TY - JOUR ID - 244773 TI - In vitro release kinetics study of Diallyl Disulphide entrapped into mesoporous silica matrix & evaluation of its antimicrobial activity JO - Nanomedicine Research Journal JA - NMRJ LA - en SN - 2476-3489 AU - Pal, Pritha AU - Dey, Rajib AU - Das, Satadal AU - Chaudhuri, Mahua Ghosh AD - School of Materials Science & Nanotechnology, Jadavpur University, Kolkata-32, India. AD - Metallurgical & Material Engg. Dept. Jadavpur University, Kolkata-32, India AD - Senior Consultant Microbiologist, Peerless Hospital & B. K. Roy Research Centre, Kolkata, India. Y1 - 2021 PY - 2021 VL - 6 IS - 2 SP - 148 EP - 157 KW - Diallyl Disulphide KW - Mesoporous silica nanoparticles KW - Sustained-release KW - kinetic modeling KW - MIC DO - 10.22034/nmrj.2021.02.006 N2 - Diallyl disulphide (DADS) is one of the major constituents of garlic which has antimicrobial activity as well as many other advantages for human health. Sulphur present in DADS is main the reactive one to deal with the microbes. Mesoporous silica nanomaterial (MSNs) is evaluated as a potential drug carrier for any organic drug molecule to keep it intact for in vitro sustained release. Comparing two different body fluids, the dissolution rate of DADS is more in SBF than SGF because of its acidic nature. In two mediums the release mechanism is super case II transport as in both cases the ā€˜nā€™ value of Koresmeyer Peppas model is greater than 0.89. MIC value of DADS against Salmonella typhi is 0.941 mg/ml. Besides this microscopic analysis confirm the deformation of microbial cells. This means MSN's entrapped with DADS and subsequently released in pH 7.4 is much more concerned with the high amount of drug availability in body fluids. UR - https://www.nanomedicine-rj.com/article_244773.html L1 - https://www.nanomedicine-rj.com/article_244773_9f6ec1a2523767e23fec74fdcb1d0794.pdf ER -