Tehran University of Medical Sciences Nanomedicine Research Journal 2476-3489 11 2 2026 06 01 Nanomedicine Enabled Prosthodontic Rehabilitation: Synergistic Roles of Dental Implants and Periodontal Surgery in Oral Tissue Engineering. 125 132 741340 10.22034/nmrj.2026.02.002 EN Zarafshan Jafari Department of Periodontics, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran Hamed Tabatabaei Department of Prosthodontics, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran Narges Damanpak Department of Orthodontics, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Mohammad Hossein Jabbedari Department of Physical Medicine and Rehabilitation, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Mohammadreza Namazikhah Private Practice, Dentist, Lux Smile Dental Clinic, Mashhad, Iran Amirreza Pourseyedi Department of Periodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Reza Ghanaatian Jobzari Department of Oral and Maxillofacial Surgery, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Journal Article 2026 02 22 Prosthodontic rehabilitation aims to restore oral function and aesthetics; however, long-term clinical success is often compromised by inadequate biomaterial integration, mechanical limitations of conventional prostheses, and the complex regenerative demands of oral tissues. Recent advances in nanomedicine and tissue engineering offer transformative strategies to overcome these challenges by enhancing biomaterial performance, promoting targeted therapeutic delivery, and facilitating biologically driven tissue regeneration. This review explores the synergistic integration of nanotechnology with dental implants and periodontal surgical strategies in the context of oral tissue engineering. Key developments in nano-engineered implant surfaces, bioactive and antibacterial coatings, nanostructured scaffolds, and controlled drug-delivery systems are discussed with emphasis on their roles in improving osseointegration, soft-tissue attachment, and periodontal regeneration. The review also highlights the incorporation of stem cells and growth-factor delivery through nanomaterials to mimic the native oral microenvironment and accelerate healing processes. In addition, current translational barriers including nanomaterial toxicity, manufacturing complexity, regulatory uncertainty, and variability in clinical outcomes are critically evaluated. By synthesizing recent biological, engineering, and clinical evidence, this review underscores the potential of nanomedicine-enabled prosthodontic rehabilitation to shift restorative dentistry toward precision-based, regenerative therapies. Continued interdisciplinary collaboration and standardized safety frameworks are essential to advance these technologies from experimental models to routine clinical practice and to realize their full potential in improving patient outcomes. https://www.nanomedicine-rj.com/article_741340_dddd7e318cd9733b55455ff468913d8d.pdf