Novel Semisolid Design Based on Bismuth Oxide (Bi2O3) nanoparticles for radiation protection

Document Type: Original Research Article


1 Industry Health Research Institute (IPIHRI), Occupational and Environmental Health Research Center (OEHRC), PIHO, Tehran, Iran

2 Department of Medical Nanotechnology, Islamic Azad University of pharmaceutical sciences (IAUPS), Tehran, Iran

3 Radiation Biology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran

4 Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran


Objective(S): The dangerous effects of X-ray have been elucidated by scientific studies in occupational health hygiene.  X-ray protective like an apron, thyroid shield and gloves have been made of lead (Pb) to protect against X-ray. However, such equipment makes a lot of safety and health problems such as toxicity, weight, inflexibility and troubles usage in a physician. To overcome such problems, X-ray absorbance’s such as semi-solids have been developed. Here in, an investigation was carried out to see whether the mixture of semi-solid material containing bismuth oxide nanoparticles.
Methods: The mixture of semi-solid containing bismuth oxide nanoparticles was prepared based on the synthesis of bismuth oxide nanoparticles and formulation of semisolid. The bismuth oxide nanoparticles were prepared via synthesis method intermediating sorbitol with optimized conditions. In X-ray dosimeter test, the protective effect of bismuth oxide nanoparticles in semisolid was evaluated in comparison to lead adsorbents when all conditions were similar (P<0.05).
Results: X-ray absorbance efficiency of bismuth nanoparticles dispersed in semisolids was more efficient than conventional lead absorbance. The percentage of X-ray absorption in the ointment of bismuth oxide nanoparticles is 56.79 while the absorption value in the 0.5-millimeter lead is between 40% and 42%.
Conclusions: The X-ray absorbent based on semi-solid containing bismuth oxide nanoparticles has many advantages in comparison to conventional lead absorbent such as; high surface area, low amount of sorbent, easy usage, high efficiency of X-ray absorbance, and lower toxic effect on the environment.

Graphical Abstract

Novel Semisolid Design Based on Bismuth Oxide (Bi2O3) nanoparticles for radiation protection


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