Pancreas recovery in diabetic rats after low dose curcumin@ZnO nanoparticles oral treatment

Document Type : Original Research Article


1 National Institute of Laser Enhanced Sciences (NILES), Department of laser applications in Metrology, photochemistry, and agriculture, Cairo University, 12613, Giza, Egypt

2 Biological Applications Department, Egyptian Atomic Energy Authority, Cairo, Egypt

3 Pathology Department, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt


The purpose of this study was to explore the pancreas recovery in diabetic rats after treatment with the synthesized, curcumin@zinc oxide nanocomposite (CUR@ZnO NPs). Type 2 diabetes mellitus (T2DM) rats received low-dose treatments with Cur@ZnO NPs (1 mg/kg) for 4 weeks. The results indicated that CUR@ZnO NPs administration completely recovered T2DM rat’s pancreas. Similarly, CUR@ZnO NPs were exceptional in improving the lipid profile of diabetic rats. The immunohistochemical investigation confirmed these results and revealed a complete recovery of pancreas and insulin production all over the pancreatic islets of the CUR@ZnO NPs group than in all other groups.  Moreover, lesion scores in the pancreas and liver of T2DM rats given CUR@ZnO NPs showed a prodigious amelioration than the other groups. The previous results confirmed each other and indicate the success of CUR@ZnO NPs administration at low doses in the restoration of pancreas and insulin production in T2DM rats. The obtained results could help and guide the dose of CUR@ZnO NPs required as a novel drug for T2DM pancreas recovery.           


Main Subjects

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