TY - JOUR ID - 249483 TI - Synthesis of 2-amino-4-(4-methoxyphenyl)-1,3-thiazole coated-magnetic nanoparticles: a potential antibacterial compound JO - Nanomedicine Research Journal JA - NMRJ LA - en SN - 2476-3489 AU - Sadiq Hawezy, Hawar Jalal AU - Bahram Nadir, Roshna AU - Hassan Faraj, Rezhna AU - Mohammed Sabri, Mohammed Faeq AU - Jamal Salih, Shameran AD - Department of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region - F.R. Iraq. Y1 - 2021 PY - 2021 VL - 6 IS - 4 SP - 352 EP - 359 KW - Synthesis KW - Fe3O4 KW - Nanomedicine KW - Schiff Base KW - Anti-bacterial DO - 10.22034/nmrj.2021.04.005 N2 - Objective(s): Schiff bases compounds are typically containing a nitrogen analogue of an aldehyde or ketone, in which the carbonyl group is substituted by an imine or azomethine group. These complexes are useful for various industrial goals, catalysis of chemical reactions, and have the capability of using as therapeutic compounds such as anti-microbial, anti-cancer, anti-inflammatory, and antiproliferative. Herein, we report the surface modification of Fe3O4 magnetic nanoparticles by a synthesized Schiff-base, named 2-amino-4-(4-methoxyphenyl)-1,3-thiazole. Methods: Various characterization techniques including, XRD, 13C-NMR, 1H-NMR, SEM, and EDXRF were employed to survey the functional and structural features of the compound. Results: Average particle size for the prepared Fe3O4 magnetic nanoparticles was calculated as about 12nm. SEM confirmed the spherical morphology of magnetic nanoparticles. Moreover, the coated Fe3O4 NPs with Schiff base displayed the desired anti-Escherichia coli and anti-Staphylococcus aureus activity. Conclusions: The herein method is beneficial for the application in diverse fields such as drug delivery, industry, and water treatment. UR - https://www.nanomedicine-rj.com/article_249483.html L1 - https://www.nanomedicine-rj.com/article_249483_00bc4ebc097426fa656543bbf6f93adb.pdf ER -