Document Type : Review Paper

Authors

1 Department of medical nanotechnology, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA

3 Departemant of chemistry, Islamic Azad University, Science and Research Branch, Tehran, Iran

4 Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

5 University of Applied Science and Technology (UAST), Zar Center, Karaj, Iran

6 School of Chemical Engineering, Iran University of Science and Technology, Narmak 16846-13114, Tehran, Iran

7 Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

8 Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Abstract

The interest in cellulose and its derivatives has been exponentially increasing due to its excellent thermal stability, biocompatibility, chemical persistence and biodegradability. Among various cellulose derivatives, cellulose acetate (CA) has been applied in many applications including sensor systems, drug delivery systems, separation membrane, and tissue engineering. Recently, the electrospun nanofibers have been employed and have gotten more attention in the biotechnology and the biomedical applications. In this case, Electrospinning methods widely used to fabricate and generate novel nanomaterials along with the well-aligned structure of electrospun nanofibers. Electrospinning has emerged as a powerful method to produce nanofibrous assemblies from a variety of polymers and composites including CA fibers. These fibers obtained from this method were applied in biomedical applications specially for sensing process in the medical diagnostic kit. In this review article, the recent progress and development of electrospun CA fibers and nanofibers and also their nanocomposites for advanced sensing systems are presented. Several sensors and biosensors including optical/colorimetric, and electrochemical-based on CA are discussed in this study. 

Graphical Abstract

The Potentials and Applications of Cellulose Acetate in biosensor technology

Keywords

1. Gheibi A, Khoshnevisan K, Ketabchi N, Derakhshan MA, Babadi AA. Application of Electrospun Nanofibrous PHBV Scaffold in Neural Graft and Regeneration: A Mini-Review. Nanomedicine Research Journal, 2016;1 (2):107-111.
2. Mehrabi F, Shamspur T, Mostafavi A, Saljooqi A, Fathirad F. Synthesis of cellulose acetate nanofibers and its application in the release of some drugs. Nanomedicine Research Journal, 2017;2 (3):199-207.
3. Idris A, Yet LK. The effect of different molecular weight PEG additives on cellulose acetate asymmetric dialysis membrane performance. Journal of Membrane Science, 2006;280 (1):920-927.
4. Lv J, Zhang G, Zhang H, Yang F. Exploration of permeability and antifouling performance on modified cellulose acetate ultrafiltration membrane with cellulose nanocrystals. Carbohydrate Polymers, 2017;174 (Supplement C):190-199.
5. Voicu SI, Condruz RM, Mitran V, Cimpean A, Miculescu F, Andronescu C, Miculescu M, Thakur VK. Sericin Covalent Immobilization onto Cellulose Acetate Membrane for Biomedical Applications. ACS Sustainable Chemistry & Engineering, 2016;4 (3):1765-1774.
6. Konwarh R, Karak N, Misra M. Electrospun cellulose acetate nanofibers: the present status and gamut of biotechnological applications. Biotechnology advances, 2013;31 (4):421-437.
7. Wang X, Kim Y-G, Drew C, Ku B-C, Kumar J, Samuelson LA. Electrostatic assembly of conjugated polymer thin layers on electrospun nanofibrous membranes for biosensors. Nano Letters, 2004;4 (2):331-334.
8. Schiffman JD, Schauer CL. A review: electrospinning of biopolymer nanofibers and their applications. Polymer reviews, 2008;48 (2):317-352.
9. Rezaei A, Nasirpour A, Fathi M. Application of cellulosic nanofibers in food science using electrospinning and its potential risk. Comprehensive Reviews in Food Science and Food Safety, 2015;14 (3):269-284.
10. Greiner A, Wendorff JH. Electrospinning: a fascinating method for the preparation of ultrathin fibers. Angewandte Chemie International Edition, 2007;46 (30):5670-5703.
11. Li D, Xia Y. Electrospinning of nanofibers: reinventing the wheel? Advanced materials, 2004;16 (14):1151-1170.
12. Rodríguez K, Gatenholm P, Renneckar S. Electrospinning cellulosic nanofibers for biomedical applications: structure and in vitro biocompatibility. Cellulose, 2012;19 (5):1583-1598.
13. Ding B, Wang M, Wang X, Yu J, Sun G. Electrospun nanomaterials for ultrasensitive sensors. Materials Today, 2010;13 (11):16-27.
14. Sapountzi E, Braiek M, Chateaux J-F, Jaffrezic-Renault N, Lagarde F. Recent Advances in Electrospun Nanofiber Interfaces for Biosensing Devices. Sensors, 2017;17 (8):1887.
15. Yildiz H, Akyilmaz E, Dinçkaya E. Catalase immobilization in cellulose acetate beads and determination of its hydrogen peroxide decomposition level by using a catalase biosensor. Artificial cells, blood substitutes, and biotechnology, 2004;32 (3):443-452.
16. Wang S, Li S, Yu Y. Immobilization of cholesterol oxidase on cellulose acetate membrane for free cholesterol biosensor development. Artificial cells, blood substitutes, and biotechnology, 2004;32 (3):413-425.
17. Elabd AA, Zidan WI, Abo-Aly MM, Bakier E, Attia MS. Uranyl ions adsorption by novel metal hydroxides loaded Amberlite IR120. Journal of Environmental Radioactivity, 2014;134 (Supplement C):99-108.
18. Sundar U, Ramamurthy V, Buche V, Rao DN, Sivadasan PC, Yadav RB. Rapid measurements of concentrations of natural uranium in process stream samples via gamma spectrometry at an extraction facility. Talanta, 2007;73 (3):476-482.
19. Brunel B, Philippini V, Mendes M, Aupiais J. Actinide oxalate complexes formation as a function of temperature by capillary electrophoresis coupled with inductively coupled plasma mass spectrometry. Radiochimica Acta, 2015;103:27-37.
20. Shaw MJ, Hill SJ, Jones P, Nesterenko PN. Determination of uranium in environmental matrices by chelation ion chromatography using a high performance substrate dynamically modified with 2,6-pyridinedicarboxylic acid. Chromatographia, 2000;51 (11):695-700.
21. Benedik L, Vasile M, Spasova Y, Wätjen U. Sequential determination of 210Po and uranium radioisotopes in drinking water by alpha-particle spectrometry. Applied Radiation and Isotopes, 2009;67 (5):770-775.
22. Rathore DPS. Advances in technologies for the measurement of uranium in diverse matrices. Talanta, 2008;77 (1):9-20.
23. Nivens DA, Zhang Y, Angel SM. Detection of uranyl ion via fluorescence quenching and photochemical oxidation of calcein. Journal of Photochemistry and Photobiology A: Chemistry, 2002;152 (1):167-173.
24. Guo Y, Huang N, Yang B, Wang C, Zhuang H, Tian Q, Zhai Z, Liu L, Jiang X. Hybrid diamond/graphite films as electrodes for anodic stripping voltammetry of trace Ag+ and Cu2+. Sensors and Actuators B: Chemical, 2016;231 (Supplement C):194-202.
25. Das SK, Kedari CS, Tripathi SC. Spectrophotometric determination of trace amount of uranium (VI) in different aqueous and organic streams of nuclear fuel processing using 2-(5-bromo-2-pyridylazo-5-diethylaminophenol). Journal of Radioanalytical and Nuclear Chemistry, 2010;285 (3):675-681.
26. Hu L, Yan X-W, Li Q, Zhang X-J, Shan D. Br-PADAP embedded in cellulose acetate electrospun nanofibers: Colorimetric sensor strips for visual uranyl recognition. Journal of Hazardous Materials, 2017;329 (Supplement C):205-210.
27. Davis BW, Niamnont N, Hare CD, Sukwattanasinitt M, Cheng Q. Nanofibers Doped with Dendritic Fluorophores for Protein Detection. ACS Applied Materials & Interfaces, 2010;2 (7):1798-1803.
28. Niamnont N, Siripornnoppakhun W, Rashatasakhon P, Sukwattanasinitt M. A Polyanionic Dendritic Fluorophore for Selective Detection of Hg2+ in Triton X-100 Aqueous Media. Organic Letters, 2009;11 (13):2768-2771.
29. Ren X, Chen D, Meng X, Tang F, Du A, Zhang L. Amperometric glucose biosensor based on a gold nanorods/cellulose acetate composite film as immobilization matrix. Colloids and Surfaces B: Biointerfaces, 2009;72 (2):188-192.
30. Gilmartin MA, Hart JP. Novel, reagentless, amperometric biosensor for uric acid based on a chemically modified screen-printed carbon electrode coated with cellulose acetate and uricase. Analyst, 1994;119 (5):833-840.
31. Tsiafoulis CG, Prodromidis MI, Karayannis MI. Development of Amperometric Biosensors for the Determination of Glycolic Acid in Real Samples. Analytical Chemistry, 2002;74 (1):132-139.
32. Moccelini SK, Franzoi AC, Vieira IC, Dupont J, Scheeren CW. A novel support for laccase immobilization: cellulose acetate modified with ionic liquid and application in biosensor for methyldopa detection. Biosensors and Bioelectronics, 2011;26 (8):3549-3554.
33. Alpat Ş, Telefoncu A. Development of an alcohol dehydrogenase biosensor for ethanol determination with toluidine blue O covalently attached to a cellulose acetate modified electrode. Sensors, 2010;10 (1):748-764.
34. Tkáč J, Voštiar I, Gemeiner P, Šturdı́k E. Stabilization of ferrocene leakage by physical retention in a cellulose acetate membrane. The fructose biosensor. Bioelectrochemistry, 2002;55 (1):149-151.
35. Bendahan M, Lauque P, Lambert-Mauriat C, Carchano H, Seguin JL. Sputtered thin films of CuBr for ammonia microsensors: morphology, composition and ageing. Sensors and Actuators B: Chemical, 2002;84 (1):6-11.
36. Mader HS, Wolfbeis OS. Optical Ammonia Sensor Based on Upconverting Luminescent Nanoparticles. Analytical Chemistry, 2010;82 (12):5002-5004.
37. Jia Y, Yu H, Zhang Y, Dong F, Li Z. Cellulose acetate nanofibers coated layer-by-layer with polyethylenimine and graphene oxide on a quartz crystal microbalance for use as a highly sensitive ammonia sensor. Colloids and Surfaces B: Biointerfaces, 2016;148 (Supplement C):263-269.