TY - JOUR ID - 703101 TI - Investigating cytotoxicity and the effect of Zn doped CeO2 nanoparticles on tooth-damaging Streptococcus mutans bacteria JO - Nanomedicine Research Journal JA - NMRJ LA - en SN - 2476-3489 AU - Alirezaei, Somayeh AU - Mahmoudi, Hamed AU - Ghodratizadeh, Soroush AU - Mohammadi Khah, Meysam AU - Titidej, Azadehzeinab AD - Oral medicine dept. faculty of dentistry,Islamic Azad university of medical sciences, Tehran,Iran AD - Resident of oral &maxillofacial surgery, School of dentistry, Tehran university of medical science, Tehran,Iran AD - Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Assistant professor, Oral & Maxillofacial Pathology Department, Qazvin University of Medical Sciences, Qazvin, Iran Y1 - 2023 PY - 2023 VL - 8 IS - 1 SP - 16 EP - 23 KW - Zn KW - CeO2 KW - NP Prosopis fracta Streptococcus mutans MTT assay DO - 10.22034/nmrj.2023.01.002 N2 - The present study presents a simple method for the provision of pure and 5% zinc doped cerium oxide nanoparticles (Zn-CeO2-NP) through application of extraction from prosopis fracta. In the following, we determined the physical-chemical properties of the product by performance of FESEM, UV-Vis, PXRD, and EDX devices. The finding of PXRD and EDX thoroughly confirmed the existence of zinc inside the structure of CeO2-NP, while results of FESEM measured the particle sizes of pure and doped NP to be below 20 and 10 nm. An assessment was conducted on the cytotoxic performance of synthesized samples on colon cancer (HT-29) cell line through usage of MTT test. According to results, doping process caused an increase in the cytotoxic effect of CeO2-NP. The next section involved the evaluation of obtained antibacterial activity on Streptococcus mutans bacteria via micro-dilution, hence resulted in displaying higher antibacterial activity of doped NP than to pure CeO2-NP.  UR - https://www.nanomedicine-rj.com/article_703101.html L1 - https://www.nanomedicine-rj.com/article_703101_4debeb5b79178df1b999aa77ea568de6.pdf ER -