Original Research Article
Development and investigation of novel alginate-hyaluronic acid bone fillers using freeze drying technique for orthopedic field

Sepehr Jamnezhad; Azadeh Asefnejad; Mehdi Motififard; Hassan Yazdekhasti; Amin Kolooshani; Saeed Saber-Samandari; Amirsalar Khandan

Volume 5, Issue 4 , November 2020, Pages 306-315


  Cartilage tissue has a low cell population with a dense extracellular matrix (ECM) and is also devoid of neurons as well as blood and lymph vessels. Bone tissue is able to heal itself but in cases of serious damage and auxiliary treatment methods are necessary. Nevertheless, they have their own restrictions ...  Read More

Original Research Article
Design and development of plumbagin loaded poly (ε -caprolactone) nanoparticles for improved cytotoxicity

Harshad S Kapare; Sarika R Metkar; Satish V Shirolkar

Volume 5, Issue 4 , November 2020, Pages 316-323


  Poly (ε -caprolactone) nanoparticles were investigated as an injectable nanocarrier for the delivery of natural anticancer naphthoquinones plumbagin with the primary aim of improvement in its solubility, drug release profile and in vitro cytotoxicity. Plumbagin loaded polymeric nanoparticle system ...  Read More

Original Research Article
Caffeic Acid Phenethyl Ester Loaded Poly (ε -caprolactone) Nanoparticles for Improved Anticancer Efficacy: Formulation Development, Characterization and in Vitro Cytotoxicity Study

Harshad S Kapare; Sathiyanarayanan Lohidasan; Arulmozhi S; Kakasaheb R Mahadik

Volume 5, Issue 4 , November 2020, Pages 324-331


  Caffeic acid phenethyl ester (CAPE) is a active constituent of propolis and well known for its anticancer potential. The therapeutic efficacy of CAPE is limited with its poor water solubility and low bioavailability. In present study CAPE loaded Poly (ε-caprolactone) nanoparticles formulation ...  Read More

Original Research Article
The silver nanoparticles induce c-Fos expression in the central nucleus of amygdala that relief the aversive effect of naloxone in the morphine relied animal

Mahnaz Rahimpour; Manizheh Karami; Ali Haeri Rohani

Volume 5, Issue 4 , November 2020, Pages 332-338


  AbstractBackground: Silver nanoparticles (Ag-NPs) that are used daily in care service can enter the body and create free radicals. Despite the toxicity at high concentrations, these particles are non-toxic and useful at low concentrations. Thus, we investigated the effectiveness of nontoxic Ag-NPs to ...  Read More

Original Research Article
Synthesis of silver nanoparticles using Salvia officinalis extract: Structural characterization, cytotoxicity, antileishmanial and antimicrobial activity

Fatemeh Sharifi; Fariba Sharififar; Sara Soltanian; Mohsen Doostmohammadi; Neda Mohamadi

Volume 5, Issue 4 , November 2020, Pages 339-346


  Objective: This study aimed to investigate the cytotoxicity, antileishmanial and antibacterial potential of silver nanoparticles (AgNPs) synthesized by (Salvia officinalis L. (Sage)) extract. Methods: The green synthesized nanoparticles were analyzed by using UV–vis spectroscopy, FTIR, and FESEM ...  Read More

Original Research Article
Preparation and characterization of O/W nanoemulsion with eucalyptus essential oil and study of in vitro antibacterial activity

Arun Dev Sharma; Mohit d Farmaha; Inderjeet d Kaur

Volume 5, Issue 4 , November 2020, Pages 347-354


  Objective(s): Eucalyptus oil is a typical essential oil used in pharmaceutical, food, cosmetic and drug industries having antimicrobial and antioxidant activities. Eucalyptus oil is highly unsteady and hydrophobic under normal conditions, so easily lose its bactericidal activity. To protect this bioactive ...  Read More

Original Research Article
Excess iron ion reduction in a thalassemia model using silver nanoparticles modified by the tannin fraction of Myrtus communis extact

Shirin Tavakoli; Mohammad Ali Ebrahimzadeh; Fatemeh Sameni; Pourya Biparva; Hamidreza Mohammadi; Ali Ziar; Afshin Zahedi Mazandarani; Soheil Vafaeinejad; Shahram Eslami

Volume 5, Issue 4 , November 2020, Pages 355-363


  Objective(s): Nowadays, iron ions intoxication is the center of attention of interest in the management and treatment of thalassemia and different sorts of anemia associated with regular blood transfusions. Due to the major side effects of current drugs, they should be replaced with safer alternatives. ...  Read More

Original Research Article
The Investigation of the Cytotoxicity of Copper Oxide Nanoparticles on Peripheral Blood Mononuclear Cells

Maryam Zivari fard; Marjan Fatholahi; Morteza Abyadeh; Azam Bakhtiarian; Seyyedeh Elaheh Mousavi; Mojtaba Falahati

Volume 5, Issue 4 , November 2020, Pages 364-368


  Copper (II) oxide nanoparticle (CuO-NP) is extensively used in wide variety of industrial and biomedical applications. Reduced size of Copper oxide (CuO) particles from micron to nano scale caused superior physical characteristics on one side while making them cytotoxic on other side. Therefore there ...  Read More

Original Research Article
Bio efficacy, and photocatalytic activity of the silver nanoparticles synthesized from Cryptolepis buchanani leaf extract

Sudipta Panja; Anutosh Patra; Kalyani Khanra; Indranil Choudhuri; Bikash Ranjan Pati; Nandan Bhattacharyya

Volume 5, Issue 4 , November 2020, Pages 369-377


  The objective of the study is to synthesis silver nanoparticles from the leaf extract of Cryptolepis buchanani, a medically important plant,by green synthesis method. The synthesized nanoparticles have an average size of 17.05±5.27 nm, crystalline in nature with face cantered cubic structure, ...  Read More

Original Research Article
Effect of processing variables on the performance of electrochemical aptasensor for determination of aflatoxin M1

Hamid Reza Rahmani; Mohsen Adabi; Kamran Pooshang Bagheri; Giti Karim

Volume 5, Issue 4 , November 2020, Pages 378-382


  A novel aptasensor based on electrospun carbon nanofiber (ECNF) mat modified with gold naoparticles (AuNPs) and aptamer was developed to detect aflatoxin M1 (AFM1) in the milk. The electrospinning and heat treatment technique were firstly used to construct the ECNF mat electrode. Then, this platform ...  Read More