal of UV-active impurities of paclitaxel extracts, Journal of Pharmaceutical Analysis, 2015;5(6):396-9.
3
4. Szczepanowicz K, Bzowska M, Kruk T, Karabasz A, Bereta J, Warszynski P. Pegylated polyelectrolyte nanoparticles containing paclitaxel as a promising candidate for drug carriers for passive targeting, Colloids and Surfaces B: Biointerfaces, 2016;143:463-71.
4
5. Chen N, Guo D, Guo Y, Sun Y, Bi H, Ma X. Paclitaxel inhibits cell proliferation and collagen lattice contraction via TGF-β signaling pathway in human tenon's fibroblasts in vitro, European journal of pharmacology, 2016;777:33-40.
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6. Esfandyari-Manesh M, Darvishi B, Ishkuh FA, Shahmoradi E, Mohammadi A, Javanbakht M, Dinarvand R, Atyabi F. Paclitaxel molecularly imprinted polymer-PEG-folate nanoparticles for targeting anticancer delivery: characterization and cellular cytotoxicity, Materials Science and Engineering: C, 2016;62:626-33.
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7. Zhao J, Lu C, He X, Zhang X, Zhang W, Zhang X. Polyethylenimine-grafted cellulose nanofibril aerogels as versatile vehicles for drug delivery, ACS applied materials & interfaces, 2015;7(4):2607-15.
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8. Sanyakamdhorn S, Agudelo D, Bekale L, Tajmir-Riahi HA. Targeted conjugation of breast anticancer drug tamoxifen and its metabolites with synthetic polymers, Colloids and Surfaces B: Biointerfaces, 2016;145:55-63.
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9. Singh B, Sharma V. Designing galacturonic acid/arabinogalactan crosslinked poly (vinyl pyrrolidone)-co-poly (2-acrylamido-2-methylpropane sulfonic acid) polymers: Synthesis, characterization and drug delivery application, Polymer, 2016;91:50-61.
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13.Volokitina MV, Korzhikov-Vlakh VA, Tennikova TB, Korzhikova-Vlakh EG. Macroporous monoliths for biodegradation study of polymer particles considered as drug delivery systems, Journal of pharmaceutical and biomedical analysis, 2017;145:169-77.
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14. Prajapati VD, Jani GK, Moradiya NG, Randeria NP. Pharmaceutical applications of various natural gums, mucilages and their modified forms, Carbohydrate polymers, 2013;92(2):1685-99.
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15. Kaewmanee T, Bagnasco L, Benjakul S, Lanteri S, Morelli CF, Speranza G, Cosulich ME. Characterisation of mucilages extracted from seven Italian cultivars of flax. , Food Chem. 2014 Apr 1;148:60-9.
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16. Nayak AK, Pal D, Das S. Calcium pectinate-fenugreek seed mucilage mucoadhesive beads for controlled delivery of metformin HCl, Food chemistry, 2013;96(1):349-57.
16
17. Bhuvaneshwari K, Gokulanathan A, Jayanthi M, Govindasamy V, Milella L, Lee S, Yang DC, Girija S. Can Ocimum basilicum L. and Ocimum tenuiflorum L. in vitro culture be a potential source of secondary metabolites?, Food chemistry, 2016;194:55-60.
17
18. Kadan S, Saad B, Sasson Y, Zaid H. In vitro evaluation of anti-diabetic activity and cytotoxicity of chemically analysed Ocimum basilicum extracts, Food Chemistry, 2016;196:1066-74.
18
19. Jouki M, Mortazavi SA, Yazdi FT, Koocheki A. Optimization of extraction, antioxidant activity and functional properties of quince seed mucilage by RSM, International Journal of Biological Macromolecules, 2014;66:113-24.
19
20. Mahdavinia GR, Afzali A, Etemadi H, Hoseinzadeh H. Magnetic/pH-sensitive nanocomposite hydrogel based carboxymethyl cellulose-g-polyacrylamide/montmorillonite for colon targeted drug delivery. Nanomedicine Research Journal, 2017;2(2):111-22.
20
21. Amoli Diva M, Pourghazi K. Magnetic nanoparticles grafted pH-responsive poly (methacrylic acid-co-acrylic acid)-grafted polyvinylpyrrolidone as a nano-carrier for oral controlled delivery of atorvastatin, Nanomedicine Research Journal, 2017;2(1):18-27.
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22. Najafi-Taher R, Amani A. Nanoemulsions: colloidal topical delivery systems for antiacne agents-A Mini-Review, Nanomedicine Research Journal, 2017;2(1):49-56.
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24. Kolakovic R, Peltonen L, Laukkanen A, Hirvonen J, Laaksonen T. Nanofibrillar cellulose films for controlled drug delivery, European Journal of Pharmaceutics and Biopharmaceutics, 2012;82(2):308-15.
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25. Amin MC, Ahmad N, Halib N, Ahmad I. Synthesis and characterization of thermo-and pH-responsive bacterial cellulose/acrylic acid hydrogels for drug delivery, Carbohydrate Polymers, 2012;88(2):465-73.
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26.Valo H, Arola S, Laaksonen P, Torkkeli M, Peltonen L, Linder MB, Serimaa R, Kuga S, Hirvonen J, Laaksonen T, European Journal of Pharmaceutical Sciences, 2013;50: 69-77.
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27.Lovskaya DD, Lebedev AE, Menshutina NV. Aerogels as drug delivery systems: in vitro and in vivo evaluations, The Journal of Supercritical Fluids, 2015;106:115-21.
27
28.Ulker Z, Erkey C. Experimental and theoretical investigation of drug loading to silica alcogels, The Journal of Supercritical Fluids, 2015, 31;106:34-41.
28
29.García-González CA, Jin M, Gerth J, Alvarez-Lorenzo C, Smirnova I. Polysaccharide-based aerogel microspheres for oral drug delivery, Carbohydrate polymers, 2015;117:797-806.
29
30.Pantić M, Knez Ž, Novak Z. Supercritical impregnation as a feasible technique for entrapment of fat-soluble vitamins into alginate aerogels, Journal of non-crystalline solids, 2016;432:519-26.
30
31.Wang R, Shou D, Lv O, Kong Y, Deng L, Shen J. pH-Controlled drug delivery with hybrid aerogel of chitosan, carboxymethyl cellulose and graphene oxide as the carrier, nternational Journal of Biological Macromolecules, 2017;103:248-53.
31
32.Veres P, Kéri M, Bányai I, Lázár I, Fábián I, Domingo C, Kalmár J. Mechanism of drug release from silica-gelatin aerogel—Relationship between matrix structure and release kinetics, Colloids and Surfaces B: Biointerfaces, 2017;152:229-37.
32
33.Eleftheriadis GK, Filippousi M, Tsachouridou V, Darda MA, Sygellou L, Kontopoulou I, Bouropoulos N, Steriotis T, Charalambopoulou G, Vizirianakis IS, Van Tendeloo G. Evaluation of mesoporous carbon aerogels as carriers of the non-steroidal anti-inflammatory drug ibuprofen, International journal of pharmaceutics, 2016;515(1):262-70.
33
34.Marin MA, Mallepally RR, McHugh MA. Silk fibroin aerogels for drug delivery applications, The Journal of Supercritical Fluids, 2014;91:84-9.
34
35.Del Gaudio P, Auriemma G, Mencherini T, Porta GD, Reverchon E, Aquino RP. Design of alginate‐based aerogel for nonsteroidal anti‐inflammatory drugs controlled delivery systems using prilling and supercritical‐assisted drying, journal of pharmaceutical sciences, 2013;102(1):185-94.
35
36.Ghoreishi SM, Hedayati A, Mohammadi S. Optimization of periodic static-dynamic supercritical CO2 extraction of taxifolin from pinus nigra bark with ethanol as entrainer, The Journal of Supercritical Fluids, 2016;113:53-60.
36
37.Ghoreishi SM, Hedayati A, Mousavi SO. Quercetin extraction from Rosa damascena Mill via supercritical CO2: Neural network and adaptive neuro fuzzy interface system modeling and response surface optimization, The Journal of Supercritical Fluids, 2016;112:57-66.
37
38.Ghoreishi SM, Hedayati A, Kordnejad M. Micronization of chitosan via rapid expansion of supercritical solution, The Journal of Supercritical Fluids, 2016;111:162-70.
38
39.Esfandiari N, Ghoreishi SM. Synthesis of 5-fluorouracil nanoparticles via supercritical gas antisolvent process, The Journal of Supercritical Fluids, 2013;84:205-10.
39
40.Esfandiari N, Ghoreishi SM. Ampicillin Nanoparticles Production via Supercritical CO2 Gas Antisolvent Process, AAPS PharmSciTech, 2015;16(6):1263-9.
40
41.Akbari I, Ghoreishi SM, Habibi N. Supercritical CO2 Generation of Nanometric Structure from Ocimum basilicum Mucilage Prepared for Pharmaceutical Applications. AAPS PharmSciTech. 2015 Apr 1;16(2):428-34.
41
42.Esfandiari N, Ghoreishi SM. Kinetics modeling of ampicillin nanoparticles synthesis via supercritical gas antisolvent process, The Journal of Supercritical Fluids, 2013;81:119-27.
42
43.Akbari I, Ghoreishi SM, Habibi N. Generation and precipitation of paclitaxel nanoparticles in basil seed mucilage via combination of supercritical gas antisolvent and phase inversion techniques, The Journal of Supercritical Fluids, 2014;94:182-8.
43
ORIGINAL_ARTICLE
Engineering of core/shell nanoparticles surface plasmon for increasing of light penetration depth in tissue (modeling and analysis)
Objectives: In this article, a new procedure for increasing the light penetration depth in a tissue is studied and simulated. It has been reported that the most important problem in biomedical optical imaging relates to the light penetration depth, and so this makes a dramatic restriction on its applications. In the optical imaging method, the detection of the backscattered photons from a deep tumor is rarely done or is done with a low efficiency; it is because of the high absorption and scattering losses. Methods: Unlike the common methods (using a high energy laser for deep penetration) by engineering the nanoparticles’ optical properties such as their anisotropy, absorption, and scattering efficiency, which are distributed into a tissue, the detected photons amplitude can be manipulated. In other words, by engineering the nanoparticle plasmon properties and their effect on the dye molecules’ quantum yield, fluorescence emission and more importantly influence on the scattering direction, the light penetration depth is dramatically increased. Results: The modeling results (Monte-Carlo statistical method) illustrate that the detected photons dramatically increased which is on order of 4 mm. So, this method can fix the light penetration problems in the optical imaging system. Conclusions: Finally, the original idea of this study attributes to the indirect and transient manipulation of the optical properties of the tissue through the nanoparticles plasmon properties engineering. Moreover, by engineering plasmonic nanoparticles, maybe, the penetration depth can be enhanced which means that we can easily send light into a soft tissue and get its back scattering.
https://www.nanomedicine-rj.com/article_27795_659e0a2fd847bc227d51ba36f8287d0a.pdf
2017-09-01
189
198
10.22034/nmrj.2017.03.007
Plasmonic
Core/shell nanoparticles
Light penetration
Monte Carlo
Sona
Faalnouri
araz.nano@gmail.com
1
Biochromatography and Biodiagnostics Research Laboratory, Chemical Department, Hacettepe University, Ankara, Turkey
AUTHOR
Ahmad
Salmanogli
tirdad.zey@gmail.com
2
Photonics and Nanocrystal Research Laboratory, Electrical Engineering Department, University of Tabriz, Tabriz, Iran
LEAD_AUTHOR
1.Xing Y, Zhao J, Conti PS, Chen K. Radiolabeled nanoparticles for multimodality tumor imaging. Theranostics, 2014;4 (3):290.
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2.Chen K, Chen X. Design and development of molecular imaging probes. Current topics in medicinal chemistry, 2010;10 (12):1227-1236.
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3.Zhao Q, Jiang H, Cao Z, Yang L, Mao H, Lipowska M. A handheld fluorescence molecular tomography system for intraoperative optical imaging of tumor margins. Medical physics, 2011;38 (11):5873-5878.
3
4.Tiwari DK, Tanaka S-I, Inouye Y, Yoshizawa K, Watanabe TM, Jin T. Synthesis and characterization of anti-HER2 antibody conjugated CdSe/CdZnS quantum dots for fluorescence imaging of breast cancer cells. Sensors, 2009;9 (11):9332-9354.
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5.F Jiao P, Y Zhou H, X Chen L, Yan B. Cancer-targeting multifunctionalized gold nanoparticles in imaging and therapy. Current medicinal chemistry, 2011;18 (14):2086-2102.
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6.SalmanOgli A. Nanobio applications of quantum dots in cancer: imaging, sensing, and targeting. Cancer nanotechnology, 2011;2 (1):1.
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ORIGINAL_ARTICLE
Synthesis of cellulose acetate nanofibers and its application in the release of some drugs
Objective(s): The purpose of this study was to compare novel sandwich-structured nanofibrous membranes, and coaxial and usual methods, to provide sustained-release delivery of morphine for drug delivery. In this work, synthesis ofnanofibrous cellulose acetate (NFC) was carried out by electrospinning. Methods: A weighed amount of cellulose acetate (CA) powder was dissolved in 3:1 v/v acetone/dimethylformamide (DMF) to obtain a CA solution at a concentration of 8 to16% w/v. Acetaminophen or morphine-loaded CA solutions were prepared by dissolving CA powder and Acetaminophen (A) or morphine in the weight ratio of 5:1, in an acetone/DMF mixture. Under optimum condition, they were electrospun into sandwich structured membranes with the coaxial method and cellulose acetate as the surface layer and cellulose acetate/drugs as the core. Results: Characterization of the radius of fiber is shown as 52.9 ± 0.1nm with scanning electron microscopy (SEM). The full range drug release profiles of nanofibers are shown as 80.7% of the contained drug in 8h. The drug release from nanofiber was controlled through a typical Fickian diffusion mechanism from the cellulose acetate matrix by a release exponent value of 0.24 for conventional nanofiber, 0.35 for coaxial nanofiber and 0.40 (less than 0.45) for sandwich nanofibers. Conclusions: All the cellulose acetate nanofibers showed that they could release large amounts of drugs in vitro for more than one day. However, among these three methods, the best one is a sandwich method because its release is slower than that of the other methods.
https://www.nanomedicine-rj.com/article_28005_ecfb88331c70e5969c8c214799d6f48c.pdf
2017-09-01
199
207
10.22034/nmrj.2017.03.008
Drug Delivery
Controlled release
Electrospinning
Coaxial
Sandwich-method
cellulose acetate
Fatemeh
Mehrabi
f_mehrabi2010@yahoo.com
1
Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, Iran
LEAD_AUTHOR
Tayebeh
Shamspur
shamspur@gmail.com
2
Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, Iran
LEAD_AUTHOR
Ali
Mostafavi
mostafavi.ali@gmail.com
3
Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, Iran
AUTHOR
Asma
Saljooqi
saljooqi.a@gmail.com
4
Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, Iran
AUTHOR
Fariba
Fathirad
f_fathirad@yahoo.com
5
Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, Iran
AUTHOR
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