TY - JOUR ID - 33842 TI - Production of Wound Dressing with Nano Fibers contain Bassorin/Ofloxacin for Improvement Burn Wound JO - Nanomedicine Research Journal JA - NMRJ LA - en SN - 2476-3489 AU - Nayeb morad, Farnaz AU - Rashidi, Abosaeed AU - Khajavi, Ramin AU - Rahimi, Mohammad karim AU - Bahador, Abbas AD - Department of Textile Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran AD - Department of Textile Engineering, Tehran South Branch, Islamic Azad University, Tehran, Iran AD - Medical Science, Tehran North Branch, Islamic Azad University, Tehran, Iran AD - Microbiology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Y1 - 2018 PY - 2018 VL - 3 IS - 4 SP - 180 EP - 189 KW - Electrospinning KW - Gum Traghacanth KW - Bassorin KW - Poly Ethylene Oxide KW - Nanofibers KW - Antibacterial KW - Burn wound DO - 10.22034/nmrj.2018.04.002 N2 - Gum Tragacanth (GT) obtained from Astragalus Gossypinus is one of the most widely used natural gums which has found applications in many areas because of its attractive features such as biodegradability, nontoxic nature, natural availability, moisture absorption and creating a network of Hydrocolloid. It also has maintenance and delivery of drugs, higher resistance to microbial attacks and long shelf-life properties.In present study, preparation nanofibers of 50 wt% Bassorin (extracted from Gum Tragacanth) has been mixed by 50 wt% Poly Ethylene Oxide and 0.01 wt% Ofloxacin (Ba/PEO/Ofx) for Electrospinning. Nanofibers coated on cotton gauze. The properties of Bassorin and produced nanofibers were examined via XRD, FTIR and SEM microscopy. The Antibacterial of nanofibers activity against Staphylococcus aureus as gram positive bacteria and Escherichia coli as a gram-negative bacteria also were investigated. Nanofibers are capable of absorbing wound’s exocrine liquid easily due to their high specific area of nanofibers which 4 to 5% more than cotton gauzes without nanofibers. When it is turned to gel by moisture sorption, the release of loaded Ofloxacin would be enhanced. The Antibacterial assay showed the cotton gauze coated with Ba/PEO/Ofx nanofibers could inhibit about 90% growth both bacterial strain on burn wound. Also, the therapeutic effect of nano-bassorin in restoring superficial second-degree burns in rats showed an accelerated effect on wound healing.Based on the results of this study, it is possible to use cotton gauzes coated with bassorin nanofibers as a suitable candidate for the treatment of second-degree superficial burns. UR - https://www.nanomedicine-rj.com/article_33842.html L1 - https://www.nanomedicine-rj.com/article_33842_57a8dc14019951f74747ca628be2d0b5.pdf ER -