TY - JOUR ID - 247463 TI - Fourier Transform Infrared Spectroscopy as diagnostic tools for bladder cancer treatment: Doxorubicin and Cisplatin and Reduced Graphene Oxide as nanocarrier JO - Nanomedicine Research Journal JA - NMRJ LA - en SN - 2476-3489 AU - Fávaro, Wagner J. AU - Villela, Renata A., AU - Ceragioli, Helder J. AU - Duran, Nelson AD - Institute of Biology, University of Campinas AD - Cidade Universitaria, Barão Geraldo UNICAMP AD - EEC, University of Campinas AD - Cidade Universitaria, Barão Geraldo UNCAMP Y1 - 2021 PY - 2021 VL - 6 IS - 3 SP - 228 EP - 236 KW - FTIR spectroscopy KW - Bladder cancer KW - Doxirubicin KW - Cisplatin. Reduced Graphene oxide DO - 10.22034/nmrj.2021.03.003 N2 - Aim: The use of Fourier Transform Infrared Spectroscopy (FTIR) as diagnostic tools for bladder cancer associate to histopathology analysis.Material and Methods: FTIR imagens of normal and bladder cancer tissues in rats o Brucker model V 70 spectrophotometer equipped with the MCT detector (Mercury Cadmium Telluride), under attenuated total reflectance (ATR). Histopathology analysis of rat tissues and comparison of diagnostics in both methods.Results: All the spectroscopic parameters analyzed showing that the progress of cancer treatment were consistent with the histopathological analyses. The ratio of FTIR bands intensity of protein/lipid (I1633/I1743) was highly increased (ratio of 3.33) in the cancer tissues compared with normal one (ratio of 1.22). After treatment with DOX-CIS-rGO nanocarrier a value of protein/lipid ratio was 1.38.Conclusion: All data of the ATR-FTIR imagens will be important tools for the most complex and expensive histopathological analysis. The ATR-FTIR diagnosis will be an important data in the final decision related to progress in the chemotherapeutic treatment. Of course, the fast analysis by ATR-FTIR methodology compared to histopathology could be an important support for monitoring all these studies. UR - https://www.nanomedicine-rj.com/article_247463.html L1 - https://www.nanomedicine-rj.com/article_247463_ba7f58f3748c56bafd5a1270e68d1154.pdf ER -