Original Research Article
1. Antioxidant, antibacterial, and antifungal properties of nanoemulsion of clove essential oil

Yasser Shahbazi

Volume 4, Issue 4 , Autumn 2019, Pages 204-208


  Objective(s): The application of synthetic antimicrobial and antifungal compounds is reducing in the last decades in the food and nutrition fields owing to their various side effects and increasing interest of consumers to eat natural foodstuffs without artificial constituents. Clove (Syzygium aromaticum) ...  Read More

Original Research Article
2. Cisplatin-loaded superparamagnetic nanoparticles modified with PCL-PEG copolymers as a treatment of A549 lung cancer cells

Sonia Fathi Karkan; Soodabeh Davaran; Abolfazl Akbarzadeh

Volume 4, Issue 4 , Autumn 2019, Pages 209-219


  Magnetic nanoparticles have been highly regarded because of their unique properties, such as hyperthermia, medicine control release, and diagnostic applications. The main aim of the current paper is to offer a new system for the modification of Fe3O4 (SPIONs) superparamagnetic nanoparticles physically ...  Read More

Original Research Article
3. Characterizing and controlling the loading of Vipera albicornuta venom in chitosan nanoparticles as an adjuvant and vaccine delivery system

Mohammad Hassan Shambayati; Mohsen Mehrabi; Nasser Mohammadpour Dounighi; Ali Ramazani; Abbas Zare Mirakabadi; Ebrahim Ahmadi

Volume 4, Issue 4 , Autumn 2019, Pages 220-227


  The aim of this study was designing and preparing the chitosan nanoparticles (CS-NPs) loading with snake (Vipera albicornuta) venom as well as evaluating the influence of different factors on the encapsulation efficiency (EE) and loading capacity (LC) of venom. The morphologies and characteristics of ...  Read More

Original Research Article
4. Acute toxicity investigation regarding clinical and pathological aspects following repeated oral administration of iron oxide nanoparticles in rats

Saba Talesh; Mohammad Koohi; Ehsan Zayerzadeh; Jalal Hasan; Meisam Shabanian

Volume 4, Issue 4 , Autumn 2019, Pages 228-233


  Iron oxide nanoparticles (IONPS) have potential different applications in nanomedicine. These new applications of IONPS have raised exposure risk of this nanomaterials to humans. Up to now, all aspects of IONPS toxicity are not fully clear following animal’s exposure with these novel compounds. ...  Read More

Original Research Article
5. Acaricidal activity of zinc oxide nanoparticles against Hyalomma spp. in vitro

Roghayeh Norouzi; Amin Ataei; Marzie Hejazy; Parisa Shahbazi

Volume 4, Issue 4 , Autumn 2019, Pages 234-238


  Objective(s): Hyalomma spp. is responsible for transmission of protozoan, bacterial, rickettsial and viral diseases in humans and animals. Recently, there was a wide number of promising attempts to evaluate and use of nanoparticles for the control of ticks. Methods: The aim of this study was to evaluate ...  Read More

Original Research Article
6. Exosome-loaded Paclitaxel: Preparation and toxicity evaluation on two glioblastoma cell lines

Soodeh Salarpour; Abbas Pardakhty; Meysam Ahmadi-Zeidabadi; Mostafa Pournamdari; Hamid Forootanfar; Marzie Esmaeeli; Sepehr Afsharipour

Volume 4, Issue 4 , Autumn 2019, Pages 239-246


  Objective(s): Exosomes are endogenous nanovesicles act as intercellular communication tools which have been considered to utilize as drug delivery systems. As transporting therapeutic molecules into brain has obstacles, preparing exosomes which have the potential to pass through its barriers is great ...  Read More

Original Research Article
7. Detection of lead ions using an electrochemical aptasensor

Mohsen Adabi

Volume 4, Issue 4 , Autumn 2019, Pages 247-252


  The aim of this research was to develop a simple, selective and sensitive aptasensor for detection of Pb2+ based on hairpin structure of complementary strand (CS) of aptamer (Apt). Screen printed carbon electrode (SPCE) was electrodeposited by gold nanoparticles to be used as the substrate for the immobilization ...  Read More

Original Research Article
8. Effects of anxiolytic doses of ZnO nanoparticle on ECG parameters in restraint and non-restraint ovariectomized female rats

Mahnaz Kesmati; Mozhgan Torabi; Nahid Pourreza; Mehrnaz Tayebkhah; Fereshteh Asadi

Volume 4, Issue 4 , Autumn 2019, Pages 253-260


  Objective(s): Based on our previous studies about nano-ZnO effects on physiological behaviors, in this study we have investigated the effects of anxiolytic doses of nano-ZnO on electrocardiogram (ECG) sings changes in the restraint and non-restraint ovariectomized (OVX) female rats. Methods: Animals ...  Read More