ORIGINAL_ARTICLE
Pluronic as nano-carier for drug delivery systems
A common approach for building a drug delivery system is to incorporate the drug within the nanocarrier that results in increased solubility, metabolic stability, and improved circulation time. However, recent developments indicate that selection of polymer nanomaterials can implement more than only inert carrier functions by being biological response modifiers. One representative of such materials is Pluronic block copolymers that cause various functional alterations in cells. The key attribute for the biological activity of Pluronics is their ability to incorporate into membranes followed by subsequent translocation into the cells and affecting various cellular functions, such as mitochondrial respiration, ATP synthesis, activity of drug efflux transporters, apoptotic signal transduction, and gene expression. As a result, Pluronics cause drastic sensitization to various anticancer agents based on multidrug resistant (MDR), enhance drug transport across the blood brain and intestinal barriers, and causes transcriptional activation of gene expression both in vitro and in vivo. On other hand, there has been a considerable research interest in the area of drug delivery using polymer based particulate delivery systems as carriers for small and large molecules. Particulate systems like nanoparticles and micelles have been used as a physical approach to alter and improve the pharmacodynamics and pharmacokinetic profiles of various types of drug molecules. Due to the wide compatibility with drug candidates of diverse nature and ingredients in formulations, poloxamers serve to be excellent polymer for drug delivery vehicles by different routes of administration. This review will highlight the poloxamers-based micelles/nanoparticles that have been developed to date.
https://www.nanomedicine-rj.com/article_33841_b1576cc2aee92abcb722689d25e18a71.pdf
2018-12-01
174
179
10.22034/nmrj.2018.04.001
ATP
Drug Delivery
Nano Carrier
Pluronic
Abbas
Rahdar
a.rahdarnanophysics@gmail.com
1
Department of Physics, University of Zabol, Zabol, Iran
LEAD_AUTHOR
Susan
kazemi
susan.kazemi1393@gmail.com
2
M.Sc. of Polymer and Materials Chemistry, Faculty of Chemistry and Petroleum Sciences, Shahid Beheshti University, Tehran, Iran
AUTHOR
Faezeh
Askari
tr4030@yahoo.com
3
M.Sc. of Nano-chemistry, Kharazmi University, Tehran, Iran
AUTHOR
1. Tong NAN, Tran NQ, Nguyen XTDT, Cao VD, Nguyen TP, Nguyen CK. Thermosensitive heparin-Pluronic® copolymer as effective dual anticancer drugs delivery system for combination cancer therapy. International Journal of Nanotechnology. ۲۰۱۸;۱۵(۱/۲/۳):۱۷۴.
1
2. Vakilzadeh H, Varshosaz J, Minaiyan M. Pulmonary Delivery of Triptorelin Loaded in Pluronic Based Nanomicelles in Rat Model. Current Drug Delivery. 2018;15(5):630-40.
2
3. Griesser J, Hetényi G, Kadas H, Demarne F, Jannin V, Bernkop-Schnürch A. Self-emulsifying peptide drug delivery systems: How to make them highly mucus permeating. International Journal of Pharmaceutics. 2018;538(1-2):159-66.
3
4. Lai Y-H, Chiang C-S, Kao T-H, Chen S-Y. Dual-drug nanomedicine with hydrophilic F127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue. International Journal of Nanomedicine. 2018;Volume 13:3011-26.
4
5. Nguyen TTC, Nguyen CK, Nguyen TH, Tran NQ. Highly lipophilic pluronics-conjugated polyamidoamine dendrimer nanocarriers as potential delivery system for hydrophobic drugs. Materials Science and Engineering: C. 2017;70:992-9.
5
6. Maulvi FA, Desai AR, Choksi HH, Patil RJ, Ranch KM, Vyas BA, et al. Effect of surfactant chain length on drug release kinetics from microemulsion-laden contact lenses. International Journal of Pharmaceutics. 2017;524(1-2):193-204.
6
7. Cieśla J, Koczańska M, Narkiewicz-Michałek J, Szymula M, Bieganowski A. Effect of α-tocopherol on the properties of microemulsions stabilized by the ionic surfactants. Journal of Molecular Liquids. 2017;236:117-23.
7
8. Cieśla J, Koczańska M, Narkiewicz-Michałek J, Szymula M, Bieganowski A. The physicochemical properties of CTAB solutions in the presence of α-tocopherol. Journal of Molecular Liquids. 2016;222:463-70.
8
9. Cieśla J, Koczańska M, Narkiewicz-Michałek J, Szymula M, Bieganowski A. Alpha-tocopherol in CTAB/NaCl systems — The light scattering studies. Journal of Molecular Liquids. 2017;233:15-22.
9
10. Dehghankelishadi P, Dorkoosh FA, Pluronic based nano-delivery systems; Prospective warrior in war against cancer.Nanomedicine Research Journal , 2016;1(1): 1-7.
10
11. Steinbach OC. Industry Update: The latest developments in therapeutic delivery. Therapeutic Delivery. 2013;4(7):779-84.
11
12. Karlsson J, Vaughan HJ, Green JJ. Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments. Annual Review of Chemical and Biomolecular Engineering. 2018;9(1):105-27.
12
13. Acharya S, Sahoo SK. PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect. Advanced Drug Delivery Reviews. 2011;63(3):170-83.
13
14. Bae WK, Park MS, Lee JH, Hwang JE, Shim HJ, Cho SH, et al. Docetaxel-loaded thermoresponsive conjugated linoleic acid-incorporated poloxamer hydrogel for the suppression of peritoneal metastasis of gastric cancer. Biomaterials. 2013;34(4):1433-41.
14
15. Batrakova EV, Kabanov AV. Pluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers. Journal of Controlled Release. 2008;130(2):98-106.
15
16. Zhou L, Wang H, Li Y. Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance. Theranostics. 2018;8(4):1059-74.
16
17. Li J, Yu F, Chen Y, Oupický D. Polymeric drugs: Advances in the development of pharmacologically active polymers. Journal of Controlled Release. 2015;219:369-82.
17
18. Almeida M, Magalhães M, Veiga F, Figueiras A. Poloxamers, poloxamines and polymeric micelles: Definition, structure and therapeutic applications in cancer. Journal of Polymer Research. 2017;25(1).
18
19. Danson S, Ferry D, Alakhov V, Margison J, Kerr D, Jowle D, et al. Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer. British Journal of Cancer. 2004;90(11):2085-91.
19
20. Buwalda S, Al Samad A, El Jundi A, Bethry A, Bakkour Y, Coudane J, et al. Stabilization of poly(ethylene glycol)-poly(ε-caprolactone) star block copolymer micelles via aromatic groups for improved drug delivery properties. Journal of Colloid and Interface Science. 2018;514:468-78.
20
21. Kataoka K, Harada A, Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Advanced Drug Delivery Reviews. 2001;47(1):113-31.
21
22. Lipinski CA. Drug-like properties and the causes of poor solubility and poor permeability. Journal of Pharmacological and Toxicological Methods. 2000;44(1):235-49.
22
23. Singh M. The preparation and characterization of polymeric antigen delivery systems for oral administration. Advanced Drug Delivery Reviews. 1998;34(2-3):285-304.
23
24. Florence AT, Attwood D. Physicochemical Principles of Pharmacy. 3 ed.1998, Pal grave: Hampshire, New York.
24
25. O’Neill VJ, Twelves CJ. Oral cancer treatment: developments in chemotherapy and beyond. British Journal of Cancer. 2002;87(9):933-7.
25
26. Feng S-S. Chemotherapeutic Engineering: Concept, Feasibility, Safety and Prospect—A Tribute to Shu Chien’s 80th Birthday. Cellular and Molecular Bioengineering. 2011;4(4):708-16.
26
27. Feng S-S, Zhao L, Tang J. Nanomedicine for oral chemotherapy. Nanomedicine. 2011;6(3):407-10.
27
28. Feng S-S, Chien S. Chemotherapeutic engineering: Application and further development of chemical engineering principles for chemotherapy of cancer and other diseases. Chemical Engineering Science. 2003;58(18):4087-114.
28
29. Barry NPE, Sadler PJ. Challenges for Metals in Medicine: How Nanotechnology May Help To Shape the Future. ACS Nano. 2013;7(7):5654-9.
29
30. Akins RL, Lust E, Ghilzai NMK, Brown BK. Book Reviews for Vol. 68, Issue 3 ROGER G. FINCH , DAVID GREENWOOD , S. RAGNAR NORRBY , AND RICHARD J. WHITLEY .Antibiotic and Chemotherapy: Anti-Infective agents and their use in therapy, 8th ed. Edinburgh: Churchill Livingstone; 2003. 964 pp (hardcover), $179.00. STEVEN B KAYNE AND MICHAEL H JEPSON , Editors.Veterinary Pharmacy. Chicago: Pharmaceutical Press, 2004. 606 pages (paperback), $59.95. RAYMOND C. ROWE , PAUL J. SHESKEY , AND PAUL J. WALK .Handbook of Pharmaceutical Excipients, 4th Edition. Washington DC: American Pharmaceutical Association (APhA), 2003. xxi + 776 pp (hardcover). L. MICHAEL POSEY .Pharmacy: An Introduction to the Profession. Washington, DC: American Pharmacists Association, 2003. x + 207 pp (softcover), $22.95. American Journal of Pharmaceutical Education. 2004;68(3):84.
30
31. Collet JH. in Handbook of Pharmaceutical Excipients American Pharmaceutical, ed. Rowe RC, Sheskey , P, Weller PJ, American Pharmaceutical Association,Washington, DC, 2003:447–50.
31
32. Gelderblom H, Verweij J, Nooter K, Sparreboom A, Cremophor EL. Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation. European Journal of Cancer, 2001;37:1590–98.
32
33. Fang X, Chen, Sha X, Jiang, Chen Y, Ren. Pluronic P105/F127 mixed micelles for the delivery of docetaxel against Taxol-resistant non-small cell lung cancer: optimization and in vitro, in vivo evaluation. International Journal of Nanomedicine. 2013:73.
33
34. Ruel-Gariépy E, Leroux J-C. In situ-forming hydrogels—review of temperature-sensitive systems. European Journal of Pharmaceutics and Biopharmaceutics. 2004;58(2):409-26.
34
35. Heron J. Mindmaps in Ophthalmology Abhishek Sharma; CRC Press, Boca Raton, FL, 2015. Ophthalmic and Physiological Optics. 2016;36(6):686-.
35
36. Schmolka IR. Poloxamers in the Pharmaceutical Industry, CRC Press, Boca Ratin FL, 1991.
36
37. Pitto-Barry A, Barry NPE. Pluronic® block-copolymers in medicine: from chemical and biological versatility to rationalisation and clinical advances. Polym Chem. 2014;5(10):3291-7.
37
38. Chen Z, Chen H, Hu H, Yu M, Li F, Zhang Q, et al. Versatile Synthesis Strategy for Carboxylic Acid−functionalized Upconverting Nanophosphors as Biological Labels. Journal of the American Chemical Society. 2008;130(10):3023-9.
38
39. Zhou J, Yu M, Sun Y, Zhang X, Zhu X, Wu Z, et al. Fluorine-18-labeled Gd3+/Yb3+/Er3+ co-doped NaYF4 nanophosphors for multimodality PET/MR/UCL imaging. Biomaterials. 2011;32(4):1148-56.
39
40. Wu Z, Guo C, Liang S, Zhang H, Wang L, Sun H, et al. A pluronic F127 coating strategy to produce stable up-conversion NaYF4:Yb,Er(Tm) nanoparticles in culture media for bioimaging. Journal of Materials Chemistry. 2012;22(35):18596.
40
41. Kurahashi M, Kanamori K, Takeda K, Kaji H, Nakanishi K. Role of block copolymer surfactant on the pore formation in methylsilsesquioxane aerogel systems. RSC Advances. 2012;2(18):7166.
41
42. Alexandridis P, Alan Hatton T. Poly(ethylene oxide) poly(propylene oxide) poly(ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 1995;96(1-2):1-46.
42
43. Ma W-D, Xu H, Wang C, Nie S-F, Pan W-S. Pluronic F127-g-poly(acrylic acid) copolymers as in situ gelling vehicle for ophthalmic drug delivery system. International Journal of Pharmaceutics. 2008;350(1-2):247-56.
43
44. Lin H-R, Li Y-S, Lin Y-J. Novel microencapsulated Pluronic–chitosan nanomicelles for lung delivery. Colloid and Polymer Science. 2016;294(7):1209-16.
44
45. Fang X, Chen, Sha X, Jiang, Chen Y, Ren. Pluronic P105/F127 mixed micelles for the delivery of docetaxel against Taxol-resistant non-small cell lung cancer: optimization and in vitro, in vivo evaluation. International Journal of Nanomedicine. 2013:73.
45
46. Basak R, Bandyopadhyay R. Encapsulation of Hydrophobic Drugs in Pluronic F127 Micelles: Effects of Drug Hydrophobicity, Solution Temperature, and pH. Langmuir. 2013;29(13):4350-6.
46
47. Sharma PK, Bhatia SR. Effect of anti-inflammatories on Pluronic® F۱۲۷: micellar assembly, gelation and partitioning. International Journal of Pharmaceutics. ۲۰۰۴;۲۷۸(۲):۳۶۱-۷۷.
47
48. Sharma PK, Reilly MJ, Jones DN, Robinson PM, Bhatia SR. The effect of pharmaceuticals on the nanoscale structure of PEO–PPO–PEO micelles. Colloids and Surfaces B: Biointerfaces. 2008;61(1):53-60.
48
49. Sharma PK, Reilly MJ, Jones DN, Robinso PM, Bhatia SR. The effects of anti-pharmaceuticals on the nanoscale structure of PEO-PPO-PEO micelles. Colloids and Surfaces B: Biointerfaces, 2008;61:53-60.
49
50. Foster B, Cosgrove T, Espidel Y. PFGSE-NMR study of pHtriggered behavior in Pluronic-Ibuprofen solutions. Langmuir, 2009;25(12):6760.
50
ORIGINAL_ARTICLE
Production of Wound Dressing with Nano Fibers contain Bassorin/Ofloxacin for Improvement Burn Wound
Gum Tragacanth (GT) obtained from Astragalus Gossypinus is one of the most widely used natural gums which has found applications in many areas because of its attractive features such as biodegradability, nontoxic nature, natural availability, moisture absorption and creating a network of Hydrocolloid. It also has maintenance and delivery of drugs, higher resistance to microbial attacks and long shelf-life properties.In present study, preparation nanofibers of 50 wt% Bassorin (extracted from Gum Tragacanth) has been mixed by 50 wt% Poly Ethylene Oxide and 0.01 wt% Ofloxacin (Ba/PEO/Ofx) for Electrospinning. Nanofibers coated on cotton gauze. The properties of Bassorin and produced nanofibers were examined via XRD, FTIR and SEM microscopy. The Antibacterial of nanofibers activity against Staphylococcus aureus as gram positive bacteria and Escherichia coli as a gram-negative bacteria also were investigated. Nanofibers are capable of absorbing wound’s exocrine liquid easily due to their high specific area of nanofibers which 4 to 5% more than cotton gauzes without nanofibers. When it is turned to gel by moisture sorption, the release of loaded Ofloxacin would be enhanced. The Antibacterial assay showed the cotton gauze coated with Ba/PEO/Ofx nanofibers could inhibit about 90% growth both bacterial strain on burn wound. Also, the therapeutic effect of nano-bassorin in restoring superficial second-degree burns in rats showed an accelerated effect on wound healing.Based on the results of this study, it is possible to use cotton gauzes coated with bassorin nanofibers as a suitable candidate for the treatment of second-degree superficial burns.
https://www.nanomedicine-rj.com/article_33842_57a8dc14019951f74747ca628be2d0b5.pdf
2018-12-01
180
189
10.22034/nmrj.2018.04.002
Electrospinning
Gum Traghacanth
Bassorin
Poly Ethylene Oxide
Nanofibers
Antibacterial
Burn wound
Farnaz
Nayeb morad
farnazpersian@yahoo.com
1
Department of Textile Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Abosaeed
Rashidi
rashidi50@yahoo.com
2
Department of Textile Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
LEAD_AUTHOR
Ramin
Khajavi
rkhajavi@gmail.com
3
Department of Textile Engineering, Tehran South Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Mohammad karim
Rahimi
mohammadkrahimi@gmail.com
4
Medical Science, Tehran North Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Abbas
Bahador
abahador@sina.tums.ac.ir
5
Microbiology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
1. Seydim AC, Sarikus G. Antimicrobial activity of whey protein based edible films incorporated with oregano, rosemary and garlic essential oils. Food Research International. 2006;39(5):639-44.
1
2. Mohammadifar MA, Musavi SM, Kiumarsi A, Williams PA. Solution properties of targacanthin (water-soluble part of gum tragacanth exudate from Astragalus gossypinus). International Journal of Biological Macromolecules. 2006;38(1):31-9.
2
3. Ranjbar-Mohammadi M, Bahrami SH. Electrospun curcumin loaded poly(ε-caprolactone)/gum tragacanth nanofibers for biomedical application. International Journal of Biological Macromolecules. 2016;84:448-56.
3
4. A. Yokoyama, K.R. Srinivasan, H.S. Fogler, J. Colloid Interface Sci. 126 (1988)141–149.
4
5. G.O. Phillips, P.A. Williams, second ed., Woodhead Publishing Limited, Cambridge,UK, 2009.
5
6. D.M.W. Anderson, Food Addit. Contam. 6 (1989) 1–12.
6
7. M.A. Eastwood, W.G. Brydon, D.M.W. Anderson, Toxicol. Lett. 21 (1984) 73–81.
7
8. A.J. Kora, J. Arunachalam, Nanomater. (2012) 1–8(Article ID 869765).
8
9. J. O’Mahony, M. O’Donoghue, J.G. Morgan, C. Hill, Int. J. Food Microbiol. 61 (2000)177–185.
9
10. A. Kiani, M. Shahbazi, H. Asempour, J. Appl. Polym. Sci. 124 (2012) 99–108.
10
11. A. Moghbel, H. Agheli, E. Kalantari,M. Naji, J. Toxicol. Lett. 18 (Supplement 1) (2008)S154.
11
12. F. Khoylou, F. Naimian, Radiat. Phys. Chem. 78 (2009) 195–198.
12
13. M.R. Siahi, M. Barzegar-Jalali, F. Monajjemzadeh, F. Ghaffari, S. Azarmi, AAPS Pharm.Sci. Tech. 6 (2005) E626–E632.
13
14. R. Khajavi, S.H.M. Pourgharbi, A. Rashidi, A. Kiumarsi, Int. J. Eng. 17 (2004) 201–208.
14
15. R. Khajavi, S.H.M. Pourgharbi, A. Kiumarsi, A. Rashidi, Appl. Sci. 7 (2007) 2861–2865.
15
16. Kenawy E-R, Layman JM, Watkins JR, Bowlin GL, Matthews JA, Simpson DG, et al. Electrospinning of poly(ethylene-co-vinyl alcohol) fibers. Biomaterials. 2003;24(6):907-13.
16
17. Verreck G, Chun I, Rosenblatt J, Peeters J, Dijck AV, Mensch J, et al. Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer. Journal of Controlled Release. 2003;92(3):349-60.
17
18. Xu C, Inai R, Kotaki M, Ramakrishna S.,(2004) ,Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering. Biomaterials. 25(5):877-86.
18
19. Kojima K, Okamoto Y, Miyatake K, Kitamura Y, Minami S.,(1998), Collagen typing of granulation tissue induced by chitin and chitosan. Carbohydrate polymers. 37(2):109-13.
19
20. Tavakol S, Nikpour MR, Hoveizi E, Tavakol B, Rezayat SM, Adabi M, et al. Investigating the effects of particle size and chemical structure on cytotoxicity and bacteriostatic potential of nano hydroxyapatite/chitosan/silica and nano hydroxyapatite/chitosan/silver; as antibacterial bone substitutes. Journal of Nanoparticle Research. 2014;16(10).
20
21. Gonzales R, Bartlett JG, Besser RE, Cooper RJ, Hickner JM, Hoffman JR, et al. Principles of Appropriate Antibiotic Use for Treatment of Acute Respiratory Tract Infections in Adults: Background, Specific Aims, and Methods. Annals of Internal Medicine. 2001;134(6):479.
21
22. Ranjbar-Mohammadi M, Zamani M, Prabhakaran MP, Bahrami SH, Ramakrishna S. Electrospinning of PLGA/gum tragacanth nanofibers containing tetracycline hydrochloride for periodontal regeneration. Materials Science and Engineering: C. 2016;58:521-31.
22
23. Ranjbar-Mohammadi M, Rabbani S, Bahrami SH, Joghataei MT, Moayer F. Antibacterial performance and in vivo diabetic wound healing of curcumin loaded gum tragacanth/poly(ε-caprolactone) electrospun nanofibers. Materials Science and Engineering: C. 2016;69:1183-91.
23
24. Sahoo S, Sasmal A, Nanda R, Phani AR, Nayak PL. Synthesis of chitosan–polycaprolactone blend for control delivery of ofloxacin drug. Carbohydrate Polymers. 2010;79(1):106-13.
24
25. Muzzarelli RAA. CHITIN CHEMISTRY. Chitin: Elsevier; 1977. p. 87-154.
25
26. Bassaris, H., Akalin, E., & Calangu, S. (1995). A randomised, multinational study with sequential therapy comparing ciprofloxacin twice daily and ofloxacin once daily. Infection, 23, 39–45.
26
27. Park, H. R., Chung, H. C., Lee, J. K., & Bark, K. M. (2000). Ionization and divalent cation complexation of quinolones antibiotics in aqueous solution. Bulletin of the Korean Chemical Society, 21(9), 849–854.
27
28. Drlica, K. (1984). Biology of bacterial deoxyribonucleic acid topoisomerases. Microbiological Reviews, 48, 273–289.
28
29. Gellert M. DNA Topoisomerases. Annual Review of Biochemistry. 1981;50(1):879-910.
29
30. Chen MH, Huang ZC, Wu GT, Zhu GM, You JK, Lin ZG. Synthesis and characterization of SnO–carbon nanotube composite as anode material for lithium-ion batteries. Materials Research Bulletin. 2003;38(5):831-6.
30
31. Sadat Hosseini M, Hemmati K, Ghaemy M. Synthesis of nanohydrogels based on tragacanth gum biopolymer and investigation of swelling and drug delivery. International Journal of Biological Macromolecules. 2016;82:806-15.
31
32. Liu X, Lin T, Fang J, Yao G, Zhao H, Dodson M, et al. In vivowound healing and antibacterial performances of electrospun nanofibre membranes. Journal of Biomedical Materials Research Part A. 2010;9999A:NA-NA.
32
33. Tomšič B, Simončič B, Orel B, Žerjav M, Schroers H, Simončič A, et al. Antimicrobial activity of AgCl embedded in a silica matrix on cotton fabric. Carbohydrate Polymers. 2009;75(4):618-26.
33
ORIGINAL_ARTICLE
‘Reversed Turkevich’ method for tuning the size of Gold nanoparticles: evaluation the effect of concentration and temperature
In this study the influence of dicarboxy acetone (DCA), as an oxidation product of sodium citrate, was evaluated by ‘reversed Turkevich’ method in this study. Gold nanoparticles (GNPs) were synthesized systematically at various sodium citrate to HAuCl4 molar ratio and temperature. TheseThe GNPs were characterized by UV-vis spectroscopy, DLS and TEM techniques. The results showed that by reversing the order of reagents addition we could synthesize GNPs were obtained in range of 12-51 nm. All of these GNPs samples were monodisperse and have had the same pattern of narrow size distribution in contrast to traditional Turkevich method in which GNPs larger than 40 nm became unstable. Moreover, Sodium citrate to HAuCl4 molar ratio and temperature had a significant role in size controlling and monodispersity of GNPs. By increasing sodium citrate to HAuCl4 molar ratio,s the size of GNPs reduced drastically. Since, temperature had a central role on the production rate of DCA, so its influence on monodispersity of GNPs was more considerable than the size of them.
https://www.nanomedicine-rj.com/article_33843_84a76f3d4b734f0204d286c0f28c2ead.pdf
2018-12-01
190
196
10.22034/nmrj.2018.04.003
Concentration
Gold nanoparticles
monodispersity
Reversed Turkevich method
Size
Temperature
Zoha
Babaei afrapoli
zbabaei@razi.tums.ac.ir
1
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
AUTHOR
Reza
Faridi Majidi
refaridi@sina.tums.ac.ir
2
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
LEAD_AUTHOR
Babak
Negahdari
b-negahdari@tums.ac.ir
3
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
AUTHOR
Gholamreza
Tavoosidana
g-tavoosi@tums.ac.ir
4
Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
AUTHOR
1. Agunloye E, Panariello L, Gavriilidis A, Mazzei L. A model for the formation of gold nanoparticles in the citrate synthesis method. Chemical Engineering Science. 2018;191:318-31.
1
2. Celentano M, Jakhmola A, Profeta M, Battista E, Guarnieri D, Gentile F, et al. Diffusion limited green synthesis of ultra-small gold nanoparticles at room temperature. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2018;558:548-57.
2
3. Tran M, DePenning R, Turner M, Padalkar S. Effect of citrate ratio and temperature on gold nanoparticle size and morphology. Materials Research Express. 2016;3(10):105027.
3
4. Kettemann F, Birnbaum A, Witte S, Wuithschick M, Pinna N, Kraehnert R, et al. Missing Piece of the Mechanism of the Turkevich Method: The Critical Role of Citrate Protonation. Chemistry of Materials. 2016;28(11):4072-81.
4
5. Iqbal M, Usanase G, Oulmi K, Aberkane F, Bendaikha T, Fessi H, et al. Preparation of gold nanoparticles and determination of their particles size via different methods. Materials Research Bulletin. 2016;79:97-104.
5
6. Schulz F, Homolka T, Bastús NG, Puntes V, Weller H, Vossmeyer T. Little Adjustments Significantly Improve the Turkevich Synthesis of Gold Nanoparticles. Langmuir. 2014;30(35):10779-84.
6
7. WANG GZaW. Synthesis of Silver Nanoparticles and their Antiproliferation against Human Lung Cancer Cells In vitro. Oriental Journal of Chemistry. 2012; 28.
7
8. Brown KR, Walter DG, Natan MJ. Seeding of Colloidal Au Nanoparticle Solutions. 2. Improved Control of Particle Size and Shape. Chemistry of Materials. 2000;12(2):306-13.
8
9. Jana NR, Gearheart L, Murphy CJ. Seeding Growth for Size Control of 5−40 nm Diameter Gold Nanoparticles. Langmuir. 2001;17(22):6782-6.
9
10. Turkevich J, Stevenson PC, Hillier J. A study of the nucleation and growth processes in the synthesis of colloidal gold. Discussions of the Faraday Society. 1951;11:55.
10
11. Sivaraman SK, Kumar S, Santhanam V. Monodisperse sub-10nm gold nanoparticles by reversing the order of addition in Turkevich method – The role of chloroauric acid. Journal of Colloid and Interface Science. 2011;361(2):543-7.
11
12. Contreras-Trigo B, Díaz-García V, Guzmán-Gutierrez E, Sanhueza I, Coelho P, Godoy S, et al. Slight pH Fluctuations in the Gold Nanoparticle Synthesis Process Influence the Performance of the Citrate Reduction Method. MDPI AG; 2018.
12
13. Ojea-Jiménez I, Bastús NG, Puntes V. Influence of the Sequence of the Reagents Addition in the Citrate-Mediated Synthesis of Gold Nanoparticles. The Journal of Physical Chemistry C. 2011;115(32):15752-7.
13
14. Haiss W, Thanh NTK, Aveyard J, Fernig DG. Determination of Size and Concentration of Gold Nanoparticles from UV−Vis Spectra. Analytical Chemistry. 2007;79(11):4215-21.
14
15. López-Lorente AI, Simonet BM, Valcárcel M. Rapid analysis of gold nanoparticles in liver and river water samples. The Analyst. 2012;137(15):3528.
15
16. Kalishwaralal K, Deepak V, Ram Kumar Pandian S, Gurunathan S. Biological synthesis of gold nanocubes from Bacillus licheniformis. Bioresource Technology. 2009;100(21):5356-8.
16
17. Khlebtsov NG. Determination of Size and Concentration of Gold Nanoparticles from Extinction Spectra. Analytical Chemistry. 2008;80(17):6620-5.
17
18. Smirnov E, Peljo P, Girault HH. Gold Raspberry-Like Colloidosomes Prepared at the Water–Nitromethane Interface. Langmuir. 2018;34(8):2758-63.
18
19. Kutsevol N, Glamazda A, Chumachenko V, Harahuts Y, Stepanian SG, Plokhotnichenko AM, et al. Behavior of hybrid thermosensitive nanosystem dextran-graft-PNIPAM/gold nanoparticles: characterization within LCTS. Journal of Nanoparticle Research. 2018;20(9).
19
20. Kumar S, Gandhi KS, Kumar R. Modeling of Formation of Gold Nanoparticles by Citrate Method†. Industrial & Engineering Chemistry Research. 2007;46(10):3128-36.
20
21. Teng C-H, Ho K-C, Lin Y-S, Chen Y-C. Gold Nanoparticles as Selective and Concentrating Probes for Samples in MALDI MS Analysis. Analytical Chemistry. 2004;76(15):4337-42.
21
22. Shen F-W, Zhou K-C, Cai H, Zhang Y-N, Zheng Y-L, Quan J. One-pot synthesis of thermosensitive glycopolymers grafted gold nanoparticles and their lectin recognition. Colloids and Surfaces B: Biointerfaces. 2019;173:504-11.
22
23. Y. Ge SL, , S. Wang, R. Moore. Nanomedicine Principles of Nanomedicine. Nanostructure Science and Technology. 2014.
23
24. Ranoszek-Soliwoda K, Tomaszewska E, Socha E, Krzyczmonik P, Ignaczak A, Orlowski P, et al. The role of tannic acid and sodium citrate in the synthesis of silver nanoparticles. Journal of Nanoparticle Research. 2017;19(8).
24
25. Thao Nguyen NL, Park CY, Park JP, Kailasa SK, Park TJ. Synergistic molecular assembly of an aptamer and surfactant on gold nanoparticles for the colorimetric detection of trace levels of As3+ ions in real samples. New Journal of Chemistry. 2018;42(14):11530-8.
25
26. Hinterwirth H, Wiedmer SK, Moilanen M, Lehner A, Allmaier G, Waitz T, et al. Comparative method evaluation for size and size-distribution analysis of gold nanoparticles. Journal of Separation Science. 2013;36(17):2952-61.
26
27. Zheng T, Bott S, Huo Q. Techniques for Accurate Sizing of Gold Nanoparticles Using Dynamic Light Scattering with Particular Application to Chemical and Biological Sensing Based on Aggregate Formation. ACS Applied Materials & Interfaces. 2016;8(33):21585-94.
27
28. Cao G. Nanostructures & nanomaterials: synthesis, properties & applications: Imperial college press; 2004.
28
ORIGINAL_ARTICLE
Time dependent difference effects of MgO and ZnO nanoparticles on the serum and hippocampus Mg2+, Zn2+, Fe2+/3+ and Ca2+ levels in the stressed rats
Objective(s): Stress is a physiological response that can disrupt body elements homeostasis and lead to neurophysiological abnormality. This study has been investigated the serum and hippocampus Mg2+, Zn2+, Fe2+/3+ and Ca2+ level changes in two times after MgO NPs and ZnO NPs single injection following restraint stress in the male rat. Methods: Animals were divided into two main groups that each of them includes: control, restraint of 90, 180 and 360 min+ saline, MgO NPs and ZnO NPs 5 mg/kg alone and with a restraint of 90 min. In one group, 30 min and in another 120 min after intraperitoneally injections of components or stress induction elements levels were measured in the serum and hippocampus. Results: MgO NPs and ZnO NPs could change elements level in the serum and hippocampus depend on acute time after injections and there was a significant positive correlation between serums Fe2+/3+ following two different acute times after ZnO NPs administration. Different times of stress induction have different effects on elements level changes in the serum and hippocampus, 30 and 120 min after induction and nanoparticles could alleviate these changes depend on the time. In restraint groups, there were positive and negative significant correlations between two different times measurements of Fe2+/3+ or Ca2+ in the serum and hippocampus. Conclusion: it seems that time is an important factor in ameliorative MgO NPs and ZnO NPs effects on elements disruption induced by stress, but their exact interaction with stress systems containing ions level changes needs to more investigation.
https://www.nanomedicine-rj.com/article_33658_ec10fd6331f87a6d48d54c6c0c9faa2f.pdf
2018-12-01
197
205
10.22034/nmrj.2018.04.004
elements
Hippocampus
MgO/ZnO Nanoparticles
Stress
Mozhgan
Torabi
mozhgan.torabii@yahoo.com
1
Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
LEAD_AUTHOR
Mahnaz
Kesmati
m.kesmati@scu.ac.ir
2
Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
AUTHOR
Nahid
Pourreza
npourreza@yahoo.com
3
Department of Chemistry, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
AUTHOR
Hossein
Najafzadeh Varzi
najafzadehvarzi@yahoo.com
4
Department of Pharmacology, Faculty of Veterinary Medicine,Shahid Chamran University of Ahvaz, Ahvaz, Iran
AUTHOR
Hamid
Galehdari
galehdari187@yahoo.com
5
Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
AUTHOR
1. Karakoc Y, Yurdakos E, Gulyasar T, Mengi M, Barutcu UB. Experimental stress-induced changes in trace element levels of various tissues in rats. The Journal of Trace Elements in Experimental Medicine. 2003;16(1):55-60.
1
2. Teng W-f, Sun W-m, Shi L-f, Hou D-d, Liu H. Effects of Restraint Stress on Iron, Zinc, Calcium, and Magnesium Whole Blood Levels in Mice. Biological Trace Element Research. 2007;121(3):243-8.
2
3. Kamal Z, Najimi M, Chigr M, El Ouahli M, Er-Raoui G, Chigr F. Trace elements distribution in the brain of stressed rats. American Journal of Neuroscience. 2012; 3(2): 79-86.
3
4. Feng H, Guo L, Gao H, Li X-A. Deficiency of calcium and magnesium induces apoptosis via scavenger receptor BI. Life Sciences. 2011;88(13-14):606-12.
4
5. Li W, Yu J, Liu Y, Huang X, Abumaria N, Zhu Y, et al. Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model. Molecular Brain. 2014;7(1).
5
6. Pantopoulos K, Porwal SK, Tartakoff A, Devireddy L. Mechanisms of Mammalian Iron Homeostasis. Biochemistry. 2012;51(29):5705-24.
6
7. Baltaci AK, Mogulkoc R, Belviranli M. Serum levels of calcium, selenium, magnesium, phosphorus, chromium, copper and iron--their relation to zinc in rats with induced hypothyroidism. Acta Clinica Croatica. 2013; 52(2):151-156.
7
8. Bicer M, Akil M, Sivrikaya A, Kara E, Baltaci AK, Mogulkoc R. Effect of zinc supplementation on the distribution of various elements in the serum of diabetic rats subjected to an acute swimming exercise. Journal of Physiology and Biochemistry. 2011;67(4):511-7.
8
9. Yang Y, Jing X-P, Zhang S-P, Gu R-X, Tang F-X, Wang X-L, et al. High Dose Zinc Supplementation Induces Hippocampal Zinc Deficiency and Memory Impairment with Inhibition of BDNF Signaling. PLoS ONE. 2013;8(1):e55384.
9
10. Yorulmaz H, Şeker FB, Demir G, Yalçın İE, Öztaş B. The Effects of Zinc Treatment on the Blood–Brain Barrier Permeability and Brain Element Levels During Convulsions. Biological Trace Element Research. 2012;151(2):256-62.
10
11. Sowa-Kućma M, Szewczyk B, Sadlik K, Piekoszewski W, Trela F, Opoka W, et al. Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims. Journal of Affective Disorders. 2013;151(3):924-31.
11
12. Doboszewska U, Szewczyk B, Sowa-Kućma M, Noworyta-Sokołowska K, Misztak P, Gołębiowska J, et al. Alterations of Bio-elements, Oxidative, and Inflammatory Status in the Zinc Deficiency Model in Rats. Neurotoxicity Research. 2015;29(1):143-54.
12
13. Horie M, Fujita K, Kato H, Endoh S, Nishio K, Komaba LK, et al. Association of the physical and chemical properties and the cytotoxicity of metal oxide nanoparticles: metal ion release, adsorption ability and specific surface area. Metallomics. 2012;4(4):350.
13
14. Teymuri Zamaneh H,Kesmati M, Malekshahi Nia H, Najafzadeh Varzi H, Torabi M. Investigating the effects of chronic magnesium oxide nanoparticles on aerobic exercise-induced antinociception in adult male rats. International Journal of Green Pharmacy. 2017; 11(4) (Suppl) S892.
14
15. Ghobadian M, Nabiuni M, Parivar K, Fathi M, Pazooki J. Toxic effects of magnesium oxide nanoparticles on early developmental and larval stages of zebrafish (Danio rerio). Ecotoxicology and Environmental Safety. 2015;122:260-7.
15
16. Karmakar A, Zhang Q, Zhang Y. Neurotoxicity of nanoscale materials. Journal of Food and Drug Analysis. 2014;22(1):147-60.
16
17. Moeini-Nodeh S, Rahimifard M, Baeeri M, Abdollahi M. Functional Improvement in Rats’ Pancreatic Islets Using Magnesium Oxide Nanoparticles Through Antiapoptotic and Antioxidant Pathways. Biological Trace Element Research. 2016;175(1):146-55.
17
18. Zhang J, Qin X, Wang B, Xu G, Qin Z, Wang J, et al. Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells. Cell Death and Disease. 2017;8(7):e2954.
18
19. Amara S, Slama IB, Omri K, Ghoul JEL, Mir LEL, Rhouma KB, et al. Effects of nanoparticle zinc oxide on emotional behavior and trace elements homeostasis in rat brain. Toxicology and Industrial Health. 2013;31(12):1202-9.
19
20. Huang Y-F, Liu H, Xiong X, Chen Y, Tan W. Nanoparticle-Mediated IgE−Receptor Aggregation and Signaling in RBL Mast Cells. Journal of the American Chemical Society. 2009;131(47):17328-34.
20
21. Ben-Slama I, Mrad I, Rihane N, EL Mir L, Sakly M. Amara S. Sub-acute oral toxicity of Zinc Oxide nanoparticles in male rats. Journal of Nanomedicine and Nanotechnology. 2015; 6(3): 1-6.
21
22. Torabi M, Kesmati M, Harooni HE, Varzi HN. Different Efficacy of Nanoparticle and Conventional ZnO in an Animal Model of Anxiety. Neurophysiology. 2013;45(4):299-305.
22
23. Kesmati M, Zadehdarvish F, Jelodar Z, Torabi M. Vitamin C potentiate sedative effect of magnesium oxide nanoparticles on anxiety and nociception in the postpartum depression model. Nanomedicine Journal. 2017; 4(1): 17-24.
23
24. Bannunah AM, Vllasaliu D, Lord J, Stolnik S. Mechanisms of Nanoparticle Internalization and Transport Across an Intestinal Epithelial Cell Model: Effect of Size and Surface Charge. Molecular Pharmaceutics. 2014;11(12):4363-73.
24
25. Cho W-S, Duffin R, Howie SEM, Scotton CJ, Wallace WAH, MacNee W, et al. Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Particle and Fibre Toxicology. 2011;8(1):27.
25
26. Veldkamp T, van Diepen JTM, Bikker P. The bioavailability of four Zn2+ Oxide Sources andZn2+ sulfate in broiler chickens; Lelystad, Wageningen UR (University & Research center) LivestockResearch, Confidential Livestock Research Report. 2014; 806 pages: 27
26
27. Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015;7(9):8199-226.
27
28. Romani AMP. Cellular magnesium homeostasis. Archives of Biochemistry and Biophysics. 2011;512(1):1-23.
28
29. Nadadur SS, Srirama K, Mudipalli A. Fe2+/3+ transport & homeostasis mechanisms: Their role in health & disease. Indian Journal of Medical Research.2008; 128: 533-544.
29
30. Roughead ZK, Zito CA, Hunt JR. Inhibitory effects of dietary calcium on the initial uptake and subsequent retention of heme and nonheme iron in humans: comparisons using an intestinal lavage method. The American Journal of Clinical Nutrition. 2005;82(3):589-97.
30
31. Zheng W, Monnot AD. Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases. Pharmacology & Therapeutics. 2012;133(2):177-88.
31
32. Li Y, Zheng Y, Qian J, Chen X, Shen Z, Tao L, et al. Preventive Effects of Zinc Against Psychological Stress-Induced Iron Dyshomeostasis, Erythropoiesis Inhibition, and Oxidative Stress Status in Rats. Biological Trace Element Research. 2012;147(1-3):285-91.
32
33. Saboor M, Qamar K, Qudsia F, Khosa SM, Moinuddin M, Usman M. Malabsorption of iron as a cause of iron deficiencyanemia in postmenopausal women. Pakistan Journal of Medical Sciences. 2015;31(2).
33
34. Donangelo CM, Woodhouse LR, King SM, Viteri FE, King JC. Supplemental Zinc Lowers Measures of Iron Status in Young Women with Low Iron Reserves. The Journal of Nutrition. 2002;132(7):1860-4.
34
35. Joels M, Velzing E, Nair S, Verkuyl JM, Karst H. Acute stress increases calcium current amplitude in rat hippocampus: temporal changes in physiology and gene expression. European Journal of Neuroscience. 2003;18(5):1315-24.
35
ORIGINAL_ARTICLE
Effect of tocopherol on Pluronic microemulsions: turbidity studies and Dynamic light scattering and dynamic surface tension measurements
The development and design of the biocompatible and biodegradable thermodynamically stable micellar and microemulsion transparent dispersions to reduce the free and unbounded drugs concentration in the blood is a basic challenge in field of drug efficacy and bioavailability of drugs. In the current work, solubilization capacity of the drug (Tocopherol), oil (Ethyl Butyrate), and oil+drug (1:1 molar ratio) into F127 pluronic microemulsions was studied as a function of F127 concentration through simple turbidity or transparency experiments. Pluronic F127-based oil-in-water microemulsions of various compositions were synthesized and titrated with concentrated Tocopherol drug, Ethyl Butyrate oil, and oil+drug (1:1 molar ratio), separately, to determine clear /turbid transition zone. We observed that, at certain Pluronic F127 concentrations , microemulsions were gel-like. This specific concentration of F127 was different for three systems mentioned. We also observed that by increasing sodium caprylate fatty acid in the system , solutions became transparent. By the simple logic, we were able to determine the optimal binding ratio of F127 and/or SC to ethyl butyrate oil, Tocopherol drug, and oil+drug (1:1 molar ratio) in microemulsion. We also measured the dynamic surface tension and dynamic light scattering of the microemulsion formulations to further prove the hypothesis that all fatty acid is bound to the F127 in the microemulsion.
https://www.nanomedicine-rj.com/article_33844_f45b8716367afc03921d62874b23e755.pdf
2018-12-01
206
218
10.22034/nmrj.2018.04.005
tocopherol
F127
Turbidity
Pluronic
oil-in-water microemulsion
Abbas
Rahdar
a.rahdarnanophysics@gmail.com
1
Department of Physics, University of Zabol, Zabol, Iran
LEAD_AUTHOR
1. Varshney M, Morey TE, Shah DO, Flint JA, Moudgil BM, Seubert CN, et al. Pluronic Microemulsions as Nanoreservoirs for Extraction of Bupivacaine from Normal Saline. Journal of the American Chemical Society. 2004;126(16):5108-12.
1
2. Habib F, El-Mahdy M, Maher S. Microemulsions for ocular delivery: evaluation and characterization. Journal of Drug Delivery Science and Technology. 2011;21(6):485-9.
2
3. Basak R, Bandyopadhyay R. Encapsulation of Hydrophobic Drugs in Pluronic F127 Micelles: Effects of Drug Hydrophobicity, Solution Temperature, and pH. Langmuir. 2013;29(13):4350-6.
3
4. Varshney M, Morey TE, Shah DO, Flint JA, Moudgil BM, Seubert CN, et al. Pluronic Microemulsions as Nanoreservoirs for Extraction of Bupivacaine from Normal Saline. Journal of the American Chemical Society. 2004;126(16):5108-12.
4
5. James-Smith MA, Shekhawat D, Cheung S, Moudgil BM, Shah DO. Effect of chain length on binding of fatty acids to Pluronics in microemulsions. Colloids and Surfaces B: Biointerfaces. 2008;62(1):5-10.
5
6. : American Chemical Society (ACS).
6
7. James-Smith MA, Shekhawat D, Cheung S, Moudgil BM, Shah DO. Role of Ethylene Oxide and Propylene Oxide Groups of Pluronics in Binding of Fatty Acid to Pluronics in Microemulsions. Journal of Surfactants and Detergents. 2008;11(3):237-42.
7
8. Maulvi FA, Desai AR, Choksi HH, Patil RJ, Ranch KM, Vyas BA, et al. Effect of surfactant chain length on drug release kinetics from microemulsion-laden contact lenses. International Journal of Pharmaceutics. 2017;524(1-2):193-204.
8
9. Narang A, Delmarre D, Gao D. Stable drug encapsulation in micelles and microemulsions. International Journal of Pharmaceutics. 2007;345(1-2):9-25.
9
10. Kataoka K, Harada A, Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Advanced Drug Delivery Reviews. 2001;47(1):113-31.
10
11. Torchilin VP. Structure and design of polymeric surfactant-based drug delivery systems. Journal of Controlled Release. 2001;73(2-3):137-72.
11
12. Sahu A, Kasoju N, Goswami P, Bora U. Encapsulation of Curcumin in Pluronic Block Copolymer Micelles for Drug Delivery Applications. Journal of Biomaterials Applications. 2010;25(6):619-39.
12
13. Crothers M, Zhou Z, Ricardo NMPS, Yang Z, Taboada P, Chaibundit C, et al. Solubilisation in aqueous micellar solutions of block copoly(oxyalkylene)s. International Journal of Pharmaceutics. 2005;293(1-2):91-100.
13
14. Rey-Rico A, Frisch J, Venkatesan JK, Schmitt G, Rial-Hermida I, Taboada P, et al. PEO-PPO-PEO Carriers for rAAV-Mediated Transduction of Human Articular Chondrocytes in Vitro and in a Human Osteochondral Defect Model. ACS Applied Materials & Interfaces. 2016;8(32):20600-13.
14
15. Takahashi YI, Underwood BA. Effect of long and medium chain length lipids upon aqueous solubility of α-tocopherol. Lipids. 1974;9(11):855-9.
15
16. Cieśla J, Koczańska M, Narkiewicz-Michałek J, Szymula M, Bieganowski A. Alpha-tocopherol in CTAB/NaCl systems — The light scattering studies. Journal of Molecular Liquids. 2017;233:15-22.
16
17. Cieśla J, Koczańska M, Narkiewicz-Michałek J, Szymula M, Bieganowski A. Effect of α-tocopherol on the properties of microemulsions stabilized by the ionic surfactants. Journal of Molecular Liquids. 2017;236:117-23.
17
18. Rozman B, Gašperlin M. Stability of Vitamins C and E in Topical Microemulsions for Combined Antioxidant Therapy. Drug Delivery. 2007;14(4):235-45.
18
19. Rozman B, Gasperlin M, Tinois-Tessoneaud E, Pirot F, Falson F. Simultaneous absorption of vitamins C and E from topical microemulsions using reconstructed human epidermis as a skin model. European Journal of Pharmaceutics and Biopharmaceutics. 2009;72(1):69-75.
19
20. Gallarate M, Carlotti ME, Trotta M, Ugazio E. Disperse systems as topical formulations containing (α-tocopherol. Journal of Drug Delivery Science and Technology. 2004;14(6):471-7.
20
21. Piculell L, Lindman B. Association and segregation in aqueous polymer/polymer, polymer/surfactant, and surfactant/surfactant mixtures: similarities and differences. Advances in Colloid and Interface Science. 1992;41:149-78.
21
22. Moudgil, B. M. The Role of Polymer-Surfactant Interactions in Interfacial Processes; School of Engineering and Applied Science, Columbia University: New York, 1981.
22
23. Allen G. The binding of sodium dodecyl sulphate to bovine serum albumin at high binding ratios. Biochemical Journal. 1974;137(3):575-8.
23
24. Argillier JF, Ramachandran R, Harris WC, Tirrell M. Polymer-surfactant interactions studied with the surface force apparatus. Journal of Colloid and Interface Science. 1991;146(1):242-50.
24
25. Goddard ED. Polymer/surfactant interaction-Its relevance to detergent systems. Journal of the American Oil Chemists’ Society. 1994;71(1):1-16.
25
26. Somasundaran P, Lee LT. Polymer-Surfactant Interactions in Flotation of Quartz. Separation Science and Technology. 1981;16(10):1475-90.
26
27. Regismond STA, Winnik FM, Goddard ED. Stabilization of aqueous foams by polymer/surfactant systems: effect of surfactant chain length. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 1998;141(2):165-71.
27
28. Drummond CJ, Grieser F. The ionization behaviour of dl-α-tocopherol (vitamin E) in model membranes: micelles and vesicles. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1985;836(2):275-8.
28
29. Lovander MD, Lyon JD, Parr DL, Wang J, Parke B, Leddy J. Critical Review—Electrochemical Properties of 13 Vitamins: A Critical Review and Assessment. Journal of The Electrochemical Society. 2018;165(2):G18-G49.
29
30. Kedika B, Patri SV. Design, Synthesis, and inVitro Transfection Biology of Novel Tocopherol Based Monocationic Lipids: A Structure−Activity Investigation. Journal of Medicinal Chemistry. 2011;54(2):548-61.
30
31. Nikolic KM. QSAR study of α-tocopherol derivatives with chemotherapeutic activity against human breast cancer cells. Journal of Molecular Structure: THEOCHEM. 2007;809(1-3):137-43.
31
32. Rahdar A, Almasi-Kashi M. Dynamic and spectroscopic studies of nano-micelles comprising dye in water/ dioctyl sodium sulfosuccinate /decane droplet microemulsion at constant water content. Journal of Molecular Structure. 2017;1128:257-62.
32
33. Rahdar A, Almasi-Kashi M. Photophysics of Rhodamine B in the nanosized water droplets: A concentration dependence study. Journal of Molecular Liquids. 2016;220:395-403.
33
34. Rahdar A, Almasi-Kashi M, Mohamed N. Light scattering and optic studies of Rhodamine B-comprising cylindrical-like AOT reversed micelles. Journal of Molecular Liquids. 2016;223:1264-9.
34
35. Rahdar A, Almasi-Kashi M, Khan AM, Aliahmad M, Salimi A, Guettari M, et al. Effect of ion exchange in NaAOT surfactant on droplet size and location of dye within Rhodamine B (RhB)-containing microemulsion at low dye concentration. Journal of Molecular Liquids. 2018;252:506-13.
35
36. Rahdar A, Almasi-Kashi M, Aliahmad M. Effect of chain length of oil on location of dye within AOT nanometer-sized droplet microemulsions at constant water content. Journal of Molecular Liquids. 2017;233:398-402.
36
37. Rahdar A, Najafi-Ashtiani H, Sanchooli E. Fluorescence and dynamics studies of dye-biomolecule interaction in the nano-colloidal systems. Journal of Molecular Structure. 2019;1175:821-7.
37
38. Rahdar A, Almasi-Kashi M. Dynamic light scattering of nano-gels of xanthan gum biopolymer in colloidal dispersion. Journal of Advanced Research. 2016;7(5):635-41.
38
39. Rahdar, A, Almasi-Kashi, M. Entrapment–D-(+)-Glucose Water Nanodroplet: Synthesis and Dynamic Light Scattering. Journal of Nanostructures, 2018; 8(2), 202-208.
39
ORIGINAL_ARTICLE
Electrochemical Detection of Insulin in Blood serum using Ppy/GF Nanocomposite Modified Pencil Graphite Electrode
In this study, pencil graphite electrode was modified using conductive polypyrrole (Ppy) and grapheme (GF) nanocomposite for electrochemical determination of insulin. Electrochemical behavior of insulin on PGE was investigated using cyclic voltammetric (CV) and differential pulse voltammetric (DPV) and chronoaprometry (CA) methods. Several effective parameters including pH, concentration, and scan rate for electrochemical modification of electrode were investigated and optimal conditions were proposed. Kinetics of the oxidation reaction and diffusion coefficient of the sensor was studied. The performed steps allow the measurement of insulin with a linear repeatability curve and appropriate accuracy at a range of 0.225 to 1.235 μM. The limit of detection was obtained at 8.65 nM for insulin. The amount of electron transfer coefficient between modified electrode and insulin was obtained to 0.5 with 0.84~1 number of electrons exchanged during oxidation of insulin. The application of proposed sensor for analyzing insulin in a human blood serum was investigated.
https://www.nanomedicine-rj.com/article_33845_278c37ea36b7ad3aab78fa37aae25f7f.pdf
2018-12-01
219
228
10.22034/nmrj.2018.04.006
Insulin
Blood Serum
nanosensor
Pencil graphite electrodes
Graphene
Saeideh
Ebrahimiasl
ebrahimi.saeideh@yahoo.com
1
Department of Chemistry, Ahar Branch, Islamic Azad University, Ahar, Iran
LEAD_AUTHOR
Elham
Fathi
ebrahimi.nano@yahoo.com
2
Department of Chemical Engineering, Ahar Branch, Islamic Azad University, Ahar, Iran
AUTHOR
Mansor
Ahmad
mansorahmad@gmail.com
3
Department of Chemistry, University Putra Malaysia, 43400, Serdang, Malaysia
AUTHOR
1. Businova P, Prasek J, Chomoucka J, Drbohlavova J, Pekarek J, Hrdy R, et al. Voltammetric Sensor for Direct Insulin Detection. Procedia Engineering. 2012;47:1235-8.
1
2. Sonksen P, Sonksen J. Insulin: understanding its action in health and disease. British Journal of Anaesthesia. 2000;85(1):69-79.
2
3. Meijnikman AS, De Block CEM, Verrijken A, Mertens I, Van Gaal LF. Predicting type 2 diabetes mellitus: a comparison between the FINDRISC score and the metabolic syndrome. Diabetology & Metabolic Syndrome. 2018;10(1).
3
4. Kowarski CR, Bado B, Shah S, Kowarski AA, Kowarski D. Comparative Study of Immunoactivity and Bioactivity of Sodium Insulin. Journal of Pharmaceutical Sciences. 1983;72(6):692-3.
4
5. Lookabaugh M, Biswas M, S. Krull I. Quantitation of insulin injection by high-performance liquid chromatography and high-performance capillary electrophoresis. Journal of Chromatography A. 1991;549:357-66.
5
6. Van Uytfanghe K, Rodríguez-Cabaleiro D, Stöckl D, Thienpont LM. New liquid chromatography/electrospray ionisation tandem mass spectrometry measurement procedure for quantitative analysis of human insulin in serum. Rapid Communications in Mass Spectrometry. 2007;21(5):819-21.
6
7. Chen Z, Caulfield MP, McPhaul MJ, Reitz RE, Taylor SW, Clarke NJ. Quantitative Insulin Analysis Using Liquid Chromatography-Tandem Mass Spectrometry in a High-Throughput Clinical Laboratory. Clinical Chemistry. 2013;59(9):1349-56.
7
8. Grimshaw J, Kane Á, Trocha-Grimshaw J, Douglas A, Chakravarthy U, Archer D. Quantitative analysis of hyaluronan in vitreous humor using capillary electrophoresis. Electrophoresis. 1994;15(1):936-40.
8
9. Blasco C, Font G, Picó Y. Comparison of microextraction procedures to determine pesticides in oranges by liquid chromatography–mass spectrometry. Journal of Chromatography A. 2002;970(1-2):201-12.
9
10. Hjemdahl P, Daleskog M, Kahan T. Determination of plasma catecholamines by high performance liquid chromatography with electrochemical detection: Comparison with a radioenzymatic method. Life Sciences. 1979;25(2):131-8.
10
11. Rafiee B, Fakhari AR. Electrocatalytic oxidation and determination of insulin at nickel oxide nanoparticles-multiwalled carbon nanotube modified screen printed electrode. Biosensors and Bioelectronics. 2013;46:130-5.
11
12. Viswanathan S, Ho J-aA. Dual electrochemical determination of glucose and insulin using enzyme and ferrocene microcapsules. Biosensors and Bioelectronics. 2007;22(6):1147-53.
12
13. Prasad BB, Madhuri R, Tiwari MP, Sharma PS. Imprinting molecular recognition sites on multiwalled carbon nanotubes surface for electrochemical detection of insulin in real samples. Electrochimica Acta. 2010;55(28):9146-56.
13
14. Serafín V, Agüí L, Yáñez-Sedeño P, Pingarrón JM. Electrochemical immunosensor for the determination of insulin-like growth factor-1 using electrodes modified with carbon nanotubes–poly(pyrrole propionic acid) hybrids. Biosensors and Bioelectronics. 2014;52:98-104.
14
15. Wu B, Zhao N, Hou S, Zhang C. Electrochemical Synthesis of Polypyrrole, Reduced Graphene Oxide, and Gold Nanoparticles Composite and Its Application to Hydrogen Peroxide Biosensor. Nanomaterials. 2016;6(11):220.
15
16. Saleh GA, Askal HF, Refaat IH, Abdel-aal FAM. Adsorptive Square Wave Voltammetric Determination of Acyclovir and Its Application in a Pharmacokinetic Study Using a Novel Sensor of β-Cyclodextrin Modified Pencil Graphite Electrode. Bulletin of the Chemical Society of Japan. 2015;88(9):1291-300.
16
17. Levent A, Yardim Y, Senturk Z. Voltammetric behavior of nicotine at pencil graphite electrode and its enhancement determination in the presence of anionic surfactant. Electrochimica Acta. 2009;55(1):190-5.
17
18. Wang J, Kawde A-N, Sahlin E. Renewable pencil electrodes for highly sensitive stripping potentiometric measurements of DNA and RNA. The Analyst. 2000;125(1):5-7.
18
19. Karimi-Maleh H, Bananezhad A, Ganjali MR, Norouzi P, Sadrnia A. Surface amplification of pencil graphite electrode with polypyrrole and reduced graphene oxide for fabrication of a guanine/adenine DNA based electrochemical biosensors for determination of didanosine anticancer drug. Applied Surface Science. 2018;441:55-60.
19
20. King D, Friend J, Kariuki J. Measuring Vitamin C Content of Commercial Orange Juice Using a Pencil Lead Electrode. Journal of Chemical Education. 2010;87(5):507-9.
20
21. Chatterjee S, Wang JW, Kuo WS, Tai NH, Salzmann C, Li WL, et al. Mechanical reinforcement and thermal conductivity in expanded graphene nanoplatelets reinforced epoxy composites. Chemical Physics Letters. 2012;531:6-10.
21
22. Chandrasekaran S, Seidel C, Schulte K. Preparation and characterization of graphite nano-platelet (GNP)/epoxy nano-composite: Mechanical, electrical and thermal properties. European Polymer Journal. 2013;49(12):3878-88.
22
23. Prolongo SG, Jimenez-Suarez A, Moriche R, Ureña A. In situ processing of epoxy composites reinforced with graphene nanoplatelets. Composites Science and Technology. 2013;86:185-91.
23
24. Ebrahimiasl S. Electrochemical Synthesis, Characterization and Gas Sensing Properties of Hybrid Ppy/CS Coated ZnO Nanospheres. International Journal of Electrochemical Science. 2016:9902-16.
24
25. Ebrahimiasl S, Zakaria A, Kassim A, Norleha Basri S. Novel conductive polypyrrole/zinc oxide/chitosan bionanocomposite: synthesis, characterization, antioxidant, and antibacterial activities. International Journal of Nanomedicine. 2014:217.
25
26. Ebrahimiasl S, Yunus WMZW, Zainal Z, Kassim A. Preparation and photovoltaic property of a new hybrid nanocrystalline SnO2/Polypyrrole p–n heterojunction. Optical and Quantum Electronics. 2011;43(11-15):129-36.
26
27. Karimi-Maleh H, Bananezhad A, Ganjali MR, Norouzi P, Sadrnia A. Surface amplification of pencil graphite electrode with polypyrrole and reduced graphene oxide for fabrication of a guanine/adenine DNA based electrochemical biosensors for determination of didanosine anticancer drug. Applied Surface Science. 2018;441:55-60.
27
28. González-Tejera MJ, de la Blanca ES, Carrillo I. Polyfuran conducting polymers: Synthesis, properties, and applications. Synthetic Metals. 2008;158(5):165-89.
28
29. Ebrahimiasl S, Seifi R, Nahli RE, Zakaria A. Ppy/Nanographene Modified Pencil Graphite Electrode Nanosensor for Detection and Determination of Herbicides in Agricultural Water. Science of Advanced Materials. 2017;9(12):2045-53.
29
30. Geim AK, Kim P. Carbon Wonderland. Scientific American. 2008;298(4):90-7.
30
31. Molina J, Bonastre J, Fernández J, del Río AI, Cases F. Electrochemical synthesis of polypyrrole doped with graphene oxide and its electrochemical characterization as membrane material. Synthetic Metals. 2016;220:300-10.
31
32. Phatthanakittiphong T, Seo G. Characteristic Evaluation of Graphene Oxide for Bisphenol A Adsorption in Aqueous Solution. Nanomaterials. 2016;6(7):128.
32
33. Xue K, Zhou S, Shi H, Feng X, Xin H, Song W. A novel amperometric glucose biosensor based on ternary gold nanoparticles/polypyrrole/reduced graphene oxide nanocomposite. Sensors and Actuators B: Chemical. 2014;203:412-6.
33
34. Sabouraud G, Sadki S, Brodie N. The mechanisms of pyrrole electropolymerization. Chemical Society Reviews. 2000;29(5):283-93.
34
35. Fard GP, Alipour E, Ali Sabzi RE. Modification of a disposable pencil graphite electrode with multiwalled carbon nanotubes: application to electrochemical determination of diclofenac sodium in some pharmaceutical and biological samples. Analytical Methods. 2016;8(19):3966-74.
35
36. Zulkarnain Z, Suprapto S, Ersam T, Kurniawan F. A Novel Selective and Sensitive Electrochemical Sensor for Insulin Detection. Indonesian Journal of Electrical Engineering and Computer Science. 2016;3(3):496.
36
37. Gerasimov JY, Schaefer CS, Yang W, Grout RL, Lai RY. Development of an electrochemical insulin sensor based on the insulin-linked polymorphicregion. Biosensors and Bioelectronics. 2013;42:62-8.
37
38. Prashanth SN, Ramesh KC, Seetharamappa J. Electrochemical Oxidation of an Immunosuppressant, Mycophenolate Mofetil, and Its Assay in Pharmaceutical Formulations. International Journal of Electrochemistry. 2011;2011:1-7.
38
39. Gosser, D.K., Cyclic voltammetry: simulation and analysis of reaction mechanisms. Vol. 43. 1993: VCH New York.
39
40. Guo C, Chen C, Luo Z, Chen L. Electrochemical behavior and analytical detection of insulin on pretreated nanocarbon black electrode surface. Analytical Methods. 2012;4(5):1377.
40
41. Ma H, Li X, Yan T, Li Y, Liu H, Zhang Y, et al. Sensitive Insulin Detection based on Electrogenerated Chemiluminescence Resonance Energy Transfer between Ru(bpy)32+ and Au Nanoparticle-Doped β-Cyclodextrin-Pb (II) Metal–Organic Framework. ACS Applied Materials & Interfaces. 2016;8(16):10121-7.
41
ORIGINAL_ARTICLE
Protective effect of silver nano particles against ovarian polycystic induced by morphine in rat
Background and Objective: Morphine can cause harmful effects in the ovaries. The silver nanoparticles (Ag-NPs) used in health care because of antimicrobial properties, can diffuse into the brain blood barrier. This study investigated the protective effect of Ag-NPs on the induction of polycystic ovary (PCO) due to injection of morphine intra-ventromedial hypothalamus (intra-VMH) of rat compared with the animal receiving the drug (10-100 mg/kg) intraperitoneally (i.p.) twice daily for 7 days to lead to addiction. Materials and Methods: The rats (bought of Pasture Institute of Iran weighing 200-250 g) were housed under standard conditions and fed ad libitum. They were randomly divided to addict to drug or morphine (0.001 to 0.4 μg/rat) receiving into the VMH (AP: -1.92) a week after stereotaxic surgery. Ag-Nps (0.01, 0.001 and 0.0001 μg/rat) were administered intra-VMH alone or prior to morphine effective dose (0.4 μg/rat). Control group was given only saline. By the end of the treatment, the animals’ ovaries and/or brain were dissected and studied histopathologically. The ovaries were also checked by the marker of the NO, NADPH-diaphorase. Results: All experimental rats’ ovaries treated morphine showed polycystic characteristics and the NO activation was evidenced in the ovaries in the comparison with the saline group (p
https://www.nanomedicine-rj.com/article_33846_36cd6563bf07b6a2544ea6fe15a76172.pdf
2018-12-01
229
235
10.22034/nmrj.2018.04.007
Polycystic ovary
Morphine
Intra-ventromedial hypothalamus
Nanosilver particles
Rat
Elham
Salami
salami.1389@yahoo.com
1
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
AUTHOR
Manizheh
Karami
karami@shahed.ac.ir
2
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
LEAD_AUTHOR
Ameneh
Jafaryan Dehkordi
ameneh.jafaryan68@gmail.com
3
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
AUTHOR
Mohammadreza
Jalali Nadoushan
jalalinadooshan@yahoo.com
4
Department of Pathology, School of Medicine, Shahed University, Tehran, Iran
AUTHOR
Abazar
Hajnorouzi
ahajnorouzi@gmail.com
5
Department of Physics, Faculty of Basic Sciences, Shahed University, Tehran, Iran
AUTHOR
1. Inturrisi CE. Clinical Pharmacology of Opioids for Pain. The Clinical Journal of Pain. 2002;18(Supplement):S3-S13.
1
2. Pasternak GW. Opiate Pharmacology and Relief of Pain. Journal of Clinical Oncology. 2014;32(16):1655-61.
2
3. Benyamin R, Trescot A, Datta S, Buenaventura R, Adlaka R, Sehgal N. et al., Opioid Complications and Side Effects. Pain Phy 2008;11:S105-S120.
3
4. Chen A, Ashburn MA. Cardiac Effects of Opioid Therapy. Pain Medicine. 2015;16(suppl 1):S27-S31.
4
5. Brennan MJ. The Effect of Opioid Therapy on Endocrine Function. The American Journal of Medicine. 2013;126(3):S12-S8.
5
6. Dehghan M, Jafarpour M, Mahmoudian A. The effect of morphine administration on structure and ultrastructure of uterus in pregnant mice. Iran J Rep Med 2010;8:111-118.
6
7. Gudin JA, Laitman A, Nalamachu S. Opioid Related Endocrinopathy: Table 1. Pain Medicine. 2015;16(suppl 1):S9-S15.
7
8. Labanca F, Ovesnà J, Milella L. Papaver somniferum L. taxonomy, uses and new insight in poppy alkaloid pathways. Phytochemistry Reviews. 2018;17(4):853-71.
8
9. Shafaroodi H, Baradaran N, Moezi L, Dehpour S, Kabiri T, Dehpour AR. Morphine sensitization in the pentylenetetrazole-induced clonic seizure threshold in mice: Role of nitric oxide and μ receptors. Epilepsy & Behavior. 2011;20(4):602-6.
9
10. Zackris U, Mikuni M, Wallin A, Delbro D, Hedin L, Brannstrom M. Ovary and ovulation: Cell-specific localization of nitric oxide synthases (NOS) in the rat ovary during follicular development, ovulation and luteal formation. Human Reproduction. 1996;11(12):2667-73.
10
11. Nakamura Y, Kashida S, Nakata M, Takiguchi S, Yamagata Y, Takayama H, et al. Changes in Nitric Oxide Synthase Activity in the Ovary of Gonadotropin Treated Rats. The Role of Nitric Oxide during Ovulation. Endocrine Journal. 1999;46(4):529-38.
11
12. Dhamyaa JH, Maha AA. Evaluation of serum homocysteine and nitric oxide levels in women with polycystic ovarian syndrome and periodontal diseases. Tikrit J Dent Sci 2017;5:57-65.
12
13. Karimi R, Karami M, Nadoushan MJ. Rat’s Polycystic Ovary Due to Intraventromedial Hypothalamus Morphine Injection. Reproductive Sciences. 2017;25(6):867-72.
13
14. Baravalle C, Salvetti NR, Mira GA, Pezzone N, Ortega HH. Microscopic Characterization of Follicular Structures in Letrozole-induced Polycystic Ovarian Syndrome in the Rat. Archives of Medical Research. 2006;37(7):830-9.
14
15. Liu F, Mahmoo M, Xu Y, Watanabe F, Biris AS, Hansen DK. et al., Front Neurosci //doi.org/10.3389/fnins.2015.00115.
15
16. He YQ, Liu SP, Kong L, Liu ZF. A study on the sizes and concentrations of gold nanoparticles by spectra of absorption, resonance Rayleigh scattering and resonance non-linear scattering. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2005;61(13-14):2861-6.
16
17. Tang L, Shukla PK, Wang LX, Wang ZJ. Reversal of morphine antinociceotive tolerance and deoendence by the accute supraspinal inhibition of Ca2+/calmodulin dependent protein kinase II. J Pharmacol Exp Ther 2006;317:901-909.
17
18. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates, 5th ed, San Diego: Elsevier Academic Press, 2005.
18
19. Persson L, Rosengren E, Sundler F. Immunohistochemical localization of ornithine decarboxylase in the rat ovary. Histochemistry. 1982;75(2):163-7.
19
20. Tracey WR, Nakane M, Pollock JS, Forstermann U. Nitric Oxide Synthases in Neuronal Cells, Macrophages and Endothelium Are NADPH Diaphorases, but Represent Only a Fraction of Total Cellular NADPH Diaphorase Activity. Biochemical and Biophysical Research Communications. 1993;195(2):1035-40.
20
21. Siddiqui A, Haq S, Shah BH. Perinatal Exposure to Morphine Disrupts Brain Norepinephrine, Ovarian Cyclicity, and Sexual Receptivity in Rats. Pharmacology Biochemistry and Behavior. 1997;58(1):243-8.
21
22. Daniell HW. Opioid Endocrinopathy in Women Consuming Prescribed Sustained-Action Opioids for Control of Nonmalignant Pain. The Journal of Pain. 2008;9(1):28-36.
22
23. Tseng L, Mazella J, Goligorsky MS, Rialas CM, Stefano GB. Dopamine and Morphine Stimulate Nitric Oxide Release in Human Endometrial Glandular Epithelial Cells. Journal of the Society for Gynecologic Investigation. 2000;7(6):343-7.
23
24. Katz N, Mazer NA. The Impact of Opioids on the Endocrine System. The Clinical Journal of Pain. 2009;25(2):170-5.
24
25. Chwalisz K, Garfield RE. Role of nitric oxide in implantation and menstruation. Human Reproduction. 2000;15(suppl 3):96-111.
25
26. Shukovski L, Tsafriri A. The involvement of nitric oxide in the ovulatory process in the rat. Endocrinology. 1994;135(5):2287-90.
26
27. Bonello N, McKie K, Jasper M, Andrew L, Ross N, Braybon E, et al. Inhibition of Nitric Oxide: Effects on Interleukin-lβ-Enhanced Ovulation Rate, Steroid Hormones, and Ovarian Leukocyte Distribution at Ovulation in the Rat1. Biology of Reproduction. 1996;54(2):436-45.
27
28. Hassani F, Karami M, JalaliNadoushan M, EftekhariYazdi P. Nitric oxide-induced polycystic ovaries in the Wistar rat. Int J Fertil Steril 2012;6:111-116.
28
29. Lakzaei F, Karami M, Darban Fooladi M, Jalali Nodoushan M. Pathological characteristics of uterus in rats with polycystic ovary. J Bas Clin Pathophysiol 2013;1:29-33.
29
30. Colameco S, Coren JS. Opioid-induced endocrinopathy. J Am Osteopath Assoc 2009;109:20-25.
30
31. Zafari M, Tofighi M, Aghamohammady A, Behmanesh F, Rakhshaee Z. Comparison of the effect of acupressure, fish oil capsules and ibuprofen on treatment of primary dysmenorrhea. Af J Pharm Pharmacol 2011;5(8):1115-1119.
31
32. Mallappa Saroja CS, Hanji Chandrashekar S. Polycystic ovaries: review of medical information on the internet for patients. Archives of Gynecology and Obstetrics. 2010;281(5):839-43.
32
33. Marshall K. Polycystic Ovary Syndrome: Clinical Considerations. Alt Med Rev 2001; 6:272-292.
33
34. Aminee F. The role of opioid system and its interaction with sympathetic nervous system in the processing of polycystic ovary syndrome modeling in rat. Rep Med 2011; 283:885-892.
34
35. Gharedaghi M, Dehpour AR. Effect of morphine on the reduced uteroplacental perfusion model of pre-eclampsia in rats. Eur J Obs Gynecol Rep Biol 2013;168:161-166.
35
ORIGINAL_ARTICLE
Synthesis of silver-cobalt nanoparticles by chemical reduction method and its effects on serum levels of thyroid hormones in adult male rats
ABSTRACTObjective(s): Silver-cobalt nanoparticles have anti-fungal properties and are used in medicine. In the present study, the effect of silver-cobalt nanoparticles on serum levels of T3 and T4 hormones was investigated. Silver-cobalt nanoparticles were synthesized by chemical reduction.Methods: In this experimental study, 28 male adult Wistar rats (approximately 180-220 gr) were used. Animals were divided into 4 groups of 7. The control group did not receive any medication. Experimental groups 1 and 2 received silver-cobalt nanoparticles, which were synthesized during 75 seconds, received doses of 25 and 100 mg / kg intraperitoneally for 14 days, respectively. The experimental group 3 received silver-cobalt nanoparticles that were synthesized during 300 seconds at a doses of 25 mg / kg intraperitoneally for 14 days. At the end of the trial, blood sampling was performed to measure hormones. The mean serum levels of T3 and T4 hormones were analyzed by appropriate statistical tests including ANOVA and Duncan test.Results: Serum levels of T4 in experimental groups 2 and 3 showed a significant decrease compared to control group. Serum T3 level did not change significantly in all experimental groups compared to control group (p
https://www.nanomedicine-rj.com/article_33847_bb3d6ec52d8ecf9e31758d635b8824eb.pdf
2018-12-01
236
244
10.22034/nmrj.2018.04.008
Silver-cobalt nanoparticles
Thyroid hormones
adult male rats
Zohreh
Parang
zohreh.parang@gmail.com
1
Department of Physics, Shiraz Branch, Islamic Azad University, Shiraz, Iran
LEAD_AUTHOR
Davood
Moghadamnia
davood.moghadamnia@gmail.com
2
Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran
AUTHOR
1. Wijnhoven S, Peijneburg W, Herberts C. Nano-silver-a review of available data and knowledge gaps in human and environmental risk assessment. J Nanotoxicology. 2009;3(2):109-138.
1
2. Ahamed M, AlSalhi MS, Siddiqui MKJ. Silver nanoparticle applications and human health. Clinica Chimica Acta. 2010;411(23-24):1841-8.
2
3. Shaheen TI, El-Naggar ME, Hussein JS, El-Bana M, Emara E, El-Khayat Z, et al. Antidiabetic assessment; in vivo study of gold and core-shell silver-gold nanoparticles on streptozotocin-induced diabetic rats. Biomedicine & Pharmacotherapy. 2016;83:865-75.
3
4. Kwan KHL, Yeung KWK, Liu X, Wong KKY, Shum HC, Lam YW, et al. Silver nanoparticles alter proteoglycan expression in the promotion of tendon repair. Nanomedicine: Nanotechnology, Biology and Medicine. 2014;10(7):1375-83.
4
5. Park E-J, Bae E, Yi J, Kim Y, Choi K, Lee SH, et al. Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles. Environmental Toxicology and Pharmacology. 2010;30(2):162-8.
5
6. Crisan D, Scharffetter-Kochanek K, Crisan M, Schatz S, Hainzl A, Olenic L, et al. Topical silver and gold nanoparticles complexed with Cornus mas suppress inflammation in human psoriasis plaques by inhibiting NF-κB activity. Experimental Dermatology. 2018;27(10):1166-9.
6
7. Liu X, Gao P, Du J, Zhao X, Wong KKY. Long-term anti-inflammatory efficacy in intestinal anastomosis in mice using silver nanoparticle-coated suture. Journal of Pediatric Surgery. 2017;52(12):2083-7.
7
8. Sivakumar AS, Krishnaraj C, Sheet S, Rampa DR, Kang DR, Belal SA, et al. Interaction of silver and gold nanoparticles in mammalian cancer: as real topical bullet for wound healing— A comparative study. In Vitro Cellular & Developmental Biology - Animal. 2017;53(7):632-45.
8
9. van den Brule S, Ambroise J, Lecloux H, Levard C, Soulas R, De Temmerman P-J, et al. Dietary silver nanoparticles can disturb the gut microbiota in mice. Particle and Fibre Toxicology. 2015;13(1).
9
10. Colognato R, Bonelli A, Ponti J, Farina M, Bergamaschi E, Sabbioni E, et al. Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro. Mutagenesis. 2008;23(5):377-82.
10
11. Park BJ, Choi K-H, Nam KC, Ali A, Min JE, Son H, et al. Photodynamic Anticancer Activities of Multifunctional Cobalt Ferrite Nanoparticles in Various Cancer Cells. Journal of Biomedical Nanotechnology. 2015;11(2):226-35.
11
12. Vinardell M, Mitjans M. Antitumor Activities of Metal Oxide Nanoparticles. Nanomaterials. 2015;5(2):1004-21.
12
13. Yan X, Liu Y, Xie T, Liu F. α-Tocopherol protected against cobalt nanoparticles and cocl2 induced cytotoxicity and inflammation in Balb/3T3 cells. Immunopharmacology and Immunotoxicology. 2018;40(2):179-85.
13
14. Magaye R, Zhao J, Bowman L, Ding MIN. Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles. Experimental and Therapeutic Medicine. 2012;4(4):551-61.
14
15. Cho WS, Duffin R, Bradley M, Megson IL, MacNee W, Howie SEM, et al. NiO and Co3O4 nanoparticles induce lung DTH-like responses and alveolar lipoproteinosis. European Respiratory Journal. 2011;39(3):546-57.
15
16. Melmed S, Polonsky KS, P. Larsen R. Williams textbook of endocrinology. 12th ed. Sunders. Elsevir; 2011: 341-346.
16
17. Hall JE, Guyton A, Guyton and Hall Physiology Review.11th ed. Philadelphia: Saunders Press; 2005: 235-259.
17
18. Cooper DS, Klibanski A, Ridgway EC. DOPAMINERGIC MODULATION OF TSH AND ITS SUBUNITS: IN VIVO AND IN VITRO STUDIES. Clinical Endocrinology. 1983;18(3):265-75.
18
19. Christy AJ, Umadevi M. Synthesis and characterization of monodispersed silver nanoparticles. Advances in Natural Sciences: Nanoscience and Nanotechnology. 2012;3(3):035013.
19
20. Garcia T, Lafuente D, Blanco J, Sánchez DJ, Sirvent JJ, Domingo JL, et al. Oral subchronic exposure to silver nanoparticles in rats. Food and Chemical Toxicology. 2016;92:177-87.
20
21. Hussein R, Sarhan O. Effects of intraperitoneally injected silver nanoparticles on histological structures and blood parameters in the albino rat. International Journal of Nanomedicine. 2014:1505.
21
22. Li TZ, Gong F, Zhang BY, Sun JD, Zhang T, Kong L, et al. Acute toxicity and bio-distribution of silver nitrate and nano-silver with different particle diameters in rats. Zhonghu Shao Shang Za Zhi. 2016;32(10):606-612.
22
23. Saedi Marghmalki V, Agha-Taheri M. Effect of silver oxide nanoparticles on liver enzymes, thyroid hormone and thyroid-stimulating hormone concentrations in rats. 24th Iranian Congress of physiology and pharmacology. 2015; 2-12.
23
24. Rejali L, Moshtaghian SJ, Mahzouni P, Davood A. The effect of chronic consumption of silver nanoparticles on thyroid gland and pregnancy in rats. Qom Univ Med Sci J. 2015;9(7):20-28.
24
25. Lavado-Autric R, Ausó E, García-Velasco JV, del Carmen Arufe M, Escobar del Rey F, Berbel P, et al. Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. Journal of Clinical Investigation. 2003;111(7):1073-82.
25
26. Ausó E, Lavado-Autric R, Cuevas E, del Rey FE, Morreale de Escobar G, Berbel P. A Moderate and Transient Deficiency of Maternal Thyroid Function at the Beginning of Fetal Neocorticogenesis Alters Neuronal Migration. Endocrinology. 2004;145(9):4037-47.
26
27. Hinther A, Vawda S, Skirrow RC, Veldhoen N, Collins P, Cullen JT, et al. Nanometals Induce Stress and Alter Thyroid Hormone Action in Amphibia at or below North American Water Quality Guidelines. Environmental Science & Technology. 2010;44(21):8314-21.
27
28. Sharifi AS,Naseri S,Rezaei Zarchi S, Rezaei R. Effect of silver nanoparticles on thyroid hormones and tissue in male rat.1st National Conference on nano science and Technology. 2010;1-340.
28
29. Afkhami-Ardakani M, Shirband A, Golzade J, Asadi-Samani M, Latifi E, Kheylapour M, et al. The effect of iron oxide nanoparticles on liver enzymes (ALT, AST and ALP), thyroid hormones (T3 and T4) and TSH in rats. J Shahrekord Univ Med Sci. 2013; 14(6): 82-8.
29
30. Seyedalipour B, Arefifar A, Khanbabaee R, Hoseini S M. Toxicity of silver nanoparticles on ALT, AST, ALP and histopathological changes in NMRI mice. J Mazandaran Univ Med Sci. 2015; 25(124): 183-193.
30
31. Jafarzadeh Samani R, Heydarnejad MS, Kabiri Samani M. A survey of acute histopathological effects of silver nanoparticles on liver, kidney with blood cells during oral administration in male mice (Mus musculus). J Shahrekord Univ Med Sci. 2015; 17(4): 97-107.
31
32. Simonsen LO, Harbak H, Bennekou P. Cobalt metabolism and toxicology—A brief update. Science of The Total Environment. 2012;432:210-5.
32
33. Dziendzikowska K, Krawczyńska A, Oczkowski M, Królikowski T, Brzóska K, Lankoff A, et al. Progressive effects of silver nanoparticles on hormonal regulation of reproduction in male rats. Toxicology and Applied Pharmacology. 2016;313:35-46.
33
34. Ahmed SM, Abdelrahman SA, Shalaby SM. Evaluating the effect of silver nanoparticles on testes of adult albino rats (histological, immunohistochemical and biochemical study). Journal of Molecular Histology. 2016;48(1):9-27.
34
35. Yu R. Cobalt Toxicity, An overlooked Cause of Hypothyroidism. Journal of Endocrinology and Thyroid Research. 2017;1(3).
35
36. Kriss JP, Carnes WH,Gross RT. Hypothyroidism and thyroid hyperplasia in patients treated with cobalt. J Am Med Assoc. 1955;157(2):117-21.
36