Nanomedicine Research Journal

Nanomedicine Research Journal

Application of nanotechnology in novel nano-based compounds development for metal poisoning treatment

Document Type : Review Paper

Authors
Ehsan Zayerzadeh 1
Mohammad Kazem Koohi 2
1 Food Toxicology Research Group, Research Center of Food Technology and Agricultural Products Standard Research Institute, Karaj, Iran
2 Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
10.22034/nmrj.2024.02.002
Abstract
Metal toxicity or metal poisoning is one of the major global health problems. Application of metals in different industries causes their widespread release in the environment. As a result, the chances of encountering them have increased. These toxicants induce multiple organ abnormalities, though the severity of their damage is related to various factors such as exposure route, exposure time, and dose of toxicant. Supportive treatment, chelation therapy, and specific antidotes are the main approaches to metal poisoning. However, this treatment protocol is not completely effective for curing many severely intoxicated patients with metals, and on some occasions, it has adverse effects, particularly chelators, which are potential agents to induce side effects in patients. Therefore, it is urgent that alternative treatments which are safer and more effective are introduced as soon as possible to save severe cases. Recently, with the help of nanotechnology using different strategies such as solid lipid nanoparticles (SLNs), polymeric nanoparticles, liposomes, microemulsions liquid crystal (LC) systems, nanoemulsions, nanogels, polymeric micelles, phytosomes, dendrimers, inclusion complexes, and precursors systems for liquid crystals (PSLCs), new, safer and more efficient compounds have been discovered, and they are at the testing process for the treatment of metal poisonings. Therefore, this review article introduces the state of the art of novel nano-based compounds for metal poisonings.
Keywords
Metals
Poisoning
Antidote
Nanomedicine

Subjects

  1. Ghannoum M, Roberts DM. Management of Poisonings and Intoxications. Clinical Journal of the American Society of Nephrology. 2023;18(9):1210-21. https://doi.org/10.2215/CJN.0000000000000057
  2. van Hoving DJ, Veale DJH, Müller GF. Clinical Review: Emergency management of acute poisoning. African Journal of Emergency Medicine. 2011;1(2):69-78. https://doi.org/10.1016/j.afjem.2011.07.006
  3. Pemmerl S. Initial diagnosis and treatment for poisoning. Medizinische Klinik, Intensivmedizin und Notfallmedizin. 2013;108(6):459-64. https://doi.org/10.1007/s00063-013-0223-5
  4. Kaswa R. An approach to the management of acute poisoning in emergency settings. South African family practice : official journal of the South African Academy of Family Practice/Primary Care. 2024;66(1):e1-e5. https://doi.org/10.4102/safp.v66i1.5841
  5. Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN. Toxicity, mechanism and health effects of some heavy metals. Interdisciplinary toxicology. 2014;7(2):60-72. https://doi.org/10.2478/intox-2014-0009
  6. Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ. Heavy metal toxicity and the environment. Experientia supplementum (2012). 2012;101:133-64. https://doi.org/10.1007/978-3-7643-8340-4_6
  7. Barlow NL, Bradberry SM. Investigation and monitoring of heavy metal poisoning. Journal of clinical pathology. 2023;76(2):82-97. https://doi.org/10.1136/jcp-2021-207793
  8. Rahman Z, Singh VP. The relative impact of toxic heavy metals (THMs) (arsenic (As), cadmium (Cd), chromium (Cr)(VI), mercury (Hg), and lead (Pb)) on the total environment: an overview. Environmental monitoring and assessment. 2019;191(7):419. https://doi.org/10.1007/s10661-019-7528-7
  9. Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio F. The History of Nanoscience and Nanotechnology: From Chemical-Physical Applications to Nanomedicine. Molecules. 2020;25. https://doi.org/10.3390/molecules25010112
  10. Ratner BD. Biomaterials: Been There, Done That, and Evolving into the Future. Annual Review of Biomedical Engineering. 2019;21(1):171-91. https://doi.org/10.1146/annurev-bioeng-062117-120940
  11. Mishra B, Patel BB, Tiwari S. Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery. Nanomedicine : nanotechnology, biology, and medicine. 2010;6(1):9-24. https://doi.org/10.1016/j.nano.2009.04.008
  12. Narmani A, Jahedi R, Bakhshian-Dehkordi E, Ganji S, Nemati M, Ghahramani-Asl R, et al. Biomedical applications of PLGA nanoparticles in nanomedicine: advances in drug delivery systems and cancer therapy. Expert opinion on drug delivery. 2023;20(7):937-54. https://doi.org/10.1080/17425247.2023.2223941
  13. Hooda N, Ahlawat A. Role of Nanomedicine for Targeted Drug Delivery in Livestock: Future Prospective. 2023. https://doi.org/10.2174/0122117385267911231109184511
  14. Singh S. Nanomedicine-nanoscale drugs and delivery systems. Journal of nanoscience and nanotechnology. 2010;10(12):7906-18. https://doi.org/10.1166/jnn.2010.3617
  15. Mainardes RM, Urban MC, Cinto PO, Chaud MV, Evangelista RC, Gremião MP. Liposomes and micro/nanoparticles as colloidal carriers for nasal drug delivery. Current drug delivery. 2006;3(3):275-85. https://doi.org/10.2174/156720106777731019
  16. Grill AE, Johnston NW, Sadhukha T, Panyam J. A review of select recent patents on novel nanocarriers. Recent patents on drug delivery & formulation. 2009;3(2):137-42. https://doi.org/10.2174/187221109788452276
  17. Venugopal J, Prabhakaran MP, Low S, Choon AT, Deepika G, Dev VR, et al. Continuous nanostructures for the controlled release of drugs. Current pharmaceutical design. 2009;15(15):1799-808. https://doi.org/10.2174/138161209788186344
  18. Di Stefano A. Nanotechnology in Targeted Drug Delivery. International journal of molecular sciences. 2023; 9(24(. https://doi.org/10.3390/ijms24098194
  19. Ben Khalifa R, Cacciatore I, Dimmito MP, Ciulla M, Grande R, Puca V, et al. Multiple lipid nanoparticles as antimicrobial drug delivery systems. Journal of Drug Delivery Science and Technology. 2022;67:102887. https://doi.org/10.1016/j.jddst.2021.102887
  20. Leroux JC. Injectable nanocarriers for biodetoxification. Nature nanotechnology. 2007;2(11):679-84. https://doi.org/10.1038/nnano.2007.339
  21. Muhammad F, Nguyen TDT, Raza A, Akhtar B, Aryal S. A review on nanoparticle-based technologies for biodetoxification. Drug and chemical toxicology. 2017;40(4):489-97. https://doi.org/10.1080/01480545.2016.1277736
  22. Liu Y, Liang Y, Yuhong J. Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs. 2024;18:1469-95. https://doi.org/10.2147/DDDT.S447496
  23. Joo J. Diagnostic and Therapeutic Nanomedicine. Advances in experimental medicine and biology. 2021;1310:401-47. https://doi.org/10.1007/978-981-33-6064-8_15
  24. Nurchi VM, Djordjevic AB, Crisponi G, Alexander J, Bjørklund G, Aaseth J. Arsenic Toxicity: Molecular Targets and Therapeutic Agents. Biomolecules. 2020;10(2). https://doi.org/10.3390/biom10020235
  25. Yamauchi H, Takata A. Arsenic metabolism differs between child and adult patients during acute arsenic poisoning. Toxicology and applied pharmacology. 2021;410:115352. https://doi.org/10.1016/j.taap.2020.115352
  26. Liu Y, Tong X, Zhao S, Yu Z, Zhang J, Ma L, et al. Four cases of fatal acute arsenic poisoning: histopathology, toxicology, and new trends. Forensic science, medicine, and pathology. 2023. https://doi.org/10.1007/s12024-023-00654-x
  27. Hutton JT, Christians BL, Dippel RL. Arsenic poisoning. The New England journal of medicine. 1982;307(17):1080. https://doi.org/10.1056/NEJM198210213071714
  28. Blow NS. Arsenic poisoning. BioTechniques. 2011;51(1):11. https://doi.org/10.2144/000113694
  29. Kosnett MJ. The role of chelation in the treatment of arsenic and mercury poisoning. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2013;9(4):347-54. https://doi.org/10.1007/s13181-013-0344-5
  30. Ghosh A, Mandal AK, Sarkar S, Panda S, Das N. Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats. Life sciences. 2009;84(3-4):75-80. https://doi.org/10.1016/j.lfs.2008.11.001
  31. Yang D, Wang T, Long M. Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine. 2020;2020:8825387. https://doi.org/10.1155/2020/8825387
  32. Amirmostofian M, Akbari F, Hashemzaei M, Safaeinejad F, Tabrizian K, Arbab H, et al. Hormetic effects of curcumin on oxidative stress injury induced by trivalent arsenic in isolated rat hepatocytes. Avicenna journal of phytomedicine. 2023;13(6):641-50.
  33. Wahlström B, Blennow G. A Study on the Fate of Curcumin in the Rat. Acta Pharmacologica et Toxicologica. 1978;43(2):86-92. https://doi.org/10.1111/j.1600-0773.1978.tb02240.x
  34. Rabanel J-M, Faivre J, Paka GD, Ramassamy C, Hildgen P, Banquy X. Effect of polymer architecture on curcumin encapsulation and release from PEGylated polymer nanoparticles: Toward a drug delivery nano-platform to the CNS. European Journal of Pharmaceutics and Biopharmaceutics. 2015;96:409-20. https://doi.org/10.1016/j.ejpb.2015.09.004
  35. Bashkeran T, Kamaruddin AH, Ngo TX, Suda K, Umakoshi H, Watanabe N, et al. Niosomes in cancer treatment: A focus on curcumin encapsulation. Heliyon. 2023;9(8):e18710-e. https://doi.org/10.1016/j.heliyon.2023.e18710
  36. Yadav A, Lomash V, Samim M, Flora SJ. Curcumin encapsulated in chitosan nanoparticles: a novel strategy for the treatment of arsenic toxicity. Chemico-biological interactions. 2012;199(1):49-61. https://doi.org/10.1016/j.cbi.2012.05.011
  37. Casarett & Doull's Essentials of Toxicology. 4th Edition ed. New York: McGraw Hill; 2022.
  38. Martinez-Finley EJ, Aschner M. Recent Advances in Mercury Research. Current environmental health reports. 2014;1(2):163-71. https://doi.org/10.1007/s40572-014-0014-z
  39. Evans M. Mercury poisoning. British medical journal. 1962;1(5290):1458-9. https://doi.org/10.1136/bmj.1.5290.1458
  40. Zhou J, Li J, Xu X, Long S, Cui N, Zhang Y, et al. Imaging gastrointestinal damage due to acute mercury poisoning using a mitochondria-targeted dual near-infrared fluorescent probe. Journal of hazardous materials. 2024;470:134269. https://doi.org/10.1016/j.jhazmat.2024.134269
  41. Feng Y, Wang F. Mercury Poisoning. The New England journal of medicine. 2022;387(20):1888. https://doi.org/10.1056/NEJMicm2202896
  42. Guzzi G, Minoia C, Ronchi A, Pigatto P. Fatal mercury poisoning and chelating agents. Forensic science international. 2010;202(1-3):e61. https://doi.org/10.1016/j.forsciint.2010.04.048
  43. Oguz MM, Altinel Acoglu E, Oztek Celebi FZ, Polat E, Yucel H, Sahin S, et al. Different Aspects of Mercury Poisoning in Children. Iranian journal of public health. 2023;52(2):451-2.
  44. Thomas JK, Janz DM. Dietary selenomethionine exposure in adult zebrafish alters swimming performance, energetics and the physiological stress response. Aquatic toxicology (Amsterdam, Netherlands). 2011;102(1-2):79-86. https://doi.org/10.1016/j.aquatox.2010.12.020
  45. Abu-Ali H, Nabok A, Smith TJ. Development of Novel and Highly Specific ssDNA-Aptamer-Based Electrochemical Biosensor for Rapid Detection of Mercury (II) and Lead (II) Ions in Water. Chemosensors. 2019;7(2):27. https://doi.org/10.3390/chemosensors7020027
  46. Phillips MA, Gran ML, Peppas NA. Targeted Nanodelivery of Drugs and Diagnostics. Nano today. 2010;5(2):59-143. https://doi.org/10.1016/j.nantod.2010.03.003
  47. Hu X, Tulsieram KL, Zhou Q, Mu L, Wen J. Polymeric nanoparticle-aptamer bioconjugates can diminish the toxicity of mercury in vivo. Toxicology letters. 2012;208(1):69-74. https://doi.org/10.1016/j.toxlet.2011.10.006
  48. Srie Rahayu SY, Aminingsih T, Fudholi A. The protective effect of nano calcium produced from freshwater clam shells on the histopathological overview of the liver and kidneys of mice exposed to mercury toxins. Journal of Trace Elements in Medicine and Biology. 2022;71:126963. https://doi.org/10.1016/j.jtemb.2022.126963
  49. Mahboub HH, Beheiry RR, Shahin SE, Behairy A, Khedr MHE, Ibrahim SM, et al. Adsorptivity of mercury on magnetite nano-particles and their influences on growth, economical, hemato-biochemical, histological parameters and bioaccumulation in Nile tilapia (Oreochromis niloticus). Aquatic toxicology (Amsterdam, Netherlands). 2021;235:105828. https://doi.org/10.1016/j.aquatox.2021.105828
  50. Dhar S, Garg D. Lead Poisoning. 2023;388(18):e63. https://doi.org/10.1056/NEJMicm2210842
  51. Markowitz M. Lead Poisoning: An Update. Pediatrics in review. 2021;42(6):302-15. https://doi.org/10.1542/pir.2020-0026
  52. Guidotti TL. Toxicity and poisoning: the example of lead. Archives of environmental & occupational health. 2014;69(1):64-5. https://doi.org/10.1080/19338244.2014.811995
  53. D'Souza H S, Dsouza SA, Menezes G, Venkatesh T. Diagnosis, evaluation, and treatment of lead poisoning in general population. Indian journal of clinical biochemistry : IJCB. 2011;26(2):197-201. https://doi.org/10.1007/s12291-011-0122-6
  54. Paeezi M, Zamani N, Hassanian-Moghaddam H, Shadnia S, Zamani N, Chaleshi V, et al. Treatment of adult lead poisoning with D-penicillamine. Drug metabolism and personalized therapy. 2019;34(2). https://doi.org/10.1515/dmpt-2019-0003
  55. Angle CR. Childhood lead poisoning and its treatment. Annual review of pharmacology and toxicology. 1993;33:409-34. https://doi.org/10.1146/annurev.pa.33.040193.002205
  56. Klein M, Kaminsky P, Duc ML, Duc M. [Current diagnosis and treatment of lead poisoning]. La Revue de medecine interne. 1994;15(2):101-9. https://doi.org/10.1016/S0248-8663(05)81182-8
  57. Mohammadi M, Ariafar S, Talebi-Ghane E, Afzali S. Comparative efficacy of silibinin and nano-silibinin on lead poisoning in Male Wistar rats. Toxicology. 2022;475:153242. https://doi.org/10.1016/j.tox.2022.153242
  58. Dehkordi AJ, Mohebbi AN, Aslani MR, Ghoreyshi SM. Evaluation of nanoselenium (Nano-Se) effect on hematological and serum biochemical parameters of rat in experimentally lead poisoning. Human & experimental toxicology. 2017;36(4):421-7. https://doi.org/10.1177/0960327116651124
  59. Sadeghian S, Kojouri GA, Mohebbi A. Nanoparticles of selenium as species with stronger physiological effects in sheep in comparison with sodium selenite. Biological trace element research. 2012;146(3):302-8. https://doi.org/10.1007/s12011-011-9266-8
  60. Hejazy M, Koohi MK. Effects of Nano-zinc on Biochemical Parameters in Cadmium-Exposed Rats. Biological trace element research. 2017;180(2):265-74. https://doi.org/10.1007/s12011-017-1008-0
  61. Satarug S. Dietary Cadmium Intake and Its Effects on Kidneys. Toxics. 2018;6(1). https://doi.org/10.3390/toxics6010015
  62. Genchi G, Sinicropi MS, Lauria G, Carocci A, Catalano A. The Effects of Cadmium Toxicity. International journal of environmental research and public health. 2020;17(11) https://doi.org/10.3390/ijerph17113782
  63. Charkiewicz AE, Omeljaniuk WJ. Cadmium Toxicity and Health Effects-A Brief Summary. 2023;28(18) https://doi.org/10.3390/molecules28186620
  64. Zhang Z, Wang Q, Gao X, Tang X, Xu H, Wang W, et al. Reproductive toxicity of cadmium stress in male animals. Toxicology. 2024;504:153787. https://doi.org/10.1016/j.tox.2024.153787
  65. Rafati Rahimzadeh M, Rafati Rahimzadeh M, Kazemi S, Moghadamnia AA. Cadmium toxicity and treatment: An update. Caspian journal of internal medicine. 2017;8(3):135-45.
  66. Raeeszadeh M, Moradian M, Khademi N, Amiri AA. The Effectiveness of Time in Treatment with Vitamin C and Broccoli Extract on Cadmium Poisoning in Mice: Histological Changes of Testicular Tissue and Cell Apoptotic Index. Biological trace element research. 2024;202(7):3278-92. https://doi.org/10.1007/s12011-023-03898-4
  67. Cotter LH. Treatment of cadmium poisoning with edathamil calcium disodium. Journal of the American Medical Association. 1958;166(7):735-6. https://doi.org/10.1001/jama.1958.02990070021005
  68. Vicas SI, Laslo V, Timar AV, Balta C, Herman H. Nano Selenium-Enriched Probiotics as Functional Food Products against Cadmium Liver Toxicity. 2021;14. https://doi.org/10.3390/ma14092257
  69. Du H, Zheng Y, Zhang W, Tang H, Jing B, Li H, et al. Nano-Selenium Alleviates Cadmium-Induced Acute Hepatic Toxicity by Decreasing Oxidative Stress and Activating the Nrf2 Pathway in Male Kunming Mice. Frontiers in Veterinary Science. 2022;9. https://doi.org/10.3389/fvets.2022.942189
  70. Saleh SM, El-Tawil OS, Mahmoud MB, Abd El-Rahman SS, El-Saied EM, Noshy PA. Do Nanoparticles of Calcium Disodium EDTA Minimize the Toxic Effects of Cadmium in Female Rats? Biological trace element research. 2024;202(5):2228-40. https://doi.org/10.1007/s12011-023-03842-6
  71. Genchi G, Carocci A, Lauria G, Sinicropi MS, Catalano A. Nickel: Human Health and Environmental Toxicology. International journal of environmental research and public health. 2020;17(3). https://doi.org/10.3390/ijerph17030679
  72. Xue CJ, Xia YJ, Ye Q. [A case of acute poisoning caused by ingestion of nickel sulfate]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2016;34(11):851.
  73. Daldrup T, Haarhoff K, Szathmary SC. [Fatal nickel sulfate poisoning]. Beitrage zur gerichtlichen Medizin. 1983;41:141-4.
  74. Bradberry SM, Vale JA. Therapeutic review: do diethyldithiocarbamate and disulfiram have a role in acute nickel carbonyl poisoning? Journal of toxicology Clinical toxicology. 1999;37(2):259-64. https://doi.org/10.1081/CLT-100102424
  75. Ahlström MG, Thyssen JP. Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment. 2019;81(4):227-41. https://doi.org/10.1111/cod.13327
  76. Wang C, Gu Z, Gu X, Tan X, Wang S, Zhang R, et al. Nano-selenium attenuates mitochondrial-associated apoptosis via the PI3K/AKT pathway in nickel-induced hepatotoxicity in vivo and in vitro. 2022;37(1):101-19. https://doi.org/10.1002/tox.23381
  77. Sane MR, Malukani K, Kulkarni R, Varun A. Fatal Iron Toxicity in an Adult: Clinical Profile and Review. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine. 2018;22(11):801-3. https://doi.org/10.4103/ijccm.IJCCM_188_18
  78. Chandran J, Sanketh R, Vyasam S, Chrysolyte A, Ebenezer K. Accidental iron poisoning in children - Experience from a teaching institution. Journal of family medicine and primary care. 2023;12(10):25. https://doi.org/10.4103/jfmpc.jfmpc_805_23
  79. Singhi SC, Baranwal AK, M J. Acute iron poisoning: clinical picture, intensive care needs and outcome. Indian pediatrics. 2003;40(12):1177-82.
  80. Baranwal AK, Singhi SC. Acute iron poisoning: management guidelines. Indian pediatrics. 2003;40(6):534-40.
  81. Abhilash KP, Arul JJ, Bala D. Fatal overdose of iron tablets in adults. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine. 2013;17(5):311-3. https://doi.org/10.4103/0972-5229.120326
  82. Hamilton JL, Kizhakkedathu JN. Polymeric nanocarriers for the treatment of systemic iron overload. Molecular and cellular therapies. 2015;3:3. https://doi.org/10.1186/s40591-015-0039-1
  83. Kang H, Han M, Xue J, Baek Y, Chang J, Hu S, et al. Renal clearable nanochelators for iron overload therapy. Nature Communications. 2019; 10(1):8134. https://doi.org/10.1038/s41467-019-13143-z
  84. Imran ul-haq M, Hamilton JL, Lai BFL, Shenoi RA, Horte S, Constantinescu I, et al. Design of Long Circulating Nontoxic Dendritic Polymers for the Removal of Iron in Vivo. ACS Nano. 2013;7(12):10704-16. https://doi.org/10.1021/nn4035074
  85. Zhu F, Zhong J, Hu J, Yang P, Zhang J, Zhang M, et al. Carrier-Free Deferoxamine Nanoparticles against Iron Overload in Brain. CCS Chemistry. 2023;5(1):257-70. https://doi.org/10.31635/ccschem.022.202101696
  86. Collins JF, Klevay LM. Copper. Advances in nutrition (Bethesda, Md). 2011;2(6):520-2. https://doi.org/10.3945/an.111.001222
  87. Perestrelo AP, Miranda G, Gonçalves MI, Belino C, Ballesteros R. Chronic Copper Sulfate Poisoning. European journal of case reports in internal medicine. 2021;8(3):002309.
  88. Oe S, Miyagawa K, Honma Y, Harada M. Copper induces hepatocyte injury due to the endoplasmic reticulum stress in cultured cells and patients with Wilson disease. Experimental cell research. 2016;347(1):192-200. https://doi.org/10.1016/j.yexcr.2016.08.003
  89. Hassan S, Shaikh MU, Ali N, Riaz M. Copper sulphate toxicity in a young male complicated by methemoglobinemia, rhabdomyolysis and renal failure. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2010;20(7):490-1.
  90. Park KS, Kwon JH, Park SH, Ha W, Lee J, An HC, et al. Acute copper sulfate poisoning resulting from dermal absorption. 2018. https://doi.org/10.1002/ajim.22892
  91. Sinkovic A, Strdin A, Svensek F. Severe acute copper sulphate poisoning: a case report. Arhiv za higijenu rada i toksikologiju. 2008;59(1):31-5. https://doi.org/10.2478/10004-1254-59-2008-1847
  92. Franchitto N, Gandia-Mailly P, Georges B, Galinier A, Telmon N, Ducassé JL, et al. Acute copper sulphate poisoning: a case report and literature review. Resuscitation. 2008;78(1):92-6. https://doi.org/10.1016/j.resuscitation.2008.02.017
  93. Takeda T, Yukioka T, Shimazaki S. Cupric sulfate intoxication with rhabdomyolysis, treated with chelating agents and blood purification. Internal medicine (Tokyo, Japan). 2000;39(3):253-5. https://doi.org/10.2169/internalmedicine.39.253
  94. Jones MM, Pratt TH. Therapeutic chelating agents. Journal of chemical education. 1976;53(6):342-7. https://doi.org/10.1021/ed053p342
  95. Sarawi WS, Alhusaini AM. Nano-Curcumin Prevents Copper Reproductive Toxicity by Attenuating Oxidative Stress and Inflammation and Improving Nrf2/HO-1 Signaling and Pituitary-Gonadal Axis in Male Rats. 2022;10(7). https://doi.org/10.3390/toxics10070356
  96. Sarawi WS, Alhusaini AM. Roles of Nrf2/HO-1 and ICAM-1 in the Protective Effect of Nano-Curcumin against Copper-Induced Lung Injury. 2023;24(18). https://doi.org/10.3390/ijms241813975
  97. Sarawi WS, Alhusaini AM. Nano-Curcumin Prevents Cardiac Injury, Oxidative Stress and Inflammation, and Modulates TLR4/NF-κB and MAPK Signaling in Copper Sulfate-Intoxicated Rats. 2021;10(9). https://doi.org/10.3390/antiox10091414
  98. Rehab Mohamed I, Fatma El Zahraa Ali Abd E, Sahar Z. Effect of Curcumin and Nano-curcumin on Reduce Aluminum Toxicity in Rats. International Journal of Food Science and Biotechnology. 2019;4(3):64-73. https://doi.org/10.11648/j.ijfsb.20190403.12
  99. Coulson JM, Hughes BW. Dose-response relationships in aluminium toxicity in humans. Clinical toxicology (Philadelphia, Pa). 2022;60(4):415-28. https://doi.org/10.1080/15563650.2022.2029879
  100. Krewski D, Yokel RA, Nieboer E, Borchelt D, Cohen J, Harry J, et al. Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. Journal of toxicology and environmental health Part B, Critical reviews. 2007;10 Suppl 1(Suppl 1):1-269. https://doi.org/10.1080/10937400701597766
  101. Lubica C, Rudolf M, Jiri L. Acute Copper Sulphate Poisoning. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2017;27(8):527-8.
  102. Vogelsang U. Aluminum poisoning in dialysis patients--diagnosis and therapy. Revue suisse de medecine Praxis. 1994;83(24):738-56.
  103. Niu Q. Overview of the Relationship Between Aluminum Exposure and Health of Human Being. Advances in experimental medicine and biology. 2018;1091:1-31. https://doi.org/10.1007/978-981-13-1370-7_1
  104. Rahimzadeh MR, Rahimzadeh MR. Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication. 2022;2022:1480553. https://doi.org/10.1155/2022/1480553
Nanomedicine Research Journal
Volume 9, Issue 2
Spring 2024
Pages 120-130