drug delivery
Pritha Pal; Rajib Dey; Satadal Das; Mahua Ghosh Chaudhuri
Abstract
Diallyl disulphide (DADS) is one of the major constituents of garlic which has antimicrobial activity as well as many other advantages for human health. Sulphur present in DADS is main the reactive one to deal with the microbes. Mesoporous silica nanomaterial (MSNs) is evaluated as a potential drug carrier ...
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Diallyl disulphide (DADS) is one of the major constituents of garlic which has antimicrobial activity as well as many other advantages for human health. Sulphur present in DADS is main the reactive one to deal with the microbes. Mesoporous silica nanomaterial (MSNs) is evaluated as a potential drug carrier for any organic drug molecule to keep it intact for in vitro sustained release. Comparing two different body fluids, the dissolution rate of DADS is more in SBF than SGF because of its acidic nature. In two mediums the release mechanism is super case II transport as in both cases the ‘n’ value of Koresmeyer Peppas model is greater than 0.89. MIC value of DADS against Salmonella typhi is 0.941 mg/ml. Besides this microscopic analysis confirm the deformation of microbial cells. This means MSN's entrapped with DADS and subsequently released in pH 7.4 is much more concerned with the high amount of drug availability in body fluids.
