Elham Mohammadi; Seyed Meysam Amini; Seyed Hossein Mostafavi; Seyed Mohammad Amini
Abstract
With emerging drug resistance microorganism, the search for a new biocidal agent has begun. The silver nanoparticle is a synthetic material with potent antimicrobial activity that applies to a diverse library of microorganisms. But toxicity and safety concerns of chemically prepared silver nanoparticles ...
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With emerging drug resistance microorganism, the search for a new biocidal agent has begun. The silver nanoparticle is a synthetic material with potent antimicrobial activity that applies to a diverse library of microorganisms. But toxicity and safety concerns of chemically prepared silver nanoparticles toward human and environment limited the extensive industrial biomedical application of silver nanoparticles. On the other hand, curcumin is a natural phenolic compound of the Indian spice turmeric that contains mild antimicrobial activity against various microorganisms. However, instability, poor absorption and low solubility of curcumin prevent its wide application in biomedical researches. Simultaneous application of these two materials is the subject of the provided manuscript. Curcumin formulation and silver nanoparticles can be applied separately or together, but the state of the art is applying curcumin for the synthesis of silver nanoparticles that represent a better biocidal activity and lower cytotoxicity in comparison to chemically synthesized silver nanoparticles.
Pegah Haghighi; Solmaz Ghaffari; Sepideh Arbabi Bidgoli; Mahnaz Qomi; Setareh Haghighat
Abstract
Objective(s): In this work, Ginkgo biloba extract (GBE) loaded solid lipid nanoparticles (SLNs) were synthesized via high pressure homogenization method and their physicochemical properties, as well as cytotoxicity and antibacterial activities were evaluated.Methods: Ginkgo biloba extract SLNs (GBE-SLNs) ...
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Objective(s): In this work, Ginkgo biloba extract (GBE) loaded solid lipid nanoparticles (SLNs) were synthesized via high pressure homogenization method and their physicochemical properties, as well as cytotoxicity and antibacterial activities were evaluated.Methods: Ginkgo biloba extract SLNs (GBE-SLNs) were prepared using high pressure homogenization method. The morphology and size of SLNs were evaluated by scanning electron microscopy (SEM) and dynamic light scattering (DLS) techniques. The drug release of SLNs was also investigated using synthetic dialysis membrane. The antibacterial activity of nanoparticles was tested against both gram negative and gram positive bacteria strains. The probability of having toxicity of SLNs was studied on the rabbits.Results: The spherical structure of GBE-SLNs was confirmed by SEM images. The mean particle size of the obtained SLNs was ranging from 104 to 621 nm for different formulations using DLS technique. An in-vitro study of synthesized SLNs illustrated that the percentage of ginkgo biloba released from the solid lipid nanoparticles was 85% of loaded GBE after 72 hours. There was no report of significant skin toxicity via in-vivo studies.Conclusions: According to the above results, SLNs loaded with ginkgo extract showed acceptable particle size and shape, suitable loading of active substance and sustained release profile as well as appropriate antimicrobial effects without any significant skin toxicity.
