Biosynthesized Co-ZnO Nanorods against breast cancer cells

Document Type : Original Research Article

Authors

1 Department of pharmacology, college of Medicine, university of Kerbala, kerbala, Iraq

2 Department of peadiatrics, collage of medicin,Aliraqia university ,Baghdad , Iraq.

3 Department of pharmacology, college of Medicine, university of Kerbala, kerbala, Iraq.

4 Department of Chemistry, Faculty of Science, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. Integrated Chemical Biophysics Research, Faculty of Science, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

Abstract

Through a successful attempt, the extract of Prosopis fracta was exerted for the green and simple production of pure and 3% cobalt doped zinc oxide Co-ZnO) nanorods (NRs), which were configured in the following through the analytical results of XRD, FESEM, and EDX procedures. The appearance of finely doped cobalt throughout the construction of zinc oxide was approved by the data of XRD and EDX. Considering how the length and diameter of pure ZnO Nanorods were determined by the FESEM process to be 500 ± 0.2 nm and 100 ± 5 nm, the doping process of cobalt into ZnO caused an enlargement respecting the doped nanorods length as well as diameter. We examined toxicity of nanorods towards breast cancer MCF-7 by the employment of WST-1 trial. In contrast to results of pure nanorods, the doped nanorods were abled to induce a stronger toxicity on MCF-7 cells and therefore, it can be indicated that the conduction of doping process on ZnO nanostructure resulted in intensifying its inhibitory impact towards MCF-7 cells.

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References

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Nanomedicine Research Journal
Volume 8, Issue 2
April 2023
Pages 141-148

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