Nanomedicine Research Journal

Nanomedicine Research Journal

Chitosan-coated PDMS sponge supported Zn-MOFs: fabrication, characterization and assessment of their biocompatibility and antibacterial activity

Document Type : Original Research Article

Authors
Zeinab Ansari-Asl 1
Zahra Shahvali 1
Reza Sacourbaravi 1
Esmaeil Darabpour 2
Elham Hoveizi 2
1 Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2 Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
10.22034/nmrj.2024.04.005
Abstract
Nanocomposite sponges composed of biocompatible polymers and inorganic materials have attracted much attention within various fields such as biomedicine, pharmaceutics, and food packaging. In this study, we have fabricated some novel nanocomposites with a combination of salt leaching for fabrication of PDMS (polydimethylsiloxane) sponge, in situ synthesis of Zn-based metal-organic framework (Zn-MOF), and dip coating process for coating Zn-MOF@PDMS sponge with chitosan. Chitosan stabilizes Zn-MOF particles and promotes the biocompatibility of the as-obtained composites. The surface morphology of PDMS and its nanocomposites was investigated by scanning electron microscope (SEM). X-ray diffraction was conducted to study the microstructure of the prepared Chitosan@Zn-MOF@PDMS sponge. The nanocomposite sponge, Chitosan@Zn-MOF@PDMS, was also studied by elemental EDS mapping technique. The antibacterial and cytotoxicity activities of the as-prepared sponges were also evaluated. Chitosan and Zn-MOF improved the antibacterial properties of the PDMS sponges against Escherichia coli and Staphylococcus aureus. The Chitosan@Zn-MOF@PDMS sponge exhibited a remarkable decline in the amount of viable bacteria cells (> 4.5 log10 CFU). The obtained Biological results showed that the as-obtained scaffolds, Zn-MOF@PDMS and Chitosan@Zn-MOF@PDMS, had suitable surfaces for attachment of cells and proliferation compared to the pure PDMS scaffold. The Chitosan@Zn-MOF@PDMS sponge has the potential for antibacterial and tissue engineering purposes owing to their biocompatibility, porosity, and good mechanical stability. 
Keywords
Metal-organic framework
Polydimethylsiloxane
Chitosan
Biocompatibility
Antibacterial Activity

Subjects

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Nanomedicine Research Journal
Volume 9, Issue 4
Autumn 2024
Pages 381-392