ORIGINAL_ARTICLE
Lipid based nanoparticles for treatment of CNS diseases: review Article
Introduction: Central Nervous System (CNS) is one of the most important organs which is managing so many functions in human body. So, impairment of its function may results in several disorders in body, or CNS diseases, which are considered very important. CNS diseases are divided into many different groups and each group is treated with its own related medication. Some drugs that are used for treating CNS impairments have disadvantages like short length effect, renal and digestive toxicities and restrictions in pharmaceutical form. Some other drugs may cause complications worse than disease itself so the scientist shouls find the ways to solve these problems. Methods: first “Scopus”, “PubMed”, and “ScienceDirect” were searched with the keywords “CNS”. “CNS diseases” and “lipid based nanoparticles” and the whole articles were collected; then the most irrelevant and inappropriate articles was removed and 105 articles were remained; at the last section of article selection the best articles was selected from the 105 articles that were remained and the finally selected articles were reviewed and this article was written. Results: The review of many important articles and summarizing them was shown that the scientists and drug designers have used many ways to overcome all or some of the disadvantages of the CNS drug delivery (as mentioned above) and they found that one of the best ways to fix these bugs is using lipid-based nanoparticles in nanotechnology field.
https://www.nanomedicine-rj.com/article_40561_00048395f2d0924920a7b27d2654403b.pdf
2020-04-01
101
113
10.22034/nmrj.2020.02.001
Keywords: Central Nervous system (CNS)
CNS diseases
infectious diseases
In vivo tests
In vitro tests
Lipid based nanoparticles
Tumor
Salar
Masoomzadeh
masoomzades@gmail.com
1
Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
LEAD_AUTHOR
Paria
Aminroaia
pariaaminroaia@gmail.com
2
Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
AUTHOR
Fateme
Darchin Tabrizi
darchinfateme@gmail.com
3
Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
AUTHOR
Sara
Rashvand
masoomzadeh@tbzmed.ac.ir
4
Department of Biotechnology, School of pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
AUTHOR
Kobra
Rostamizadeh
rostamizadeh@gmail.com
5
Department of Medical chemistry, School of pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
AUTHOR
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42
ORIGINAL_ARTICLE
Ratio of Drug/carrier as Dominant Factor in Determining Size of Doxorubicin-Loaded Beta-1,3- Glucan Nanoparticles: An Artificial Neural Networks Study
Size of nanoparticles is an important parameter in determining many of their properties. In this work, nanoparticles of β-1,3-glucan containing doxorubicin (Dox) in conjugated and unconjugated forms (Con-Dox-Glu and Un-Dox-Glu, respectively) were prepared. Then, artificial neural networks (ANNs) were used to find the effect of different formulation/processing parameters on their particle size, which was measured using dynamic light scattering (DLS). The parameters included ratio of Dox/Carrier as well as concentrations of polyethyleneimine (PEI), NaOH and succinic anhydride (Sa). To do so, fifty samples having different values of the four parameters were prepared and their particle size was measured. The data were divided randomly into training, test and unseen data. The ANN model demonstrated that in both conjugated and unconjugated forms, Dox/Carrier ratio is the dominant factor determining the particle size. Also, concentration of PEI showed to be important in determining particle size of unconjugated form of the nanoparticles. The remaining parameters indicated no considerable effect on the particle size
https://www.nanomedicine-rj.com/article_40562_d8cacdba2c56cb195e6d17dbffcebd5f.pdf
2020-04-01
114
119
10.22034/nmrj.2020.02.002
Artificial neural networks. glucan nanoparticles
Particle Size
conjugation
Zahra
Nasrollahi
znasrollahi2@gmail.com
1
Medical Faculty, Qom University of Medical Sciences, Qom, Iran
AUTHOR
Samira
Khani
samira.khani1@gmail.com
2
Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran.
AUTHOR
Amir
Amani
aamani@tums.ac.ir
3
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
LEAD_AUTHOR
1. Xiao Y, Xu W, Zhu Q, Yan B, Yang D, Yang J, et al. Preparation and characterization of a novel pachyman-based pharmaceutical aid. II: A pH-sensitive, biodegradable and biocompatible hydrogel for controlled release of protein drugs. Carbohydrate Polymers. 2009;77(3):612-20.
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3. Ohno N, Terui T, Chiba N, Kurachi K, Adachi Y, Yadomae T. Resistance of Highly Branched (1.RAR.3)-.BETA.-D-Glucans to Formolysis. CHEMICAL & PHARMACEUTICAL BULLETIN. 1995;43(6):1057-60.
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4. Wang H, Weening D, Jonkers E, Boer T, Stellaard F, Small AC, et al. A curve fitting approach to estimate the extent of fermentation of indigestible carbohydrates. European Journal of Clinical Investigation. 2008;38(11):863-8.
4
5. Sen IK, Maity K, Islam SS. Green synthesis of gold nanoparticles using a glucan of an edible mushroom and study of catalytic activity. Carbohydrate Polymers. 2013;91(2):518-28.
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20
21. Sakhtianchi R, Atyabi F, Yousef P, Vasheghani-Farahani E, Movahedi M, Dinarvand R. Targeted delivery of doxorubicin-utilizing chitosan nanoparticles surface-functionalized with anti-Her2 trastuzumab. International Journal of Nanomedicine. 2011:1977.
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22. Nasrollahi Z, Mohammadi SR, Mollarazi E, Yadegari MH, Hassan ZM, Talaei F, et al. Functionalized nanoscale β-1,3-glucan to improve Her2+ breast cancer therapy: In vitro and in vivo study. Journal of Controlled Release. 2015;202:49-56.
22
23. Rac O, Suchorska-Woźniak P, Fiedot M, Teterycz H. Influence of stabilising agents and pH on the size of SnO2 nanoparticles. Beilstein Journal of Nanotechnology. 2014;5:2192-201.
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24. Hecold M, Buczkowska R, Mucha A, Grzesiak J, Rac-Rumijowska O, Teterycz H, et al. The Effect of PEI and PVP-Stabilized Gold Nanoparticles on Equine Platelets Activation: Potential Application in Equine Regenerative Medicine. Journal of Nanomaterials. 2017;2017:1-11.
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25
ORIGINAL_ARTICLE
Preparation, statistical optimization and in vitro characterization of solid lipid nanoparticles as a potential vehicle for transdermal delivery of tramadol hydrochloride as a hydrophilic Compound
As encapsulation of hydrophilic drugs in the solid lipid nanoparticles (SLNs) is still a challenging issue, the aim of this study was to prepare SLNs containing tramadol hydrochloride as a hydrophilic compound.The SLNs were prepared using glycerol monostearate (GMS), soy lecithin and tween 80 by double emulsification-solvent evaporation technique. The nanoparticles were optimized through a central-composite response surface (RSM) method. The independent variables were GMS/lecithin ratio and the amount of drug while dependent responses were size, polydispersity index (PdI) and zeta potential. The optimized nanoparticles were then freeze dried and their morphology was examined using transmission electron microscopy (TEM). Finally, the in vitro drug release profile from nanoparticles was evaluated and the kinetic of the release was determined. The particle size, PdI, zeta potential, entrapment efficiency and loading efficiency of the optimized SLNs were 13117.25 nm, 0.210.013, -11.2 1.04 mV, 89.42.38% and 9.49±0.14%, respectively. TEM images revealed de-agglomerated spherical nanoparticles. In vitro release studies showed sustained release of tramadol over 72 h and the release kinetic was best fitted to the first order and Korsmeyer-Peppas kinetic model. The obtained results indicated that tramadol as a hydrophilic drug can appropriately entrap in the solid lipid nanoparticles exhibiting favorable physico-chemical properties.
https://www.nanomedicine-rj.com/article_40563_1ee307fea7f1d2da01d1c319fc52ea9b.pdf
2020-04-01
120
131
10.22034/nmrj.2020.02.003
Tramadol Hydrochloride
Hydrophilic drug
Solid lipid nanoparticles (SLN)
Double emulsification-Solvent evaporation technique
Central-composite response surface methodology
Transdermal delivery
Mina
Abbasnia
mina.abbasnia@gmail.com
1
Department of Pharmaceutics, Faculty of pharmacy, Hamedan University of Medical Science, Hamedan, Iran
AUTHOR
Ali Reza
Vatanara
vatanara@sina.tums.ac.ir
2
Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
AUTHOR
Reza
Mahjub
rmahjub@gmail.com
3
Department of Pharmaceutics, Faculty of pharmacy, Hamedan University of Medical Science, Hamedan, Iran
LEAD_AUTHOR
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11. Vakilinezhad MA, Tanha S, Montaseri H, Dinarvand R, Azadi A, Akbari Javar H. Application of Response Surface Method for Preparation, Optimization, and Characterization of Nicotinamide Loaded Solid Lipid Nanoparticles. Advanced Pharmaceutical Bulletin. 2018;8(2):245-56.
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14. Mahjub R, Radmehr M, Dorkoosh FA, Ostad SN, Rafiee-Tehrani M. Lyophilized insulin nanoparticles prepared from quaternizedN-aryl derivatives of chitosan as a new strategy for oral delivery of insulin:in vitro, ex vivoandin vivocharacterizations. Drug Development and Industrial Pharmacy. 2013;40(12):1645-59.
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21. Shahsavari S, Bagheri G, Mahjub R, Bagheri R, Radmehr M, Rafiee-Tehrani M, et al. Application of Artificial Neural Networks for Optimization of Preparation of Insulin Nanoparticles Composed of Quaternized Aromatic Derivatives of Chitosan. Drug Research. 2013;64(03):151-8.
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30
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38
ORIGINAL_ARTICLE
Fabrication and Characterization of Biosynthesized Silver Nanoparticles using Cymbopogon citratus and Evaluation of its Antioxidant, Free Radicals and Reducing Power Activity
The study aims at synthesizing silver nanoparticles using leaf extract of Cymbopogon citratus along with the evaluation of its antioxidant, free radicals scavenging, and reducing power properties. Biosynthesized silver nanoparticles were characterized X-Ray diffractometry, Scanning Electron Microscopy, Transmission Electron Microscopy, Fourier Transform Infrared spectroscopy and Energy Dispersive X-ray spectroscopy. The antioxidant, free radicals and reducing power activity were determined by 2, 2-diphenyl-1-picrylhydrazyl, hydrogen peroxide scavenging, hydroxyl radicals scavenging, superoxide scavenging and reducing power activity methods. The silver nanoparticles were synthesized by Cymbopogon citratus extract that was confirmed by visible color changes of solution and spectral analysis. The biosynthesized silver nanoparticles having a surface plasmon resonance band centered at 450 nm were characterized using different techniques. The data obtained from SEM and TEM revealed the formation of spherical shape nanoparticles with size ranging from 5-35 nm in diameter while XRD suggested highly crystalline nanoparticles having Bragg’s peak at (111), (200) and (220) plane. FTIR confirmed the presence of various function groups in the extract and on the surface silver nanoparticles. The biosynthesized silver nanoparticles had greater antioxidant, free radicals scavenging and reducing power activity than Cymbopogon citratus extract while lesser activity than vitamin C.
https://www.nanomedicine-rj.com/article_40565_e52ea8a8c86e9ef39cdfa10f2fd35ced.pdf
2020-04-01
132
142
10.22034/nmrj.2020.02.004
Cymbopogon citratus
Silver nanoparticles
Green synthesis
Antioxidant Activity
Anand
Keshari
akbt87@gmail.com
1
Research Scholar, Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P., India
AUTHOR
Gaurav
Pal
gauravpal1989@gmail.com
2
Research Scholar, Department of Botany, Institute of Science, Banaras Hindu University, Varanasi, U.P., India
AUTHOR
Samiksha
Saxena
samikshasaxena01@gmail.com
3
Research Scholar, National Institute of Plant Genome Research, New Delhi, India
AUTHOR
Ragini
Srivastava
ragsriv@gmail.com
4
Professor, Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P., India
AUTHOR
Vishal
Srivashtav
vishal_bt85@yahoo.com
5
Assistant Professor, Plant Biotechnology, Rajiv Gandhi South Campus, Banaras Hindu University, Barkachha, Mirzapur, U.P.- 231001
LEAD_AUTHOR
1. Kelly KL, Coronado E, Zhao LL, Schatz GC. The Optical Properties of Metal Nanoparticles: The Influence of Size, Shape, and Dielectric Environment. ChemInform. 2003;34(16).
1
2. Rai M, Yadav A, Gade A. Silver nanoparticles as a new generation of antimicrobials. Biotechnology Advances. 2009;27(1):76-83.
2
3. Sharma VK, Yngard RA, Lin Y. Silver nanoparticles: Green synthesis and their antimicrobial activities. Advances in Colloid and Interface Science. 2009;145(1-2):83-96.
3
4. Joerger R, Klaus T, Granqvist CG. Biologically Produced Silver-Carbon Composite Materials for Optically Functional Thin-Film Coatings. Advanced Materials. 2000;12(6):407-9.
4
5. Oliveira MM, Ugarte D, Zanchet D, Zarbin AJG. Influence of synthetic parameters on the size, structure, and stability of dodecanethiol-stabilized silver nanoparticles. Journal of Colloid and Interface Science. 2005;292(2):429-35.
5
6. Iravani S. Green synthesis of metal nanoparticles using plants. Green Chemistry. 2011;13(10):2638.
6
7. Kouvaris P, Delimitis A, Zaspalis V, Papadopoulos D, Tsipas SA, Michailidis N. Green synthesis and characterization of silver nanoparticles produced using Arbutus Unedo leaf extract. Materials Letters. 2012;76:18-20.
7
8. Konwarh R, Gogoi B, Philip R, Laskar MA, Karak N. Biomimetic preparation of polymer-supported free radical scavenging, cytocompatible and antimicrobial “green” silver nanoparticles using aqueous extract of Citrus sinensis peel. Colloids and Surfaces B: Biointerfaces. 2011;84(2):338-45.
8
9. Silver S. Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. FEMS Microbiology Reviews. 2003;27(2-3):341-53.
9
10. Ahmad A, Mukherjee P, Senapati S, Mandal D, Khan MI, Kumar R, et al. Extracellular biosynthesis of silver nanoparticles using the fungus Fusarium oxysporum. Colloids and Surfaces B: Biointerfaces. 2003;28(4):313-8.
10
11. Sondi I, Salopek-Sondi B. Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Journal of Colloid and Interface Science. 2004;275(1):177-82.
11
12. Singh PK, Bhardwaj K, Dubey P, Prabhune A. UV-assisted size sampling and antibacterial screening of Lantana camara leaf extract synthesized silver nanoparticles. RSC Adv. 2015;5(31):24513-20.
12
13. Singhal G, Bhavesh R, Kasariya K, Sharma AR, Singh RP. Biosynthesis of silver nanoparticles using Ocimum sanctum (Tulsi) leaf extract and screening its antimicrobial activity. Journal of Nanoparticle Research. 2011;13(7):2981-8.
13
14. Rajasekharreddy P, Rani PU. Biofabrication of Ag nanoparticles using Sterculia foetida L. seed extract and their toxic potential against mosquito vectors and HeLa cancer cells. Materials Science and Engineering: C. 2014;39:203-12.
14
15. Banerjee P, Satapathy M, Mukhopahayay A, Das P. Leaf extract mediated green synthesis of silver nanoparticles from widely available Indian plants: synthesis, characterization, antimicrobial property and toxicity analysis. Bioresources and Bioprocessing. 2014;1(1).
15
16. Nadagouda MN, Varma RS. Green synthesis of silver and palladium nanoparticles at room temperature using coffee and tea extract. Green Chemistry. 2008;10(8):859.
16
17. Dias ACP, Marslin G, Selvakesavan, Gregory F, Sarmento B. Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera. International Journal of Nanomedicine. 2015:5955.
17
18. Leite J, De Lourdes V. Seabra M, Maluf E, Assolant K, Suchecki D, Tufik S, et al. Pharmacology of lemongrass (Cymbopogon citratus Stapf). III. Assessment of eventual toxic, hypnotic and anxiolytic effects on humans. Journal of Ethnopharmacology. 1986;17(1):75-83.
18
19. Banala RR, Nagati VB, Karnati PR. Green synthesis and characterization of Carica papaya leaf extract coated silver nanoparticles through X-ray diffraction, electron microscopy and evaluation of bactericidal properties. Saudi Journal of Biological Sciences. 2015;22(5):637-44.
19
20. Maleki H, Naghibzadeh M, Amani A, Adabi M, Khosravani M. Preparation of Paclitaxel and Etoposide Co-loaded mPEG-PLGA Nanoparticles: an Investigation with Artificial Neural Network. Journal of Pharmaceutical Innovation. 2019.
20
21. Kumar Keshari A, Srivastava R, Yadav S, Nath G, Gond KK. Synergistic Activity of Green Silver Nanoparticles with Antibiotics. Nanomed Res J 2020;5:44–54.
21
22. Keshari A, Srivastava A, Verma A, Srivastava R. Free Radicals Scavenging and Protein Protective Property of Ocimum sanctum (L). British Journal of Pharmaceutical Research. 2016;14(4):1-10.
22
23. Keshari AK, Srivastava A, Upadhayaya M, Srivastava R. Antioxidants and free radicals scavenging activity of Medicinal Plants. J Pharmacogn Phytochem 2018;7:1499–1504.
23
24. Keshari AK, Srivastava R, Singh P, Yadav VB, Nath G. Antioxidant and antibacterial activity of silver nanoparticles synthesized by Cestrum nocturnum. Journal of Ayurveda and Integrative Medicine. 2020;11(1):37-44.
24
25. Adabi M, Saber R, Adabi M, Sarkar S. Examination of incubation time of bare gold electrode inside cysteamine solution for immobilization of multi-walled carbon nanotubes on a gold electrode modified with cysteamine. Microchimica Acta. 2010;172(1-2):83-8.
25
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26
27. Selvi BCG, Madhavan J, Santhanam A. Cytotoxic effect of silver nanoparticles synthesized from Padina tetrastromatica on breast cancer cell line. Advances in Natural Sciences: Nanoscience and Nanotechnology. 2016;7(3):035015.
27
28. Masurkar SA, Chaudhari PR, Shidore VB, Kamble SP. Rapid Biosynthesis of Silver Nanoparticles Using Cymbopogan Citratus (Lemongrass) and its Antimicrobial Activity. Nano-Micro Letters. 2011;3(3):189-94.
28
29. Ramamurthy CH, Padma M, mariya samadanam ID, Mareeswaran R, Suyavaran A, Kumar MS, et al. The extra cellular synthesis of gold and silver nanoparticles and their free radical scavenging and antibacterial properties. Colloids and Surfaces B: Biointerfaces. 2013;102:808-15.
29
ORIGINAL_ARTICLE
Nanohydroxyapatite and its polycaprolactone nanocomposite for lead sorbent from aqueous solution
Objective(s): Lead is a very strong poison in the environment. Lead toxicity can be affected on the human body and caused disease. Therefore, the design of lead sorbent can be had the great help to the medical field. In this work, the nanohydroxyapatite (n-HA) was used for removal of lead from aqueous solution. Then, polycaprolactone (PCL) nanocomposite was modified with n-HA by simple preparation method as lead sorbent. Methods: The samples were characterized by X-ray diffraction (XRD) analysis, field emission scanning electron microscope (FE-SEM), BET surface area, and Ultraviolet–visible (UV–Vis) spectroscopy. The effect of parameters including pH and temperature of solution, amount and concentration of sorbent was investigated on lead absorption. Results: FE-SEM results confirmed that the samples are in nano scale. The lead absorption was approved by UV–Vis spectroscopy and BET surface area. The absorption value was increased by increase of concentration, pH, and temperature. Conclusions: This work focuses on preparing an efficient lead sorbent system based on nanohydroxyapatite and its polycaprolactone nanocomposite. The results indicate that this nanocomposite can have a good potential to develop different adsorbents.
https://www.nanomedicine-rj.com/article_40564_6bc53f908ffe405b71e244f3f9a143ec.pdf
2020-04-01
143
151
10.22034/nmrj.2020.02.005
Nanohydroxyapatite
Polycaprolactone
Nanocomposite
Lead sorbent
Masomeh
Odar
m.odar1388@gmail.com
1
Department of Nanochemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
AUTHOR
CNegar
Motakef-Kazemi
negar.motakef@gmail.com
2
Department of Medical Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
LEAD_AUTHOR
1. Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ. Heavy Metal Toxicity and the Environment. Experientia Supplementum: Springer Basel; 2012. p. 133-64.
1
2. Cheraghi M, Lorestani B, Yousefi N. Effect of Waste Water on Heavy Metal Accumulation in Hamedan Province Vegetables. International Journal of Botany. 2009;5(2):190-3.
2
3. Adabi M. Detection of lead ions using an electrochemical aptasensor. Nanomed Res J. 2019;4(4):247-252.
3
4. Latif Wani A, Ara a, Ahmad Usmani J. Lead toxicity: a review. Interdiscip Toxicol. 2015; 8(2):55–64.
4
5. Iconaru S, Motelica-Heino M, Guegan R, Beuran M, Costescu A, Predoi D. Adsorption of Pb (II) Ions onto Hydroxyapatite Nanopowders in Aqueous Solutions. Materials. 2018;11(11):2204.
5
6. González-Muñoz MJ, Rodríguez MA, Luque S, Álvarez JR. Recovery of heavy metals from metal industry waste waters by chemical precipitation and nanofiltration. Desalination. 2006;200(1-3):742-4.
6
7. Hajiashrafi S, Motakef Kazemi N. Preparation and evaluation of ZnO nanoparticles by thermal decomposition of MOF-5. Heliyon. 2019;5(9):e02152.
7
8. Motakef-Kazemi N, Shojaosadati SA, Morsali A. In situ synthesis of a drug-loaded MOF at room temperature. Microporous and Mesoporous Materials. 2014;186:73-9.
8
9. Motakef-Kazemi N, Shojaosadati SA, Morsali A. Evaluation of the effect of nanoporous nanorods Zn2(bdc)2(dabco) dimension on ibuprofen loading and release. Journal of the Iranian Chemical Society. 2016;13(7):1205-12.
9
10. Miri B, Motakef-Kazemi N, Shojaosadati SA, Morsali A. Application of a nanoporous metal organic framework based on iron carboxylate as drug delivery system. Iran J Pharm Res. 2018;17(4):1164–1171.
10
11. Adibzadeh P, Motakef-Kazemi N. Preparation and characterization of curcumin-silver nanoparticle and evaluation of the effect of poly ethylene glycol and temperature. J Nanoanalysis. 2018;5(3): 156-162.
11
12. Hajiashrafi S, Motakef-Kazemi N. Green synthesis of zinc oxide nanoparticles using parsley extract. Nanomed Res J. 2018;3(1):44-50.
12
13. Feizi Langaroudi N, Motakef-Kazemi N. Preparation and characterization of O/W nanoemulsion with Mint essential oil and Parsley aqueous extract and the presence effect of chitosan. Nanomed Res J. 2019;4(1):48-55.
13
14. Sharma C, Dhiman R, Rokana N, Panwar H. Nanotechnology: An Untapped Resource for Food Packaging. Frontiers in Microbiology. 2017;8.
14
15. Sadat Ebnerasool F, Motakef Kazemi N. Preparation and Characterization of Chitosan Nanocomposite Based on Nanoscale Silver and Nanomontmorillonite. Analytical Methods in Environmental Chemistry Journal. 2019;2(2):5-12.
15
16. Serrano E, Rus G, García-Martínez J. Nanotechnology for sustainable energy. Renewable and Sustainable Energy Reviews. 2009;13(9):2373-84.
16
17. Motakef Kazemi N, Salimi AA. Chitosan Nanoparticle for Loading and Release of Nitrogen, Potassium, and Phosphorus Nutrients. Iranian Journal of Science and Technology, Transactions A: Science. 2019;43(6):2781-6.
17
18. Abiodun Solanke IMF, Ajayi DM, Arigbede AO. Nanotechnology and its application in dentistry. Annals of Medical and Health Sciences Research. 2014;4(9):171.
18
19. Mehmandoust MR, Motakef-Kazemi N, Ashouri F. Nitrate Adsorption from Aqueous Solution by Metal–Organic Framework MOF-5. Iranian Journal of Science and Technology, Transactions A: Science. 2018;43(2):443-9.
19
20. Motakef Kazemi N. A novel sorbent based on metal–organic framework for mercury separation from human serum samples by ultrasound assisted- ionic liquid-solid phase microextraction. Analytical Methods in Environmental Chemistry Journal. 2019:67-78.
20
21. González-Muñoz MJ, Rodríguez MA, Luque S, Álvarez JR. Recovery of heavy metals from metal industry waste waters by chemical precipitation and nanofiltration. Desalination. 2006;200(1-3):742-4.
21
22. Khedr MG. Nanofiltration and low energy reverse osmosis in rejection of radioactive isotopes and heavy metal cations from drinking water sources. DESALINATION AND WATER TREATMENT. 2009:342-50.
22
23. Wang S, Wu H. Environmental-benign utilisation of fly ash as low-cost adsorbents. Journal of Hazardous Materials. 2006;136(3):482-501.
23
24. Yang J, Hou B, Wang J, Tian B, Bi J, Wang N, et al. Nanomaterials for the Removal of Heavy Metals from Wastewater. Nanomaterials. 2019;9(3):424.
24
25. Alghamdi AA, Al-Odayni A-B, Saeed WS, Al-Kahtani A, Alharthi FA, Aouak T. Efficient Adsorption of Lead (II) from Aqueous Phase Solutions Using Polypyrrole-Based Activated Carbon. Materials. 2019;12(12):2020.
25
26. Sadati Behbahani N, Rostamizadeh K, Yaftian MR, Zamani A, Ahmadi H. Covalently modified magnetite nanoparticles with PEG: preparation and characterization as nano-adsorbent for removal of lead from wastewater. Journal of Environmental Health Science and Engineering. 2014;12(1).
26
27. Ricco R, Konstas K, Styles MJ, Richardson JJ, Babarao R, Suzuki K, et al. Lead(ii) uptake by aluminium based magnetic framework composites (MFCs) in water. Journal of Materials Chemistry A. 2015;3(39):19822-31.
27
28. Wang Y, Xie J, Wu Y, Ge H, Hu X. Preparation of a functionalized magnetic metal–organic framework sorbent for the extraction of lead prior to electrothermal atomic absorption spectrometer analysis. Journal of Materials Chemistry A. 2013;1(31):8782.
28
29. Shen J, Wang N, Wang Y, Yu D, Ouyang Xk. Efficient Adsorption of Pb(II) from Aqueous Solutions by Metal Organic Framework (Zn-BDC) Coated Magnetic Montmorillonite. Polymers. 2018;10(12):1383.
29
30. Musico YLF, Santos CM, Dalida MLP, Rodrigues DF. Improved removal of lead(ii) from water using a polymer-based graphene oxide nanocomposite. Journal of Materials Chemistry A. 2013;1(11):3789.
30
31. Ragab A, Ahmed I, Bader D. The Removal of Brilliant Green Dye from Aqueous Solution Using Nano Hydroxyapatite/Chitosan Composite as a Sorbent. Molecules. 2019; 24(5): 847.
31
32. Wang Z, Sun K, He Y, Song P, Zhang D, Wang R. Preparation of hydroxyapatite-based porous materials for absorption of lead ions. Water Science and Technology. 2019;80(7):1266-75.
32
33. Irandoost M, Pezeshki-Modaress M, Javanbakht V. Removal of lead from aqueous solution with nanofibrous nanocomposite of polycaprolactone adsorbent modified by nanoclay and nanozeolite. Journal of Water Process Engineering. 2019;32:100981.
33
34. Seema KM, Mamba BB, Njuguna J, Bakhtizin RZ, Mishra AK. Removal of lead (II) from aqeouos waste using (CD-PCL-TiO2) bio-nanocomposites. International Journal of Biological Macromolecules. 2018;109:136-42.
34
35. Andrade FAC, Vercik LCdO, Monteiro FJ, Rigo ECdS. Preparation, characterization and antibacterial properties of silver nanoparticles–hydroxyapatite composites by a simple and eco-friendly method. Ceramics International. 2016;42(2):2271-80.
35
36. Mousa SM, Ammar NS, Ibrahim HA. Removal of lead ions using hydroxyapatite nano-material prepared from phosphogypsum waste. Journal of Saudi Chemical Society. 2016;20(3):357-65.
36
37. Kmiec E, Borjigin, Eskridge, Niamat, Strouse B, Bialk. Electrospun fiber membranes enable proliferation of genetically modified cells. International Journal of Nanomedicine. 2013:855.
37
ORIGINAL_ARTICLE
Au nanoparticles/g-C3N4 modified biosensor for electrochemical detection of gastric cancer miRNA based on hairpin locked nucleic acids probe
Objective: The annual incidence of cancer in the world is growing rapidly. The most important factor in the cure of cancers is their early diagnosis. miRNA, as a biomarker for early detection of cancer, has attracted a lot of attention. Methods: In this study, an electrochemical biosensor was developed to detect the amount of miR-106a, the biomarker of gastric cancer, by modifying a glassy carbon electrode (GCE) with a composite of graphitic carbon nitride and gold nanoparticles. Complementary DNA strand of miR-106a which modified with biotin was used as a probe. Nanoparticles of titanium phosphate modified with Streptavidin and zinc ions were used to generate the electrochemical signal in square wave voltammetry. To characterize the g-C3N4 functional group, the chemical composition of the titanium phosphate nanoparticles, the morphology and elemental composition of composite Fourier transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), and Energy Dispersive X-Ray Spectroscopy (EDS) were used, respectively. Results: The peaks of C, N, and Au in EDS spectrum confirmed composite formation. The linear range and detection limit of the modified biosensor for miRNA-106a were obtained from 0.6 to 6.4 nM and 80 pM, respectively. Conclusion: Ultimately, Au nanoparticles/ g-C3N4 composite modified electrode can be a good platform for making electrochemical biosensor to diagnosis cancer in early stages.
https://www.nanomedicine-rj.com/article_40566_815fa174b189a9030c2e935b01f334ee.pdf
2020-04-01
152
159
10.22034/nmrj.2020.02.006
Au/ g-C3N4 composite
Biosensors
Gastric Cancer
miRNA-106a
square wave voltammetry
Mohammad Reza
Mohammad Shafiee
mohammad.r.mohammadshafiee@gmail.com
1
Department of chemistry Faculty of Sciences, Islamic Azad University – Najafabad Branch, Najafabad, Iran.
LEAD_AUTHOR
Janan
Parhizkar
jananparhizkar@gmail.com
2
Nanotechnology Laboratory, Department of Chemistry, University of Isfahan, Isfahan, Iran.
AUTHOR
1. Thrift AP, El-Serag HB. Burden of Gastric Cancer. Clinical Gastroenterology and Hepatology. 2020;18(3):534-42.
1
2. Crew KD, Neugut AI. Epidemiology of gastric cancer. World Journal of Gastroenterology. 2006;12(3):354.
2
3. Zhang Y, Gao G, Liu H, Fu H, Fan J, Wang K, et al. Identification of Volatile Biomarkers of Gastric Cancer Cells and Ultrasensitive Electrochemical Detection based on Sensing Interface of Au-Ag Alloy coated MWCNTs. Theranostics. 2014;4(2):154-62.
3
4. Fock KM. Review article: the epidemiology and prevention of gastric cancer. Alimentary Pharmacology & Therapeutics. 2014;40(3):250-60.
4
5. Gurtan AM, Sharp PA. The Role of miRNAs in Regulating Gene Expression Networks. Journal of Molecular Biology. 2013;425(19):3582-600.
5
6. Song B, Ju J. Impact of miRNAs in gastrointestinal cancer diagnosis and prognosis. Expert Reviews in Molecular Medicine. 2010;12.
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7.Chan SH, Wu CW, Li AFY, Chi CW, Lin WC. miR-21 microRNA expression in human gastric carcinomas and its clinical association. Anticancer research. 2008; 28(2A): 907-911.
7
8. Zhang Z, Li Z, Gao C, Chen P, Chen J, Liu W, et al. miR-21 plays a pivotal role in gastric cancer pathogenesis and progression. Laboratory Investigation. 2008;88(12):1358-66.
8
9.Simonian M, Mosallayi M, Mirzaei H. Circulating miR-21 as novel biomarker in gastric cancer: diagnostic and prognostic biomarker. Journal of cancer research and therapeutics. 2018; 14(2).
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10.Hou X, Zhang M, Qiao H. Diagnostic significance of miR-106a in gastric cancer. International journal of clinical and experimental pathology. 2015; 8(10): 13096.
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11. Leshkowitz D, Horn-Saban S, Parmet Y, Feldmesser E. Differences in microRNA detection levels are technology and sequence dependent. RNA. 2013;19(4):527-38.
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12. Lei J, Ju H. Signal amplification using functional nanomaterials for biosensing. Chemical Society Reviews. 2012;41(6):2122.
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13.Niri A, Faridi-Majidi R, Saber R, Khosravani M, Adabi M. Electrospun carbon nanofiber-based electrochemical biosensor for the detection of hepatitis B virus. Biointerface Research in Applied Chemistry. 2019; 9(4);4022-4026.
13
14. Cheng F-F, He T-T, Miao H-T, Shi J-J, Jiang L-P, Zhu J-J. Electron Transfer Mediated Electrochemical Biosensor for MicroRNAs Detection Based on Metal Ion Functionalized Titanium Phosphate Nanospheres at Attomole Level. ACS Applied Materials & Interfaces. 2015;7(4):2979-85.
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15. Loo F-C, Ng S-P, Wu C-ML, Kong SK. An aptasensor using DNA aptamer and white light common-path SPR spectral interferometry to detect cytochrome-c for anti-cancer drug screening. Sensors and Actuators B: Chemical. 2014;198:416-23.
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16. Huang H, Bai W, Dong C, Guo R, Liu Z. An ultrasensitive electrochemical DNA biosensor based on graphene/Au nanorod/polythionine for human papillomavirus DNA detection. Biosensors and Bioelectronics. 2015;68:442-6.
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17. Cheng N, Tian J, Liu Q, Ge C, Qusti AH, Asiri AM, et al. Au-Nanoparticle-Loaded Graphitic Carbon Nitride Nanosheets: Green Photocatalytic Synthesis and Application toward the Degradation of Organic Pollutants. ACS Applied Materials & Interfaces. 2013;5(15):6815-9.
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18. Gulati P, Kaur P, Rajam MV, Srivastava T, Mishra P, Islam SS. Single-wall carbon nanotube based electrochemical immunoassay for leukemia detection. Analytical Biochemistry. 2018;557:111-9.
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19. Riccelli PV. Hybridization of single-stranded DNA targets to immobilized complementary DNA probes: comparison of hairpin versus linear capture probes. Nucleic Acids Research. 2001;29(4):996-1004.
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20. Abolhasan R, Mehdizadeh A, Rashidi MR, Aghebati-Maleki L, Yousefi M. Application of hairpin DNA-based biosensors with various signal amplification strategies in clinical diagnosis. Biosensors and Bioelectronics. 2019;129:164-74.
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21.Zhang D, Gao Q, Peng Y, Qi H, Zhang C. Label-free electrochemical DNA biosensor array for simultaneous detection of the HIV-1 and HIV-2 oligonucleotides incorporating different hairpin-DNA probes and redox indicator Electrolysis of coal slurries to produce hydrogen gas Biosensors and Bioelectronics. 2010, 25(5): 1088-1094.
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22. Li Z, Huang P, He R, Lin J, Yang S, Zhang X, et al. Aptamer-conjugated dendrimer-modified quantum dots for cancer cell targeting and imaging. Materials Letters. 2010;64(3):375-8.
22
23. Zhang J, Qi H, Li Y, Yang J, Gao Q, Zhang C. Electrogenerated Chemiluminescence DNA Biosensor Based on Hairpin DNA Probe Labeled with Ruthenium Complex. Analytical Chemistry. 2008;80(8):2888-94.
23
24. Wang S, Li D, Sun C, Yang S, Guan Y, He H. Synthesis and characterization of g-C3N4/Ag3VO4 composites with significantly enhanced visible-light photocatalytic activity for triphenylmethane dye degradation. Applied Catalysis B: Environmental. 2014;144:885-92.
24
25. Zhou Y, Zhang Z, Xu Z, Yin H, Ai S. MicroRNA-21 detection based on molecular switching by amperometry. New Journal of Chemistry. 2012;36(10):1985.
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26. Wen J, Xie J, Chen X, Li X. A review on g-C 3 N 4 -based photocatalysts. Applied Surface Science. 2017;391:72-123.
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27. Zhu J, Xiao P, Li H, Carabineiro SAC. Graphitic Carbon Nitride: Synthesis, Properties, and Applications in Catalysis. ACS Applied Materials & Interfaces. 2014;6(19):16449-65.
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28
ORIGINAL_ARTICLE
Safety Evaluation of Nano Iron Zero Valente Green Synthesized: A Comparative Study
Objective(s): Nowadays, examining the toxicity of nanoparticles including the synthesized and functionalized iron nanoparticles using methods like green synthesis is highly considered, due to their increasing usage in various fields of medicine, biology, industrial, and pollution removal. Hence, in this study, the toxicity of the zero valent iron nanoparticles synthesized by plant-Myrtus communis (MC-ZVINP) was investigated. Methods: Human normal Foreskin Fibroblast (HFF) cells were used for cytotoxicity examination using MTT method. Also, biochemical factors such as liver enzymes level, and factors such as the number of white and red globules, lymphocytes, platelets, amount of blood hemoglobin, and histopathological test of liver tissue in laboratory small rats were examined after intraperitoneal injections of the MC-ZVINP with different concentrations daily and a duration of 3-month, with the groups receiving trivalent iron, the extract of plant-case, and normal saline. Results: Cytotoxicity concentration of iron-case nanoparticles was obtained for 50% of HFF cells (CC50=149.23±4.45μg/mL). The results obtained from the blood factors examination showed a decreased the serum level of liver enzymes as well as an increase in the number of red and white globules and hemoglobin rate in mice receiving iron nanoparticles compared to the trivalent iron receiving group. Receiving the concentrations of 100 and 200 mg/kg/bw of iron nanoparticles have caused the incidence of mild and moderate inflammation in the liver of mice. Conclusions: Generally, it can be concluded that, the MC-ZVINP have shown no significant toxicity on the levels of blood cells, enzymes, and liver tissue.
https://www.nanomedicine-rj.com/article_40567_f33779b1a75a4019136b9b4ef872eb0a.pdf
2020-04-01
160
170
10.22034/nmrj.2020.02.007
Iron nanoparticles
Myrtus communis
Green synthesis
Cytotoxicity
Shirin
Tavakoli
shirintavakoli67@yahoo.com
1
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Fatemeh
Sameni
sameni.f@yahoo.com
2
Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
AUTHOR
Mohammad Ali
Ebrahimzadeh
zadeh20@gmail.com
3
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Pourya
Biparva
p.biparva@sanru.ac.ir
4
Department of Basic Sciences, Sari University of Agricultural Sciences and Natural Resources, Sari, Iran
AUTHOR
Hamidreza
Mohammadi
hmohammadi@farabi.tums.ac.ir
5
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Afshin
Zahedi
afshinzahedim@gmail.com
6
Department of Medical Entomology and Vector Control, School of Public Health and Health Sciences Research Center, Mazandaran of University of Medical Sciences, Sari, Iran
AUTHOR
Alireza
Rafiei
rafiei1710@gmail.com
7
Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Mostafa
Kardan
kardan.mostafa66@gmail.com
8
Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Shahram
Eslami
eslamish540@gmail.com
9
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
LEAD_AUTHOR
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2
3. Madani F, Esnaashari SS, Mujokoro B, Dorkoosh F, Khosravani M, Adabi M. Investigation of Effective Parameters on Size of Paclitaxel Loaded PLGA Nanoparticles. Advanced Pharmaceutical Bulletin. 2018;8(1):77-84.
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26. Eslami S, Ebrahimzadeh MA, Biparva P. Green synthesis of safe zero valent iron nanoparticles by Myrtus communis leaf extract as an effective agent for reducing excessive iron in iron-overloaded mice, a thalassemia model. RSC Advances. 2018;8(46):26144-55.
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47
ORIGINAL_ARTICLE
Green synthesis of multifunctional silver nanoparticles using quercetin and their therapeutic potential
Objective(s): Active species used in bio-chemical for synthesizing nanoparticles is poly phenolic compounds. The ability of flavonoids (e.g. quercetin) to dissolve in water is low and the production of metallic nanoparticles from them in the aqueous medium is hard. Previous studies recommend that quercetin was not capable of reducing Ag+ to Ag0. The current research aimed at synthesizing quercetin-mediated silver nanoparticles (Q-AgNPs) and evaluate the antioxidant and anticancer activities of Q-AgNPs in vitro. Methods: The green synthesis of Q-AgNPs in an aqueous medium has been demonstrated. The resultant nanoparticles were characterized by several analytical techniques of imaging and spectroscopic. The improved antioxidant activity of Q-AgNPs (DPPH and nitric oxide scavenging and iron chelating assay) was determined by the colorimetric method. Possible biomedical applications such as antioxidant and anticancer activities of Q-AgNPs have been assessed. Results: The DPPH and nitric oxide radical scavenging activity of Q-AgNPs was found to be (IC50=46.47±1.79 and 30.64±3.18μg/mL, respectively). Q-AgNPs exhibited better iron chelating activity than standard EDTA (IC50=3.12 ±0.44μg/mL). Significant anticancer activity of Q-AgNPs (IC50=57.42μg/mL) was found against HepG2 cell lines after 24-hour exposure. Furthermore, the antifungal activity (MIC = 4, 8 and > 64 μg/mL) was found against Candida krusei, Candida parapsilosis and Aspergillus fumigatus, respectively. Conclusions: The present method is a competitive option to produce multifunctional nanoscale hybrid materials with higher efficiency and using natural sources for diverse biomedical applications such as antioxidant and anticancer activities.
https://www.nanomedicine-rj.com/article_40568_8c3eb5cc988a5a98296c16d93e748ad1.pdf
2020-04-01
171
181
10.22034/nmrj.2020.02.008
Quercetin
Green synthesis
Silver Nanoparticle
Antioxidant
Anticancer
Antifungal
Saeedeh
Maghsoodloo
smaghsood91@yahoo.com
1
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Mohammad Ali
Ebrahimzadeh
zadeh20@gmail.com
2
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Shirin
Tavakoli
shirintavakoli67@yahoo.com
3
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Hamidreza
Mohammadi
hmohammadi@farabi.tums.ac.ir
4
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Pourya
Biparva
p.biparva@sanru.ac.ir
5
Department of Basic Sciences, Sari University of Agricultural Sciences and Natural Resources, Sari, Iran
AUTHOR
Alireza
Rafiei
rafiei1710@gmail.com
6
Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Mostafa
Kardan
kardan.mostafa66@gmail.com
7
Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Mahsa
Mohammadyan
moon.mo92@gmail.com
8
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Shahram
Eslami
eslamish540@gmail.com
9
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
LEAD_AUTHOR
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8
9. Madani F, Esnaashari SS, Mujokoro B, Dorkoosh F, Khosravani M, Adabi M. Investigation of Effective Parameters on Size of Paclitaxel Loaded PLGA Nanoparticles. Advanced Pharmaceutical Bulletin. 2018;8(1):77-84.
9
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17. Mujokoro B, Madani F, Esnaashari SS, Khosravani M, Adabi M. Combination and Co-delivery of Methotrexate and Curcumin: Preparation and In Vitro Cytotoxic Investigation on Glioma Cells. Journal of Pharmaceutical Innovation. 2019.
17
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20. de Oliveira MR, Nabavi SM, Braidy N, Setzer WN, Ahmed T, Nabavi SF. Quercetin and the mitochondria: A mechanistic view. Biotechnology Advances. 2016;34(5):532-49.
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21. Eslami S, Mozdastan S, Ebrahimzadeh MA. Antioxidant activity of polyphenol and flavonoid rich extracts from leaves of myrtle (Myrtus communis L). Pharmacologyonline 2016;2: 132-136.
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22. Eslami S, Ebrahimzadeh MA, Biparva P. Green synthesis of safe zero valent iron nanoparticles by Myrtus communis leaf extract as an effective agent for reducing excessive iron in iron-overloaded mice, a thalassemia model. RSC Advances. 2018;8(46):26144-55.
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25. Badiee P, Choopanizadeh M, Moghadam AG, Nasab AH, Jafarian H, Shamsizadeh A, Soltani J. Antifungal susceptibility patterns of colonized Candida species isolates from immunocompromised pediatric patients in five university hospitals. Iranian journal of microbiology, 2017;9 (6):363.
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26. Mittal AK, Kaler A, Banerjee UC. Free Radical Scavenging and Antioxidant Activity of Silver Nanoparticles Synthesized from Flower Extract of Rhododendron dauricum. Nano Biomedicine and Engineering. 2012;4(3).
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27. Veerasamy R, Xin TZ, Gunasagaran S, Xiang TFW, Yang EFC, Jeyakumar N, et al. Biosynthesis of silver nanoparticles using mangosteen leaf extract and evaluation of their antimicrobial activities. Journal of Saudi Chemical Society. 2011;15(2):113-20.
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28. Pattanayak M, Nayak P. Ecofriendly green synthesis of iron nanoparticles from various plants and spices extract. International Journal of Plant, Animal and Environmental Sciences, 2013;3 (1):68-78.
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29. Kundu S, Nithiyanantham U. In situ formation of curcumin stabilized shape-selective Ag nanostructures in aqueous solution and their pronounced SERS activity. RSC Advances. 2013;3(47):25278.
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31
32. El Khoury E, Abiad M, Kassaify ZG, Patra D. Green synthesis of curcumin conjugated nanosilver for the applications in nucleic acid sensing and anti-bacterial activity. Colloids and Surfaces B: Biointerfaces. 2015;127:274-80.
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44
ORIGINAL_ARTICLE
Comparative Studies of High Contrast Fluorescence Imaging Efficiency of Silica-coated CdSe Quantum Dots with Green and Red Emission
Herein we report the possibility of using green and red emitting silica-coated cadmium selenide (CdSe) quantum dots (QDs) for remarkable stem and cancer cellular imaging, efficient cellular uptake and fluorescence imaging of semi and ultra-thin sections of tumor for in vivo tumor targeted imaging applications. The comparative studies of high contrast cellular imaging behaviours of the silica-coated CdSe QDs with green and red emission have been exploited to visualize rabbit adipose tissue-derived mesenchymal stem cells (RADMSCs) and human cervical cancerous (HeLa) cells in vitro. The in vitro cellular uptake characteristics of QDs were performed in cultured HeLa cells using Confocal Laser Scanning Microscopy (cLSM) after staining with 4,6-diamidino-2-phenylindole (DAPI). The in vitro cellular imaging and uptake results showed that green and red emitting silica-coated CdSe QDs were efficiently taken up by the cells and exhibits excellent fluorescence from the cytoplasm. Subsequently, the in vivo tumor targeting was conducted using both QDs, of Dalton’s Lymphoma Ascites (DLA) cells bearing solid tumor mice. Fluorescence imaging and effective tumor targeting characteristics of QDs at tumor site were confirmed by the semithin (~15 µm thickness) and ultrathin sections of tumor (~100 nm thickness) under cLSM. Overall, these in vitro and in vivo results are represented with focus on efficient cellular imaging, cellular localization and even distribution of the green and red emitting silica-coated CdSe QDs in tumor, and comparatively red emitting is exhibits higher fluorescence than green emitting one, in view of their potential applications in cellular imaging in cancer and other diseases.
https://www.nanomedicine-rj.com/article_40569_4f8941d576addfca556e353c73e09ee2.pdf
2020-04-01
182
191
10.22034/nmrj.2020.02.009
Cervical
DLA cells
Fluorescence
Tumor-targeting
Semithin
Ultrathin
Vibin
Muthunayagam
vbnano@gmail.com
1
Department of Biochemistry, University of Kerala, Kariavattom Campus,Thiruvananthapuram, Kerala, India.
AUTHOR
Vinayakan
R
rvinayakan@gmail.com
2
Department of Chemistry, NSS Hindu College, Changanacherry, Mahatma Gandhi University, Kottayam, Kerala, India.
AUTHOR
Annie
Abraham
annieab20001@gmail.com
3
Department of Biochemistry, University of Kerala, Kariavattom Campus,Thiruvananthapuram, Kerala, India.
LEAD_AUTHOR
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ORIGINAL_ARTICLE
Promising antibacterial activity of a mat of polycaprolactone nanofibers impregnated with a green nanogel
Skin is the body's first defense line against environmental pathogens. However, open skin wounds can interfere with the normal function of the skin and the entry of opportunistic bacteria into the body. Recently, the development of nano-dressing containing green antibiotics has been received much attention around the world. In this study, the essential oil of Citrus sinensis (CSEO) was used as an antibacterial agent. The ingredients of CSEO were identified by GC-MS analysis with five major components of Limonene (61.83%), trans-p-2, 8-Menthadien-1-ol (4.95%), Trans-Limonene oxide (2.29 %), Cis- Limonene oxide (2.58 %), and trans-Carveol (2.90%). Nanogel of CSEO was prepared by the addition of a gelling agent (carbomer 940 2%) to its optimum nanoemulsion with a particle size of 125 ± 4 nm. Also, electrospun nanofibers of polycaprolactone with a mean diameter of 186 ± 36 nm were prepared. Characterization of the nanofibers, including SEM, ATR-FTIR, and contact-angle measurement, were carried out. After that, the nanogel was impregnated on the surface of the nanofibers, NGelNFs. Interestingly, NGelNFs completely inhibited the growth (~ 0%) of four important human bacteria strains, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumonia. The prepared prototype, NGelNFs, can be used as a potent antibacterial agent. Furthermore, this work introduced an effective and new method for the preparation of green antibacterial agents as well as antibiotic-free wound dressings.
https://www.nanomedicine-rj.com/article_40570_169af6704536f3158ab56c6d9755116c.pdf
2020-04-01
192
201
10.22034/nmrj.2020.02.010
Citrus sinensis
essential oil
PCL nanofibers
Electrospinning
Nanogel
Antibacterial activity
Abbas
Abdollahi
a.abdollahi360@yahoo.com
1
Department of Microbiology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
AUTHOR
Elham
Zarenezhad
el.zarenezhad@gmail.com
2
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
AUTHOR
Mahmoud
Osanloo
osanloo_mahmood@yahoo.com
3
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran.
LEAD_AUTHOR
Ghazal
Ghaznavi
ghaznavi172@gmail.com
4
Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
AUTHOR
Marzieh
Khalili pour
marzi707ieh@gmail.com
5
Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran
AUTHOR
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37