Nanomedicine Research Journal

Nanomedicine Research Journal

BiFeO3@BSA-Gd2O3 Nanoparticles as Contrast Agent for Dual Imaging

Document Type : Original Research Article

Authors
Zohreh Joorabchi Bokharaei 1
Elham Askarizadeh 2
Mehdi Khoobi 3
Majid Karimi 4
Ali Masjedi 2
1 Department of pharmaceutics, Tehran Azad University of Medical Sciences, Islamic Azad University, Tehran, Iran
2 Department of Applied Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Azad University of Medical Sciences, Islamic Azad University, Tehran, Iran
3 Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4 Polymerization Engineering Department, Iran Polymer and Petrochemical Institute (IPPI), Tehran, Iran
10.22034/nmrj.2024.03.005
Abstract
Developing nanoparticles with multimodal contrast agents with therapeutic and contrast effects can greatly improve disease diagnosis. Magnetic resonance imaging (MRI) and computed tomography (CT) are sophisticated medical imaging modalities utilized for visualizing internal tissues and bones, facilitating the diagnosis of organ-related ailments and diseases. In MRI, bovine serum albumin (BSA) is a well-known compound used to carry gadolinium oxide as a contrast agent. Bismuth ferrite nanoparticles (BiFeO3 NPs) have been identified as a novel multifunctional therapeutic agent suitable for applications in radiotherapy, MRI, CT, and as mediators for magnetic hyperthermia. This study presents new NPs that can serve as dual imaging contrast agents for MRI and CT. These novel nanoparticles (BiFeO3@BSA-Gd2O3) consist of BiFeO3 nanoparticles, with BSA acting as a carrier for gadolinium oxide nanoparticles. BiFeO3 was synthesized by the sol-gel method and covered with a BSA layer, then gadolinium oxide was added to the BSA layer. Synthesized nanoparticles were identified using different physicochemical methods. The Inductively Coupled Plasma Spectroscopy (ICP) confirms the existence of Gd, Bi, and Fe in the nanoparticle and the average size of nanoparticles regarding to SEM was 120 nm. The presence of BiFeO3 nanoparticles as a promising agent with multi-functional properties such as CT and MRI imaging and BSA-Gd2O3 as an MRI contrast agent, the newly synthesized nanoparticle has the potential to be used as nanomedicine for simultaneous MRI and CT as a Dual imaging contrast.
Keywords
BiFeO3
BSA-Gd2O3 nanoparticles
CT
MRI
Dual imaging contrast

Subjects

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Nanomedicine Research Journal
Volume 9, Issue 3
Autumn 2024
Pages 274-282