Mina Saliminasab; Hadi Jabbari; Hanieh Farahmand; Meysam Asadi; Milad Soleimani; Amirhossein Fathi
Abstract
Green Synthesis is a method for synthesizing nanoparticles using protein, carbohydrates, plant extracts, and similar structures, which has made it a simple, cost-effective, environmentally friendly, and repeatable method compared to chemical methods. This study was conducted to investigate the antibacterial ...
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Green Synthesis is a method for synthesizing nanoparticles using protein, carbohydrates, plant extracts, and similar structures, which has made it a simple, cost-effective, environmentally friendly, and repeatable method compared to chemical methods. This study was conducted to investigate the antibacterial effect of silver nanoparticles (Ag-NP), synthesized by the extract fruit of Prosopis fracta, on Streptococcus mutans bacteria as the cause of tooth decay. The synthesized nanoparticles were identified through the UV-Vis spectrophotometer, transmission electron microscope (TEM), and powder X-ray diffraction (PXRD) methods, while their antibacterial effect was evaluated by the usage of microbroth dilution test. UV-Vis spectroscopic analysis displayed the presence of a peak in the range of 425-445 nm and indicated the successful synthesis of nanoparticles in the extract. Meanwhile, the average size of our product was determined by the TEM image to be about 30 nm. According to the investigation results, the synthesized nanoparticles exhibited satisfying antibacterial effects against the studied bacteria.
drug delivery
Pritha Pal; Rajib Dey; Satadal Das; Mahua Ghosh Chaudhuri
Abstract
Diallyl disulphide (DADS) is one of the major constituents of garlic which has antimicrobial activity as well as many other advantages for human health. Sulphur present in DADS is main the reactive one to deal with the microbes. Mesoporous silica nanomaterial (MSNs) is evaluated as a potential drug carrier ...
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Diallyl disulphide (DADS) is one of the major constituents of garlic which has antimicrobial activity as well as many other advantages for human health. Sulphur present in DADS is main the reactive one to deal with the microbes. Mesoporous silica nanomaterial (MSNs) is evaluated as a potential drug carrier for any organic drug molecule to keep it intact for in vitro sustained release. Comparing two different body fluids, the dissolution rate of DADS is more in SBF than SGF because of its acidic nature. In two mediums the release mechanism is super case II transport as in both cases the ‘n’ value of Koresmeyer Peppas model is greater than 0.89. MIC value of DADS against Salmonella typhi is 0.941 mg/ml. Besides this microscopic analysis confirm the deformation of microbial cells. This means MSN's entrapped with DADS and subsequently released in pH 7.4 is much more concerned with the high amount of drug availability in body fluids.
