In Vivo Study of New Oral Docetaxel -Loaded Nanomicelles

Atefeh Hekmat; Hossein Attar; Ali Akbar Seifkordi; Maryam Iman; Mahmoud Reza Jaafari

Volume 6, Issue 1 , January 2021, , Pages 79-88

  Poor solubility, low bio-stability, and the high toxicity of docetaxel medicine result in limited consumption, common side effects, and low efficacy. The current commercial form of the product, Taxotere®, with intravenous administration caused hypersensitivity due to hemolysis by separating hemoglobin ...  Read More

Cytotoxic effects investigation of nanomicelle and free curcuminoids against cancer and normal cells

Elham Zendedel; Fatemeh Gheybi; Jamshidkhan Chamani; Mahmoud Reza Jaafari

Volume 4, Issue 2 , April 2019, , Pages 63-68

  Abstract Curcumin, which is derived from the turmeric rhizomes (curcuma longa) as a natural polyphenol, is a substantially lipophilic molecule. This commonly used substance is employed as a spice and coloring agent in food and contains potent antioxidant, as well as anti-inflammatory, and anti-proliferative ...  Read More

On the Benefit of Nanocurcumin on Aluminium Phosphide-induced Cardiotoxicity in a Rat Model

Nahid Fakhraei; Reza Hashemibakhsh; Seyed Mahdi Rezayat; Amir Hossein Abdolghafari; Mahmoud Reza Jaafari; Faiza Mumtaz; Seyedeh Ellaheh Mousavi

Volume 4, Issue 2 , April 2019, , Pages 111-121

  Objectives: Cardiotoxicity is considered the primary cause of death in aluminum phosphide (ALP)-poisoned cases. Curcumin, the active ingredient of turmeric, is a potent protective polyphenol compound against cardiac diseases including cardiotoxicity. This study aimed to examine the probable cardioprotection ...  Read More

Chemotherapeutic activity of Silymarin combined with doxorubicin liposomes in 4T1 breast cancer cells

Fatemeh Gheybi; Seyedeh Hoda Alavizadeh; Seyed Mahdi Rezayat; Elham Zendedel; Mahmoud Jaafari

Volume 4, Issue 1 , February 2019, , Pages 29-34

  Cancer is the second leading cause of death worldwide. Despite great efforts over many years, today cancer treatment is not very effective. The main reasons for cancer chemotherapy failure are high cytotoxicity, low response rates in solid tumors, and development of resistance. Different experimental ...  Read More