TY - JOUR ID - 40568 TI - Green synthesis of multifunctional silver nanoparticles using quercetin and their therapeutic potential JO - Nanomedicine Research Journal JA - NMRJ LA - en SN - 2476-3489 AU - Maghsoodloo, Saeedeh AU - Ebrahimzadeh, Mohammad Ali AU - Tavakoli, Shirin AU - Mohammadi, Hamidreza AU - Biparva, Pourya AU - Rafiei, Alireza AU - Kardan, Mostafa AU - Mohammadyan, Mahsa AU - Eslami, Shahram AD - Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran AD - Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran AD - Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran AD - Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran AD - Department of Basic Sciences, Sari University of Agricultural Sciences and Natural Resources, Sari, Iran AD - Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran AD - Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Y1 - 2020 PY - 2020 VL - 5 IS - 2 SP - 171 EP - 181 KW - Quercetin KW - Green synthesis KW - Silver Nanoparticle KW - Antioxidant KW - Anticancer KW - Antifungal DO - 10.22034/nmrj.2020.02.008 N2 - Objective(s): Active species used in bio-chemical for synthesizing nanoparticles is poly phenolic compounds. The ability of flavonoids (e.g. quercetin) to dissolve in water is low and the production of metallic nanoparticles from them in the aqueous medium is hard. Previous studies recommend that quercetin was not capable of reducing Ag+ to Ag0. The current research aimed at synthesizing quercetin-mediated silver nanoparticles (Q-AgNPs) and evaluate the antioxidant and anticancer activities of Q-AgNPs in vitro. Methods: The green synthesis of Q-AgNPs in an aqueous medium has been demonstrated. The resultant nanoparticles were characterized by several analytical techniques of imaging and spectroscopic. The improved antioxidant activity of Q-AgNPs (DPPH and nitric oxide scavenging and iron chelating assay) was determined by the colorimetric method. Possible biomedical applications such as antioxidant and anticancer activities of Q-AgNPs have been assessed. Results: The DPPH and nitric oxide radical scavenging activity of Q-AgNPs was found to be (IC50=46.47±1.79 and 30.64±3.18μg/mL, respectively). Q-AgNPs exhibited better iron chelating activity than standard EDTA (IC50=3.12 ±0.44μg/mL). Significant anticancer activity of Q-AgNPs (IC50=57.42μg/mL) was found against HepG2 cell lines after 24-hour exposure. Furthermore, the antifungal activity (MIC = 4, 8 and > 64 μg/mL) was found against Candida krusei, Candida parapsilosis and Aspergillus fumigatus, respectively. Conclusions: The present method is a competitive option to produce multifunctional nanoscale hybrid materials with higher efficiency and using natural sources for diverse biomedical applications such as antioxidant and anticancer activities. UR - https://www.nanomedicine-rj.com/article_40568.html L1 - https://www.nanomedicine-rj.com/article_40568_8c3eb5cc988a5a98296c16d93e748ad1.pdf ER -