Lipid based nanoparticles for treatment of CNS diseases: review Article

Salar Masoomzadeh; Paria Aminroaia; Fateme Darchin Tabrizi; Sara Rashvand; Kobra Rostamizadeh

Volume 5, Issue 2 , April 2020, Pages 101-113


  Introduction: Central Nervous System (CNS) is one of the most important organs which is managing so many functions in human body. So, impairment of its function may results in several disorders in body, or CNS diseases, which are considered very important. CNS diseases are divided into many different ...  Read More

Original Research Article
Ratio of Drug/carrier as Dominant Factor in Determining Size of Doxorubicin-Loaded Beta-1,3- Glucan Nanoparticles: An Artificial Neural Networks Study

Zahra Nasrollahi; Samira Khani; Amir Amani

Volume 5, Issue 2 , April 2020, Pages 114-119


  Size of nanoparticles is an important parameter in determining many of their properties. In this work, nanoparticles of β-1,3-glucan containing doxorubicin (Dox) in conjugated and unconjugated forms (Con-Dox-Glu and Un-Dox-Glu, respectively) were prepared. Then, artificial neural networks (ANNs) ...  Read More

Original Research Article
Preparation, statistical optimization and in vitro characterization of solid lipid nanoparticles as a potential vehicle for transdermal delivery of tramadol hydrochloride as a hydrophilic Compound

Mina Abbasnia; Ali Reza Vatanara; Reza Mahjub

Volume 5, Issue 2 , April 2020, Pages 120-131


  As encapsulation of hydrophilic drugs in the solid lipid nanoparticles (SLNs) is still a challenging issue, the aim of this study was to prepare SLNs containing tramadol hydrochloride as a hydrophilic compound.The SLNs were prepared using glycerol monostearate (GMS), soy lecithin and tween 80 by double ...  Read More

Original Research Article
Fabrication and Characterization of Biosynthesized Silver Nanoparticles using Cymbopogon citratus and Evaluation of its Antioxidant, Free Radicals and Reducing Power Activity

Anand Keshari; Gaurav Pal; Samiksha Saxena; Ragini Srivastava; Vishal Srivashtav

Volume 5, Issue 2 , April 2020, Pages 132-142


  The study aims at synthesizing silver nanoparticles using leaf extract of Cymbopogon citratus along with the evaluation of its antioxidant, free radicals scavenging, and reducing power properties. Biosynthesized silver nanoparticles were characterized X-Ray diffractometry, Scanning Electron Microscopy, ...  Read More

Original Research Article
Nanohydroxyapatite and its polycaprolactone nanocomposite for lead sorbent from aqueous solution

Masomeh Odar; CNegar Motakef-Kazemi

Volume 5, Issue 2 , April 2020, Pages 143-151


  Objective(s): Lead is a very strong poison in the environment. Lead toxicity can be affected on the human body and caused disease. Therefore, the design of lead sorbent can be had the great help to the medical field. In this work, the nanohydroxyapatite (n-HA) was used for removal of lead from aqueous ...  Read More

Original Research Article
Au nanoparticles/g-C3N4 modified biosensor for electrochemical detection of gastric cancer miRNA based on hairpin locked nucleic acids probe

Mohammad Reza Mohammad Shafiee; Janan Parhizkar

Volume 5, Issue 2 , April 2020, Pages 152-159


  Objective: The annual incidence of cancer in the world is growing rapidly. The most important factor in the cure of cancers is their early diagnosis. miRNA, as a biomarker for early detection of cancer, has attracted a lot of attention. Methods: In this study, an electrochemical biosensor was developed ...  Read More

Original Research Article
Safety Evaluation of Nano Iron Zero Valente Green Synthesized: A Comparative Study

Shirin Tavakoli; Fatemeh Sameni; Mohammad Ali Ebrahimzadeh; Pourya Biparva; Hamidreza Mohammadi; Afshin Zahedi; Alireza Rafiei; Mostafa Kardan; Shahram Eslami

Volume 5, Issue 2 , April 2020, Pages 160-170


  Objective(s): Nowadays, examining the toxicity of nanoparticles including the synthesized and functionalized iron nanoparticles using methods like green synthesis is highly considered, due to their increasing usage in various fields of medicine, biology, industrial, and pollution removal. Hence, in this ...  Read More

Original Research Article
Green synthesis of multifunctional silver nanoparticles using quercetin and their therapeutic potential

Saeedeh Maghsoodloo; Mohammad Ali Ebrahimzadeh; Shirin Tavakoli; Hamidreza Mohammadi; Pourya Biparva; Alireza Rafiei; Mostafa Kardan; Mahsa Mohammadyan; Shahram Eslami

Volume 5, Issue 2 , April 2020, Pages 171-181


  Objective(s): Active species used in bio-chemical for synthesizing nanoparticles is poly phenolic compounds. The ability of flavonoids (e.g. quercetin) to dissolve in water is low and the production of metallic nanoparticles from them in the aqueous medium is hard. Previous studies recommend that quercetin ...  Read More

Original Research Article
Comparative Studies of High Contrast Fluorescence Imaging Efficiency of Silica-coated CdSe Quantum Dots with Green and Red Emission

Vibin Muthunayagam; Vinayakan R; Annie Abraham

Volume 5, Issue 2 , April 2020, Pages 182-191


  Herein we report the possibility of using green and red emitting silica-coated cadmium selenide (CdSe) quantum dots (QDs) for remarkable stem and cancer cellular imaging, efficient cellular uptake and fluorescence imaging of semi and ultra-thin sections of tumor for in vivo tumor targeted imaging applications. ...  Read More

Original Research Article
Promising antibacterial activity of a mat of polycaprolactone nanofibers impregnated with a green nanogel

Abbas Abdollahi; Elham Zarenezhad; Mahmoud Osanloo; Ghazal Ghaznavi; Marzieh Khalili pour

Volume 5, Issue 2 , April 2020, Pages 192-201


  Skin is the body's first defense line against environmental pathogens. However, open skin wounds can interfere with the normal function of the skin and the entry of opportunistic bacteria into the body. Recently, the development of nano-dressing containing green antibiotics has been received much attention ...  Read More