Nanomedicine Research Journal

Nanomedicine Research Journal

Preparation and evaluation of Zn2(BDC)2(DABCO) MOF-hydroxyapatite nanocomposite to remove tetracycline from aqueous solution

Document Type : Original Research Article

Authors
Zainab Qutbi 1
Negar Motakef-Kazemi 2
Ensieh Ghasemi 1
1 Department of Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2 Department of Medical Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
10.22034/nmrj.2024.04.006
Abstract
Objective(s): In recent years, porous materials have shown good potential for adsorption due to their high surface area. Among them, hydroxyapatite (HA) is important as an inorganic material. While metal-organic frameworks (MOFs) have attracted much attention as hybrid materials consisting of organic and inorganic compounds with special properties
Methods: In this study, Zn2(BDC)2(DABCO) MOF-HA nanocomposite (NC) was prepared by solvothermal method with precursors that are: Zn = zinc acetate dehydrates, BDC = 1,4-benzenedicarboxylate, and DABCO = 1,4-diazabicyclo [2.2.2] octane. This nanostructure was used to remove tetracycline drug from aqueous solution. Samples were characterized by Fourier Transform InfraRed (FTIR) spectroscopy to evaluate functional groups, X-Ray diffraction (XRD) analysis of crystal structure, field emission scanning electron microscope (FESEM) to determine morphology and size, BET analysis for measurement of surface area, and Ultraviolet–Visible (UV–Vis) spectroscopy to study drug adsorption. The effect of some important parameters on removal efficiency, such as drug concentration, nanocomposite amount, removal time and solution pH were studied. In order to reach best removal condition, the effect of the parameters and their interactions was optimized using the Box-Behnken Design (BBD) and the response surface methodology.
Results: The synthesis of Zn2(BDC)2(DABCO) MOF-hydroxyapatite nanocomposite was confirmed using identification methods. The functional groups, crystal structure and surface area were evaluated by FTIR, XRD and BET respectively. The nanoscale size was approved by FESEM. In the optimum condition, the removal efficiency more than 98% was obtained. 
Conclusions: According to the results, MOF and its nanocomposite can be a good choice for tetracycline removal and have good potential for the development of different adsorbents.
Keywords
Hydroxyapatite
Metal-organic framework
Nanocomposite
Tetracycline
Zn2(BDC)2(DABCO)

Subjects

1.    Zhu QL, Xu Q. Metal-organic framework composites. Chem Soc Rev. 2014;43:5468-512. https://doi.org/10.1039/C3CS60472A
2.    Liu Y, Zhao Y, Chen X. Bioengineering of metal-organic frameworks for nanomedicine. Theranostics. 2019;9(11):3122-33. https://doi.org/10.7150/thno.31918
3.    Shet SP, Priya SS, Sudhakar K, Tahir M. A review on current trends in potential use of metal-organic framework for hydrogen storage. Int J Hydrogen Energy. 2021;46(21):11782-803. https://doi.org/10.1016/j.ijhydene.2021.01.020
4.    Gangu KK, Jonnalagadda SB. A review on metal-organic frameworks as congenial heterogeneous catalysts for potential organic transformations. Front Chem. 2021;9:747615. https://doi.org/10.3389/fchem.2021.747615
5.    Alhumaimess MS. Metal-organic frameworks and their catalytic applications. J Saudi Chem Soc. 2020;24(6):461-73. https://doi.org/10.1016/j.jscs.2020.04.002
6.    Gupta G, Thakur A. A comprehensive review on luminescent metal-organic framework detectors. Mater Today. 2022;50(5):1721-5. https://doi.org/10.1016/j.matpr.2021.09.170
7.    Kreno LE, et al. Metal-organic framework materials as chemical sensors. Chem Rev. 2012;112(2):1105-25. https://doi.org/10.1021/cr200324t
8.    Rani L, et al. A critical review on recent developments in MOF adsorbents for the elimination of toxic heavy metals from aqueous solutions. Environ Sci Pollut Res Int. 2020;27:44771-96. https://doi.org/10.1007/s11356-020-10738-8
9.    Stavila V, Talin AA, Allendorf MD. MOF-based electronic and opto-electronic devices. Chem Soc Rev. 2014;43:5994-6010. https://doi.org/10.1039/C4CS00096J
10.    Sun H, et al. Metal-organic frameworks as surface enhanced Raman scattering substrates with high tailorability. J Am Chem Soc. 2019;141:870-8. https://doi.org/10.1021/jacs.8b09414
11.    Vilela SMF, et al. Multifunctionality in an ion-exchanged porous metal-organic framework. J Am Chem Soc. 2021;143(3):1365-76. https://doi.org/10.1021/jacs.0c10421
12.    Chen B, et al. Emerging applications of metal-organic frameworks and derivatives in solar cells: Recent advances and challenges. Mater Sci Eng R Rep. 2023;152:100714. https://doi.org/10.1016/j.mser.2022.100714
13.    Mallakpour S, Nikkhoo E, Hussain CM. Application of MOF materials as drug delivery systems for cancer therapy and dermal treatment. Coord Chem Rev. 2022;451:214262. https://doi.org/10.1016/j.ccr.2021.214262
14.    Wyszogrodzka G, et al. Metal-organic frameworks: mechanisms of antibacterial action and potential applications. Drug Discov Today. 2016;21(6):1009-18. https://doi.org/10.1016/j.drudis.2016.04.009
15.    Ryzhikov MR, Kozlova SG. Interactions between building blocks of the Zn2(BDC)2DABCO metal-organic framework. J Struct Chem. 2020;61:161-5. https://doi.org/10.1134/S0022476620020018
16.    Tranchemontagne DJ, Hunt JR, Yaghi OM. Room temperature synthesis of metal-organic frameworks: MOF-5, MOF-74, MOF-177, MOF-199, and IRMOF-0. Tetrahedron. 2008;64:8553-7. https://doi.org/10.1016/j.tet.2008.06.036
17.    Li Y, et al. Synthesis and shaping of metal-organic frameworks: a review. Chem Commun. 2022;58:11488-506. https://doi.org/10.1039/D2CC04190A
18.    Sattar T, Athar M. Hydrothermal synthesis and characterization of copper glycinate (Bio-MOF-29) and its in vitro drugs adsorption studies. J Inorg Chem. 2017;7(2):17-27. https://doi.org/10.4236/ojic.2017.72002
19.    Wang Z, Li Z, Ng M, Milner PJ. Rapid mechanochemical synthesis of metal-organic frameworks using exogenous organic base. Dalton Trans. 2020;49:16238-44. https://doi.org/10.1039/D0DT01240H
20.    Al-Kutubi H, et al. Electrosynthesis of metal-organic frameworks: challenges and opportunities. ChemElectroChem. 2015;2(4):462-74. https://doi.org/10.1002/celc.201402429
21.    Son WJ, Kim J, Kim J, Ahn WS. Sonochemical synthesis of MOF-5. Chem Commun. 2008;(47):6336-8. https://doi.org/10.1039/b814740j
22.    Wang Y, et al. Microwave hydrothermally synthesized metal-organic framework-5 derived C-doped ZnO with enhanced photocatalytic degradation of rhodamine B. Langmuir. 2020;36(33):9658-67. https://doi.org/10.1021/acs.langmuir.0c00395
23.    Ribeiro EL, et al. Laser-induced synthesis of ZIF-67: a facile approach for the fabrication of crystalline MOFs with tailored size and geometry. Mater Chem Front. 2019;3:1302-9. https://doi.org/10.1039/C8QM00671G
24.    Haider A, et al. Recent advances in the synthesis, functionalization and biomedical applications of hydroxyapatite: a review. RSC Adv. 2017;7:7442-58. https://doi.org/10.1039/C6RA26124H
25.    Balasooriya IL, et al. Applications of nano hydroxyapatite as adsorbents: A review. Nanomaterials. 2022;12(14):2324. https://doi.org/10.3390/nano12142324
26.    Halim NAA, Hussein MZ, Kandar MK. Nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery. Int J Nanomedicine. 2021;16:6477-96. https://doi.org/10.2147/IJN.S298936
27.    Larsson DGJ, Flach CF. Antibiotic resistance in the environment. Nat Rev Microbiol. 2022;20:257-69. https://doi.org/10.1038/s41579-021-00649-x
28.    Kraemer SA, Ramachandran A, Perron GG. Antibiotic pollution in the environment: From microbial ecology to public policy. Microorganisms. 2019;7(6):180. https://doi.org/10.3390/microorganisms7060180
29.    Gopal G, et al. A review on tetracycline removal from aqueous systems by advanced treatment techniques. RSC Adv. 2020;10:27081-95. https://doi.org/10.1039/D0RA04264A
30.    Eniola JO, Kumar R, Barakat MA. Adsorptive removal of antibiotics from water over natural and modified adsorbents. Environ Sci Pollut Res Int. 2019;26:34775-88. https://doi.org/10.1007/s11356-019-06641-6
31.    Ferchichi K, et al. Low-cost posidonia oceanica bio-adsorbent for efficient removal of antibiotic oxytetracycline from water. Environ Sci Pollut Res Int. 2022;29(55):83112-25. https://doi.org/10.1007/s11356-022-21647-3
32.    Swapna Priya S, Radha KV. A review on the adsorption studies of tetracycline onto various types of adsorbents. Chem Eng Commun. 2017;204(8):821-39. https://doi.org/10.1080/00986445.2015.1065820
33.    Malakootian M, Yaseri M, Faraji M. Removal of antibiotics from aqueous solutions by nanoparticles: a systematic review and meta-analysis. Environ Sci Pollut Res Int. 2019;26(9):8444-58. https://doi.org/10.1007/s11356-019-04227-w
34.    Debnath B, et al. The effective adsorption of tetracycline onto zirconia nanoparticles synthesized by novel microbial green technology. J Environ Manage. 2020;261:110235. https://doi.org/10.1016/j.jenvman.2020.110235
35.    Althumayri K, et al. Enhanced adsorption and evaluation of tetracycline removal in an aquatic system by modified silica nanotubes. ACS Omega. 2023;8(7):6762-77. https://doi.org/10.1021/acsomega.2c07377
36.    Yang J, et al. Effectively removing tetracycline from water by nanoarchitecture carbons derived from CO2: Structure and surface chemistry influence. Environ Res. 2021;195:110883. https://doi.org/10.1016/j.envres.2021.110883
37.    Yu F, Ma J, Han S. Adsorption of tetracycline from aqueous solutions onto multi-walled carbon nanotubes with different oxygen contents. Sci Rep. 2014;4:5326. https://doi.org/10.1038/srep05326
38.    Lu L, et al. Effective removal of tetracycline antibiotics from wastewater using practically applicable iron(III)-loaded cellulose nanofibers. R Soc Open Sci. 2021;8:210336. https://doi.org/10.1098/rsos.210336
39.    Abbasnia A, et al. Removal of tetracycline antibiotics by adsorption and photocatalytic-degradation processes in aqueous solutions using metal organic frameworks (MOFs): A systematic review. Inorg Chem Commun. 2022;145:109959. https://doi.org/10.1016/j.inoche.2022.109959
40.    Beiranvand M, Farhadi S, Mohammadi-Gholami A. Adsorptive removal of tetracycline and ciprofloxacin drugs from water by using a magnetic rod-like hydroxyapatite and MIL-101(Fe) metal-organic framework nanocomposite. RSC Adv. 2022;12(53):34438-53. https://doi.org/10.1039/D2RA06213E
41.    Oliveira C, et al. Zinc (II) modified hydroxyapatites for tetracycline removal: Zn (II) doping or ZnO deposition and their influence in the adsorption. Polyhedron. 2021;194:114879. https://doi.org/10.1016/j.poly.2020.114879
42.    Ersan M, et al. Synthesis of hydroxyapatite/clay and hydroxyapatite/pumice composites for tetracycline removal from aqueous solutions. Process Saf Environ Prot. 2015;96:22-32. https://doi.org/10.1016/j.psep.2015.04.001
43.    Motakef-Kazemi N, Asadi A. Methylene blue adsorption from aqueous solution using Zn2(Bdc)2(Dabco) metal-organic framework and its polyurethane nanocomposite. Iran J Chem Chem Eng. 2022;41(12):3950-62.
44.    Gheisari H, Karamian E, Abdellahi M. A novel hydroxyapatite-Hardystonite nanocomposite ceramic. Ceram Int. 2015;41(4):5967-75. https://doi.org/10.1016/j.ceramint.2015.01.033
45.    Rahmani F, et al. Synthesis of Zn2(BDC)2(DABCO) metal-organic framework and its polyethylene glycol composite for acetaminophen delivery. Iran J Sci. 2024;48:397-407. https://doi.org/10.1007/s40995-023-01544-1
46.    Wei F, et al. The application of bimetallic metal-organic frameworks for antibiotics adsorption. J Saudi Chem Soc. 2022;26(6):101562. https://doi.org/10.1016/j.jscs.2022.101562
47.    Ghourchian F, et al. Zn-based MOF-chitosan-Fe3O4 nanocomposite as an effective nano-catalyst for azo dye degradation. J Environ Chem Eng. 2021;9(6):106388. https://doi.org/10.1016/j.jece.2021.106388
Nanomedicine Research Journal
Volume 9, Issue 4
Autumn 2024
Pages 393-401