drug delivery
Cancer stem cells (CSCs): the blockage of metastatic and stemness properties by metal nanoparticles

Samin Shokravi; Farnoosh Ebrahimzadeh; Farnoosh Farahbod; Aref Nooraei

Volume 6, Issue 4 , November 2021, , Pages 304-326

http://dx.doi.org/10.22034/nmrj.2021.04.001

Abstract
  Cancer stem cells (CSCs) are comprised of hierarchically-organized subpopulations of cells with  distinguished phenotypes and tumorigenic capabilities that concrete to metastasis and cancer recurrence. According to related studies, their presence stands as the main reason of cancer associated fatalities. ...  Read More

Design, fabrication, and characterization of sesamol loaded polymeric nanoparticles: In vivo hepatoprotective potential in Wistar rats

Vipul A Sansare; Manish Kumar Gupta; Birendra Shrivastava; Santosh Jadhav

Volume 6, Issue 3 , September 2021, , Pages 296-303

http://dx.doi.org/10.22034/nmrj.2021.03.010

Abstract
  Objective(s): Liver diseases affect millions of people worldwide, which are difficult to treat with conventional drug delivery. Numerous drugs have been investigated for treatment of diseases associated with liver however correct drug delivery system need to be find for delivery of drugs. Sesamol is ...  Read More

Design and development of plumbagin loaded poly (ε -caprolactone) nanoparticles for improved cytotoxicity

Harshad S Kapare; Sarika R Metkar; Satish V Shirolkar

Volume 5, Issue 4 , November 2020, , Pages 316-323

http://dx.doi.org/10.22034/nmrj.2020.04.002

Abstract
  Poly (ε -caprolactone) nanoparticles were investigated as an injectable nanocarrier for the delivery of natural anticancer naphthoquinones plumbagin with the primary aim of improvement in its solubility, drug release profile and in vitro cytotoxicity. Plumbagin loaded polymeric nanoparticle system ...  Read More

Catgut enriched with CuSO4 nanoparticles as a surgical suture: Morphology, Antibacterial activity, Cytotoxicity and Tissue reaction

Ali alirezaie alavijeh; Milad Rajabi; Farid Barati; Moosa Javdani; Iraj Karimi; Mohammad Barati; Mohsen Moradian

Volume 5, Issue 3 , September 2020, , Pages 256-264

http://dx.doi.org/10.22034/nmrj.2020.03.006

Abstract
  Catgut was enriched with copper sulfate nanoparticles (CSNPs@Catgut), in order to develop a new composited suture with antibacterial and healing properties. Introducing copper sulfate nanoparticles to catgut was performed using a reverse micro-emulsion technique. It is an interesting method because of ...  Read More

Silver nanoparticles Synthesis by coffee residues extract and their antibacterial activity

Mahnaz Baghaienezhad; Meshkat Boroghani; Romina Anabestani

Volume 5, Issue 1 , March 2020, , Pages 29-34

http://dx.doi.org/10.22034/nmrj.2020.01.004

Abstract
  Objective(s): Today, nanotechnology is growing rapidly due to its high application in science and industry. Particularly in recent years, the synthesis of green nanoparticles has been of great interest with plant extracts. It is a simple, inexpensive and environmentally friendly method. The possibility ...  Read More

Investigation of the dose enhancement effect of spherical bismuth oxide nanoparticles in external beam radiotherapy

Zahra Alyani Nezhad; Ghazale Geraily; Fatemeh Hataminia; Somayeh Gholami; Seyed Mohammad Mahdi Abtahi; Hossien Ghanbari

Volume 5, Issue 1 , March 2020, , Pages 55-62

http://dx.doi.org/10.22034/nmrj.2020.01.007

Abstract
  Introduction: External radiotherapy is the most common method of radiotherapy which the most important problem associated with is that there is no difference between healthy and tumor tissues in dose absorption. One way to differentiate the dose sensitivity is to use metal-based nanoparticles. Bismuth ...  Read More

Characterizing and controlling the loading of Vipera albicornuta venom in chitosan nanoparticles as an adjuvant and vaccine delivery system

Mohammad Hassan Shambayati; Mohsen Mehrabi; Nasser Mohammadpour Dounighi; Ali Ramazani; Abbas Zare Mirakabadi; Ebrahim Ahmadi

Volume 4, Issue 4 , December 2019, , Pages 220-227

http://dx.doi.org/10.22034/nmrj.2019.04.003

Abstract
  The aim of this study was designing and preparing the chitosan nanoparticles (CS-NPs) loading with snake (Vipera albicornuta) venom as well as evaluating the influence of different factors on the encapsulation efficiency (EE) and loading capacity (LC) of venom. The morphologies and characteristics of ...  Read More

Effects of anxiolytic doses of ZnO nanoparticle on ECG parameters in restraint and non-restraint ovariectomized female rats

Mahnaz Kesmati; Mozhgan Torabi; Nahid Pourreza; Mehrnaz Tayebkhah; Fereshteh Asadi

Volume 4, Issue 4 , December 2019, , Pages 253-260

http://dx.doi.org/10.22034/nmrj.2019.04.008

Abstract
  Objective(s): Based on our previous studies about nano-ZnO effects on physiological behaviors, in this study we have investigated the effects of anxiolytic doses of nano-ZnO on electrocardiogram (ECG) sings changes in the restraint and non-restraint ovariectomized (OVX) female rats. Methods: Animals ...  Read More

Evaluation of Antibacterial Activity in Nanoparticles Ointment Preparation using Ethanol Extract of Miana Leaves (Coleus Atropurpureus (L.) Benth)

Tria Prayoga

Volume 4, Issue 2 , April 2019, , Pages 69-76

http://dx.doi.org/10.22034/nmrj.2019.02.003

Abstract
  Objective(s): Compared the nanoparticles form of Miana leaves with its extracts, even in single state or ointment preparation. Hence, SPSS program using Paired T Test is obtained to know the differences between them. Method: The method used in this research is experiment in which try to change the extract ...  Read More

Investigation on the teratogenic and embryotoxic effects of nanozeolite on chick embryos model

Marzie Hejazy; Masoome Moradi; Ghasem Akbari; Mohammad Rasool Amini

Volume 3, Issue 3 , September 2018, , Pages 169-173

http://dx.doi.org/10.22034/nmrj.2018.03.008

Abstract
  Objective(s): In veterinary medicine, zeolites are used as toxin binder in animal feed, ammonia purification of aquatic pools, animal smell and moisture control. This study investigated on the risk assessment of nano zeolite on development of embryonic chicken models, anomalies, tetratogenic and ...  Read More

Toxicity of manufactured copper nanoparticles - A review

Marzie Hejazy; Mohammad Kazem Koohi; Adele Bassiri Mohamad Pour; Davood Najafi

Volume 3, Issue 1 , January 2018, , Pages 1-9

http://dx.doi.org/10.22034/nmrj.2018.01.001

Abstract
  The health effects of nanoparticles (NPs) are raising considerable and growing concerns from the public and government around the world. Nano-metals are new forms of metal with special properties, but are characterized by having a particle size of less than 100 nm. Copper is an essential trace element ...  Read More

New Approaches to Use Nanoparticles for Treatment of Colorectal Cancer; a Brief Review

Leila Hamzehzadeh; Armin Imanparast; Amir Tajbakhsh; Mahdi Rezaee; Alireza Pasdar

Volume 1, Issue 2 , October 2016, , Pages 59-68

http://dx.doi.org/10.7508/nmrj.2016.02.001

Abstract
  Nanoparticles have been at the center of research focus as a new promising material for the treatment of cancer in recent years. Although many chemotherapy drugs for cancer treatment are available, their potential toxicity is the main point of concern. On the other hand, the conventional chemotherapeutic ...  Read More

Design and Characterization of Mesalamine Loaded Nanoparticles for Controlled Delivery System

Simin Seifirad; Hasan Karami; Shadab Shahsavari; Farzad Mirabasi; Farid Dorkoosh

Volume 1, Issue 2 , October 2016, , Pages 97-106

http://dx.doi.org/10.7508/nmrj.2016.02.006

Abstract
  Objective(s): Nanoparticles (NPs) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. The main objective of this work is to attain mesalamine loaded chitosan nanoparticles as a carrier ...  Read More