Neuroprotective effects of cobalt ferrite nanoparticles coated with sumac on damaged sciatic nerve recovery

Document Type : Original Research Article


1 Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran

2 Department of Bioinformatics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran

3 Department of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran


Objective(s): Although damaged peripheral nerves have the ability to repair, axon regeneration proceeds slowly and often poor functional results are observed. Many methods are used to repair peripheral nerve lesions, but very few have demonstrated clinical success. Hence, the intention of the present study was to explore the regenerative outcomes of cobalt ferrite nanoparticles coated with sumac on rat sciatic nerve injury.
Methods: Forty male Wistar rats were separated into four groups: the sham group (surgery without damage to the nerve), the negative control (nerve compression without nanoparticle injection), the experimental group 1 (nerve compression given 10 mg/kg dose of drug), and the experimental group 2 (nerve compression given 20 mg/kg dose of drug). The sciatic nerve was then compressed one centimeter above the point where it splits into three branches, tissue and muscle sections were examined in addition to foot print and hot plate tests.
Results: When compared to the negative control group, the speed of recovery and restoration of sensory and motor neuron function was significantly faster in groups treated with cobalt ferrite nanoparticles coated with sumac. 
Conclusions: Injection of cobalt ferrite nanoparticle coated with sumac increases the speed of repair of peripheral nerve damage in rats.


Main Subjects

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