Tehran University of Medical Sciences Nanomedicine Research Journal 2476-3489 10 2 2025 06 01 Nanorobots and Smart Nanodevices with Artificial Intelligence for Precision Orthodontic Surgery and Treatment Monitoring 148 155 730580 10.22034/nmrj.2025.02.005 EN Mahsa Kazemi Deparment of Prosthodontics, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran Mina Abasi School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Faezeh Salehabadi Department of Prosthodontics, Kerman University of Medical Sciences, Kerman, Iran Atieh Nouralishahi Department of Community Medicine, Health Information and Decision-Making, Faculty of Medicine, University of Porto, Portugal Mohammad Davoudi Department of Oral and Maxillofacial Pathology, Mashhad Dental School, Mashhad University of Medical Sciences, Mashhad, Iran Parsa Farzan Faculty of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran Sajjad Rostamzadeh Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran Journal Article 2025 09 08 The convergence of nanorobotics, smart nanodevices, and artificial intelligence (AI) heralds a new era in precision orthodontic surgery and treatment monitoring. Nanorobots, operating at the cellular level, enable minimally invasive, highly accurate interventions such as targeted drug delivery, tooth repair, and orthodontic adjustments, significantly reducing patient discomfort and recovery time. The integration of AI enhances these capabilities by enabling real-time data analysis, predictive treatment planning, and continuous monitoring, which not only optimizes clinical outcomes but also improves operational efficiency and patient engagement. Smart nanodevices embedded with advanced sensors facilitate precise measurement of orthodontic forces and remote data transmission, supporting personalized treatment adjustments and remote patient monitoring. Despite challenges in fabrication, biocompatibility, regulatory approval, and ethical concerns such as data privacy, ongoing advancements suggest a transformative potential for these technologies in orthodontics. This review explores the current state, applications, challenges, and future directions of AI-integrated nanorobotics and smart nanodevices in orthodontic practice, highlighting their promise for revolutionizing patient care through precision, personalization, and enhanced treatment efficacy. https://www.nanomedicine-rj.com/article_730580_59a0eda2796dc7dfd1b2282062d99927.pdf