TY - JOUR ID - 46178 TI - Development of two stable green nanoformulations with potent anticancer properties JO - Nanomedicine Research Journal JA - NMRJ LA - en SN - 2476-3489 AU - Ghanbariasad, Ali AU - Osanloo, Mahmoud AD - Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences AD - Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran Y1 - 2020 PY - 2020 VL - 5 IS - 3 SP - 234 EP - 244 KW - Artemisia dracunculus KW - Zataria multiflora KW - Nanoemulsion KW - MCF-7 KW - MDA-MB-175 KW - MDA-MB-231 KW - and MDA-MB-468 DO - 10.22034/nmrj.2020.03.004 N2 - Breast cancer is the most common cause of cancer death among women; thus, developing new drugs is crucial. Essential oils (EO)s with a wide range of bioactivities, such as anticancer effects, have provided a valuable source for this purpose. In this study, components of two medicinally important EOs were identified using GC-MS analysis. Moreover, antioxidant effects, as well as anti-cancer properties, were evaluated.The EOs formulated into nanoemulsion using the spontaneous emulsification approach, separately. Comprehensive stability tests were performed to select the optimum nanoemulsions of each EO. Anticancer effect of the most stable nanoemulsion of Zataria multiflora with a particle size of 43 ± 4 nm (PDI 0.4 ± 0.2 and SPAN 0.6 ± 0.1) was significantly better non-formulated form against four human breast cancer cell lines, MCF-7, MDA-MB-175, MDA-MB-231, and MDA-MB-468. Interestingly, the anticancer effect of Artemisia dracunculus nanoemulsion (16 ± 4 nm, 0.2 ± 0.1, and 0.4 ± 0.1) was also significantly improved in compassion to the essential oil. Considering the results, prepared nanoemulsions could be used as supplementary drugs or food additives. UR - https://www.nanomedicine-rj.com/article_46178.html L1 - https://www.nanomedicine-rj.com/article_46178_e7ad712ec3d867905640f47c7740a790.pdf ER -