Pancreas recovery in diabetic rats after low dose curcumin@ZnO nanoparticles oral treatment

Document Type : Original Research Article

Authors

1 National Institute of Laser Enhanced Sciences (NILES), Department of laser applications in Metrology, photochemistry, and agriculture, Cairo University, 12613, Giza, Egypt

2 Biological Applications Department, Egyptian Atomic Energy Authority, Cairo, Egypt

3 Pathology Department, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt

Abstract

The purpose of this study was to explore the pancreas recovery in diabetic rats after treatment with the synthesized, curcumin@zinc oxide nanocomposite (CUR@ZnO NPs). Type 2 diabetes mellitus (T2DM) rats received low-dose treatments with Cur@ZnO NPs (1 mg/kg) for 4 weeks. The results indicated that CUR@ZnO NPs administration completely recovered T2DM rat’s pancreas. Similarly, CUR@ZnO NPs were exceptional in improving the lipid profile of diabetic rats. The immunohistochemical investigation confirmed these results and revealed a complete recovery of pancreas and insulin production all over the pancreatic islets of the CUR@ZnO NPs group than in all other groups.  Moreover, lesion scores in the pancreas and liver of T2DM rats given CUR@ZnO NPs showed a prodigious amelioration than the other groups. The previous results confirmed each other and indicate the success of CUR@ZnO NPs administration at low doses in the restoration of pancreas and insulin production in T2DM rats. The obtained results could help and guide the dose of CUR@ZnO NPs required as a novel drug for T2DM pancreas recovery.           

Keywords

Main Subjects

References

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Nanomedicine Research Journal
Volume 8, Issue 2
April 2023
Pages 149-160

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