ORIGINAL_ARTICLE
Nanocurcumine Ameliorates Lipopolysaccharide-induced Depressive-like Behavior in Mice
Objective(s): Curcumin, a plant alkaloid from Curcuma longa, possess antioxidant and anti-inflammatory properties. Recently, the antidepressant activities of curcumin were reported. Nevertheless, bioavailability of curcumin limits its therapeutic utility. Nanotechnology is a developing field that potentially enhances bioavailability and the plasma concentration of curcumin. This study investigates effect of acute intraperitoneal (i.p.) curcumin C3 complex nanoparticles on lipopolysaccharide (LPS)-induced depressive-like behavior in a mouse model.Methods: Depression-like behavior was induced by LPS (0.83 mg/kg, i.p.). Twenty four hrs later, immobility time in forced-swimming test (FST) and tail suspension test (TST) was recorded as depression-like index. Locomotor activity also was evaluated in open field test (OFT). Curcumin and nanocurcumin were administered 75 min prior to the behavioral assessments.Results: LPS-treated mice remained considerably more immobile in FST and TST (P<0.01). On the other hand, nanocurcumin at doses 40 and 80 mg/kg, i.p., PConclusions: Acute administration of nanocurcumin and curcumin reduced the index of immobility in FST and TST without influencing the general locomotor activity in OFT. Notably, nanocurcumin at lower doses compared with curcumin decreased the immobility figure in a dose-dependent manner. This neuroprotive effect of nanocurcumin would be related to its anti-inflammatory and anti-oxidant properties as well as modulation of neurotransmitter levels in the brain.
https://www.nanomedicine-rj.com/article_32290_81bb6a6f34f0cbbe8dae651e95489bd7.pdf
2018-04-01
58
64
10.22034/nmrj.2018.02.001
Depression
Lipopolysaccharide
Mice
Nanocurcumin
Nahid
Fakhraei
n.fakhraei@gmail.com
1
Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Seyyedeh Elaheh
Mousavi
semousavi@sina.tums.ac.ir
2
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Seyed Pouyan
Pishva
epouyan@hotmail.com
3
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
AUTHOR
Seyed Mahdi
Rezayat
rezayat@tums.ac.ir
4
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Fatemeh
Mohammadi
famohammadi14@gmail.com
5
Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
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23. Wong ML, Dong C, Maestre-Mesa J, Licinio J. Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. Molecular Psychiatry. 2008;13(8):800-12.
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24. Garcea G, Jones DJL, Singh R, Dennison AR, Farmer PB, Sharma RA, et al. Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. British Journal of Cancer. 2004;90(5):1011-5.
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25. Hoehle SI, Pfeiffer E, Sólyom AM, Metzler M. Metabolism of Curcuminoids in Tissue Slices and Subcellular Fractions from Rat Liver. Journal of Agricultural and Food Chemistry. 2006;54(3):756-64.
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26. Bisht S, Feldmann G, Soni S, Ravi R, Karikar C, Maitra A, et al. Polymeric nanoparticle-encapsulated curcumin (“nanocurcumin”): a novel strategy for human cancer therapy. Journal of Nanobiotechnology. 2007;5(1):3.
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27. Mythri RB, Jagatha B, Pradhan N, Andersen J, Bharath MMS. Mitochondrial Complex I Inhibition in Parkinson’s Disease: How Can Curcumin Protect Mitochondria? Antioxidants & Redox Signaling. 2007;9(3):399-408.
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28. Tsai Y-M, Chien C-F, Lin L-C, Tsai T-H. Curcumin and its nano-formulation: The kinetics of tissue distribution and blood–brain barrier penetration. International Journal of Pharmaceutics. 2011;416(1):331-8.
28
29. Flora G, Gupta D, Tiwari A. Nanocurcumin: A Promising Therapeutic Advancement over Native Curcumin. Critical Reviews in Therapeutic Drug Carrier Systems. 2013;30(4):331-68.
29
30. Ghalandarlaki N, Alizadeh AM, Ashkani-Esfahani S. Nanotechnology-Applied Curcumin for Different Diseases Therapy. BioMed Research International. 2014;2014:1-23.
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31. Chereddy KK, Coco R, Memvanga PB, Ucakar B, des Rieux A, Vandermeulen G, et al. Combined effect of PLGA and curcumin on wound healing activity. Journal of Controlled Release. 2013;171(2):208-15.
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32. Farhangi B, Alizadeh AM, Khodayari H, Khodayari S, Dehghan MJ, Khori V, et al. Protective effects of dendrosomal curcumin on an animal metastatic breast tumor. European Journal of Pharmacology. 2015;758:188-96.
32
33. Jangra A, Kwatra M, Singh T, Pant R, Kushwah P, Sharma Y, et al. Piperine Augments the Protective Effect of Curcumin Against Lipopolysaccharide-Induced Neurobehavioral and Neurochemical Deficits in Mice. Inflammation. 2016.
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34. Aminirad A, Mousavi SE, Fakhraei N, Mousavi SM, Rezayat SM. The role of nitric oxide in anticonvulsant effect of nanocurcumine on pentylenetetrazole-induced seizure in mice. Neuroscience Letters. 2017;651:226-31.
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35. Jiang X, Liu J, Lin Q, Mao K, Tian F, Jing C, et al. Proanthocyanidin prevents lipopolysaccharide-induced depressive-like behavior in mice via neuroinflammatory pathway. Brain Research Bulletin. 2017;135:40-6.
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48. Sanmukhani, J., A. Anovadiya, and C.B. Tripathi, Evaluation of antidepressant like activity of curcumin and its combination with fluoxetine and imipramine: an acute and chronic study. Acta Pol Pharm, 2011. 68(5): p. 769-75.
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49. Wang Z, Zhang Q, Yuan L, Wang S, Liu L, Yang X, et al. The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration. Behavioural Brain Research. 2014;274:282-90.
49
50. He X, Zhu Y, Wang M, Jing G, Zhu R, Wang S. Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression. International Journal of Nanomedicine. 2016;Volume 11:4975-90.
50
51. Chang C-Z, Wu S-C, Lin C-L, Kwan A-L. Curcumin, encapsulated in nano-sized PLGA, down-regulates nuclear factor κB (p65) and subarachnoid hemorrhage induced early brain injury in a rat model. Brain Research. 2015;1608:215-24.
51
ORIGINAL_ARTICLE
Novel silicon dioxide -based nanocomposites as an antimicrobial in poly (lactic acid) nanocomposites films
Objective(s): Due to nanocomposites antimicrobial properties, one of the most extensive usages of nano-products is in packing industry. Thus, the production of packages with nanotechnology can effectively prevent against a variety of microorganisms. In this study, the silicon dioxide nanoparticles the poly (lactic acid) PLA films on antimicrobial and permeability was investigated. Methods: In order to measure the effect of antibacterial nano-covers, the direct contact of 1%, 3% and 5% silicon dioxide nanoparticles was used. Furthermore, the sample was contaminated with standard strains of gram-negative (Escherichia coli –code of 1399 (ATCC 25992)) and bacteria gram-positive (Staphylococcus aureus–code of 1431 (ATCC 25923)) provided. Diameters of inhibition zones were measured after 24 h incubation of plates at 37 °C, by using Digital Caliper. Also, the water vapor permeability was investigated according to ASTM E96 and oxygen standards according to ASTM D 3985 standard from film surface.Results: Comparison the mean diameter of the inhibition zone of Escherichia coli, PLA containing 3% silicon dioxide with PLA film containing 5% silica showed no significant difference between the two groups (P> 0.05) as well as, the average diameter of Staphylococcus aureus (P> 0.05). The results showed that the permeability compared to water vapor and oxygen vapor in pure PLA films with PLA containing 1%, 3% and 5% silicon dioxide showed a significant difference (P <0.05). Conclusion: PLA /nanocomposite SiO2 films have been identified as the most efficient cover in reducing the microbial load and have been useful as active antimicrobial nanopackaging.
https://www.nanomedicine-rj.com/article_32291_1c0a2f0cae7b114e5e58be3dec4f0b71.pdf
2018-04-01
65
70
10.22034/nmrj.2018.02.002
Antimicrobial
Permeability
Poly Lactic Acid Nanocomposite Films
Silicon Dioxide -Based Nanocomposites
Alireza
Monadi Sefidan
tums.monadi@gmail.com
1
Department of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
1. Lunt J. Large-scale production, properties and commercial applications of polylactic acid polymers. Polymer Degradation and Stability. 1998;59(1-3):145-52.
1
2. Drumright RE, Gruber PR, Henton DE. Polylactic Acid Technology. Advanced Materials. 2000;12(23):1841-6.
2
3. Garlotta, D., A literature review of poly (lactic acid). Journal of Polymers and the Environment, 2001. 9(2): p. 63-84.
3
4. Jamshidian M, Tehrany EA, Imran M, Jacquot M, Desobry S. Poly-Lactic Acid: Production, Applications, Nanocomposites, and Release Studies. Comprehensive Reviews in Food Science and Food Safety. 2010;9(5):552-71.
4
5. Ahmed J, Varshney SK. Polylactides—Chemistry, Properties and Green Packaging Technology: A Review. International Journal of Food Properties. 2011;14(1):37-58.
5
6. Neethirajan S, Jayas DS. Nanotechnology for the Food and Bioprocessing Industries. Food and Bioprocess Technology. 2010;4(1):39-47.
6
7. Weiss J, Takhistov P, McClements DJ. Functional Materials in Food Nanotechnology. Journal of Food Science. 2006;71(9):R107-R16.
7
8. Tabari M. Characterization of a new biodegradable edible film based on Sago Starch loaded with Carboxymethyl Cellulose nanoparticles. Nanomedicine Research Journal, 2018. 3(1): 25-30, Winter 2018.
8
9. Chaudhry Q, Scotter M, Blackburn J, Ross B, Boxall A, Castle L, et al. Applications and implications of nanotechnologies for the food sector. Food Additives & Contaminants: Part A. 2008;25(3):241-58.
9
10. Silvestre C, Cimmino S, Pezzuto M, Marra A, Ambrogi V, Dexpert-Ghys J, et al. Preparation and characterization of isotactic polypropylene/zinc oxide microcomposites with antibacterial activity. Polymer Journal. 2013;45(9):938-45.
10
11. Marra, A., Biodegradable PLA composites with different fillers for food packaging application. 2015.
11
12. Azeredo HMCd. Nanocomposites for food packaging applications. Food Research International. 2009;42(9):1240-53.
12
13. Wu G, Liu S, Jia H, Dai J. Preparation and properties of heat resistant polylactic acid (PLA)/Nano-SiO2 composite filament. Journal of Wuhan University of Technology-Mater Sci Ed. 2016;31(1):164-71.
13
14. Hosseini MH, Razavi SH, Mousavi MA. Antimicrobial, physical and mechanical properties of chitosan-based films incorporated with thyme, clove and cinnamon essential oils. Journal of Food Processing and Preservation. 2009;33(6):727-43.
14
15. Alzoreky NS, Nakahara K. Antibacterial activity of extracts from some edible plants commonly consumed in Asia. International Journal of Food Microbiology. 2003;80(3):223-30.
15
16. Shan B, Cai Y-Z, Brooks JD, Corke H. The in vitro antibacterial activity of dietary spice and medicinal herb extracts. International Journal of Food Microbiology. 2007;117(1):112-9.
16
17. Kalemba D, Kunicka A. Antibacterial and Antifungal Properties of Essential Oils. Current Medicinal Chemistry. 2003;10(10):813-29.
17
18. Li XH, Xing YG, Li WL, Jiang YH, Ding YL. Antibacterial and Physical Properties of Poly(vinyl chloride)-based Film Coated with ZnO Nanoparticles. Food Science and Technology International. 2010;16(3):225-32.
18
1. Lunt J. Large-scale production, properties and commercial applications of polylactic acid polymers. Polymer Degradation and Stability. 1998;59(1-3):145-52.
19
2. Drumright RE, Gruber PR, Henton DE. Polylactic Acid Technology. Advanced Materials. 2000;12(23):1841-6.
20
3. Garlotta, D., A literature review of poly (lactic acid). Journal of Polymers and the Environment, 2001. 9(2): p. 63-84.
21
4. Jamshidian M, Tehrany EA, Imran M, Jacquot M, Desobry S. Poly-Lactic Acid: Production, Applications, Nanocomposites, and Release Studies. Comprehensive Reviews in Food Science and Food Safety. 2010;9(5):552-71.
22
5. Ahmed J, Varshney SK. Polylactides—Chemistry, Properties and Green Packaging Technology: A Review. International Journal of Food Properties. 2011;14(1):37-58.
23
6. Neethirajan S, Jayas DS. Nanotechnology for the Food and Bioprocessing Industries. Food and Bioprocess Technology. 2010;4(1):39-47.
24
7. Weiss J, Takhistov P, McClements DJ. Functional Materials in Food Nanotechnology. Journal of Food Science. 2006;71(9):R107-R16.
25
8. Tabari M. Characterization of a new biodegradable edible film based on Sago Starch loaded with Carboxymethyl Cellulose nanoparticles. Nanomedicine Research Journal, 2018. 3(1): 25-30, Winter 2018.
26
9. Chaudhry Q, Scotter M, Blackburn J, Ross B, Boxall A, Castle L, et al. Applications and implications of nanotechnologies for the food sector. Food Additives & Contaminants: Part A. 2008;25(3):241-58.
27
10. Silvestre C, Cimmino S, Pezzuto M, Marra A, Ambrogi V, Dexpert-Ghys J, et al. Preparation and characterization of isotactic polypropylene/zinc oxide microcomposites with antibacterial activity. Polymer Journal. 2013;45(9):938-45.
28
11. Marra, A., Biodegradable PLA composites with different fillers for food packaging application. 2015.
29
12. Azeredo HMCd. Nanocomposites for food packaging applications. Food Research International. 2009;42(9):1240-53.
30
13. Wu G, Liu S, Jia H, Dai J. Preparation and properties of heat resistant polylactic acid (PLA)/Nano-SiO2 composite filament. Journal of Wuhan University of Technology-Mater Sci Ed. 2016;31(1):164-71.
31
14. Hosseini MH, Razavi SH, Mousavi MA. Antimicrobial, physical and mechanical properties of chitosan-based films incorporated with thyme, clove and cinnamon essential oils. Journal of Food Processing and Preservation. 2009;33(6):727-43.
32
15. Alzoreky NS, Nakahara K. Antibacterial activity of extracts from some edible plants commonly consumed in Asia. International Journal of Food Microbiology. 2003;80(3):223-30.
33
16. Shan B, Cai Y-Z, Brooks JD, Corke H. The in vitro antibacterial activity of dietary spice and medicinal herb extracts. International Journal of Food Microbiology. 2007;117(1):112-9.
34
17. Kalemba D, Kunicka A. Antibacterial and Antifungal Properties of Essential Oils. Current Medicinal Chemistry. 2003;10(10):813-29.
35
18. Li XH, Xing YG, Li WL, Jiang YH, Ding YL. Antibacterial and Physical Properties of Poly(vinyl chloride)-based Film Coated with ZnO Nanoparticles. Food Science and Technology International. 2010;16(3):225-32.
36
ORIGINAL_ARTICLE
Preparation, characterization and evaluation of Ginkgo biloba solid lipid nanoparticles
Objective(s): In this work, Ginkgo biloba extract (GBE) loaded solid lipid nanoparticles (SLNs) were synthesized via high pressure homogenization method and their physicochemical properties, as well as cytotoxicity and antibacterial activities were evaluated.Methods: Ginkgo biloba extract SLNs (GBE-SLNs) were prepared using high pressure homogenization method. The morphology and size of SLNs were evaluated by scanning electron microscopy (SEM) and dynamic light scattering (DLS) techniques. The drug release of SLNs was also investigated using synthetic dialysis membrane. The antibacterial activity of nanoparticles was tested against both gram negative and gram positive bacteria strains. The probability of having toxicity of SLNs was studied on the rabbits.Results: The spherical structure of GBE-SLNs was confirmed by SEM images. The mean particle size of the obtained SLNs was ranging from 104 to 621 nm for different formulations using DLS technique. An in-vitro study of synthesized SLNs illustrated that the percentage of ginkgo biloba released from the solid lipid nanoparticles was 85% of loaded GBE after 72 hours. There was no report of significant skin toxicity via in-vivo studies.Conclusions: According to the above results, SLNs loaded with ginkgo extract showed acceptable particle size and shape, suitable loading of active substance and sustained release profile as well as appropriate antimicrobial effects without any significant skin toxicity.
https://www.nanomedicine-rj.com/article_32292_4968a5c4fc7a58c55ff3262e9f814bb1.pdf
2018-04-01
71
78
10.22034/nmrj.2018.02.003
Antimicrobial Properties
Ginkgo Biloba
Particle Size
Solid Lipid Nanoparticle
Toxicity
Pegah
Haghighi
pegahhaghighi@yahoo.com
1
Department of Medicinal Plant Sciences, Faculty of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
AUTHOR
Solmaz
Ghaffari
soligh@yahoo.com
2
Department of Medical Nanotechnology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
LEAD_AUTHOR
Sepideh
Arbabi Bidgoli
drsarbabi@yahoo.com
3
Department of Toxicology and Pharmacology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
AUTHOR
Mahnaz
Qomi
irmahnaz@yahoo.com
4
Active Pharmaceutical Research Center (APIRC), Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
AUTHOR
Setareh
Haghighat
setareh_haghighat@yahoo.com
5
Department of Microbiology, Faculty of Advanced Sciences and Technology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
AUTHOR
1. Bent S. Herbal Medicine in the United States: Review of Efficacy, Safety, and Regulation. Journal of General Internal Medicine. 2008;23(6):854-9.
1
2. van Beek TA, Montoro P. Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals. Journal of Chromatography A. 2009;1216(11):2002-32.
2
3. Smith PF, Maclennan K, Darlington CL. The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF). Journal of Ethnopharmacology. 1996;50(3):131-9.
3
4. Le Bars PL, Katz MM, Berman N, et al. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo bilobafor dementia. North American EGb Study Group. JAMA1997;278:1327-1332.
4
5. Pietri S, Seguin JR, d’Arbigny P, et al. Ginkgo bilobaextract (EGb 761) pretreatment limits free radical-induced oxidative stress in patients undergoing coronary bypass surgery. Cardiovasc Drugs Ther 1997;11:121-131.
5
6. Gessner B, Voelp A, Klasser M. Study of the long-term action of a Ginkgo bilobaextract on vigilance and mental performance as determined by means of quantitative pharmaco-EEG and psychometric measurements. Arzneimittelforschung 1985;35:1459-1465.
6
7. Tamborini A, Taurelle R. Value of standardized Ginkgo bilobaextract (EGb 761) in the management of congestive symptoms of premenstrual syndrome. Rev Fr Gynecol Obstet 1993;88:447-457. [Article in French]
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8. Cohen AJ, Bartlik B. Ginkgo biloba for antidepressant-induced sexual dysfunction. Journal of Sex & Marital Therapy. 1998;24(2):139-43.
8
9. Peters H, Kieser M, Holscher U. Demonstration of the efficacy of Ginkgo bilobaspecial extract EGb 761 on intermittent claudication – a placebo-controlled, double-blind multicenter trial. Vasa 1998;27:106-110.
9
10. Li W, Dai QT, Liu ZE. Preliminary study on early fibrosis of chronic hepatitis B treated with Ginkgo bilobaComposita. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih1995;15:593-595. [Article in Chinese]
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11. Lebuisson DA, Leroy L, Rigal G. Treatment of senile macular degeneration with Ginkgo bilobaextract. A preliminary double-blind drug vs. placebo study. Presse Med1986;15:1556-1558. [Article in French]
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12. Drew S. Effectiveness of Ginkgo biloba in treating tinnitus: double blind, placebo controlled trial. BMJ. 2001;322(7278):73-.
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13. Cesarani A, Meloni F, Alpini D, et al. Ginkgo biloba(EGb 761) in the treatment of equilibrium disorders. Adv Ther1998;15:291-304.
13
14. Wesnes KA, Ward T, McGinty A, Petrini O. The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers. Psychopharmacology. 2000;152(4):353-61.
14
15. Hauns B, Hring B, Khler S, Mross K, Unger C. Phase II Study of Combined 5-Fluorouracil/Ginkgo biloba Extract (GBE 761 ONC) Therapy in 5-Fluorouracil Pretreated Patients with Advanced Colorectal Cancer. Phytotherapy Research. 2001;15(1):34-8.
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18. . Le Bars, P.L. Magnitude of effect and special approach to Ginkgo biloba extract EGb761 in cognitive disorders. Pharmacopsychiatry 2003, 36, S44–S49
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29
ORIGINAL_ARTICLE
Preparation of new nanocomposite film for controlling Listeria monocytogenes and Staphylococcus aureus in raw rainbow trout fillet
Objective(s): This study was aimed to evaluate the effect of chitosan-zinc oxide (CH-ZnO) film containing pomegranate peel extract (PPE; 0.5, 1 and 1.5%) on survival of Listeria monocytogenes and Staphylococcus aureus in raw rainbow trout fillets during refrigerated storage for 12 days.Methods: Total polyphenolic contents of CH-ZnO films containing different concentrations of methanolic PPE were determined with Folin-Ciocalteu reagent. In order to enumerate the inoculated pathogenic bacteria in raw rainbow trout fillets, Palcam Listeria selective agar (L. monocytogenes, incubated at 30 °C for 48 h) and Baird Parker agar (S. aureus, incubated at 37 °C for 48 h) were used. Results: Total phenolic content of CH-ZnO enriched with PPE was recorded to be 72-139 mg gallic acid/g film. For un-treated samples, the initially recorded population of 5 log CFU/g of L. monocytogenes and S. aureus were reached 5.36 and 3.03 log CFU/g at the end of designated study period, respectively. There were significant differences between samples packed with CH-ZnO films enriched with different concentrations of PPE (0.5, 1 and 1.5%) and untreated ones (P < 0.05). In both samples treated with 1 and 1.5% PPE, the final bacterial population were reached below 1 log CFU/g at the end of storage period.Conclusions: The results of the present study indicate a potential use of CH-ZnO film enriched with PPE as an effective type of antimicrobial packaging to inhibit the growth of L. monocytogenes and S. aureus in raw rainbow trout fillets.
https://www.nanomedicine-rj.com/article_32293_7fc67bd99d7668ac0dfd9c1e30c02b56.pdf
2018-04-01
79
88
10.22034/nmrj.2018.02.004
Chitosan
Listeria monocytogenes
Pomegranate Peel Extract
Rainbow Trout Fillets
Staphylococcus aureus
Zinc oxide
Yasser
Shahbazi
yasser.shahbazi@yahoo.com
1
Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
LEAD_AUTHOR
Nassim
Shavisi
nassim.shavisi@yahoo.com
2
Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
AUTHOR
1. Ojagh SM, Rezaei M, Razavi SH, Hosseini SMH. Effect of chitosan coatings enriched with cinnamon oil on the quality of refrigerated rainbow trout. Food Chemistry. 2010;120(1):193-8.
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2
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3
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16
17. Basiri S, Shekarforoush SS, Aminlari M, Akbari S. Corrigendum to “The effect of pomegranate peel extract (PPE) on the polyphenol oxidase (PPO) and quality of Pacific white shrimp (Litopenaeus vannamei) during refrigerated storage” [LWT – Food Sci and Technol 60 (2015) 1025–1033]. LWT - Food Science and Technology. 2015;63(1):798.
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19
20. Berizi E, Hosseinzadeh S, Shekarforoush SS, Barbieri G. Microbial, chemical, textural and sensory properties of coated rainbow trout by chitosan combined with pomegranate peel extract during frozen storage. International Journal of Biological Macromolecules. 2018;106:1004-13.
20
21 Özdemir H, Soyer A, Tağı Ş, Turan M. Nar kabuğu ekstraktının antimikrobiyel ve antioksidan aktivitesinin köfte kalitesine etkisi. GIDA-Journal of Food. 2014;39 (6):1-4.
21
22. Mohebi E, Shahbazi Y. Application of chitosan and gelatin based active packaging films for peeled shrimp preservation: A novel functional wrapping design. LWT - Food Science and Technology. 2017;76:108-16.
22
23. Kanatt SR, Chander R, Sharma A. Antioxidant and antimicrobial activity of pomegranate peel extract improves the shelf life of chicken products. International Journal of Food Science & Technology. 2010;45(2):216-22.
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24. Özdemİr H, Soyer A, Tağı Ș, Turan M. Effects of antimicrobial and antioxidant activity of pomegranate peel extract on the quality of beef meatballs. GIDA-Journal of Food. ۲۰۱۴;۳۹ (۶):۳۵۵-۳۶۲.
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25. Rezaei F, Shahbazi Y. Shelf-life extension and quality attributes of sauced silver carp fillet: A comparison among direct addition, edible coating and biodegradable film. LWT - Food Science and Technology. 2018;87:122-33.
25
26. Khezrian A, Shahbazi Y. Application of nanocompostie chitosan and carboxymethyl cellulose films containing natural preservative compounds in minced camel’s meat. International Journal of Biological Macromolecules. 2018;106:1146-58.
26
27. Ojagh SM, Rezaei M, Razavi SH, Hosseini SMH. Development and evaluation of a novel biodegradable film made from chitosan and cinnamon essential oil with low affinity toward water. Food Chemistry. 2010;122(1):161-6.
27
28. Azizkhani M, Misaghi A, Basti AA, Gandomi H, Hosseini H. Corrigendum to “Effects of Zataria multiflora Boiss. Essential Oil on Growth and Gene Expression of Enterotoxins A, C and E in Staphylococcus aureus ATCC 29213.” [Int. J. Food Microbiol. 163 (2013) 159–165]. International Journal of Food Microbiology. 2013;166(1):125.
28
29. Hui G, Liu W, Feng H, Li J, Gao Y. Effects of chitosan combined with nisin treatment on storage quality of large yellow croaker ( Pseudosciaena crocea ). Food Chemistry. 2016;203:276-82.
29
30. Moradi M, Tajik H, Razavi Rohani SM, Oromiehie AR, Malekinejad H, Aliakbarlu J, et al. Characterization of antioxidant chitosan film incorporated with Zataria multiflora Boiss essential oil and grape seed extract. LWT - Food Science and Technology. 2012;46(2):477-84.
30
31. Shahbazi Y. Application of carboxymethyl cellulose and chitosan coatings containing Mentha spicata essential oil in fresh strawberries. International Journal of Biological Macromolecules. 2018;112:264-72.
31
32. Sivarooban T, Hettiarachchy NS, Johnson MG. Physical and antimicrobial properties of grape seed extract, nisin, and EDTA incorporated soy protein edible films. Food Research International. 2008;41(8):781-5.
32
33. Corrales M, Han JH, Tauscher B. Antimicrobial properties of grape seed extracts and their effectiveness after incorporation into pea starch films. International Journal of Food Science & Technology. 2009;44(2):425-33.
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34. Rahman PM, Mujeeb VMA, Muraleedharan K. Flexible chitosan-nano ZnO antimicrobial pouches as a new material for extending the shelf life of raw meat. International Journal of Biological Macromolecules. 2017;97:382-91.
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35. Vanamudan A, Pamidimukkala P. Chitosan, nanoclay and chitosan–nanoclay composite as adsorbents for Rhodamine-6G and the resulting optical properties. International Journal of Biological Macromolecules. 2015;74:127-35.
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37. Arfat YA, Benjakul S, Prodpran T, Sumpavapol P, Songtipya P. Properties and antimicrobial activity of fish protein isolate/fish skin gelatin film containing basil leaf essential oil and zinc oxide nanoparticles. Food Hydrocolloids. 2014;41:265-73.
37
38. Shahbazi Y. The properties of chitosan and gelatin films incorporated with ethanolic red grape seed extract and Ziziphora clinopodioides essential oil as biodegradable materials for active food packaging. International Journal of Biological Macromolecules. 2017;99:746-53.
38
39. Çam M, Hışıl Y. Pressurised water extraction of polyphenols from pomegranate peels. Food Chemistry. ۲۰۱۰;۱۲۳(۳):۸۷۸-۸۵.
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46
47. Al-Zoreky NS. Antimicrobial activity of pomegranate (Punica granatum L.) fruit peels. International Journal of Food Microbiology. 2009;134(3):244-8.
47
48. Shahbazi Y. Antibacterial and Antioxidant Properties of Methanolic Extracts of Apple (Malus pumila), Grape (Vitis vinifera), Pomegranate (Punica granatum L.) and Common Fig (Ficus carica L.) Fruits. Pharmaceutical Sciences. 2017;23(4):308-15.
48
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49
50. Prashanth D, Asha MK, Amit A. Antibacterial activity of Punica granatum. Fitoterapia. 2001;72(2):171-3.
50
51. Shahbazi Y, Karami N, Shavisi N. Effect of Ziziphora clinopodioides essential oil on shelf life and fate of Listeria monocytogenes and Staphylococcus aureus in refrigerated chicken meatballs. Journal of Food Safety. 2017;38(1):e12394.
51
52. Higginbotham KL, Burris KP, Zivanovic S, Davidson PM, Stewart CN. Aqueous extracts of Hibiscus sabdariffa calyces as an antimicrobial rinse on hot dogs against Listeria monocytogenes and methicillin-resistant Staphylococcus aureus. Food Control. 2014;40:274-7.
52
ORIGINAL_ARTICLE
Effects of Surface Chemistry Modification using Zwitterionic Coatings on the Surface of Silica Nanoparticles on Prevention of Protein Corona: A Test Study
Objective(s): The purpose of this study was investigation of the protein corona formation on the surface of zwitterionic nanoparticles when they exposed to bio-fluid like human plasma.Methods: Silica nanoparticles with zwitterionic surface coating, cysteine and sulfobetaine were employed as zwitterionic ligands, were synthesized and characterized in terms of physicochemical properties. To probe protein corona formation, synthesized nanoparticles were incubated at 37 °C for 1h in human plasma solutions (10 and 55% (v/v)).Results: Our results show no significant changes in size and zeta potential of nanoparticles after treatment with human plasma and elimination of loosely attached proteins. The size of zwitterionic nanoparticles after incubation with human plasma remained around 100 nm and their zeta potential was near zero. The results from gel-electrophoresis and MALDI-TOF mass spectrometry of nanoparticles after incubation with plasma proved that zwitterionic nanoparticles are non-interacting with proteins.Conclusions: Our observations confirm the hypothesis that zwitterionic surface modified nanoparticles could provide the potential to regulate the interaction of the nanomaterials with biological systems and successfully overcome the protein corona issue in the field of nanomedicine.
https://www.nanomedicine-rj.com/article_32466_ca00bd56a8850ae6e860d5a32153917c.pdf
2018-04-01
89
95
10.22034/nmrj.2018.02.005
Engineerd-Nanoparticles
MALDI-TOF Mass Spectrometry
Protein Corona
Silica Nanoparticles
Surface Chemistry
Zwitterionic Coating
Reihaneh
Safavi-Sohi
reihaneh.safavi@gmail.com
1
Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
AUTHOR
Alireza
Ghassempour
a-ghassempour@sbu.ac.ir
2
Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
LEAD_AUTHOR
1. Mahmoudi M, Lynch I, Ejtehadi MR, Monopoli MP, Bombelli FB, Laurent S. Protein−Nanoparticle Interactions: Opportunities and Challenges. Chemical Reviews. 2011;111(9):5610-37.
1
2. Maiolo D, Del Pino P, Metrangolo P, Parak WJ, Baldelli Bombelli F. Nanomedicine delivery: does protein corona route to the target or off road? Nanomedicine. 2015;10(21):3231-47.
2
3. Choi CHJ, Alabi CA, Webster P, Davis ME. Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles. Proceedings of the National Academy of Sciences. 2009;107(3):1235-40.
3
4. Lynch I, Dawson KA. Protein-nanoparticle interactions. Nano Today. 2008;3(1-2):40-7.
4
5. Farokhzad OC, Cheng J, Teply BA, Sherifi I, Jon S, Kantoff PW, et al. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proceedings of the National Academy of Sciences. 2006;103(16):6315-20.
5
6. Mahon E, Salvati A, Baldelli Bombelli F, Lynch I, Dawson KA. Designing the nanoparticle–biomolecule interface for “targeting and therapeutic delivery”. Journal of Controlled Release. 2012;161(2):164-74.
6
7. Bertrand N, Leroux J-C. The journey of a drug-carrier in the body: An anatomo-physiological perspective. Journal of Controlled Release. 2012;161(2):152-63.
7
8. Monopoli MP, Walczyk D, Campbell A, Elia G, Lynch I, Baldelli Bombelli F, et al. Physical−Chemical Aspects of Protein Corona: Relevance toin Vitroandin VivoBiological Impacts of Nanoparticles. Journal of the American Chemical Society. 2011;133(8):2525-34.
8
9. Lesniak A, Salvati A, Santos-Martinez MJ, Radomski MW, Dawson KA, Åberg C. Nanoparticle Adhesion to the Cell Membrane and Its Effect on Nanoparticle Uptake Efficiency. Journal of the American Chemical Society. 2013;135(4):1438-44.
9
10. Salvati A, Pitek AS, Monopoli MP, Prapainop K, Bombelli FB, Hristov DR, et al. Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface. Nature Nanotechnology. 2013;8(2):137-43.
10
11. Dai Q, Yan Y, Guo J, Björnmalm M, Cui J, Sun H, et al. Targeting Ability of Affibody-Functionalized Particles Is Enhanced by Albumin but Inhibited by Serum Coronas. ACS Macro Letters. 2015;4(11):1259-63.
11
12. Mirshafiee V, Mahmoudi M, Lou K, Cheng J, Kraft ML. Protein corona significantly reduces active targeting yield. Chemical Communications. 2013;49(25):2557.
12
13. Wang RLC, Kreuzer HJ, Grunze M. Molecular Conformation and Solvation of Oligo(ethylene glycol)-Terminated Self-Assembled Monolayers and Their Resistance to Protein Adsorption. The Journal of Physical Chemistry B. 1997;101(47):9767-73.
13
14. Efremova NV, Sheth SR, Leckband DE. Protein-Induced Changes in Poly(ethylene glycol) Brushes: Molecular Weight and Temperature Dependence. Langmuir. 2001;17(24):7628-36.
14
15. Kim HR, Andrieux K, Delomenie C, Chacun H, Appel M, Desmaële D, et al. Analysis of plasma protein adsorption onto PEGylated nanoparticles by complementary methods: 2-DE, CE and Protein Lab-on-chip® system. ELECTROPHORESIS. 2007;28(13):2252-61.
15
16. Pozzi D, Colapicchioni V, Caracciolo G, Piovesana S, Capriotti AL, Palchetti S, et al. Effect of polyethyleneglycol (PEG) chain length on the bio–nano-interactions between PEGylated lipid nanoparticles and biological fluids: from nanostructure to uptake in cancer cells. Nanoscale. 2014;6(5):2782.
16
17. Estephan ZG, Schlenoff PS, Schlenoff JB. Zwitteration As an Alternative to PEGylation. Langmuir. 2011;27(11):6794-800.
17
18. Moyano DF, Saha K, Prakash G, Yan B, Kong H, Yazdani M, et al. Fabrication of Corona-Free Nanoparticles with Tunable Hydrophobicity. ACS Nano. 2014;8(7):6748-55.
18
19. Aldeek F, Muhammed MAH, Palui G, Zhan N, Mattoussi H. Growth of Highly Fluorescent Polyethylene Glycol- and Zwitterion-Functionalized Gold Nanoclusters. ACS Nano. 2013;7(3):2509-21.
19
20. García KP, Zarschler K, Barbaro L, Barreto JA, O’Malley W, Spiccia L, et al. Zwitterionic Coatings: Zwitterionic-Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System (Small 13/2014). Small. 2014;10(13):2505-.
20
21. Liu W, Choi HS, Zimmer JP, Tanaka E, Frangioni JV, Bawendi M. Compact Cysteine-Coated CdSe(ZnCdS) Quantum Dots for in Vivo Applications. Journal of the American Chemical Society. 2007;129(47):14530-1.
21
22. Safavi-Sohi R, Maghari S, Raoufi M, Jalali SA, Hajipour MJ, Ghassempour A, et al. Bypassing Protein Corona Issue on Active Targeting: Zwitterionic Coatings Dictate Specific Interactions of Targeting Moieties and Cell Receptors. ACS Applied Materials & Interfaces. 2016;8(35):22808-18.
22
23. Ibrahim IA, Zikry A, Sharaf MA. Preparation of spherical silica nanoparticles: Stober silica. J Am Sci. 2010;6(11):985-9.
23
24. Estephan ZG, Jaber JA, Schlenoff JB. Zwitterion-Stabilized Silica Nanoparticles: Toward Nonstick Nano. Langmuir. 2010;26(22):16884-9.
24
25. Schaub S, Wilkins J, Weiler T, Sangster K, Rush D, Nickerson P. Urine protein profiling with surface-enhanced laser-desorption/ionization time-of-flight mass spectrometry. Kidney International. 2004;65(1):323-32.
25
26. Villanueva J, Philip J, Entenberg D, Chaparro CA, Tanwar MK, Holland EC, et al. Serum Peptide Profiling by Magnetic Particle-Assisted, Automated Sample Processing and MALDI-TOF Mass Spectrometry. Analytical Chemistry. 2004;76(6):1560-70.
26
ORIGINAL_ARTICLE
Morphological and mechanical properties of Poly (lactic Acid) /zinc oxide nanocomposite films
Objective(s): Nowadays, tendency to use green materials can reduce environmental pollution and plastic waste. Poly (lactic Acid) PLA is one of the natural biodegradable polymers mainly used in the production of bioplastics for packaging which is made of non-toxic compounds and is easily biodegradable. In this research, the effect of 1, 3 and 5% nanocomposite zinc oxide on the morphological, mechanical properties and chemicals interaction of poly-lactic acid films was investigated.Methods: To study morphological structure of nanocomposites, scanning electron microscope (SEM) was used. For evaluating the mechanical properties of films, tensile strength, elongation at break and young's modulus were measured by the ASTM D882 standard. Also, The Fourier-transform infrared spectroscopy (FT-IR) spectrum of films with PERKIN ELMER 1650, FT-IR spectrophotometer was recorded.Results: Morphological shows that zinc oxide nanoparticles are well distributed in polymer matrix in all nanocomposite samples. It is clear from the result of mechanical properties that the Young’s modulus was increased significantly (p<0.05) when the percentage of zinc oxide in the poly-lactic acid film increased from 1% to 5%. The tensile strength values of films zinc oxide nanocomposites were significantly (p <0.05) less than the control film. Also, elongation at break was no statistically significant. In the investigation of FTIR spectra, the percentage of created bonds between nanozinc oxide and poly lactic acid are increased by enhancing the percentage of nanozinc oxide.Conclusions: Due to the good functional mechanical and morphological properties of PLA-nanozinc oxide films, they can be employed for various packaging.
https://www.nanomedicine-rj.com/article_32467_7c43666df0847972128e70349824746a.pdf
2018-04-01
96
101
10.22034/nmrj.2018.02.006
Mechanical
morphological
Poly (Lactic Acid)/ Zinc Oxide Nanocomposite Films
Mahya
Shafiee Nasab
mahya.sh.n@gmail.com
1
Agricultural Engineering-Food Sciences and Industries, Islamic Azad University, Tehran North Branch, Tehran, Iran
AUTHOR
Mahsa
Tabari
ma.tabari@gmail.com
2
Department of Food Sciences and Technology, Faculty of Agriculture, Tehran North Branch, Islamic Azad University, Tehran, Iran
LEAD_AUTHOR
Mohammad Hossein
Azizi
azizi@sina.tums.ac.ir
3
Department of Food Sciences and Technology, Faculty of Agriculture, Tarbiat Modarres University, Tehran, Iran
AUTHOR
1. Ghanbarzadeh, B., H. Almasi, and Y. Zahedi, Biodegradable edible biopolymers in food and drug packaging, 2009, Tehran Polytechnic Press.
1
2. Tabari M. Investigation of Carboxymethyl Cellulose (CMC) on Mechanical Properties of Cold Water Fish Gelatin Biodegradable Edible Films. Foods. 2017;6(6):41.
2
3. Garlotta, D., A literature review of poly (lactic acid). Journal of Polymers and the Environment, 2001. 9(2): p. 63-84.
3
4 Tabari M. Characterization of a new biodegradable edible film based on Sago Starch loaded with Carboxymethyl Cellulose nanoparticles. Nanomedicine Research Journal, 2018. 3(1): 25-30, Winter 2018.
4
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17
ORIGINAL_ARTICLE
Antibody Conjugated Gold Nanoparticles for Detection of Small Amounts of Antigen Based on Surface Plasmon Resonance (SPR) Spectra
In this paper, a fast and sensitive localized surface plasmon resonance (LSPR) based biosensor was developed and the optimization of gold – antibody conjugates through investigation of different parameters were performed. Gold nanoparticles (AuNPs) with a size of ~20 nm were synthesized via chemical reduction of HAuCl4 with trisodium citrate as reducing and stabilizing agent. The impacts of pH of gold colloids and antibody concentrations on conjugation of electrostatically absorbed antibodies on the AuNPs surface were evaluated. The diverse amounts of antigens were added to the selected gold – antibody conjugate and the calibration curve and limit of detection of the system were successfully obtained. The UV- Vis and DLS outputs were utilized to prove the efficiency and repeatability of the system. As a result, the designed biosensor shows a convincing LOD of 400 ng/ml of antigen. It is suggested that electrostatic absorption strategy of AuNPs with negative charge to the positively charged antibodies can be an efficient methodology. Results showed an effective LSPR system for detection of small amounts of antigen in short time as well as with high accuracy.
https://www.nanomedicine-rj.com/article_32468_8f486f9e73b93b546b96d44ea3e357e4.pdf
2018-04-01
102
108
10.22034/nmrj.2018.02.007
Biosensors
Gold nanoparticles
Localized Surface Plasmon Resonance
Yasamin
Davatgaran Taghipour
y.davatgaran@gmail.com
1
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Sharmin
Kharrazi
sh-kharrazi@tums.ac.ir
2
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Seyed Mohammad
Amini
m_amini@sina.tums.ac.ir
3
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
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31
ORIGINAL_ARTICLE
Characterization of active nanochitosan film containing natural preservative agents
Objective(s): The aim of this study was to improve different characteristics including antibacterial, antioxidant and physical properties of nanochitosan film by incorporating Mentha spicata essential oil (EO) and methanolic pomegranate peel and grape seed extracts. Methods: The determination of the chemical composition of M. spicata EO was conducted by means of gas chromatography with mass spectrometry (GC-MS). Thickness, color, in-vitro antioxidant and antimicrobial properties of prepared films were evaluated. Results: The most abundant constituents of M. spicata EO were carvone (78.76%), limonene (11.50%) and β-bourbonene (11.23%). The thickness of designated films and straight chitosan film were similar, however, the increasing value was observed for films containing M. spicata EO, pomegranate peel and grape seed extracts (P > 0.05). The lower lightness, higher redness and consequently a darker color was found in film incorporated with methanolic pomegranate peel and grape seed extracts. The highest antioxidant activity was found in nanochitosan enriched with the EO and grape seed extract. The antibacterial activities of all extracts and the EO were in the order: M. spicata EO > grape extract > pomegranate peel extract. Conclusions: The nanochitosan film incorporated with EO and extracts have shown good antibacterial and antioxidant activities which can be barrier against microbial and chemical contamination in food industries.
https://www.nanomedicine-rj.com/article_32469_1e58dce25f102b6e99ef358be53fbf58.pdf
2018-04-01
109
116
10.22034/nmrj.2018.02.008
Film
Grape Seed
Mentha Spicata Essential Oil
nanochitosan
Pomegranate Peel
Yasser
Shahbazi
yasser.shahbazi@yahoo.com
1
Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
AUTHOR
Nassim
Shavisi
nassim.shavisi@yahoo.com
2
Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
LEAD_AUTHOR
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