Nanomedicine Research Journal (Abbreviation: Nanomed Res J)

is an international, open access, peer-reviewed, electronic and print quarterly publication released by the Iranian Society of Nanomedicine (ISNM). Nanomedicine Research Journal publishes original research articles, review papers, mini review papers, case reports and short communications covering a wide range of field-specific and interdisciplinary theoretical and experimental results related to applications of nanoscience and nanotechnology in medicine including, but not limited to, diagnosis, treatment, monitoring, prediction and prevention of diseases, tissue engineering, nano bio-sensors, functionalized carriers and targeted drug delivery systems.

* Publication process of manuscripts submitted to Nanomed Res J is free of charge.

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About the publisher

Founded in 2011 by the leading of School of Advanced Technologies in medicine (SATiM), Tehran University of Medical Sciences (TUMS) and Iran Nanotechnology Initiative Council, the Iranian Society of Nanomedicine (ISNM) attempts to promote and develop medical nanotechnology in Iran. For more information about the publisher, please visit us at


Review Paper
Therapeutic utility of nanomaterial in oral and maxillofacial tissue regeneration

Hamed Mahmoudi

Volume 7, Issue 4 , October 2022, Pages 312-319

  Oral and craniomaxillofacial diseases contain conditions affecting both the soft and hard tissues of face and also dentalarches. Exploiting the bioactive nanomaterials (NMs) in clinical utility has been extensively evolved. The NMs offer incredible progress in the averting and cure of oral and maxillofacial ...  Read More

Original Research Article
A new theranostic complex based on bismuth-iron oxide nanoparticle for myocardial ischemia: in vitro study

Mohammad Reza Kordani; Fatemeh Hataminia; Fateme Karimi; Negar Motakef Kazemi; Hossien Ghanbari

Volume 7, Issue 4 , October 2022, Pages 320-329

  Objective(s): Magnetic nanoparticles of bismuth oxide and iron oxide (BOIO NPs) are extensively used for more accurate medical diagnosis in MRI and CT imaging due to their improved X-ray absorbance and magnetic properties. The nanoparticles (NPs) utilized in the diagnosis of damaged tissue can also be ...  Read More

Original Research Article
Potential use of Nanostructured Lipid Carriers mediated neuronal delivery of Carbamazepine

Salar Masoomzadeh; Somayeh Sadighian; Tooba Gholikhani; Kobra Rostamizadeh

Volume 7, Issue 4 , October 2022, Pages 330-337

  Carbamazepine (CZB) as a medication for epilepsy and anxiety therapy, presenting a complex pharmacokinetic profile and severe side effects. Therefore, the development of strategies that significantly decrease the side effects and frequency of administration, together with a simple administration, is ...  Read More

Original Research Article drug delivery
Structural and morphological investigation of polycaprolactone multi-component scaffold containing collagen microsphere/bioglass nanoparticles

Hamed Sahrapeyma; Azadeh Asefnejad; Mahmoud Azami; Esmaeil Sadroddiny

Volume 7, Issue 4 , October 2022, Pages 338-349

  Bioglass nano-ceramic containing cerium (Ce) with various amounts of Ce were synthesized by sol-gel method for enhanacement polycaprolactone (PCL) fiber scaffolds for tissue engineering approaches. The prepared scaffold was analysize using scanning electron microscopy (SEM) and X-ray diffraction (XRD) ...  Read More

Original Research Article
Investigation of mechanical stability of lithium disilicate ceramic reinforced with titanium nanoparticles

Aida Rajaei; Mehrdad Kazemian; Amirsalar Khandan

Volume 7, Issue 4 , October 2022, Pages 350-359

  The use of lithium disilicate (LD) glass-ceramic in dentistry is increasing due to its proper mechanical properties and aesthetic appearance. On the other hand, due to the forces acting on dental restorations, materials with mechanical properties as well as suitable tooth color are very important. Titanium ...  Read More

Original Research Article
Preparation of titania-hydroxyapatite composite nanoparticles as a potential drug carrier for ibuprofen

Fateme Ghourchian; Leila Torkian; Negar Motakef Kazemi

Volume 7, Issue 4 , October 2022, Pages 360-369

  Objective(s): Hydroxyapatite (HAP) is a natural calcium apatite mineral. Hydroxyapatite has many applications in the field of biomedicine and drug delivery systems. Titanium dioxide (TiO2) is becoming increasingly important because of its potential use in new medical treatments. In this study, titania-hydroxyapatite ...  Read More

Original Research Article
Cytotoxic study of green synthesized pure and Ag-doped α-Fe2O3 nanoparticles on breast cancer (MCF-7) cell line

Amir Abbas Esmaeilzadeh; Soheil Rasoolzadegan; Ali Reza Arabi; Dadkhoda Soofi; Seyed Saied Rajaei Ramsheh; Wasan Saad Ahmed; Raziyeh Moaref Pour

Volume 7, Issue 4 , October 2022, Pages 370-377

  In this research attempted to prepare hematite (α-Fe2O3) and silver doped hematite nanoparticles (Ag-doped α-Fe2O3 NPs) by using the aqueous extract of Prosopis farcta fruit. The synthesized NPs were identified through the results of X-ray Diffraction (XRD), Field Energy Scanning Electron ...  Read More

Original Research Article
Mesenchymal stem cell -derived exosomes as natural nanoparticles (NPs) stimulate the growth of limbal stem cells (LSCs) by regulating Wnt/β-catenin, p38 MPAK and ERK pathway

Amin Samiei; Parsa Aliabadi; Mohsen Parandavar; Mohammad Shirvani; Mohamad Saeid Hoseinzade Firozabdi; Navid Fazlinejad

Volume 7, Issue 4 , October 2022, Pages 378-384

  Objective(s): In the current study, we investigated the impacts of the mesenchymal stem cell (MSCs)- exosome on limbal stem cells (LSCs) proliferation.Methods: Exosomes firstly were isolated from the human MSCs. Then, they characterized by expression of CD9, CD63 and CD81using the western blotting and ...  Read More

Original Research Article
T lymphocyte cell-derived nano-size exosome impedes the proliferation and induces apoptosis of breast cancer MDA-MB231 cells by negative regulation of microRNA27

Nafiseh Javadi

Volume 7, Issue 4 , October 2022, Pages 385-390

  Objective(s): To study the anti-cancer effects of the human immune T lymphocyte cell derived exosomes on breast cancer MDA-MB-231 cells in vitro.Methods: The exosome was isolated from human T cells and then characterized by western blotting respecting the expression of CD9, 63 and 81 and also morphological ...  Read More

Original Research Article
Study of antibacterial performance of synthesized silver nanoparticles on Streptococcus mutans bacteria

Mina Saliminasab; Hadi Jabbari; Hanieh Farahmand; Meysam Asadi; Milad Soleimani; Amirhossein Fathi

Volume 7, Issue 4 , October 2022, Pages 391-396

  Green Synthesis is a method for synthesizing nanoparticles using protein, carbohydrates, plant extracts, and similar structures, which has made it a simple, cost-effective, environmentally friendly, and repeatable method compared to chemical methods. This study was conducted to investigate the antibacterial ...  Read More

drug delivery
Cancer stem cells (CSCs): the blockage of metastatic and stemness properties by metal nanoparticles

Samin Shokravi; Farnoosh Ebrahimzadeh; Farnoosh Farahbod; Aref Nooraei

Volume 6, Issue 4 , November 2021, , Pages 304-326

  Cancer stem cells (CSCs) are comprised of hierarchically-organized subpopulations of cells with  distinguished phenotypes and tumorigenic capabilities that concrete to metastasis and cancer recurrence. According to related studies, their presence stands as the main reason of cancer associated fatalities. ...  Read More

Green synthesis and characterization of zinc oxide nanoparticles using Berberis tinctoria Lesch. leaves and fruits extract of multi-biological applications.

Vignesh Arumugam; Selvakumar Subramaniam; Vasanth Krishnan

Volume 6, Issue 2 , April 2021, , Pages 128-147

  Abstract: The green synthesis of B. tinctoria zinc oxide nanoparticles (ZnO NPs) was rendered by using leaves and fruits extract. These extracts acted as a capping and reducing agent in stabilizing the formation of ZnO NPs. The obtained NPs were characterized by using absorption spectroscopy analysis ...  Read More

Green Synthesis of Stable Silver Nanoparticles Using Teucrium polium Extract: In-vitro Anticancer Activity on NALM-6

Seyed Mohammad Amini; Maryam Samareh Salavati Pour; Reza Vahidi; Seyedeh Mehrnaz Kouhbananinejad; Mahla Sattarzadeh Bardsiri; Alireza Farsinejad; Mohamad Javad Mirzaei-Parsa

Volume 6, Issue 2 , April 2021, , Pages 170-178

  Abstract: The therapeutic effect of silver nanoparticles on leukaemia cancerous cells has been demonstrated in several studies. However, most of these nanoparticles are toxic to normal cells as well as cancerous cells. In the present study, green chemistry has been applied for the synthesis of silver ...  Read More

An overview of antimicrobial efficacy of curcumin-silver nanoparticles

Elham Mohammadi; Seyed Meysam Amini; Seyed Hossein Mostafavi; Seyed Mohammad Amini

Volume 6, Issue 2 , April 2021, , Pages 105-111

  With emerging drug resistance microorganism, the search for a new biocidal agent has begun. The silver nanoparticle is a synthetic material with potent antimicrobial activity that applies to a diverse library of microorganisms. But toxicity and safety concerns of chemically prepared silver nanoparticles ...  Read More

Antibacterial Properties of Silver Nanoparticle (AgNPs) on Stainless Steel 316L

Aminatun - -; Ilham Alif Furqon; Dyah Hikmawati; Che Azurahanim Che Abdullah

Volume 6, Issue 2 , April 2021, , Pages 117-127

  Objective(s) : The probability of contracting an infection when implanting an Stainless Steel 316L (SS316L) implant has been increasing. Infection due to implant placement is called osteomyelitis which is bone inflammation caused by biofilms formed by pyogenic bacteria. Biofilms can be prevented by giving ...  Read More