Tehran University of Medical Sciences Nanomedicine Research Journal 2476-3489 11 1 2026 03 01 Periodontal, Implant, and Oral Medicine: Nanoscale Innovations in Radiology and Imaging 11 18 737690 10.22034/nmrj.2026.01.002 EN Negin Neshanifard Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran Shayan Ghobadian Department of Dentistry, Faculty of Dentistry, Istanbul Okan University, Istanbul, Turkey Mohammad Gerayeli Lux Smile Dental Clinic, Mashhad, Iran Afsoon Jalali Ara Department of Oral and Maxillofacial Radiology, Dental School, Islamic Azad University of Medical Sciences, Tehran, Iran Bahareh Purtaji Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran Maryam Rahmani Faculty of Dentistry, Bushehr University of Medical Sciences, Bushehr, Iran Ghazal Soleimani Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Journal Article 2026 01 03 Nanoscale innovations are transforming radiology and imaging in periodontal, implant, and oral medicine by enabling earlier, more precise, and personalized diagnosis. This review summarizes key nanoscale contrast agents, including silica nanoparticles, carbon nanotubes, gadolinium-based nanostructures, quantum dots, and gold nanoparticles, and their roles in enhancing MRI, CT, CBCT, OCT, and nano-CT imaging performance. Applications in periodontal diagnostics, implantology, and oral medicine are highlighted, such as nano-probes for biofilm and inflammatory marker detection, nano-engineered implant surfaces, and nano-enabled strategies for oral cancer and mucosal lesions. The review also outlines how integration with artificial intelligence, including deep learning-based image analysis and emerging Nano-AI theranostic platforms, can further improve diagnostic accuracy and treatment planning while emphasizing current challenges related to safety, regulation, cost, and ethical considerations. https://www.nanomedicine-rj.com/article_737690_a8f881629e1fd415b309cc93822ed9e9.pdf